by Regiani Aparecida de Almeida  , Ricardo Vicente de Paula Rezende  , Flavia Aparecida Reitz Cardoso  and Lucio Cardozo Filho

Received: 17 December 2022;  Published: 18 April 2023;  doi: 10.21926/jept.2302016

In this work with CFD simulations, the evaluation of the supercritical anti-solvent (SAS) process for producing nanoparticles from an expanded solution of ethanol/solute in carbon dioxide is reported. The influence of the solution and antisolvent flow rates on mean particle size, the flow dynamic, and the supercritical mixture's jet velocity must be well established in the literature and analyzed. The high flow rate of the anti-solvent resulted in increased mean particle sizes for all studied cases. At the lowe [...]

by William E Vargas  , Federico Muñoz-Rojas  , Esteban Avendaño  , Victoria Quirós-Cordero  and Marcela Hernández-Jiménez

Received: 30 July 2022;  Published: 12 October 2022;  doi: 10.21926/rpm.2204019

Spectrophotometry has been widely used to retrieve the dielectric function of a bulk iridium sample using an extended version of the Drude–Lorentz model. The parameters of the model are optimized using a spectral-projected-gradient-method-assisted acceptance-probability-controlled simulated annealing approach. Furthermore, optimized values of Drude parameters corresponding to the optical response of electrons and holes (scattering frequency of electrons, the ratio between scattering frequencies of holes and electro [...]

by Clément Dumont  , Madeleine Lefèvre  , Quiterie Aussedat  , Pierre-Louis Régnier  , Alexandra Masson-Lecomte  , Evanguelos Xylinas  , Hélène Gauthier  , Virginie Fossey-Diaz  , Amélie Arégui  and Stéphane Culine

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of [...]

by Takeshi Hatta  , Taketoshi Hatta  , Junko Hatta  , Akihiko Iwahara  , Kazumi Fujiwara  , Kimiko Kato  and Yukiharu Hasegawa

Received: 15 October 2021;  Published: 24 February 2022;  doi: 10.21926/obm.geriatr.2201190

In the present study, we identified the factors of cognitive and physical performances predicting self-rated health perception (SRH) using an SRH questionnaire in 660 (298 men and 362 women) upper-middle-aged community dwellers. In addition, neuropsychological test battery and physical ability tests were applied. A multiple regression analysis was conducted using the forced entry method; digit cancellation test (D-CAT1), logical memory test, verbal fluency test, back strength, timed-up and-go (TUG), balancing test, [...]

by Nicholas J. Geraghty  , Amal Elhage  , Peter Cuthbertson  , Debbie Watson  and Ronald Sluyter

Received: 06 June 2022;  Published: 06 September 2022;  doi: 10.21926/obm.transplant.2203166

Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. The immune cell receptor channel P2X7 and its ligand adenosine 5’-triphosphate (ATP) have been implicated in GVHD pathogenesis. Therefore, this signaling axis represents a potential therapeutic target. This study aime [...]

by Raffaele Pezzilli

Received: 07 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.hg.1902017

Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic necrosis is a new entity of complications of acute pancreatitis. It is defined as a mature, encapsulated collection of pancreatic and/or peripancreatic necrosis which has developed a well-defined inflammatory wall. WON us [...]

by Carsten Croonenbroeck  and David Hennecke

Received: 20 July 2021;  Published: 25 October 2021;  doi: 10.21926/jept.2104044

In this study, we address the wind farm layout optimization (WFLO) problem and tackle the issue of optimal turbine placement by incorporating additional aspects of an economically driven target function. Firstly, we have analyzed the effect of wind direction on a given turbine arrangement. Based on the direction-dependent wake pattern, practitioners sometimes shut down certain turbines on their farms. Our method computes which turbines should be shut down in which wake situation. On this basis, we have developed a [...]

by Jennifer Marchbank  , KJ Reed  , Claire Robson  , Gloria Gutman  and Balbir Gurm

Received: 04 January 2024;  Published: 18 March 2024;  doi: 10.21926/obm.geriatr.2401274

Elder abuse occurs to older adults who are members of gender and sexual minorities (GSM). Whilst most of that abuse is similar to that experienced by their heterosexual and cisgender peers GSM older adults face particular vulnerabilities due to their life experiences and changes. In this article we report on our findings from a literature search and knowledge synthesis, conducted as part of a larger project to inform Canadian policy makers working to eliminate gender and sexuality-based inequalities. The review inc [...]

by David J. Ross

Received: 27 March 2020;  Published: 31 March 2020;  doi: 10.21926/obm.transplant.2001106

by Gerhard Litscher

Received: 02 April 2024;  Published: 03 April 2024;  doi: 10.21926/obm.icm.2402022

Acupuncture, as a promising complementary therapy for cancer patients, offers personalized symptom management and improved quality of life alongside conventional treatments. With its proven efficacy in alleviating chemotherapy-induced side effects such as nausea, fatigue, and pain, acupuncture stands as a holistic approach to cancer care. Tailored to individual needs and boasting a favorable safety profile, acupuncture addresses both physical symptoms and psychological distress, promoting resilience and quality of [...]

