by Abbas Ishaq  and Gabriele Saretzki

Received: 13 April 2022;  Published: 05 July 2022;  doi: 10.21926/rpn.2203016

Accumulating evidence demonstrates that senescence and the associated inflammatory phenotype (SASP) also occur in post-mitotic cells such as mature adipocytes. Visceral adipose tissue in humans is susceptible to inflammation due to nutritional imbalance and ageing. However, while adipose tissue has been well researched in the context of obesity, senescence of differentiated adipocytes has not been investigated thoroughly. Our group recently demonstrated that ageing and normal ad libitum (AL) nutrition in mice resul [...]

by Alejandro Ochoa-Ramirez  , Evelyn M. Kuhn  , Jitsupa Sirinit  and Theresa A. Mikhailov

Received: 11 October 2021;  Published: 26 January 2022;  doi: 10.21926/obm.icm.2201003

Many clinical, biochemical, and anthropometric factors have been used to determine the nutritional status of critically ill children. One of the most commonly used anthropometric measurements in children is the head circumference. It is used to assess their development, and in some instances, can be an indicator of chronic malnutrition. We aim to study the association between head circumference and the nutritional status of critically ill children under 2 years old. We retrospectively obtained the head circumferenc [...]

by Stephanie Brown  , Catherine L Wall  , Chris Frampton  , Richard B Gearry  and Andrew S Day

Received: 11 February 2023;  Published: 29 June 2023;  doi: 10.21926/rpn.2302009

The low FODMAP diet (LFD) is a dietary intervention developed for and used particularly for the management of functional GI symptoms (FGIS) in adults with irritable bowel syndrome (IBS). It has also been proposed to improve coincident functional gut symptoms in adults with inflammatory bowel disease (IBD). This report describes the outcomes of the LFD in a series of children with IBD with concurrent FGIS. This study included children aged between 7-14 years with quiescent IBD and overlapping FGIS. All participants [...]

by Katia Belvedere  , Elio Rossi  , Mariella Di Stefano  and Sonia Baccetti

Received: 22 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.icm.1902022

Complementary Medicine (CM) is being increasingly used by European citizens in order to increase their overall state of health and well-being, as well as to treat various illnesses and diseases. The interest for these therapies has progressively risen also in Italy and in Tuscany as well. In response to the increasing demand in the past few years by the Tuscan citizens, the region of Tuscany has started their integration in the healthcare service. Since 1996, the Tuscan Regional Healthcare Plans (RHPs) have been co [...]

by Yassamine Bentata

Received: 24 January 2024;  Published: 25 July 2024;  doi: 10.21926/obm.transplant.2403221

Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy (BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a significant and severe viral complication in kidney transplantation (KT). More than twenty years after Gardner's discovery of BKv in 1971, Purighalla described, in 1995, the first case of BKvN. Four years later in 1999, Nickeleit et al. published a first series of five cases of BKvN and made very precious and pertinent contributions to understanding t [...]

by Melita Vidakovic  , Jessica Marinello  , Maija Lahtela-Kakkonen  , Daumantas Matulis  , Vaida Linkuvienė  , Benoît Y. Michel  , Ruta Navakauskiene  , Michael S. Christodoulou  , Danielle Passarella  , Saulius Klimasauskas  , Christophe Blanquart  , Muriel Cuendet  , Judit Ovadi  , Stéphane Poulain  , Fabien Fontaine-Vive  , Alain Burger  and Nadine Martinet

Received: 30 May 2018;  Published: 16 August 2018;  doi: 10.21926/obm.genet.1803029

Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic activities. In this study, we screened a small natural compound library for epigenetic activities. Methods: Seventy-one different natural products plus 17 controls collected from all collaborating laboratories were screened. Localized DNA methylation (DNAm) was studied on a stretch of the retinoic a [...]

by Alexandra Rose  , Max Tupper  and Chris Irons

Received: 15 November 2022;  Published: 17 February 2023;  doi: 10.21926/obm.icm.2301015

An individual’s wellbeing at work is now recognised as key, particularly for those in challenging environment’s such as health and social care. Focusing on the cultivation of (mindful) compassion has been shown to be an effective way of improving mental health. This service evaluation focused on a pilot drop-in group for council and NHS staff, informed by Compassionate Mind Training. It was facilitated during the COVID-19 pandemic, between April – August 2020. The group was evaluated by recording the number and cha [...]

by Phil Ayers  , Megan Harlow  and LeAnn Scott

Received: 30 December 2021;  Published: 15 February 2022;  doi: 10.21926/rpn.2201002

Parenteral nutrition (PN) is a complex medication administered to adult, pediatric, and neonatal patients. PN is recognized as a high-alert medication by the Institute for Safe Medication Practices (ISMP). The American Society for Parenteral and Enteral Nutrition (ASPEN) has published several key recommendations regarding safe use of PN. This manuscript will review several of the important PN papers published in 2020-2021 by ASPEN.

by Eli Cwinn  , Tobyn Bell  and James Kirby

Received: 20 August 2023;  Published: 29 November 2023;  doi: 10.21926/obm.icm.2304056

This paper reviews key theories underlying the interpersonal process in Compassion Focused Therapy (CFT) and links these to purported mechanisms of action in CFT. The paper goes on to provide a concrete practice example of an exampled dialogue between a clinician and client and narrates the interpersonal processes and mechanisms of action in an attempt to elucidate how interpersonal processes can be leveraged to facilitate therapeutic change. In so doing, this paper seeks to advance scholarship on precise mechanism [...]

by Gina Sizemore  , Brandon Lucke-Wold  , Charles Rosen  , James W. Simpkins  , Sanjay Bhatia  and Dandan Sun

Received: 12 January 2018;  Published: 31 May 2018;  doi: 10.21926/obm.neurobiol.1802009

The brain is an integrated network of multiple variables that when compromised create a diseased state. The neuropathology of temporal lobe epilepsy (TLE), stroke, and traumatic brain injury (TBI) demonstrate both similarity and complexity that reflects this integrated variability; TLE with its live human tissue resection provides opportunity for translational science to demonstrate scale equivalent experimentation between the macroscopic world of clinical disease and the microscopic world of basic science. The ext [...]