by Walter Paganin

Received: 30 July 2025;  Published: 27 January 2026;  doi: 10.21926/obm.neurobiol.2601321

Difficult-to-treat depression (DTD) with inflammatory features (e.g., hs-CRP ≥3 mg/L and/or elevated IL-6) may represent a clinically and biologically distinct presentation characterized by chronicity, functional impairment, prominent cognitive-motivational symptoms, and suboptimal response to conventional treatments. Classical anti-inflammatory strategies (e.g., COX-2 inhibitors or cytokine-targeting biologics) have shown signals of efficacy in selected biomarker-enriched subgroups; however, overall evidence remai [...]

by Jennifer Vasquez  and April C. Bowie-Viverette

Received: 25 July 2025;  Published: 04 January 2026;  doi: 10.21926/obm.icm.2601001

Research shows that trauma therapists often experience secondary trauma, which can lead to secondary traumatic stress, compassion fatigue, and burnout. Trauma-informed care training has shown promise in enhancing practitioners' professional quality of life, particularly for those regularly exposed to trauma. To our knowledge, no prior studies have examined the training outcomes of NeuroAffective Relational Model (NARM) therapists on professional quality-of-life indicators. This cross-sectional observational study a [...]

by Mahintaj Dara  , Negar Azarpira  , Nasrin Motazedian  , Mahdokht Hossein-Aghdaie  , Seyed-Mohsen Dehghani  , Bita Geramizadeh  and Elaheh Esfandiari

Received: 24 May 2025;  Published: 26 November 2025;  doi: 10.21926/obm.genet.2504319

Biliary atresia (BA), a severe pediatric liver disease of unknown etiology, causes neonatal jaundice, progressive cholestasis, and life-threatening liver fibrosis. Emerging evidence suggests microRNAs (miRNAs) – small non-coding RNAs that regulate gene expression by binding target mRNAs may play a role in BA pathogenesis. Circulating miRNAs have shown diagnostic potential for various diseases, prompting our investigation of miR-21 and miR-19 as potential biomarkers in BA. We conducted a case-control study comparing [...]

by Irina G. Udina  , Marina A. Gubina  and Alesya S. Gracheva

Received: 04 June 2025;  Published: 12 January 2026;  doi: 10.21926/obm.genet.2601324

The purpose of the study was to consider the distribution of Y-chromosome DNA markers in samples from the populations of the three largest megalopolises (Moscow, Saint Petersburg, and Novosibirsk) in the Russian Federation, in the context of developing genetic databases. The study aimed to compare the frequency profiles of 18 Y-chromosome STRs (Short tandem repeats) and the level of genetic differentiation. Based on FST estimates for the distribution of these 18 Y-chromosome STRs, the senior generations of Moscow a [...]

by Vikash Chandra Mishra  , Dinesh Chandra  and Vimarsh Raina

Received: 15 July 2025;  Published: 25 November 2025;  doi: 10.21926/obm.transplant.2504260

Though the role of clinical histocompatibility testing is fundamental to successful transplant, systematic risk assessment and mitigation strategies remain underutilised in this domain. This review addresses risk identification, analysis, and control measures across the pre-analytical, analytical, and post-analytical phases of clinical histocompatibility testing, in line with international standards such as ISO 15189:2022. A structured, risk-based quality management system (QMS) is imperative for ensuring accurate [...]

by Adel Razek

Received: 07 October 2025;  Published: 17 December 2025;  doi: 10.21926/rpse.2504017

A relevant objective of managing an electromagnetic (EM) device is to improve its expected results and reduce its undesirable side effects. In this context, this paper aims to evaluate the interest of the two One Health and Responsible Attitude methods in the daily practice of wireless transmission (or transfer) in EM energy devices. These approaches are respectively linked to device eco-design and optimization, as well as to the protection of biodiversity and ecosystems against device side effects related to EM fi [...]

by Uchechukwu Nwaiwu  , Fan He  , Matthew Leach  and Lirong Liu

Received: 31 July 2025;  Published: 12 January 2026;  doi: 10.21926/jept.2601002

Increasing local energy access in developing countries, particularly in off-grid regions where mini-grids are often overloaded, remains a critically underexplored area in energy transition. These regions often face significant technical and economic challenges, such as low generation capacity, high energy costs, limited energy access, and heavy reliance on diesel fuels. This study explores capacity expansion by integrating small-scale geothermal energy into such a mini-grid system to enhance the local energy supply [...]

by Oteja Lightheart  and Helané Wahbeh

Received: 09 August 2025;  Published: 07 January 2026;  doi: 10.21926/obm.icm.2601004

Older adults in the U.S. have higher rates of depression, stress, and chronic diseases. There is an urgent need for effective interventions to reduce depressive symptoms and enhance overall health and well-being. Meditation presents an appealing therapeutic option due to its cost-effectiveness, minimal risks, ease of use, and active patient involvement, with growing evidence indicating its effectiveness in reducing depressive symptoms. Online platforms may provide more accessible options for meditation intervention [...]

by Hanuman Singh Jatav

Received: 21 December 2025;  Published: 24 December 2025;  doi: 10.21926/aeer.2504035

The rising concerns of soil erosion, organic waste generation and global warming have shown the need to address them through multifaceted methods that transcend conventional linear models of resource utilization. Circular economy is a regenerative model that is anchored on caring about waste valorisation, resource effectiveness and environmental fortitude. In this paradigm, biochar has been developed as a multifunctional compound capable of integrating waste management, soil rehabilitation, climate control and rene [...]

by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Ali Reza Modarresi-Alam  and Mohammad Hasan Mohammadi

Received: 03 May 2025;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601318

The study explores the crucial biological function of nitrogen in cyclic and acyclic structures with resonance potential, including tetrazoles, pyrroles, piperidines, and carbamates, within the realm of chemical neuroscience. It highlights the importance of these compounds for their biological properties and their ability to cross the blood-brain barrier (BBB) to reach the central nervous system (CNS). The study emphasizes the necessity for neurochemical drugs, like morphine, to effectively cross the BBB, as modifi [...]