Table of Content

Open Access Original Research

In Silico Evaluation of Anti-SARS-CoV-2 Bioactive Compounds from Jatropha curcas

Received: 12 March 2025;  Published: 25 May 2025;  doi: 10.21926/obm.genet.2502295

Abstract

Jatropha curcas L., a medicinal shrub renowned for its diverse phytochemicals, has been traditionally used to treat various ailments, including ulcers, neoplasms, and dermatological conditions. Despite its pharmacological promise, its potential against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) remains unexplored. This study investigates the antiviral efficacy of J. curcas phytochemicals targeting the SARS-CoV-2 main protease (Mpro), a critical enzyme for viral replication, using advanced computat [...]

1059 5772

Open Access Research Article

A Randomized Control Trial of the Effects of a Hatha Yoga Program on Psychological Well-Being

Received: 11 March 2025;  Published: 23 September 2025;  doi: 10.21926/obm.icm.2503039

Abstract

Hatha yoga is a common style of yoga used for physical, emotional, mental, and spiritual benefits, enhancing quality of life and well-being. The current study used a randomized control trial (RCT) to investigate whether completing an eight-week posture-based Hatha yoga program would lead to greater psychological benefits than taking part in an eight-week lecture series about the history and philosophy of yoga. Fifty-five participants (42 female, age range 18-32) completed five self-report measures both before and a [...]

796 5758

Open Access Original Research

The Geriatric Impact in the Management of Complex Cancer Patients: A Monocenter Experience

Received: 17 November 2022;  Published: 13 June 2023;  doi: 10.21926/obm.geriatr.2302238

Abstract

New technologies, aging-related changes, and evolution in patients' needs have led to a new scenario in all oncological fields in front of which we have to move on. Technological progress has made it possible to increase the number of patients treated, including elderly patients and generally those at higher risk of toxicity. However, this scenario has led to new problems requiring new skills to be addressed. For this reason, Gemelli-ART (Advanced Radiation Therapy) of Fondazione Policlinico Universitario A. Gemell [...]

934 5747

Open Access Commentary

Is There Hope for Chronic Pain Patients?

Received: 22 August 2023;  Published: 11 January 2024;  doi: 10.21926/obm.icm.2401009

Abstract

Many websites are dedicated to educating the public about chronic pain and its management. The majority of these websites say there is no cure for chronic pain, but encourage patients to try exercise, diet, stress reduction and other techniques to decrease the severity of chronic pain. Patients are also taught to use oral or injected drugs to treat their chronic pain. This can be dangerous and leads to adverse events and death in some patients. The majority of these websites teach patients that chronic pain comes f [...]

1149 5746

Open Access Short Report

Developing an Independent International Research Team: Research Ensemble for Advancement in Cross-Cultural Healthcare (REACH)

Received: 14 February 2024;  Published: 22 August 2024;  doi: 10.21926/obm.icm.2403048

Abstract

This short report presents an international research group, Research Ensemble for Advancement in Cross-cultural Healthcare (REACH). REACH is an independent research group, and no one is paid to do research for REACH. All members participate because they are intrinsically motivated to pursue cross-cultural healthcare. REACH consists of 28 healthcare workers and educators from 13 countries, researching about cross-cultural issues in healthcare (18 publications on average per year as of February 2024). REACH is multi- [...]

1400 5739

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...]

987 5739

Open Access Review

Non-Celiac Gluten Sensitivity in Children: Controversial Role of Gluten and Diagnostic Enigma

Received: 07 July 2021;  Published: 22 July 2021;  doi: 10.21926/obm.hg.2103059

Abstract

Non-celiac gluten sensitivity (NCGS) is a debatable condition that affects less than 6% of children. The absence of specific diagnostic markers and standardized diagnostic procedures make the diagnosis of NCGS challenging, covering patients with different and varied symptoms. Generally, the parents of small and younger children introduce a gluten-free diet (GFD) based on their personal experiences and expectations. Additionally, a “fad component” exists, contributing to the recent rise in the popularity of GFD. Thu [...]

