Table of Content

Open Access Original Research

Observational Study on Auriculotherapy in the Treatment of Chronic Musculoskeletal Pain: Preliminary Data

Received: 26 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902028

Abstract

Introduction: Pain in musculoskeletal disorders is a common problem that involves high social and individual costs. Systematic reviews and randomized controlled trials show that a number of treatments usually applied in this field are not effective. On the other hand, there is clinical evidence of the effectiveness of physical exercise, acupuncture, and auriculotherapy. Side effects of current medication limit their use. Aim: To evaluate the effectiveness of auriculotherapy on the pain of patients suffering from ch [...]

2287 17124

Open Access Research Article

Integrated Medicine Strongly Improves Post-Stroke Rehabilitative Performance in a Public Health Facility in Italy

Received: 30 September 2018;  Published: 17 April 2019;  doi: 10.21926/obm.icm.1902024

Abstract

Since 2011, the Tuscany Regional Authority has been funding the use of Integrated Medicine (IM) in a clinical setting in Pitigliano Hospital, with the aim of testing the true efficacy of complementary and alternative medicine (CAM) in a hospital setting. The clinical setting also comprises the Manciano rehabilitation facility whose services include post-stroke rehabilitation. This study aims to establish if IM helps to improve the rehabilitation performance of stroke patients. The study compared 212 patients divide [...]

1917 17118

Open Access Review

Chemical Strategies for Improving Islet Transplant Outcomes

Received: 08 October 2018;  Published: 28 December 2018;  doi: 10.21926/obm.transplant.1804036

Abstract

Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplantation processes. Increasing islet survival would increase the long-term effectiveness of the procedure and allow this technique to be used in more patients. A number of factors have been shown to improve the outcomes of [...]

1547 17117

Open Access Original Research

The Impacts of Offshore Wind Farms (OWFs) on Local Tourism and Recreation -- Evolving Lessons from Practice

Received: 06 July 2022;  Published: 16 November 2022;  doi: 10.21926/jept.2204037

Abstract

The article examines the nature of impacts of the rapidly growing Offshore Wind Farm (OWF) industry on tourism and recreation in coastal communities, especially in the UK. The multi-methods research approach includes reviews of literature, content of OWF Environmental Statements (ESs) for predicted impacts, recent practice for actual impacts, and the use of mitigation and enhancement measures. Findings from literature indicate that the overall impact on tourism appears relatively benign, and sometimes positive. The [...]

1789 17108

Open Access Original Research

New Holistic Enrichment Program Utilizing Maslow’s Hierarchy of Needs Designed for Institutionalized Residential Care Facilities

Received: 19 January 2018;  Published: 10 October 2018;  doi: 10.21926/obm.geriatr.1804014

Abstract

Background: The growing aging population requires care support resources which engage older adults in many different aspects of human functioning and experiences [1]. The purpose of this applied research project was to develop, and pilot test a holistic enrichment program manual used with Institutionalized Residential Care Facilities (IRCF) that encompasses motor skill, social, cognitive and self- enrichment outcomes, and to pilot test the enrichment program manual to be both cost-effective and a time savings to IR [...]

2469 17051

Open Access Review

Is Self-Compassion Important for Health Care Practitioners?

Received: 25 November 2018;  Published: 31 January 2019;  doi: 10.21926/obm.icm.1901007

Abstract

The cornerstone of health care practice is the provision of competent, compassionate care. Compassion is generally considered an important component in the provision of health care; however, self-compassion may be of equal importance for health care practitioners (HCP) to observe and develop. Self-compassion promotes well-being and overall mental health and may reduce fatigue and “burn-out” for HCPs [1]. Estimates of burn out in physicians and nurses range from 35-50% and is associated with emotional exhaustion, hi [...]

2751 17017

Open Access Original Research

Comparison of Respiratory Sinus Arrhythmia between Zen-meditation and Control Groups

Received: 30 July 2018;  Published: 01 April 2019;  doi: 10.21926/obm.icm.1902021

Abstract

Background: This research aims to develop new methods to investigate the cardiorespiratory interaction of Zen-meditation practitioners (Zen-meditation group) and healthy ordinary young people (control group) by quantitatively evaluating respiratory sinus arrhythmia (RSA) behavior. Methods: Twenty-five voluntary controls and seven Zen-meditation practitioners were recruited. The experimental protocol involved five sessions of different mental-stress levels (control group) and five sessions of Zen-meditation practice [...]