by Annapaola Mariniello  and Silvia Novello

Received: 15 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.genet.1901069

Immune oncology treatment with immune checkpoint inhibitors (ICIs) is revolutionizing therapeutic approach for advanced non-small cell lung cancer (NSCLC) patients, in terms of longer survival and improved quality of life. To date, the widely used and approved biomarker is programmed death ligand 1 (PD-L1) expression on tumour cells, but it is considered not accurate and it is more likely that many factors, related to both cancer and host, may better predict response to ICI. Among those factors, great attention is [...]

by Diana Eréndira Lara-Llanderal  , Juan Carlos Castro Dominguez  and Karla Graciela Cedano Villavicencio

Received: 02 September 2024;  Published: 07 February 2025;  doi: 10.21926/aeer.2501010

This article explores a strategy to empower vulnerable communities by transferring solar technology as a path to energy justice development. The proposed methodology is based on preliminary research on energy uses according to the needs, practices, and customs of the communities. The study focuses on the cases of three women with productive vocations based on entrepreneurship in different phases of incubation found in a peri-urban community in central Mexico. In this community, productive energy uses include a) the [...]

by Gilda F. Pardey Bracho  , Karine Collomb  and Astrig Topouzkhanian

Received: 09 May 2022;  Published: 28 July 2022;  doi: 10.21926/obm.icm.2203030

The patient as the custodian of their own care is a concept that has been evolving for several years and can help the patient to a better and quicker recovery. Medical Hypnosis (MH) assist the practitioner to reduce the patient’s pain and disorders and help the patient to understand, accept, and manage their situation. Recently, this technique has been increasingly used in awake surgery protocols. This paper describes three examples of the successful perioperative management of patients who benefited from an awake [...]

by Russell Razzaque

Received: 28 January 2018;  Published: 27 March 2018;  doi: 10.21926/obm.icm.1801001

The value of mindfulness for clinical staff in the mental health field has thus been increasingly recognised over recent year and thus is now culminating in the evaluation and, potential future role out, of whole system approaches like Open Dialogue that put clinician mindfulness at the heart of the model. It is anticipated that this will ultimately be for the benefit of both staff and clients of these services alike, creating improvements and improving lives, therefore, on many levels.

by Keita Kiuchi  , Katsumasa Kishi  and Kanto Araki

Received: 23 December 2020;  Published: 17 March 2021;  doi: 10.21926/obm.icm.2101010

This study investigated the physical and psychological impacts of elements related to coronavirus disease (COVID-19) and demographic data in Japan both directly and as mediated by stressors, immediately following the rescinding of the state of emergency declaration accompanying the severe acute respiratory syndrome coronavirus 2 outbreak. An online survey was administered to 1,500 Japanese registered with an online outsourcing service. Data were analyzed with structural equation modeling using Mplus. Relatively lar [...]

by Vardan Apinyan

Received: 30 March 2023;  Published: 24 June 2023;  doi: 10.21926/rpm.2302026

This paper considers a finite-sized two-leg ladder of spin-1/2 particles with local inter-chain Ising interaction. We include the effects of an external magnetic field by incorporating a Zeeman-type coupling between the magnetic field and the spins localized on the lattice sites. To analyze the system, we utilize the transfer-matrix formalism to calculate the partition function. We compute the magnetization for different configurations by varying the system's parameters. We observe the presence 3of spontaneous magn [...]

by Tammy Lennox  and Angela Kennedy

Received: 08 February 2022;  Published: 20 July 2023;  doi: 10.21926/obm.icm.2303030

The current article describes the application of the Compassion Focussed (CF) formulation to the interaction between individuals and their social context. The standard CF formulation [1] would see the person’s fears as inadvertently reinforced by their attempts to cope with the underlying issue. However, sometimes such attempts to cope can also reinforce the fears of another person or party. Interpersonal CF formulations could provide a compassionate, non-blaming way of enlightening people in their interactions to [...]

by Jigar Jogia

Received: 17 April 2017;  Published: 09 July 2017;  doi: 10.21926/obm.neurobiol.1702006

There is a need for early diagnosis, monitoring and treatment of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Traditional assessments of cognitive decline have been found to lack sensitivity and accuracy in differentiating varying stages of Dementia and cognitive decline as well as being time consuming in their administration. Key components of cognition namely memory and executive function have been identified as most predicative of AD status. Brief cognitive screening tools such as the Montreal C [...]

by Sigal Shaklai  , Meital Grafi-Cohen  , Orli Sharon  , Gabi Shefer  , Dalia Somjen  and Naftali Stern

Received: 17 April 2019;  Published: 27 August 2019;  doi: 10.21926/obm.transplant.1903082

Background: Estradiol 17-beta (E2) enhances the function and survival of pancreatic beta-cells, but its clinical use has been questioned due to concerns regarding oncogenic potential and feminizing effects in males. The G-protein coupled estrogen receptor (GPER), expressed in pancreatic islets, exhibits estrogenic beta-cell protective effects without the feminizing effects of the nuclear ERs. Here, we examine the outcome of selective activation of the three estrogen receptors ERα, ERβ, and GPER on rep [...]