1296 5735

Open Access Original Research

Using a Gamification Approach to Enhance Continued Use of Assistive Technology Intervention in Persons Living with Dementia

Received: 18 October 2024;  Published: 09 May 2025;  doi: 10.21926/obm.geriatr.2502311

Abstract

Assistive technology (AT) interventions have shown promising results in supporting cognitive, social, and physical activities in persons living with dementia (PLWD) and their caregivers. Despite strong evidence of the effectiveness of AT, PLWD and their caregivers can disengage with the technology after it is used for a time – i.e., the “stickiness challenge”. Diminished use of AT reduces the opportunity for it to have optimal impact. We asked whether the opportunity to engage in cognitive games may enhance continu [...]

1154 5728

Open Access Interview

An Interview with Dr. José Pinela

Received: 22 June 2025;  Published: 23 June 2025;  doi: 10.21926/rpse.2502010

571 5717

Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

Received: 23 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.transplant.2402219

Abstract

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii) assess the association between pepA and isolation of typical gastrointestinal microorganisms from BAL fluid, and iii) explore the accuracy of using pepA concentration as a biomarker of ACR. After IRB approval, we conducted a retrospective observational study analy [...]

1037 5717

Open Access Research Article

Demographic Factors, COVID-19-related Factors, and PTSD Symptom Clusters: Exploring Associations and Implications for Mental Health

Received: 26 April 2023;  Published: 25 September 2023;  doi: 10.21926/obm.neurobiol.2303184

Abstract

The COVID-19 pandemic was characterized as a continuous traumatic stressor and associated with high levels of posttraumatic stress disorder (PTSD). This study examines the associations between demographic factors, COVID-19-related factors (fear of COVID-19 and perceived stress), and PTSD, as well as the associations between PTSD and indices of mental health. The participants in the study were university students (n = 322) who completed the PTSD Checklist for the Diagnostic and Statistical Manual-5 (DSM-5), the Fear [...]

1000 5712

Open Access Original Research

How Viniyoga Supports Health and Healing

Received: 17 January 2025;  Published: 14 March 2025;  doi: 10.21926/obm.icm.2501014

Abstract

In this qualitative study, the impact of therapeutic Viniyoga on health and healing was explored from the perspective of 14 Viniyoga therapists who were interviewed on their perceptions of how yoga therapy contributes to the health and healing of their clients. A philosophical definition of Therapeutic Viniyoga was developed. Three themes related to health and healing from the perspective of Viniyoga therapists were identified using NVivo and Interpretative Phenomenological Analysis procedures: The definition of he [...]

830 5708

Open Access Case Report

Exploring the Genetic Landscape of Knobloch Syndrome: Novel Variant Identification and Literature Review

Received: 22 November 2024;  Published: 14 April 2025;  doi: 10.21926/obm.genet.2502291

Abstract

Knobloch Syndrome (KS) is a rare genetic disorder characterized by ocular abnormalities and central nervous system (CNS) defects, which are attributed to collagenopathy. The primary gene implicated in KS is COL18A1, which encodes the alpha chain of type XVIII collagen. This type of collagen functions as a proteoglycan, predominantly located in the basement membrane of human tissues. This study examined an Iranian female presenting with symptoms of horizontal nystagmus, strabismus, and suspected vision loss, with a [...]

943 5704

Open Access Original Research

Characterization of ‘Ca. Phytoplasma asteris’, ‘Ca. Phytoplasma australiense’ and ‘Ca. Phytoplasma mali’ Associated with Russian Olive Witches’-Broom Disease in Iran Using Next-Generation Sequencing

Received: 31 August 2023;  Published: 04 December 2023;  doi: 10.21926/obm.genet.2304204

Abstract

Russian olive trees showing witches’-broom disease symptoms in urban green spaces and orchards in northwest Iran were sampled for phytoplasma detection. PCR assays and Sanger sequencing of 16S rRNA gene confirmed that ‘Ca. Phytoplasma asteris’ was associated with Russian olive witches’-broom disease. For genomic characterization of phytoplasma associated with disease, the total DNA of an infected tree was analyzed by Illumina next-generation sequencing (NGS). The NGS analysis generated 46011 [...]

