Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future Directions
Abstract
508 2975
Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future DirectionsAbstract
The cartilage is avascular and has limited regenerative capacity, posing a significant clinical challenge. Conventional treatments often do not restore hyaline cartilage, leading to progressive osteoarthritis. Recent advances in tissue engineering have focused on integrating biomaterials, stem cells, growth factors, and gene-delivery approaches. In addition, in vivo models serve as critical platforms for translational validation. Biomaterial scaffolds, including polycaprolactone, silk fibroin, chitosan, and composi [...] 508 2975 |
Sleep and Mood as Mechanisms Linking Trauma Exposure to Alcohol Use in South African First Responders: A Serial Mediation AnalysisAbstract
First responders are routinely exposed to traumatic events in the line of duty, placing them at heightened risk for adverse mental health outcomes, including substance use. This study investigated the psychological mechanisms linking trauma exposure to alcohol use, specifically examining the serial mediating roles of insomnia and depression. A sample of 429 first responders (309 police officers and 120 paramedics) from the Western Cape, South Africa, completed an online survey comprising the Life Events Checklist-5 [...] 736 2937 |
Environmental Risk Assessment of Antiretrovirals Consumed in Belo Horizonte, BrazilAbstract
The development and utilization of pharmaceuticals, notably antiretrovirals (ARVs), have significantly enhanced both human quality of life and life expectancy. Nevertheless, the excretion of these compounds into aquatic environments, often exacerbated by inadequate sanitation infrastructure, poses considerable risks to biota. This investigation evaluated the environmental impact of 14 ARVs consumed within the municipality of Belo Horizonte (BH), Brazil. The assessment employed the Environmental Risk Assessment (ERA [...] 975 2919 |
Technology Support to Enable People with Severe Intellectual Disability and Blindness to Carry Out Occupational Activities and Transition Between Them Independentlyby
Abstract
People with severe intellectual disability and blindness tend to perform only simple occupational activities and are mostly unable to transition between those activities. This inability makes their level of occupation independent of staff support fairly limited. Technology-aided programs may be one of the few opportunities available to increase their independent occupation. This study assessed one such program designed to (a) monitor the participants’ responses and guide them to transition to a new activity once th [...] 743 2901 |
Cultural Distance, Host Acculturation Orientation, and Psychological Adaptation among African International Students at Portuguese Universitiesby
Abstract
International students represent a significant sojourner group. Increasing international student numbers makes it ever more relevant to understand the determinants of their psychological adaptation. This research investigates the question of how perceived cultural distance (PCD) impacts acculturation variables (social contact with host nationals and host national identity) and outcomes such as saudade and life satisfaction among African international students. The sample comprised 422 college students (195 from Ang [...] 613 2900 |
Immunologic Response after COVID-19 Vaccination in Heart Transplant Recipientsby
Abstract
To date, all large-scale randomized controlled trials for COVID-19 vaccines have excluded solid organ transplant recipients; therefore, the effectiveness and safety of COVID-19 vaccines in preventing coronavirus infection using COVID-19 vaccines in patients with heart transplants have not been sufficiently studied. This paper presents the characteristics of humoral and cellular immunity in heart transplant recipients following vaccination against coronavirus infection. The study group consisted of 40 patients who u [...] 696 2894 |
Biochar and Circular Economy Approaches in Environmental SustainabilityAbstract
The rising concerns of soil erosion, organic waste generation and global warming have shown the need to address them through multifaceted methods that transcend conventional linear models of resource utilization. Circular economy is a regenerative model that is anchored on caring about waste valorisation, resource effectiveness and environmental fortitude. In this paradigm, biochar has been developed as a multifunctional compound capable of integrating waste management, soil rehabilitation, climate control and rene [...] 983 2868 |
Wind Turbine Tower Structural and Cost Optimisation within Acceptable Structural Integrityby
Abstract
As the demand for cleaner-greener energy surges owing to more nations adopting Net Zero Emission by 2050, wind turbine (WT) technology is increasingly poised as one of the technologies to match the demand. Capacity building in the development of cost-effective WT tower with improved reliability and safety has become critical to delivering Net Zero mandate. This research demonstrates implementation of Taguchi Design of Experiment (DoE) in conjunction with Signal-to-noise ratio (S/N) to optimise both structural desig [...] 796 2852 |
Integrated Evaluation of Electric Submersible Pump Failures under Diverse Field Operating ConditionsAbstract
Electrical submersible pumps (ESPs) are an efficient and reliable artificial lift method for lifting large volumes of fluids from wellbores at flexible rates. Despite their advantages, including high flow rates and real-time downhole telemetry, ESPs are prone to frequent and unforeseen failures under harsh reservoir conditions, resulting in costly production delays and interventions. This paper presents an integrated evaluation of ESP failure mechanisms based on an analysis of run and pull reports, dismantle inspec [...] 1042 2847 |
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