2055 17006

Open Access Research Article

Key Dimensions of Therapeutic Lies in Dementia Care: A New Taxonomy

Received: 12 December 2018;  Published: 11 February 2019;  doi: 10.21926/obm.geriatr.1901032

Abstract

Background: Research suggests that the use of lies and deception is prevalent within dementia care settings, despite ongoing debates raised about the ethics of this approach. There has been increasing exploration of when and why deceptive practices should be used, but the lack of clarity as to what constitutes a lie has caused difficulty in ensuring that lies are used ethically. The aim of this study was to widen our understanding of the key dimensions that underpin the use of lies, and further to use this informat [...]

2185 17000

Open Access Case Report

Use of Measuring Creatinine Kinase in Detection of Emerging Catatonia: Literature Review and Case Series Report

Received: 02 March 2022;  Published: 23 May 2022;  doi: 10.21926/obm.neurobiol.2202123

Abstract

Catatonia, particularly malignant catatonia (MC), continues to manifest in severe sequalae such as hyperthermia, rhabdomyolysis, cardiovascular collapse and failure, and even death as, although identification of the syndrome has significantly improved once its developed, several precarious factors continue to inhibit prompt and efficacious treatment. In this context, we evaluated the cases of six patients who were treated at our center for eventual MC manifestation with the aim of elucidating a pre-MC sensitive pre [...]

1411 16992

Open Access Research Article

Life Cycle Assessment (LCA) of Wood Flour and Pellets for Manufacturing Wood-Plastic Composites (WPCs)

Received: 07 December 2021;  Published: 09 February 2022;  doi: 10.21926/rpm.2201003

Abstract

This study is expanding the previous studies that were focused on the material properties and transportation costs of the two alternative feedstocks for manufacturing wood-plastic composites (WPCs): wood flour and pellets. Besides the material properties and cost analysis, life-cycle assessment (LCA) is equally important to assess the environmental impacts of these two alternative wood feedstocks to manufacture WPCs and gain the knowledge of influences from the manufacturing and transportation processes. The main g [...]

1523 16983

Open Access Original Research

Diversity in the Bacterial Genus Dickeya Grouping Plant Pathogens and Waterways Isolates

Received: 25 July 2019;  Published: 26 November 2019;  doi: 10.21926/obm.genet.1904098

Abstract

Background: Genus Dickeya comprises aggressive soft rot plant pathogens with wide geographic distribution and host ranges. Ten Dickeya species were characterized. Seven of them (Dickeya chrysanthemi, D. dadantii, D. dianthicola, D. fangzhongdai, D. solani, D. paradisiaca, and D. zeae) group causative agents of maceration-associated diseases that impact a wide variety of crops or ornamentals as well as isolates from fresh water. The other three species (D. aquatica, D. lacustris, D. undicola) were recently isolated [...]

2537 16968

Open Access Review

Does Dementia Increase the Risk of Dental Decay?

Received: 09 January 2019;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901040

Abstract

The amount of patients who suffer with dementia is set to rise with an ageing population. As well as living longer, patients will be retaining their natural teeth into their later life and will be less reliant on dentures. From both the current evidence available in the literature, and anecdotally from clinicians experienced in treating patients with dementia, it can be concluded that on balance, patients with dementia appear to be at a greater risk from dental caries (dental decay). However, more research in this [...]

1872 16952

Open Access Original Research

Autonomous Hydrogen Production for Proton Exchange Membrane Fuel Cells PEMFC

Received: 04 March 2020;  Published: 28 April 2020;  doi: 10.21926/jept.2002004

Abstract

This paper focuses on hydrogen production for green mobility applications (other applications are currently under investigation). Firstly, a brief state of the art of hydrogen generation by hydrolysis with magnesium is shown. The hydrolysis performance of Magnesium powder ball–milled along with different additives (graphite and transition metals TM = Ni, Fe, and Al) is taken for comparison. The best performance was observed with Mg–10 wt.% g mixtures (95% of theoretical hydrogen generation yield in about 3 min). An [...]