1157 5688

Open Access Original Research

Taste Impairment and Compliance Improvement of Branched-Chain Amino Acids in Patients with Liver Cirrhosis

Received: 25 September 2018;  Published: 26 December 2018;  doi: 10.21926/obm.hg.1804011

Abstract

Background: Branched-chain amino acids (BCAA) are nutrients with a bitter taste, which causes low compliance in patients who need BCAA supplementation. Moreover, chronic liver disease is frequently complicated by taste impairment. The present study was designed to improve patient noncompliance regarding nutrients in liver disease. Methods: A taste questionnaire was administered to healthy controls, chronic hepatitis patients, and cirrhotic patients. Eleven different flavored powders that can be added to BCAA nutri [...]

1281 5679

Open Access Case Report

Varicella-Zoster Gastritis in a Liver Transplant Patient: A Call to Attention

Received: 01 March 2021;  Published: 21 June 2021;  doi: 10.21926/obm.hg.2102057

Abstract

The reactivation of the Varicella-zoster virus (VZV) is a rare cause of acute gastritis in adults. About 30 cases have been reported in the literature, mostly with immunocompromised patients and mainly after bone marrow transplantation or during the development of malignant hematological diseases. Clinically, it is usually accompanied by cutaneous manifestations. Here, we studied a case of VZV gastritis in a liver transplant (LT) patient. We described the main symptoms, endoscopic findings, histologic changes, and [...]

1189 5668

Open Access Editorial

Advanced Catalysis for Green Fuel Production from Biomass and Wastes

Received: 19 August 2024;  Published: 22 August 2024;  doi: 10.21926/cr.2403012

1347 5667

Open Access Research Article

How to Keep Doing What You Like Doing: A Qualitative Study of Active Older Adults’ Insights on the Facilitators and Barriers to Maintenance of Physical Activity (From the MOVEAGE-Act Project)

Received: 05 June 2024;  Published: 17 December 2024;  doi: 10.21926/obm.geriatr.2404292

Abstract

While the facilitators/barriers for the initiation of physical activity (PA) are well documented, there is less known about these facilitators/barriers for maintenance of PA in the older population in general and not following an intervention. This study aimed to explore older adults’ perspectives on the facilitators/barriers to maintaining PA. The study used descriptive qualitative design, with three focus groups, one in Ireland and two in France. Participants were community-dwelling older adults (≥60 years) 66% w [...]

868 5665

Open Access Original Research

Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Center

Received: 05 May 2024;  Published: 04 June 2024;  doi: 10.21926/obm.transplant.2402217

Abstract

Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) have emerged as potential biomarkers in various diseases, including cancer. This study aimed to evaluate the expression of lncRNAs HOTTIP and HOTAIR in CNS patients and healthy contr [...]

942 5660

Open Access Case Report

Management of Posttraumatic Cerebrospinal Fluid Leak with Secondary Diffuse Pneumocephalus Complicated by Meningitis and Communicating Hydrocephalus – Illustrative Case Report

Received: 10 January 2024;  Published: 13 March 2024;  doi: 10.21926/obm.neurobiol.2401214

Abstract

Rhinorrhea is a possible complication after different types of traumatic brain injury or neurosurgical procedures, such as skull base operations. Pneumocephalus is a rarely noted complication after severe traumatic brain injury, and it may be accompanied by meningitis and ventriculitis, especially when treatment has been delayed. Treatment of these entities includes conservative and surgical approaches. Pneumocephalus may result in neurologic disturbances threatening a life. Therefore, active patient management wit [...]

