by Manal Hadi Ghaffoori Kanaan  , Beom-Jin Lee  , Sura Saad Abdullah  , Chulhun Park  , Abdolmajid Ghasemian  and Steward Mudenda

Received: 10 October 2025;  Published: 14 January 2026;  doi: 10.21926/obm.genet.2601325

Stem cell-derived exosomes (SDEs) have emerged as revolutionary mediators in cancer immunotherapy, offering unprecedented potential to reprogram the immunosuppressive tumor immune microenvironment (TIME). These nano-sized extracellular vesicles, laden with non-coding RNAs (ncRNAs), serve as natural biocompatible carriers, capable of orchestrating immune cell dynamics, stromal remodeling, and tumor cell fate. Unlike their tumor-derived counterparts, which often propagate oncogenic signals, SDEs uniquely harbor immun [...]

by Marcella Anggatama  , Hanggoro Tri Rinonce  , Dwinanda Almira Rizkiani  , Eddy Supriyadi  , Raden Roro Rini Andayani  , Yohanes Widodo Wirohadidjojo  and Retno Danarti

Received: 26 October 2025;  Published: 11 December 2025;  doi: 10.21926/obm.genet.2504320

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by early-onset poikiloderma and multisystem abnormalities. Diagnosis is often confirmed through genetic testing, but in many resource-limited settings, molecular studies are unavailable, necessitating reliance on clinical and histopathological evaluation. We report a 1-year-old boy referred for assessment of progressive pigmented skin lesions. The patient was referred by a pediatrician with febrile neutropenia, bicytopenia suspicio [...]

by Mosebetsi J. Leotlela

Received: 21 April 2025;  Published: 19 December 2025;  doi: 10.21926/jept.2504018

The effective neutron multiplication factor (keff) of a fissile system is a function of space and time f(x, y, z, t), where (x, y, z) are the coordinates of the reference point in space, and t is time. The evidence of the time-dependence of the neutron multiplication factor of a fissile system was published in 2017. The spatial dependence is as important as the time dependence, as interacting arrays of fissile material during storage can lead to an increase in the system (keff). Therefore, evaluation of how the sto [...]

by Ola A. E. Mohamed  and Ibtisam E. M. El Zubeir

Received: 30 July 2025;  Published: 22 December 2025;  doi: 10.21926/rpn.2504026

This study was conducted to process frozen yoghurt (FY) from camel milk (CM) flavored with either 5% or 8% banana (B) or dates (D). The mix of FY consists of stirred yoghurt, sugar, Gum Arabic, and banana (Musa lutea) or dates (Phoenix dactylifera). The mix was divided into 4 portions and then each mix was sub-derived into an ice-cream machine and then packed into plastic cups that were stored at -18°C for 5 weeks. The chemical composition and sensory evaluation were conducted weekly. The chemical composition of FY [...]

by Zekeriya Temircan

Received: 09 March 2025;  Published: 31 December 2025;  doi: 10.21926/obm.neurobiol.2504316

This study aimed to examine the psychological flexibility of individuals diagnosed with borderline personality disorder (BPD) compared to healthy controls. Psychological flexibility is a key construct related to mental health and adaptive functioning, and understanding its levels in BPD can provide insight into symptom severity and treatment outcomes. The study included 58 individuals diagnosed with BPD and 62 healthy volunteer controls, all meeting specific inclusion and exclusion criteria. Participants completed [...]

by Orlando N. Guiñazú  , Edgar M. Sánchez Faba  , Griselda A. Eimer  , Laura E. Moyano  and Horacio Falcón

Received: 15 October 2025;  Published: 12 January 2026;  doi: 10.21926/cr.2601002

Pyrolysis is a promising technology for converting biomass waste into bio-oil, a liquid product that can serve as feedstock for fuels and high-value chemicals. In this study, bio-oil was produced via catalytic pyrolysis of pear pulp waste, a byproduct from juice and jam manufacturing, using a fixed-bed reactor. Initial non-catalytic experiments were conducted under nitrogen and vacuum atmospheres at temperatures ranging from 300 to 450°C for 15 minutes to evaluate the effect of temperature on bio-oil yield. The res [...]

by Mojtaba Ehsanifar  , Akram Gholami  , Nioosha Pahnavar  , Reyhaneh Shenasi  and Maryam Golmohammadi

Received: 27 October 2025;  Published: 09 February 2026;  doi: 10.21926/obm.neurobiol.2601322

Mycotoxins, toxic secondary metabolites produced by fungi and molds, have negative health impacts on both humans and animals. They are commonly found in foods such as nuts, coffee, cereals, and grains, particularly in regions with warm, humid climates. Among the most prevalent mycotoxins in these foods are aflatoxin B1, ochratoxin A, zearalenone, patulin, and deoxynivalenol (DON). The presence of mold capable of producing mycotoxins within food contributes to an elevated risk of various illnesses, including those r [...]

by Chawannuch Ruaengsri  , Marc Leon  , Miguel Alvarez-Cortes  , Manuel Quiroz-Flores  and Yasuhiro Shudo

Received: 30 June 2025;  Published: 21 January 2026;  doi: 10.21926/obm.transplant.2601264

To address the pressing shortage of donor lungs, Donation after Circulatory Death (DCD) transplantation has become a vital strategy for expanding the donor pool. Minimizing warm ischemic injury is crucial for optimizing organ viability and function. This review synthesizes current evidence on Normothermic Regional Perfusion (NRP) and Ex-Vivo Lung Perfusion (EVLP) in DCD lung transplantation. Analysis reveals their growing efficacy in minimizing ischemic damage, facilitating organ assessment, and expanding the trans [...]

by Rustam Nailevich Mustafin

Received: 29 September 2025;  Published: 08 January 2026;  doi: 10.21926/obm.genet.2601323

Tuberous sclerosis (TS) is one of the most common hereditary tumor syndromes, occurring with an average incidence of 1 in 9,000 newborns worldwide. The disease manifests itself through the development of tumors of the brain, kidneys, heart, lungs, and skin, along with characteristic depigmented spots. Tuberous sclerosis is caused by germline variants in the TSC1 (encoding hamartin) and TSC2 (encoding tuberin) genes. The hamartin-tuberin protein complex, together with the TBC1D7 molecule, inhibits the serine/threoni [...]

by María Montero-López Lena  , Livia Sánchez Carrasco  and Montserrat Celdrán Castro

Received: 20 June 2025;  Published: 17 December 2025;  doi: 10.21926/obm.geriatr.2504332

This study aimed to evaluate the psychometric properties of the Family Inclusion Scale (FIS) for administration to adults and older Mexican adults. To this end, a questionnaire was structured with scales to evaluate family inclusion, loneliness, and perceived stress; the last two scales were previously validated. The sample (n = 347) consisted of young university adults aged 20 to 24 years and their grandparents aged 60 years. The conceptual emphasis of the Family Inclusion Scale generated was the identification of [...]