2597 16917

Open Access Original Research

Consumption of a Recommended Serving of Wheat Bran Cereals Significantly Increases Human Faecal Butyrate Levels in Healthy Volunteers and Reduces Markers of Inflammation Ex Vivo

Received: 08 October 2021;  Published: 17 December 2021;  doi: 10.21926/rpn.2104002

Abstract

Wheat bran cereals are an important source of dietary fibre. The aim of the study was to investigate if a high intake (120 g) of fibre rich breakfast cereal (which delivers the UK Government guidelines for fibre intake in one serving but is three-fold higher than the manufacturers recommended serving) has additional potential health benefits compared to the recommended serving (40 g, containing 11 g of dietary fibre). To assess this, the study determined the short chain fatty acid (SCFA) profiles in human faecal, u [...]

2260 16916

Open Access Review

Unusual Ways to Lose a Y Chromosome and Survive with Changed Autosomes: a Story of Mole Voles Ellobius (Mammalia, Rodentia)

Received: 16 May 2018;  Published: 22 July 2018;  doi: 10.21926/obm.genet.1803023

Abstract

Species of mole voles Ellobius demonstrate a broad variation in sex chromosomes and autosomes, which is unique among mammals. In four species, a Y chromosome was lost, and X0 or XX sex chromosomes in both sexes were obtained. The key testis-determining Sry (Sex-determining Region on Y) gene is absent in these species, and the regulation of its target, the Sox9 (SRY -box 9) gene, is questionable due to deletion in the key enhancer. In a single species, E. fuscocapillus, with routine XX-XY, the same deletion is prese [...]

2528 16890

Open Access Project Report

SOFC Stack and System Modeling, Fault Diagnosis and Control

Received: 31 July 2020;  Published: 18 January 2021;  doi: 10.21926/jept.2101004

Abstract

This report is an account of research and development activities undertaken by the Centre for Process Systems Computations, Department of Chemical Engineering at Curtin University, Western Australia in the area of solid oxide fuel cells. The focus of work of the group included 1)effect of cell macrostructure and microstructure on electrochemical performance with a view to optimise both macro- and micro-structure 2) electrochemistry modeling for simulating electrochemical performance 3) internal reforming aspects im [...]

2935 16869

Open Access Communication

A Neurotransmitter Approach to the Trolley Problem

Received: 25 February 2019;  Published: 28 June 2019;  doi: 10.21926/obm.neurobiol.1902030

Abstract

Is it ethically permissible to sacrifice the life of one human being in order to save the lives of five others? This question forms the basis of the famous thought experiment called “the trolley problem.” Surveys have found that 90 percent of people agree it is permissible when the victim to be sacrificed is described as off in the distance, whereas the opposite result occurs if the victim is described as up close. No consistent ethical principle has been identified that account for these results. In this paper we [...]

2261 16853

Open Access Review

Genetic and Epigenetic Regulation of Telomere Length: Current Findings, Methodological Limitations and Possibilities for Future Studies

Received: 29 October 2018;  Published: 19 December 2018;  doi: 10.21926/obm.genet.1804055

Abstract

Telomeres are TTAGGG repeats located at the end of chromosomes that maintain DNA stability. Telomere length (TL) has been widely implicated as a marker of biological age, and is associated with several human diseases, including depression, cardiovascular disease and cancer. Twin studies and cohort studies estimate heritability of TL between 78-82%. Moreover, several genomic loci which influence TL have been identified. Despite the success of genetic studies in furthering our understanding of telomere biology, ident [...]

2083 16837

Open Access Original Research

Durability of Alkali-Activated Materials Made with a High-Calcium, Basic Slag

Received: 09 June 2021;  Published: 13 October 2021;  doi: 10.21926/rpm.2104041

Abstract

Alkali activated (AA) materials have been investigated for decades as an alternative to Portland cement (PC) products. Most consist of a silicate waste activated with alkalis, which leads to lower green-house gas emissions and a substantial drop in the use of unrenewable material resources. This paper studies the durability of AA materials made with a ground granulated blast furnace slag (GGBS) from Dublin, activated with sodium hydroxide (NaOH), and sodium silicate (Na2SiO3), both combined and separately, and cure [...]