1016 5656

Open Access Original Research

Location, Season and Source Effects on Gross Composition of Raw Cow’s Milk Across Khartoum State, Sudan

Received: 06 April 2024;  Published: 27 April 2025;  doi: 10.21926/rpn.2502009

Abstract

This study was conducted to investigate the effect of sources. locations and seasons (late summer and winter) on the chemical composition of cow milk collected from Khartoum State. The samples were collected randomly in the morning or the evening. Two hundred and seventy milk samples were collected from farms (90 samples), groceries (90 samples) and vendors (90 samples) in Khartoum State during the late summer and winter seasons, 135 samples each. The milk samples were kept in cool cracked ice and transported immed [...]

837 5654

Open Access Original Research

LFO Damping Enhancement in Multimachine Network Using African Vulture Optimization Algorithm

Received: 20 June 2023;  Published: 30 January 2024;  doi: 10.21926/jept.2401003

Abstract

The prolonged presence of low-frequency oscillation (LFO) in power system networks (PSN) poses a significant threat to their stability. Hence, engineers and researchers have continuously developed effective strategies to mitigate the issue and enhance the stability of the PSN. This article proposes a new approach using the African Vultures Optimization Algorithm (AVOA) to design robust Power System Stabilizers (PSS) and enhance the LFO damping in multi-machine networks. The damping ratio-based objective function mi [...]

1010 5650

Open Access Concept Paper

The Bio Steel Cycle Meets Indoor Farming - CCUS with the SusCiP Principle in Agriculture

Received: 06 September 2024;  Published: 15 January 2025;  doi: 10.21926/aeer.2501006

Abstract

The World climate is changing, with a great impact on global food production systems. Extreme weather events, floods, wildfires and draughts are phenomena of disrupted previously stable natural weather patterns, which are vital for crop production and animal husbandry alike. Most of the World’s food is produced in temperate climatic zones rich in arable land and those are affected by the increasing unpredictability of previously naturally occurring seasons and weather conditions. This work aims to provide a possibl [...]

1053 5647

Open Access Original Research

Knowledge and Attitudes Towards Use of Complementary and Integrative Health Therapies for Veterans with Opioid Use Disorder in the Veterans Health Administration

Received: 20 December 2023;  Published: 31 January 2024;  doi: 10.21926/obm.icm.2401012

Abstract

The Veterans Health Administration (VA) offers complementary and integrative health (CIH) therapies to Veterans with chronic pain and opioid use disorder (OUD). While CIH therapies have known benefits for chronic pain, less research exists on its use for patients with OUD. In this qualitative study, we aimed to assess provider and patient perceptions of CIH therapies for Veterans with OUD. We interviewed 45 providers involved in OUD care and 17 Veterans with OUD from five VA medical centers as part of a larger mixe [...]

1071 5633

Open Access Original Research

The Exploration of the Experience of Expressive Therapies in a Pediatric Medical Setting in the COVID-19 Pandemic through Arts-Based Research

Received: 03 June 2023;  Published: 24 October 2023;  doi: 10.21926/obm.icm.2304044

Abstract

The COVID-19 pandemic presented a host of issues for hospitalized patients including increased anxiety, fear, isolation, and depression [1]. Expressive Therapies have been used in the pediatric medical setting for decades to support patients and families with coping, expression, processing, and rehabilitation [2,3,4,5]. Additionally, some studies suggest that Expressive Therapies were effective in helping ease the increase in mental health symptoms that occurred during the pandemic. During the pandemic the expressi [...]

1070 5632

Open Access Original Research

The Impact of Therapeutic Viniyoga on State Change

Received: 30 May 2024;  Published: 23 September 2024;  doi: 10.21926/obm.icm.2403054

Abstract

While many studies have discussed the effectiveness of interventions using different yoga techniques and teachings with various populations, there has been less research on the effectiveness of yoga therapy. Viniyoga therapists utilize the principles of Viniyoga, a type of yoga developed by Krishnamacharya, to provide therapeutic yogic interventions to individual clients in order to improve functioning and relieve suffering. This qualitative study conducted interviews with fourteen Viniyoga trained yoga therapists [...]

