by Amy J Hopper  and Angus M Brown

Received: 19 May 2024;  Published: 17 March 2025;  doi: 10.21926/obm.neurobiol.2501278

The legacy of Hodgkin and Huxley rests on their squid giant axon studies, which were summarised in an empirical model of impressive predictive power that successfully quantified the permeability changes of excitable membranes and accurately reconstructed the action potential. Hodgkin and Huxley applied the independence principle to their experimental data in order to reveal potential mechanism(s) of trans-membrane ion movements. This was motivated by their lack of information on the manner in which ions crossed the [...]

by Lucia Urbanová  , Silvia Farkasova  , Ivana Speváková  , Matúš Kyseľ  , Veronika Šimora  , Miroslava Kacaniova  and Jana Žiarovská

Received: 21 May 2024;  Published: 26 September 2024;  doi: 10.21926/obm.genet.2403263

Medicinal plants have been a part of human life from a very early age. In the field of plant genetics, they are still widely investigated for their genomic variability. This study used two DNA marker techniques to obtain polymorphic profiles in selected species from Lamiaceae. Both are based on the variability of plant genes that code for allergens - BBAP (Bet v 1-Based Amplicon Polymorphism) and PBAP (Profilin-Based Amplicon Polymorphism). Variability of Bet v 1 homologues within individual genomes showed similari [...]

by Tessa M. Andermann  , Ke Zeng  , Sayal Guirales-Medrano  , Adam Groth  , Bhanu C. Ramachandran  , Shan Sun  , Alicia A. Sorgen  , Lauren Hill  , Amy T. Bush  , Hongwei Liu  , Corbin Jones  , Jeffrey Roach  , Brian P. Conlon  , Gauri Rao  , Nelson J. Chao  , Anthony A. Fodor  and Anthony D. Sung

Received: 24 April 2025;  Published: 25 August 2025;  doi: 10.21926/obm.transplant.2503255

Home-based hematopoietic stem cell transplantation (HCT) is an innovative care model with growing interest, but its impact on the gut microbiome remains unexplored in a randomized setting. We present interim results from the first randomized controlled trials (RCT) evaluating the effect of HCT location—home versus hospital—on gut microbial diversity and antimicrobial resistance (AMR) gene carriage. We hypothesize that patients randomized to undergo home HCT would have higher gut taxonomic diversity and lower AMR ge [...]

by Nicole E. Mahrer  , Gabrielle R. Rinne  , Christine M. Guardino  , Danielle A. Swales  , Madeleine Ullman Shalowitz  , Sharon Landesman Ramey  and Christine Dunkel Schetter

Received: 02 September 2024;  Published: 04 March 2025;  doi: 10.21926/obm.icm.2501011

Certain observable parenting behaviors contribute to the risk of children developing internalizing and externalizing problems. Yet parenting behaviors do not affect all children uniformly and effects may depend on identifiable child characteristics. One factor is a child’s biological sensitivity to the caregiving environment, an indicator of which is a stress hormone, cortisol. This longitudinal study examines two dimensions of observable parenting behaviors, responsive and rejecting/harsh. These parenting behavior [...]

by Leandro Goulart de Araujo

Received: 25 June 2025;  Published: 27 June 2025;  doi: 10.21926/cr.2502005

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 20 October 2024;  Published: 25 February 2025;  doi: 10.21926/obm.neurobiol.2501271

Brain development (BD) is an important factor. To effectively enhance BD, institutions employ digital tools, technology, and innovative digital competencies to improve students’ entrepreneurial ambitions. The present paper examines the role of digital technology in developing BD among entrepreneurial ambitions in Egypt. The study modes are quantitative and cross-sectional to collect data from the entrepreneurial aspirations of Egyptian universities where business, management, economics, and commerce students [...]

by Robert Marx

Received: 24 April 2024;  Published: 20 August 2024;  doi: 10.21926/obm.icm.2403047

It is an axiomatic in secular mindfulness that to become present is to direct attention away from thinking to physical sensation. While this can be a useful strategy to manage depressive rumination, as an automatic default position, it risks demonising our fundamental human capacity to purposefully think about the causes of suffering and how to reduce it. Many approaches within Mahayana Buddhism in particular explicitly use reflection on key ideas as necessary pre-requisites to meditation, and in these traditions, [...]

by Vladimir A. Trifonov

Received: 21 February 2024;  Published: 09 April 2024;  doi: 10.21926/obm.genet.2402224

This review provides a critical assessment of the content and structure of the recently published book by Dr. Thomas Liehr, 'Small Supernumerary Marker Chromosomes: Basics.'

by Irina Shtangeeva

Received: 24 March 2025;  Published: 08 July 2025;  doi: 10.21926/rpse.2503012

Lanthanum (La) is widely used in various fields. As a consequence, it can accumulate in soil and thus pose a potential hazard to the environment, including a decrease of plant biomass and chlorophyll content. To date, most experimental studies on the biogeochemistry of La have focused on toxic effects resulting from its accumulation in plants growing in La-contaminated areas, while the behavior of La in plants growing in uncontaminated soils has been the subject of much less research. The primary objectives of this [...]

by Shayan Balkhi  , Marie Saghaeian Jazi  , Nader Mansour Samaei  , Nahid Rezaie  and Mahtab Farahmandrad

Received: 14 March 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503301

Glioblastoma (GBM) is the most aggressive primary brain tumor, with a poor prognosis despite advancements in understanding its biology. Melatonin, a key regulator of metabolism and cellular homeostasis, is known for its neuroprotective and anti-cancer properties. While traditionally linked to pineal gland secretion, emerging evidence suggests that glioblastoma cells can produce melatonin within their mitochondria. This study investigates whether serum shock can influence endogenous melatonin production and mitochon [...]