1727 16817

Open Access Review

Genomic Analysis for Citrus Disease Detection

Received: 26 October 2020;  Published: 18 February 2021;  doi: 10.21926/obm.genet.2101124

Abstract

Citrus is an important group of globally produced fruit crops, holding great economic, cultural, and health value. Belonging to the Rutacaeae family, the genus Citrus includes some of the most iconic and widely appreciated variants of fruits such as the orange, lemon, lime, grapefruit, and tangerine. The spread of various diseases threatens the worldwide production of citrus fruit crops. Diseases such as Asiatic citrus canker, citrus tristeza virus, citrus leprosis, and especially citrus greening disease (also know [...]

2246 16793

Open Access Review

Molecular Mechanisms of Canine Cancers

Received: 30 January 2019;  Published: 01 April 2019;  doi: 10.21926/obm.genet.1902071

Abstract

Cancer is the leading cause of death in dogs, and 50 percent of dogs over the age of 10 develop cancer at some point. The most common cancers in dogs include lymphoma, mast cell tumors, osteosarcoma, mammary gland tumors, and melanoma, and many of them share marked similarities with their human counterparts. Although canines are afflicted with many of the same types of cancers as humans, the genetic basis behind these cancers are not as well understood. Thus, the aim of this study is to elucidate some of the molecu [...]

2222 16781

Open Access Review

Molecular Markers Used to Reveal Genetic Diversity and Phylogenetic Relationships in Crop Plants

Received: 16 June 2024;  Published: 12 December 2024;  doi: 10.21926/obm.genet.2404274

Abstract

Genetic diversity allows plants to adapt to changing environmental conditions to survive and increases their ability to respond to yield, production, pests and diseases. The application of molecular markers developed due to developments in biochemistry, molecular biology, and plant technology has shed light on plant genetics and breeding studies and produced an enormous amount of knowledge. The theoretical knowledge will guide in determining the scope, amount, and distribution of different aspects of genetic divers [...]

1539 16757

Open Access Original Research

Sustainable Synthesis of Zeolitic Imidazolate Framework-8 Nanoparticles and Application in the Adsorption of the Drug Chlorhexidine

Received: 06 December 2022;  Published: 13 March 2023;  doi: 10.21926/cr.2301012

Abstract

In an attempt to synthesize nanomaterial concerning chemistry, the sustainable synthesis of Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles by a low-cost approach through the recycling of waste mother liquors was explored and then indicated the potential to remove chlorhexidine (CHLX) from an aqueous solution. ZIF-8 was produced under solvothermal reaction at 25°C and characterized by Fourier Transform Infrared Spectroscopy, X-ray diffraction, adsorption/desorption of N2, dynamic light scattering and con [...]

2460 16751

Open Access Review

Potentially Beneficial Effects of St. John’s Wort (Hypericum perforatum) in Patients with Metabolic Syndrome

Received: 27 June 2018;  Published: 27 September 2018;  doi: 10.21926/obm.icm.1803021

Abstract

St. John’s wort (SJW), or Hypericum perforatum, is a perennial herb that is used to treat depression in several countries. Based on the available evidence, it can be hypothesized that SJW would also have beneficial prophylactic and therapeutic effects in patients with metabolic syndrome. In this review, we summarize and discuss the best designed studies that have investigated the effects of SJW extract on adipocyte differentiation, the inflammatory process, and glucose metabolism, all of which are relevant to [...]

2153 16702

Open Access Case Report

Increase in Electrodermal Activity on Acupuncture Points of Lymphatic, Lung, Nervous, Endocrine and Heart Meridians after Running Exercise, a Single Case Study

Received: 10 December 2018;  Published: 25 March 2019;  doi: 10.21926/obm.icm.1901019

Abstract

Background: Electrodermal measurement of acupuncture points has been correlated to physiologic and pathologic conditions with clinical and laboratory studies. Emerging evidence indicates that in addition to therapeutic effect, acupuncture points may also have diagnostic properties. However, physiologic basis of this phenomenon is still unknown. Objective: To determine how electrodermal activity of acupuncture points on hands and feet responds to exercise-induced sympathetic stress and how electrodermal measurement [...]