715 5610

Open Access Editorial

Potential Applications of Nanomedicine

Received: 03 December 2023;  Published: 05 December 2023;  doi: 10.21926/rpm.2304036

Abstract

EditorialPotential Applications of NanomedicineHossein Hosseinkhani *Innovation Center for Advanced Technology, Matrix HT, Inc., New York, NY 10019, USA; E-Mail: hh@matrix-inc.com* Correspondence: Hossein Hosseinkhani; E-Mail: hh@matrix-inc.comRecent Progress in Materials2023, volume 5, issue 4doi:10.21926/rpm.2304036Received: December 03, 2023Accepted: December 04, 2023Published: December 05, 2023

1148 5607

Open Access Research Article

Grid-Connected Photovoltaic System for Generating Energy to Dairy Farm Activities

Received: 28 April 2024;  Published: 26 August 2024;  doi: 10.21926/jept.2403016

Abstract

Minas Gerais is the leading milk-producing state in Brazil, and many dairy activities are supplied with electricity by the cable aerial network of the electrical energy state company. Given that the Brazilian energy matrix relies primarily on hydroelectric power, studies on the potential of other renewable energy sources in the context of dairy farms are innovative. Additionally, frequent disturbances and interruptions have motivated the installation of solar energy systems on dairy farms. However, the scarcity of [...]

1022 5600

Open Access Original Research

Synergistic Effect of Resveratrol and Paclitaxel in the Treatment of Malignant Pleural Mesothelioma

Received: 11 June 2024;  Published: 18 October 2024;  doi: 10.21926/obm.genet.2404268

Abstract

Malignant pleural mesothelioma (MPM) is a lethal and aggressive cancer due to exposure to asbestos since this carcinogen is still being used in industrial buildings and housing in several countries. Untreated MPM has a median survival time of 12 months, and most people die within 24 months after diagnosis. If caught early, surgery may be performed. Treatment option for palliative care is limited using platinum with pemetrexed. Malignant transformation of a cell is attributed to a series of genetic and epigenetic ev [...]

949 5579

Open Access Original Research

Natural Neurostimulation for Chronic Pain Management: A Case Series of 3 Patients with Dysmenorrhea and Menstrual Migraine

Received: 09 February 2025;  Published: 03 July 2025;  doi: 10.21926/obm.neurobiol.2503290

Abstract

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field an [...]

881 5575

Open Access Case Report

Cyclic Exclusive Enteral Nutrition as an Alternative to Medical Maintenance in Crohn Disease—A Case Report

Received: 10 July 2024;  Published: 24 October 2024;  doi: 10.21926/rpn.2404017

Abstract

We present a case report of an 11-year-old girl diagnosed with Crohn’s Disease and managed with maintenance cyclic exclusive enteral nutrition with satisfactory long-term biochemical and symptomatic control.

1064 5571

Open Access Review

The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications

Received: 06 November 2024;  Published: 28 February 2025;  doi: 10.21926/obm.neurobiol.2501273

Abstract

Interactions in the gut-brain crosstalk have led to the development of an entirely new concept: the "microbiota-gut-brain axis". Microbiota has gained considerable attention in relation to disorders of a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, and mood disorders. This review aims to summarize the recent trends and insights into the role and consequences of gut microbiota in brain health and pediatric neurological disorders. Dysbiosi [...]

