by Daniel Szoke  and Holly Hazlett-Stevens

Received: 17 June 2025;  Published: 09 October 2025;  doi: 10.21926/obm.icm.2504042

Chronic stress increases a person’s vulnerability for physical and mental health conditions that take root in the “common soil” of inflammation. Dispositional, or trait, mindfulness has been identified as a protective factor against perceived stress. However, the theory that trait mindfulness can prospectively predict lower perceived stress in natural settings has yet to be thoroughly tested. The current study used a daily diary prospective design to observe perceived stress in response to difficult events. Partici [...]

by Gerhard Litscher

Received: 08 December 2025;  Published: 09 December 2025;  doi: 10.21926/obm.icm.2504053

Acupuncture has become an increasingly relevant complementary modality in modern gynecology and assisted reproduction. Its uses include the management of menstrual disorders, menopausal symptoms, infertility, polycystic ovary syndrome (PCOS), endometriosis, and others. Scientific progress in neurophysiology, laser acupuncture, and biomedical imaging has enabled a deeper understanding of the central and peripheral mechanisms underlying acupuncture’s effects. This editorial summarizes current evidence regarding physi [...]

by Dominique Huvent-Grelle  , Victoire Leroy  , Mikael Horvath  , Laurence Grymonprez  , David Faucomprez  and François Puisieux

Received: 23 May 2025;  Published: 10 October 2025;  doi: 10.21926/obm.geriatr.2504328

Caring for patients with neurocognitive disorders (NCD) can be challenging for caregivers, with the risk of malnutrition. Observational, retrospective, monocentric study carried out with patient-caregiver dyads admitted to the Memory Day Hospital of the Gerontology Center of the University Hospital of Lille over 6 months in 2023. Our objectives were to identify the socio-characteristics of caregivers who had recently experienced a variation in their weight, their degree of fatigue (using the Fatigue Numerical Ratin [...]

by Tyrone Pretorius  and Anita Padmanabhanunni

Received: 15 June 2025;  Published: 14 November 2025;  doi: 10.21926/obm.neurobiol.2504308

First responders are routinely exposed to traumatic events in the line of duty, placing them at heightened risk for adverse mental health outcomes, including substance use. This study investigated the psychological mechanisms linking trauma exposure to alcohol use, specifically examining the serial mediating roles of insomnia and depression. A sample of 429 first responders (309 police officers and 120 paramedics) from the Western Cape, South Africa, completed an online survey comprising the Life Events Checklist-5 [...]

by Garzain Bint e Attar  and Mohd. Ashif Khan

Received: 15 May 2025;  Published: 31 December 2025;  doi: 10.21926/obm.transplant.2504262

Bone grafting remains a cornerstone technique in orthopedic and reconstructive surgery, yet achieving successful graft integration continues to pose significant challenges, particularly in conditions such as osteoporosis, diabetes mellitus, and large bone defects. Traditional graft materials such as autografts, allografts, xenografts, and synthetics, often encounter limitations including immune rejection, poor vascularization, and insufficient osteogenic support. Emerging pharmacological strategies have shown promi [...]

by Mohammad Azimi Tabas  , Maryam Kazerani  , Azam Shahbodaghi  and Reza Taherian

Received: 24 June 2025;  Published: 19 November 2025;  doi: 10.21926/obm.neurobiol.2504311

The widespread use of social media among college students has become a significant concern due to its potential impact on mental health and addictive behaviors. Social media platforms, while offering numerous benefits, can also foster environments that contribute to addiction, depression, and anxiety. College students, in particular, are vulnerable to these effects due to their high levels of social media engagement and the pressures of academic life. Mental health literacy, which involves understanding and managin [...]

by Brandi M. Crowe  , Karen Kemper  and Marieke Van Puymbroeck

Received: 11 June 2025;  Published: 05 November 2025;  doi: 10.21926/obm.geriatr.2504330

Falls and fall-related injuries are one of the leading causes of death among older adults aged 65+ in the United States. Americans’ life expectancy has increased and fall risk grows with age. While several evidence-based fall prevention programs are utilized to decrease fall risk among community-dwelling older adults, little research focuses on challenges or strategies related to sustained fall prevention program implementation. The purpose of this multi-method descriptive study was to assess fall risk outcome chan [...]

by Poppy L.A. Schoenberg

Received: 26 May 2025;  Published: 26 November 2025;  doi: 10.21926/obm.icm.2504050

Legacy, profit-driven organizational structures often lack the adaptability, equity, and innovation required for the evolving complexities of contemporary patient-centered care. They can limit access, constrain options, impose financial burdens, and hinder optimized delivery. Here, we propose a new architecture for metaversal integrative healthcare using decentralized autonomous organizations (DAOs). Blockchain technology and smart contracts underpin equitable, transparent, and resilient health ecosystems beyond in [...]

by Giustino Varrassi  , Matteo Luigi Giuseppe Leoni  , Giacomo Farì  , Annalisa Caruso  , Ameen Abdulhasan Al-Alwany  , Marco Mercieri  , Joseph V. Pergolizzi  and Rocìo Guillen

Received: 10 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.neurobiol.2504315

Chronic cancer pain results from the complex interaction of nociceptive, neuropathic, and neuroimmune mechanisms, which vary according to tumor type, location, stage, and treatment history. Recent advances in cancer neuroscience have reframed pain as a dynamic manifestation of reciprocal tumor–nerve–immune interactions, rather than a mere consequence of tissue damage. In this model, malignant, stromal, and immune cells remodel nociceptive circuits at peripheral and central levels. This narrative review, conducted i [...]

by Recai Aci  , Adem Keskin  , Özlem Sezer  , Taner Karakaya  , Samet Semiz  and Melek Bilgin

Received: 01 October 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504318

This study investigated three novel complete blood count–derived inflammatory biomarkers Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Pan-Immune-Inflammation Value (PIV) and their relationship with clinical features of Behçet’s Disease (BD). Established markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were also analyzed. Seventy HLA-B51–positive BD patients and 114 HLA-B51–negative healt [...]