2186 16681

Open Access Review

Review on Material Performance of Carbon Nanotube-Modified Polymeric Nanocomposites

Received: 21 March 2023;  Published: 16 August 2023;  doi: 10.21926/rpm.2303031

Abstract

The chemically functionalized carbon nanotubes (f-CNTs) and hydrogen bonding modified polymer composites (CPCs) exhibit unique chemical, mechanical, electrical, and thermal properties and are emerging as promising materials to achieve extraordinarily high electrical and thermal conductivity, lightweight and anticorrosion, superior strength and stiffness for potential applications in the aerospace and automotive industries, energy conversion, and optical and electronic devices, therefore, attracting considerable res [...]

2381 16681

Open Access Research Article

Aging and the Art of Happiness: Time Effects of A Positive Psychology Program with Older Adults

Received: 31 October 2018;  Published: 10 January 2019;  doi: 10.21926/obm.geriatr.1901029

Abstract

Background: Research has shown that positive psychology interventions can enhance subjective well-being and reduce depression. However, the efficacy of these programs with older adult populations has been minimally studied. The present study studied the short and long term impact of an intervention enhancing happiness and overall mental well-being in older adults. Methods: The Art of Happiness is an 8-week program conducted at 2 senior centers in the state of Delaware. Each 90-minute class examined a different topi [...]

2193 16668

Open Access Original Research

Homeopathy and Photobiomodulation for Healing Diabetic Wounds in vitro

Received: 12 April 2021;  Published: 19 August 2021;  doi: 10.21926/obm.icm.2103024

Abstract

Photobiomodulation (PBM), as well as plant extracts of Calendula officinalis (Calen), Hypericum perforatum (Hyper), and Echinacea purpurea (Echi-p), have been used to accelerate wound healing. However, the use of homeopathic preparations of these medicinal plants, in combination with PBM, is unknown. The objective of this study was to investigate the combined wound healing potential of these therapies in vitro. Various cell models were created in vitro in commercially available human skin fibroblasts (WS1). PBM was [...]

1597 16658

Open Access Original Research

Development of an Efficient Bi-Functional Catalyst made of a Novel Hybrid Material for Rechargeable Zn-Air Battery

Received: 24 May 2021;  Published: 16 July 2021;  doi: 10.21926/cr.2103001

Abstract

One-pot synthesis of mesoporous hybrid material consisting of Mn-Co/CoO nanoparticles encapsulated in an N-doped graphene shell decorated with Mo2C nanoparticles (Mo2C-NC@Mn-Co/CoO) was reported. The Mn and Mo components synergistically refined the graphitized carbons due to the interactions with N and C atoms while promoting the stability of the Co/CoO nanoparticles. These components exhibited a beneficial effect on the dispersion of the active metal/metal oxide nanoparticles and the formation of a mesoporous stru [...]

4349 16595

Open Access Original Research

Leveraging Mindfulness to Build Resilience and Professional Quality of Life in Human Service Professionals

Received: 04 April 2018;  Published: 15 May 2018;  doi: 10.21926/obm.icm.1802007

Abstract

Objective: Mindfulness-based interventions (MBIs) have shown promise in cultivating resilience and are widely accepted as efficacious in the treatment of a range of psychological disorders. This paper explores the feasibility of a Mindful-Awareness and Resilience Skills Training (MARST) program to enhance mindfulness and resilience, as a means of increasing psychological well-being and alleviating burnout and compassion fatigue in human service professionals. Method: In this randomised control trial, 46 human servi [...]

2291 16569

Open Access Research Article

Synthetical Optimal Design for Passive-Damped LCL Filters in Islanded AC Microgrid

Received: 19 May 2021;  Published: 08 July 2021;  doi: 10.21926/jept.2103032

Abstract

In AC microgrid systems, technical issues resulting from the power control effect are the power control method efficiency and the filter resonance since voltage-frequency interference and filtering resonance may cause significant control input reduction and oscillation. A simple and robust solution is to regulate active power flow by adding an optimal passive damping resistor. The optimal LCL filter parameterization process in this paper provides an innovative approach to obtain the optimal quality factor and the o [...]