1008 5570

Open Access Original Research

Immune-Suppression Modulation in Solid Organ Transplant Recipients Admitted for COVID-19

Received: 14 June 2023;  Published: 01 December 2023;  doi: 10.21926/obm.transplant.2304204

Abstract

SARS-CoV-2 infection has significantly impacted solid organ transplant (SOT) recipients, who are at high risk of disease and worse outcomes. Moreover, therapeutic management in this population is not precise yet. Our study aimed to evaluate the overall survival of SOT recipients and predictive factors for mortality. We also aimed to assess the impact of antiviral treatments and immunosuppressant changes on overall mortality and to evaluate the length of hospital stay of SOT compared to the general population. This [...]

1001 5560

Open Access Concept Paper

Improving Outcomes in Elderly Patients with Ovarian and Pancreatic Cancer through Multimodal Prehabilitation

Received: 19 August 2024;  Published: 19 March 2025;  doi: 10.21926/obm.geriatr.2501304

Abstract

Elderly patients with ovarian and pancreatic cancer frequently experience malnutrition and sarcopenia, which negatively impact treatment tolerance, functional outcomes, and survival. The increasing use of neoadjuvant chemotherapy in this population necessitates structured interventions to mitigate these challenges. While prehabilitation has shown promise in enhancing treatment tolerance and quality of life, its role during chemotherapy remains underexplored. This prospective study evaluates the feasibility and impa [...]

965 5555

Open Access Original Research

The Timing of Endoscopic Evaluation of Anti-TNFα Therapy Patients with Ulcerative Colitis

Received: 10 August 2020;  Published: 09 July 2021;  doi: 10.21926/obm.hg.2103058

Abstract

Anti-TNFα Therapy are used to induce remission and as maintenance therapy in refractory ulcerative colitis (UC) to achieve mucosal healing (MH). However, the time at which mucosal healing should be assessed is unclear. We retrospectively examined the optimal timing for colonoscopy and the criteria to determine the need for the continuation of treatment. We evaluated 44 UC patients that were treated with anti-TNFα Therapy and categorized them into the following groups according to the degree of MH within 12 months: [...]

1039 5548

Open Access Original Research

Morpho-Biochemical Characterization and Genetic Analyses of the Traits of Mungbean Genotypes Confined with Yield Attributing Traits and Salinity Stress Tolerance

Received: 31 May 2025;  Published: 07 August 2025;  doi: 10.21926/obm.genet.2503306

Abstract

Low phenotypic and genotypic variability for yield-attributing traits and susceptibility to salinity stress are constraints of mungbean productivity. The objectives of the study are to phenotype a set of exotic mungbean genotypes for yield-attributing traits and salinity tolerance, as well as to conduct genetic analysis of these traits for efficient selection. Three consecutive experiments were conducted to fulfill these objectives. In the first experiment, 26 mungbean genotypes were evaluated for yield traits unde [...]

1129 5534

Open Access Editorial

Acknowlegement to Reviewers of Journal of Energy and Power Technology in 2020

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/jept.2101002

Abstract

The editors of Journal of Energy and Power Technology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a cer [...]

1123 5533

Open Access Interview

An Interview with Dr. Sok Cheon Pak

Received: 18 September 2022;  Published: 20 September 2022;  doi: 10.21926/obm.icm.2203043

Abstract

Interview with Dr. Sok Cheon Pak. Dr Pak as a physiologist currently leads and guides research into nutraceuticals to provide relevant and impactful clinical applications. The best example is the rice bran arabinoxylan compound (RBAC). RBAC is a functional food produced from hydrolysed rice bran denatured with shiitake mushroom enzymes. RBAC demonstrates strong immunomodulatory properties, particularly for enhancing the natural killer cell activity. Additionally, RBAC is a potent antiproliferative food supplement w [...]

884 5523

Open Access Concept Paper

Four Decades of Newborn Screening: A Historical Perspective of Laboratory Practices

Received: 21 March 2023;  Published: 30 October 2023;  doi: 10.21926/obm.genet.2304201

Abstract

The personal experience of 36 years in charge of the Newborn Screening Laboratory in Galicia and the consequences of the recent advancement of sampling from 3 days to 24 hours of the newborn's life are reviewed. The implication in the results of the assay of reducers in urine with the Mandelin reagent and its alternatives is commented. The implication in the effects of TSH in blood and the possible ways of dealing with the situation. Since 1978, the Newborn Screening Program in Galicia has maintained the urine samp [...]

