by Abdulmalik A. Lawan  and Nadire Cavus

Received: 31 May 2022;  Published: 30 September 2022;  doi: 10.21926/obm.neurobiol.2203138

Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved the clinical relevan [...]

by Maria Lúcia dos Santos  , Ana Cristina Monteiro  , Andréa Nascimento  , Sívia Barbosa  , Artur Delgado  and Patrícia Zamberlan

Received: 11 April 2024;  Published: 17 July 2024;  doi: 10.21926/rpn.2403010

Epidermolysis Bullosa (EB) is a rare genetic disorder characterized by fragile skin that blisters and tears easily, leading to significant morbidity and mortality. Depending on the specific genetic mutations and the proteins involved, EB can be classified into several subtypes whose molecular complexity is compounded by the variability in mutation types (missense, nonsense, insertions, deletions), their locations within the genes, and the resultant effects on protein function. This systematic review aimed to identi [...]

by Joni Indah Sari  , Nydia Rena Benita Sihombing  , Nani Maharani  , Tri Indah Winarni  and Agustini Utari

Received: 30 December 2024;  Published: 14 February 2025;  doi: 10.21926/obm.genet.2501285

DiGeorge syndrome (DGS) or 22q11.2 deletion syndrome (22q11.2DS) is the most common genetic microdeletion in humans, with an incidence rate of 1:3000 to 6000 live births. Early detection and diagnosis of DiGeorge syndrome are challenging to clinicians due to its phenotype variability. We report two cases of DiGeorge syndrome, each demonstrating a different combination of clinical phenotypes. Two girls (2 years-3 months old and 2 years-2 months old) were diagnosed with 22q11.2DS following chromosomal microarray anal [...]

by Andrey Koptyug  , Yurij Sukhovei  , Elena Kostolomova  , Irina Unger  and Vladimir A. Kozlov

Received: 14 April 2023;  Published: 22 December 2023;  doi: 10.21926/obm.geriatr.2304263

Understanding processes related to human aging and rejuvenation relies on experimental data and advanced models operating at different levels. There are several existing conceptual and specific modeling approaches. However, one of the existing tasks is compiling generic models linking properties at cell and cell-element levels to properties at systemic levels - tissue, organ, and whole body. One of the critical issues in the relevant models is the enormity of interacting components at the cell and sub-cell levels n [...]

by Ya Wen

Received: 28 November 2017;  Published: 05 December 2017;  doi: 10.21926/obm.neurobiol.1704007

More and more studies revealed links amongst neurological disorders, heart diseases and cancers. For example, people with subclinical cardiovascular diseases are at higher risk for Alzheimer's disease, Parkinson’s disease is associated with varied risk of cancer, Autism Spectrum Disorders and cancer have overlapping genes and molecular pathways, heart disease and cancer share common risk factors, etc. It is intriguing how are these conditions that appear to be completely different linked together.

by Luana Góes Soares  and Annelise Alves

Received: 14 December 2022;  Published: 17 April 2023;  doi: 10.21926/cr.2302016

The synthesis of fibers by electrospinning allows for obtaining nanostructures of one-dimensional materials with good flexibility, optical and catalytic properties, high surface area and porosity. They can be used in applications such as: catalysts, solar cells, fuel cells, membranes, and hydrogen batteries, among others. Here we emphasize that few reports in the literature describe the existing synergism between the optical and photocatalytic properties of TiO2, and the influence of this synergism on the formation [...]

by Aniebiet D. Udoh  , Ogheneruona E. Diemuodeke  , Mohammed M. Ojapah  , Fidelis I. Abam  and Joseph C. Ofodu

Received: 29 December 2022;  Published: 13 April 2023;  doi: 10.21926/jept.2302015

The quest to decarbonize the energy space to avert the negative climate change consequences calls for using low/zero-carbon energy conversion technologies in the energy generation space. The Organic Rankine Cycle is a low/zero-carbon energy conversion technology for recovering waste heat from low to medium-temperature heat sources and for biomass conversion. Therefore, this paper presents the thermodynamic optimization, with an artificial bee colony algorithm, of different ORC configurations, including simple organ [...]

by Michael Frass

Received: 13 November 2019;  Published: 14 November 2019;  doi: 10.21926/obm.icm.1904063

Highlights of Application of Homeopathy in Oncology Patients: An Interview with Prof. Michael Frass

by Sofie Amalie Andersson  , Mathias Møller Thygesen  , Anita Dittrich  and Henrik Lauridsen

Received: 07 March 2022;  Published: 06 July 2022;  doi: 10.21926/obm.neurobiol.2203127

The Mexican axolotl salamander is an important model species in regenerative medical research and experiments involving this species often require anesthesia which is usually limited to the duration of the surgical procedure or other interventions, usually lasting no more than a few hours. This study aimed to examine the potential for increasing the duration of anesthesia by continued propofol infusion for a week. Neurobehavioral changes in response to prolonged anesthesia were evaluated after two and seven days of [...]

by Nicole Mölders

Received: 11 August 2020;  Published: 17 August 2020;  doi: 10.21926/aeer.2003001