2236 16545

Open Access Case Report

Chronic Pain after Reported Whiplash Injury – A Patient Case Report

Received: 13 April 2018;  Published: 25 February 2019;  doi: 10.21926/obm.icm.1901012

Abstract

Chronic pain is notoriously multifactorial, multifaceted and difficult to manage. Twenty per cent of reported whiplash-injured persons go on to develop a Whiplash Associated Disorder (WAD) where persistent pain becomes chronic with no prospect of change [1]. Paucity of effective therapies to address the effect of WAD enforces new approaches. This case report, with a patient’s perspective, illustrates a novel therapy, Adapted Reflextherapy (AdRx), which is akin to reflexology and has been used, developed and revised [...]

1967 16542

Open Access Opinion

Moving Towards Routine Non-Invasive Prenatal Testing (NIPT): Challenges Related to Women’s Autonomy

Received: 10 February 2018;  Published: 19 April 2018;  doi: 10.21926/obm.genet.1802018

Abstract

Women’s reproductive autonomy, and its translation into informed free choice regarding prenatal screening, is a dominant concept in the bioethical discourse concerning prenatal screening. This discourse is based on the premise that access to information regarding the pregnancy promotes autonomous decision-making. However, studies show that the offer of prenatal screening as a routine part of pregnancy care is not supported, to a large degree, by appropriate informed consent mechanisms. This means that the implement [...]

2775 16539

Open Access Review

The Role of Genetic Counseling in Gynecological Oncology

Received: 15 July 2019;  Published: 12 December 2019;  doi: 10.21926/obm.genet.1904101

Abstract

Background: Clinical or medical genetics deals with the study and diagnosis of genetic diseases. It is oriented to the formulation of the clinical diagnosis of genetic diseases and genetic counseling to evaluate the possible reproductive risk for the patient and his/her family. The geneticists here play a role in the diagnosis and prevention of some of the diseases occurring most frequently, such as cancer and cardiovascular diseases. Methods: State-of-the-art through literature review. Results: Genetic counseling [...]

2029 16517

Open Access Research Article

Somatic Self-Compassion Training Reduces Perceived Stress, Internalized Shame, and Bodily Shame while Increasing Coping Self-efficacy and Self-compassion

Received: 27 October 2020;  Published: 31 March 2021;  doi: 10.21926/obm.icm.2101011

Abstract

Somatic Self-Compassion® training is a newly developed trauma-informed self-compassion training that was designed to combine interoception and sensory modulation in order to teach individuals to more effectively cope with current and past stress. Thirty-two non-clinical adults across five cohorts participated in this pre-post design feasibility study. Participation in Somatic Self-Compassion® Online resulted in significant reductions in perceived stress, internalized shame, and bodily shame and significant improvem [...]

2772 16507

Open Access Original Research

Molecular Cytogenetic Characterization of Two Murine Colorectal Cancer Cell Lines

Received: 30 July 2018;  Published: 19 September 2018;  doi: 10.21926/obm.genet.1803037

Abstract

(1) Background: Colorectal cancer (CRC) is the third most common cancer in human and the fourth leading cause of adult man’s death. Murine tumor cell lines have been established as a model system for CRC, but their cytogenetic properties have so far been only poorly understood. (2) Methods: The two murine colon tumor cell lines CMT-93 and CT26 (also called CT26.WT, CT-26 or CT-26 WT) were investigated in this study by molecular cytogenetic methods, i.e. by multicolor-fluorescence in situ hybridization (mFISH), muri [...]

2804 16495

Open Access Review

From Bioactive Molecules to Their Nutritional Effect, Biodynamic Interpretation Between Productional and Functional Aspects of Nutrients

Received: 10 October 2022;  Published: 21 December 2022;  doi: 10.21926/rpn.2204023

Abstract

In this article, the long journey from the production of food ingredients to their transformation into nutrients was described. The essential function of nutrients is to satisfy the primary needs of living organisms, namely energy, morphology and reproduction, through the consumption of food. Fulfilling its primary role, food must contain nutrients that are essential for the well-being of the living, along with others that are not essential but are still important for proper metabolism. These substances are known a [...]