1006 5518

Open Access Case Report

Maternally Derived Complex Small Supernumerary Marker Chromosome 22 Associated with Cat-Eye Syndrome Like Features

Received: 14 October 2024;  Published: 27 January 2025;  doi: 10.21926/obm.genet.2501282

Abstract

Cat-eye syndrome (CES) is a rare genetic disease first reported in 1965. The estimated prevalence of CES is 1:50,000 to 1:150,000, and it is typically associated with an inverted duplicated small supernumerary marker chromosome (sSMC) derived from chromosome 22. The specific chromosomal band involved in CES causing partial tetrasomy is 22q11.21, where chromosomal rearrangements occur due to the presence of low-copy repeats (LCR22). The phenotype of CES is extremely diverse, ranging from normal to multiple abnormali [...]

1030 5513

Open Access Review

Newborn Screening for Neuromuscular Disorders, Disorders of Glycogen Metabolism, and Fatty Acid Oxidation

Received: 08 February 2024;  Published: 18 April 2024;  doi: 10.21926/obm.genet.2402228

Abstract

Newborn screening for neuromuscular disorders and glycogen or fatty acid oxidation disorders aims to identify infants at risk for these conditions, allowing for early intervention and management. While not all neuromuscular disorders currently have established newborn screening programs, there are various disorders for which screening is available or under investigation. Neuromuscular disorders encompass a wide range of conditions that affect the nerve, muscle, or the connection between them. Examples include spina [...]

1185 5511

Open Access Original Research

Where Older Patients with Cancer Die? A Retrospective Study

Received: 10 July 2023;  Published: 16 November 2023;  doi: 10.21926/obm.geriatr.2304258

Abstract

Home is the preferred place of death for most cancer patients. We examined which characteristics of older patients with cancer may have influenced this choice and how important may be relevant an early collaboration between oncologists and palliatives. Hospitalized patients aged ≥70 were screened by G8 questionnaire and evaluated by Comprehensive Geriatric Assessment (CGA) to identify frail and unfit ones and define the most appropriate end-of-life setting with palliatives. Using the G8 questionnaire, we screened 1 [...]

1303 5500

Open Access Review

Spirituality as an International Coping Method during Covid-19

Received: 20 January 2024;  Published: 15 October 2024;  doi: 10.21926/obm.icm.2404059

Abstract

The Covid-19 pandemic has brought forth global challenges in socioeconomic, political, and public health dimensions. For many, spirituality was a powerful source of support during this pandemic experience. The current review provides an apt overview of spirituality as a coping method to mitigate the mental and emotional impact of global turmoil of Covid-19 within the context of Europe. Using select studies from Czechia, Italy, and Turkey which have low, middle, and high religiosity indexes respectively, the potenti [...]

935 5485

Open Access Original Research

On the Relation between Overwater Friction Velocity and the Wind Speed During Tropical Cyclones

Received: 17 October 2024;  Published: 15 January 2025;  doi: 10.21926/aeer.2501007

Abstract

In the realm of marine meteorology, physical oceanography, and coastal and ocean engineering, the wind-stress across the air-sea interface plays a dominant role. However, under tropical cyclone conditions, there is no consensus for the formulation of the drag coefficient, Cd, in the literature. Based on the wind-gust method and the measurements from data buoy 42001 during Hurricane Lili, it is demonstrated that, U* = 0.073U10 - 0.44, which is valid up to wind speed 47 m s-1 and wind gust to 66 m s-1, here U* is the [...]

