by Kristen R Szempruch  , Alec D Martschenko  , Harendra Arora  , Robert S Isaak  , Ravindra Prasad  , John L Schmitz  , Chuning Liu  , Fei Zou  and Pablo Serrano Rodriguez

Received: 13 February 2023;  Published: 18 April 2023;  doi: 10.21926/obm.transplant.2302181

Fluid management intra- and post-operatively for kidney transplant recipients (KTR) is essential to maintain adequate perfusion to the kidney. 0.9% normal saline (NS) is commonly used, but it can cause hyperchloremic metabolic acidosis, which may result in hyperkalemia and lead to delayed graft function (DGF). Plasma-Lyte A (PA) is an alternative option that has a lower amount of chloride and a neutral pH, which may offset the risk of hyperkalemia. The aim of this study is to determine the incidence of DGF in KTRs [...]

by Upasana Ramphal  , Derek Tshiabuila  , Yajna Ramphal  , Jennifer Giandhari  , Carel van Heerden  , Cheryl Baxter  , Stephanie van Wyk  , Sureshnee Pillay  , Oluwakemi Laguda-Akingba  , Eduan Wilkinson  , Richard Lessells  and Tulio de Oliveira

Received: 01 March 2024;  Published: 30 May 2024;  doi: 10.21926/obm.genet.2402239

During the SARS-CoV-2 pandemic, next-generation sequencing (NGS) technologies like the Ion Torrent S5 and Illumina MiSeq, alongside advanced software, improved genomic surveillance in South Africa. This study analysed anonymized samples from the Eastern Cape using Genome Detective and NextClade, showing Ion Torrent S5 and Illumina MiSeq success rates of 96% and 94%, respectively. The study focused on genomic coverage (above 80%) and mutation detection (below 100), with the Ion Torrent S5 achieving 99% coverage comp [...]

by Omotayo B. Ilesanmi  , Rosephine Enadeghe  , Chinenyenwa U. Aleneme  , Esther F. Adeogun  and Ufuoma J. Okotie

Received: 29 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203135

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and Cd [...]

by Vikas Dhikav  , Pankaj Kumar  and Praveen Kumar Anand

Received: 23 August 2022;  Published: 23 November 2022;  doi: 10.21926/obm.geriatr.2204214

Various grades of cognitive impairment generally occur in older adults over the age of 55, where cardiovascular risk factors such as diabetes and/or hypertension, coronary artery disease, or cerebrovascular accidents are also common. Cognitive impairment occurs in various forms, from mild or amnesia such as forgetting today's date to more ominous and progressive forms, such as frank dementia. Over 5 million people worldwide suffer from dementia, most of whom live in low- and middle-income countries. It has been env [...]

by Jacques De Reuck  , Florent Auger  , Nicolas Durieux  , Claude-Alain Maurage  , Vincent Deramecourt  , Charlotte Cordonnier  , Florence Pasquier  , Didier Leys  and Regis Bordet

Received: 24 September 2020;  Published: 10 December 2020;  doi: 10.21926/obm.geriatr.2004142

The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. The examined post-mortem brains included 30 AD-CAA cases and 20 AD [...]

by S.Amitha Banu  and Khan Sharun

Received: 25 May 2023;  Published: 02 June 2023;  doi: 10.21926/obm.transplant.2302187

Platelet-rich plasma (PRP) is a promising tool in regenerative medicine because it stimulates tissue repair and regeneration. PRP contains a high concentration of platelets, growth factors, and cytokines involved in the healing process. This editorial paper aims to give an overview of PRP in regenerative medicine and its potential applications in various medical fields such as orthopedics, dentistry, dermatology, and wound healing. PRP can be integrated with other regenerative therapies, such as stem cell and gene [...]

by Vincenza Rita Lo Vasco

Received: 27 January 2023;  Published: 05 May 2023;  doi: 10.21926/obm.geriatr.2302234

Illnesses following the degeneration of the nervous system can occur due to aging or genetic mutations and represent a clinical concern. In neurodegenerative diseases, loss of neuronal structure and functions mainly causes cognitive impairment, representing an increasing social burden. In neurodegenerative diseases, the progressive loss of vulnerable populations of neurons in specific regions of the central nervous system was traced to different pathological events, such as misfolded proteins’ accumulation, abnorma [...]

by Rene J. Duquesnoy

Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018

The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes

by Buti Obaid Saeed Alfalahi  , Imane Lamdjad  , Mustafa Alnujaifi  , Noaman Atallah Alheety  and Abdul Qayyum

Received: 05 February 2024;  Published: 12 June 2024;  doi: 10.21926/obm.genet.2402242

Understanding the impact of melatonin (N-acetyl-5-methoxytryptamine) on plant gene expression is crucial for unlocking its full potential as a tool for crop improvement and stress tolerance. Melatonin has emerged to have several influences on the transcriptional activity of numerous genes, helping to orchestrate plant responses to environmental cues. Furthermore, it has been shown that melatonin signaling pathways control downstream gene expression to ensure proper plant growth and development. Therefore, clearing [...]

by Michael D. Owens  and Megan Halliday

Received: 24 December 2020;  Published: 30 August 2021;  doi: 10.21926/obm.icm.2103025

The coronavirus (COVID-19) pandemic continues to bring challenges in identification and management of which the “happy hypoxic” or silent hypoxia presentation has been found to present its own unique challenge. A 67-year-old African American COVID-19 positive female presents to the emergency department (ED) with a chief complaint of decreased oral intake and responsiveness, oriented and stable, with oxygen saturations found to drop as low as 47%. The patient was successfully managed with supplemental oxygen and det [...]