1594 16470

Open Access Editorial

OBM Geriatrics—An International Open Access Journal for 21st Century Geriatrics Medicine

Received: 11 December 2016;  Published: 06 January 2017;  doi: 10.21926/obm.geriatr.1701001

Abstract

Geriatrics, and much of clinical medicine, is on the verge of a profound transformational shift. Until now, there has been a sharp conceptual divide between diseases which can be readily and effectively treated, and diseases which we have thought to be beyond clinical intervention. In the first disease category, are many of the most common infections that respond to antibiotics and immunizations. We have made dramatic changes in the demographics and the mortality of many such treatable diseases. At the other extrem [...]

1554 16462

Open Access Review

Insulin-Like Growth Factor 2 in Physiology, Cancer, and Cancer Treatment

Received: 14 May 2019;  Published: 14 October 2019;  doi: 10.21926/obm.genet.1904096

Abstract

Insulin-like growth factor 2 (IGF2) is a strong mitogenic peptide with an imprinted gene that is primarily involved in fetal development. It is highly expressed in the fetus where it is involved in fetal growth and tissue differentiation. However, postnatally, the expression of IGF2 decreases despite higher expression levels in the blood as compared with that of IGF1. In adults, the physiological function of IGF2 is poorly understood; however, the possibility of a metabolic function exists. Although the expression [...]

2431 16452

Open Access Review

Neural Mechanisms of Hypnotic Analgesia

Received: 18 February 2020;  Published: 24 April 2020;  doi: 10.21926/obm.icm.2002023

Abstract

There is increasing evidence demonstrating that hypnosis could be effective in the down-modulation of pain sensation in both acute and chronic pain states. In the neurophysiological context, recent evidence has deciphered, to a certain extent, the mystery of pain relief upon hypnosis. It is probable that hypnotic suggestions of analgesia are able to modulate pain processing at multiple levels and sites within the central nervous system (CNS). At the peripheral level, hypnosis may modulate the nociceptive input thro [...]

2061 16393

Open Access Original Research

Potential of Wastewater Valorization after Wet Extraction of Proteins from Faba Bean and Pea Flours

Received: 02 December 2020;  Published: 21 April 2021;  doi: 10.21926/rpm.2102013

Abstract

The present study aimed to characterize wastewater fractions obtained after the wet extraction of proteins from legumes. In addition, the suitability of wastewater fractions for the potential recovery of high value-added compounds was also examined, and consequently, the prevention of the environmental impact of these wastes was explored. Similar to the industrial production of proteins, wet alkaline and acidic extractions of proteins from faba bean and pea flours were performed in two stages of extraction. The dif [...]

2246 16356

Open Access Review

IVIG Replacement for Hypogammaglobulinemia in Lung Transplant Patients

Received: 10 March 2017;  Published: 22 June 2017;  doi: 10.21926/obm.transplant.1701003

Abstract

After lung transplant, infection is a leading contributor to morbidity and mortality, and hypogammaglobulinemia (HGG) may be an important risk factor for many of these infections. Some reports suggest that HGG not only increases the risk of various infections, but also worsens survival. The incidence of HGG has been shown to increase after lung transplant, and may be as high as 70%. In order to mitigate this risk, intravenous immunoglobulin G (IVIG) replacement for the treatment of HGG has been utilized. However, t [...]

1687 16332

Open Access Original Research

The Art of (Up)Recycling: How Plastic Debris Has Become a Matter of Art?

Received: 11 June 2021;  Published: 18 October 2021;  doi: 10.21926/aeer.2104025

Abstract

Since 1907, when Bakelite was invented, there has been a dramatic rise in the daily usage of plastic-like materials. Today, its negative impacts are a part of scientific studies and public debates. Art and artists play a significant role in these discussions. They mediate between the specialist content and public awareness. This study is dedicated to the artworks of artists using plastic waste collected from the seashore. I organized their works into three lines, within which artists have different threads of plast [...]

