by Katarina Tomulic Brusich

Received: 30 August 2022;  Published: 15 November 2022;  doi: 10.21926/obm.transplant.2204169

Transplantation is a widely accepted and successful life-saving treatment for hundreds of thousands of patients. However, transplant medicine still faces a number of obstacles. One of the most significant is the large disparity between the number of donors and recipients and the growing need for re-transplantation. In the last two decades, the improvement and organization of the national transplantation program in Croatia have resulted in a steadily increasing donor rate and therefore the transplantation numbers. A [...]

by OBM Geriatrics Editorial Office

Received: 01 July 2022;  Published: 03 July 2022;  doi: 10.21926/obm.geriatr.2203201

by Giacinto Libertini

Received: 22 July 2022;  Published: 14 October 2022;  doi: 10.21926/obm.geriatr.2204208

The interpretation of aging as an adaptive and programmed phenomenon implies the existence of specific genetically determined and regulated aging-causing mechanisms. This interpretation is in contrast to the explanation of aging as the gradual accumulation of the effects of harmful factors that are only partially countered by natural selection. The subtelomere–telomere theory of aging offers what is required by the interpretation of aging as a programmed phenomenon. The experimentally documented mechanisms that are [...]

by Axel Ferreira  , Filipa Guimarães  and Paulo Simões Coelho

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

by Abhay Vashishth  , Mohd Shuaib  , Tanya Bansal  and Shashank Kumar

Received: 03 September 2022;  Published: 21 June 2023;  doi: 10.21926/obm.genet.2302183

Lung cancer is a leading cause of death among all the cancer worldwide and it has the highest occurrence and mortality rates. Mycobacterium tuberculosis (MTB) induced tuberculosis has been known as one of the risk factors for lung carcinogenesis. The exact mechanism of MTB is understood to date. Several research and epidemiological studies about the link between tuberculosis and lung cancer exist. It has been proposed that tuberculosis causes chronic inflammation, which increases the risk of lung cancer by creating [...]

by Hidehiro Kamezaki  , Tatsuo Kanda  , Osamu Yokosuka  , Yasunori Kasahara  and Takayuki Sakurai

Received: 16 November 2016;  Published: 21 January 2017;  doi: 10.21926/obm.hg.1701001

(1) Background: Preventative treatment for Pneumocystis jirovecii pneumonia (PCP) has been recommended for patients receiving ≥20 mg/day prednisolone. We describe a patient who developed PCP while receiving a dose of 15 mg/day prednisolone, and consider criteria for the initiation of preventative therapy for PCP in patients with autoimmune hepatitis (AIH) treated with prednisolone. (2) Case Report: A 71-year-old woman initially possessed dark-colored urine, white stool, and decreased appetite, which indicated hepat [...]

by Marcel Mannens

Received: 24 April 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902075

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by Lindsay E. Turgeon-Brown

Received: 19 November 2024;  Published: 07 April 2025;  doi: 10.21926/obm.icm.2502017

Teachers face at-work risk factors including compassion fatigue, burnout, dealing with violence, and a teacher shortage. A review of the literature shows that self-care can have positive benefits that mitigate and help to buffer these at-work risk factors This study examines teachers’ stories of self-care. The data suggests that self-care is a positive practice for teachers professionally and personally.

by Sai Batchu  , Michael J. Diaz  , Lauren Ladehoff  and Brandon Lucke-Wold

Received: 27 September 2022;  Published: 03 February 2023;  doi: 10.21926/obm.neurobiol.2301153

Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are commonly used to mimic tumors for in vitro experiments, but the extent to which they resemble GBM tumors in relation to the membranome is unclear. The present study explores the resemblance of GBM cell lines to primary tumors regarding membranome expression. Gene expression data was [...]

by Hana Alharbi  and Miao He

Received: 16 April 2023;  Published: 31 August 2023;  doi: 10.21926/obm.genet.2303191

The aim of newborn screening (NBS) program is to detect and manage treatable conditions in the early stages prior to the occurrence of long-term and irreversible sequalae. Phenylketonuria was the first screened disorder, but panels rapidly expanded after the introduction of tandem mass spectrometry technology into the program. Significant differences in the diseases screened by NBS were noted between programs in United States. Therefore, the recommended uniform screening panel was developed in 2006 to include a lis [...]