856 5477

Open Access Original Research

Utilizing Machine Learning to Map Aquatic Weed Yields for Biochar Production: A Case Study in the Bangweulu Wetlands, Zambia

Received: 26 September 2024;  Published: 17 April 2025;  doi: 10.21926/aeer.2502020

Abstract

Aquatic weeds present significant ecological and socio-economic challenges in the Bangweulu Wetlands of northern Zambia, where their proliferation disrupts aquatic ecosystems, impedes fishing activities, and affects local livelihoods. Despite these challenges, aquatic weeds also offer a unique opportunity for sustainable biochar production, a clean alternative cooking fuel that can alleviate pressure on diminishing forest resources. This study explores the application of machine learning (ML) techniques to estimate [...]

1149 5473

Open Access Research Article

Possibilities of Predicting a Person's Substance Use Behaviour and Mental Health Through Social Media in a COVID-19 Crisis Context

Received: 18 July 2023;  Published: 01 November 2023;  doi: 10.21926/obm.icm.2304049

Abstract

The negative psychological consequences of the COVID-19 pandemic and the forced isolation of a large proportion of people worldwide have demonstrated the need to develop ways and technologies to reduce the effects of sudden threats of this type. The basis of any practical work to minimize the negative psychological consequences of the COVID-19 pandemic associated with substance use is the monitoring and diagnosis of the psychological resources of the individual. The article aims to show the possibilities of predict [...]

1023 5468

Open Access Original Research

Attenuation of Blood Glucose by the Ketone Monoester (R)-3-betahydroxybutyrate Glyceride in Healthy Male Sprague Dawley Rats in Response to a Standard Oral Glucose Tolerance Test

Received: 31 January 2025;  Published: 25 July 2025;  doi: 10.21926/rpn.2503014

Abstract

Efficient glucose uptake by peripheral tissue is important for individuals who desire to maintain optimal wellbeing. Various methods to regulate postprandial blood glucose have been reported in the research literature, however, few have examined the effect of ketone esters on blood glucose levels. The present study evaluated blood glucose following the administration of an oral glucose tolerance test, with and without ketone esters delivered at two different dosages, in a sample of healthy Sprague-Dawley rats. We h [...]

1026 5464

Open Access Interview

An Interview with Dr. Carlo Pedrolli

Received: 01 June 2022;  Published: 09 June 2022;  doi: 10.21926/obm.geriatr.2202199

Abstract

InterviewAn Interview with Dr. Carlo PedrolliOBM Geriatrics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: geriatrics@lidsen.comOBM Geriatrics 2022, volume 6, issue 2 doi:10.21926/obm.geriatr.2202199Received: June 01, 2022Accepted: June 02, 2022Published: June 09, 2022

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Open Access Editorial

Long-Term Effects of Auricular Medicine – A Key to the Future of Preventive Medicine?

Received: 17 September 2024;  Published: 19 September 2024;  doi: 10.21926/obm.icm.2403053

Abstract

Auricular medicine, based on the concept that the ear reflects the entire body, has gained recognition for treating various conditions through targeted acupuncture. Despite documented short-term benefits, such as pain relief and nervous system regulation, research into its long-term effects is limited. This editorial discusses the need for further long-term studies to explore whether regular auricular acupuncture can offer sustained health benefits and serve a preventive role. It summarizes two studies: one on auri [...]

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Open Access Editorial

Battlefield Acupuncture: Remembering a Pioneer and a Friend—In Memory of Dr. Richard C. Niemtzow, MD PhD MPH (1942–2025)

Received: 26 April 2025;  Published: 29 April 2025;  doi: 10.21926/obm.icm.2502020

Abstract

This contribution honours the life and legacy of Dr. Richard C. Niemtzow (1942–2025), the founder of Battlefield Acupuncture (BFA) – a method that combines military medicine and traditional Eastern healing principles. Developed in the early 2000s for rapid, drug-free pain relief, BFA has since gained international recognition for its effectiveness and simplicity. The author reflects on the scientific collaboration with Dr. Niemtzow, which included advanced neurophysiological studies demonstrating BFA’s impact on pa [...]

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