1734 16317

Open Access Research Article

Evaluating the Performance of Hollow Core Slabs (HCS)-Concrete and Simplifying Their Implementation

Received: 02 March 2023;  Published: 19 April 2023;  doi: 10.21926/rpm.2302016

Abstract

The largest proportion of the material used in multistory buildings, and thus its carbon impact, is attributed to their slabs being the main contributor of weight. Because of their high strength and concrete self-weight reduction, composite beams with hollow-core slabs were created for their technical and economic benefits, making this system inexpensive and with a reduced environmental impact, thereby lowering carbon emissions. Geometrically, the hollow slab has a sequence of T and L form pieces on both sides. Hol [...]

2914 16292

Open Access Communication

One-Pot Tandem Synthesis of Nitriles and Amides from Biomass Platform Compounds

Received: 28 December 2021;  Published: 21 February 2022;  doi: 10.21926/cr.2201004

Abstract

In recent years, research on converting biomass platform compounds into high-value chemicals and pharmaceutical intermediates has garnered huge interest. Nitrile and amide groups are key structures in natural products and biologically active molecules. The direct conversion of biomass platform compounds into nitriles and amides will undoubtedly be an important guide for biomass utilization. In this paper, a facile and efficient triphosgene-assisted one-pot conversion for aldehydes and ketones into nitrile and amide [...]

3328 16276

Open Access Original Research

CrossFit Participation and Medication Use: Observations from a UK Population Survey

Received: 01 June 2024;  Published: 08 November 2024;  doi: 10.21926/obm.icm.2404066

Abstract

Chronic diseases, responsible for 74% of global mortality, impose a substantial health burden. This study investigates the perceived effects of CrossFit, a form of functional training, on medication use in the UK population. The research aims to provide insights into how CrossFit might relate to medical interventions for individuals with long-term health conditions. The study, encompassing 1,211 UK residents (over 18yrs.) recruited via CrossFit Affiliates, involved a 14-question online survey covering information p [...]

2504 16267

Open Access Research Article

Meat Waste Valorization through Protein Hydrolysis using Different Types of Proteases

Received: 12 May 2021;  Published: 08 November 2021;  doi: 10.21926/rpm.2104045

Abstract

Five different commercial proteases (Alcalase 2.4L, Flavourzyme 1000L, Neutrase, Protamex, and PTN) were evaluated for the simultaneous recovery of protein and lipids through hydrolysis. The hydrolysis reaction was monitored using the pH-stat procedure, in which samples were collected after 240 min of hydrolysis using each enzyme. The samples were analyzed for the degree of hydrolysis, protein hydrolysate, collagen, lipids, and fatty acids. A clear relationship was observed between the degree of hydrolysis and the [...]

2068 16266

Open Access Review

Enhancing University Students’ Mental Health under Artificial Intelligence: Principles of Behaviour Therapy

Received: 13 March 2024;  Published: 24 May 2024;  doi: 10.21926/obm.neurobiol.2402225

Abstract

The increasing prevalence of mental health issues among university students has become a growing concern globally. This review explores the potential of Artificial Intelligence (AI) integrated with principles of behaviour therapy to address mental health challenges among university students. The paper examines how AI technologies, including chatbots, virtual reality, and machine learning algorithms, can be harnessed to provide accessible, personalized, and effective mental health interventions. Furthermore, it disc [...]

1600 16264

Open Access Review

Efficacy of Motor Imagery in the Rehabilitation of Stroke Patients: A Scope Review

Received: 29 May 2024;  Published: 06 August 2024;  doi: 10.21926/obm.neurobiol.2403236

Abstract

This review examines the efficacy of motor imagery (MI) as a supplementary rehabilitation technique for stroke patients. Nine randomized controlled trials (RCTs) were analyzed, highlighting MI's potential to enhance motor recovery, mobility, balance, and psychological well-being. Significant improvements in upper-limb function were observed with combined mental and physical practice, evidenced by notable gains in Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT) scores. MI-based exercise programs impr [...]

982 16236

Open Access Review

Behaviors of Persons with Dementia: A Review and New Perspective for Future Research

Received: 30 July 2019;  Published: 07 February 2020;  doi: 10.21926/obm.geriatr.2001104

Abstract

Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review considers the illness experience and the need for more research using self-report methodology with persons with dementia in order to address the current gaps within the behaviour literature. With three main objectives, this [...]

1893 16226

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