by Nicholas J Cook

Received: 14 April 2021;  Published: 25 June 2021;  doi: 10.21926/jept.2102027

A refined and extended version of the Offset Elliptical Normal mixture model has been developed to parameterise the seasonal diurnal wind vector automatically. Automated using R scripts, the method eliminates any potential risk of confirmation bias posed by the manual supervision in the original method. Refinements to the method include the latest algorithms for clustering of Gaussian mixtures, with Bayesian regularisation to set the number of components and to limit the predisposition to overfit. A new extension u [...]

by Bin Ni  , Nidhi Sharma  , Ashley Rosko  , Don M. Benson  and Yvonne A. Efebera

Received: 12 April 2021;  Published: 09 July 2021;  doi: 10.21926/obm.transplant.2103148

Prior to the advent of anti-retroviral therapy (ART), autologous stem cell transplant (ASCT) was relatively contraindicated for multiple myeloma (MM) patients with human immunodeficiency virus (HIV) due to issues associated with stem cell harvest and the risk of opportunistic infections. With the widespread use of ART for control of HIV, ASCT is now the preferred treatment for relapsed lymphoma, the leading hematopoietic malignancy associated with HIV/AIDS. Hence, MM patients with HIV controlled by ART may benefit [...]

by Ibrahim El-Serafi  , Sandra Oerther  , Ying Zhao  and Moustapha Hassan

Received: 08 July 2022;  Published: 27 July 2022;  doi: 10.21926/obm.transplant.2203163

Cytochrome P450 2J2 (CYP2J2) is one of the recently discovered enzymes that is involved in the metabolism of several drugs. It is mainly an extrahepatic enzyme which can, to some extent, explain some the drugs’ side effects such as cyclophosphamide (Cy). Cyclophosphamide is an alkylating agent that is commonly used in conditioning prior to stem cell transplantation. It is a prodrug that is bio-activated by several CYPs including CYP2J2. Cy is known to have several side effects and its extrahepatic activation by CYP [...]

by Joep Geraedts

Received: 13 January 2020;  Published: 14 January 2020;  doi: 10.21926/obm.genet.2001102

At the beginning of a new year it is always good to look both backwards and forwards and to highlight a few items that are relevant with respect to the long-term development of our journal. As everybody knows, the principle of open access publishing is that the authors pay fees (the article‐processing charges or APCs) to publish in the journal rather than that the readers pay subscription costs for the journal. Three years ago, OBM Genetics started as an open access journal publishing its first papers totally free [...]

by Niamh Flynn

Received: 01 July 2019;  Published: 26 September 2019;  doi: 10.21926/obm.icm.1903057

Hypnosis interventions consistently produce significant decreases in pain associated with a variety of chronic-pain problems (Elkins, Jensen & Patterson 2007) while neurophysiological studies have shown that specific hypnotic suggestions have clear effects on the brain and spinal cord functioning (Jensen & Patterson 2014; Flynn, 2019). Thus, it isuseful for clinicians who practise hypnotherapy to understand pain paradigms.

by Whitney Rabacal  , Emily Rayens  and Karen Norris

Received: 02 November 2018;  Published: 27 December 2018;  doi: 10.21926/obm.genet.1804057

Pneumocystis causes life-threatening pneumonia in immunocompromised populations. More recently it has been implicated as a co-factor in a number of chronic lung diseases including chronic obstructive pulmonary disease (COPD), severe asthma, and cystic fibrosis (CF). In this review, we will examine the current literature regarding Pneumocystis and lung diseases in the HIV-infected patients and non-HIV immunocompromised populations, and the barriers to prophylaxis and treatment in these patients. Trimethoprim sulfame [...]

by Lucy Watts  , Joanna Smith  , Wilfred McSherry  , Michael Tatterton  and Alison Rodriguez

Received: 08 May 2020;  Published: 08 May 2020;  doi: 10.21926/obm.icm.2002027

by C. Shawn Sun  , Nahid Farzana  , Dinesha Kuruppuarachchi  , Mohammadamin Azimi  and Huayuan Zhong

Received: 10 September 2022;  Published: 04 May 2023;  doi: 10.21926/rpm.2302019

Infrastructure degradation attributable to concrete deterioration and corrosion of reinforcing steel has been a long-standing challenge to the owners and engineers. This problem becomes more evident when concrete structures are subject to aggressively corrosive environments. The use of advanced materials such as ultra-high performance concrete (UHPC) and carbon fiber reinforced polymer (CFRP) bars has a strong potential to overcome this challenge and help build new infrastructure that is durable and sustainable. Ho [...]

by Jacqueline Cramer

Received: 24 September 2023;  Published: 21 November 2023;  doi: 10.21926/aeer.2304050

This paper investigates the practical implementation of transitioning to a circular economy through network governance in conjunction with public governance. The research focuses on a comparative, longitudinal analysis of three Dutch product chains (mattresses, concrete, and textiles) from 2016 to the present. The study based on action research, utilizes documents, reports from all meetings, and personal observations. Drawing from the fields of public administration and transition management, the paper addresses tw [...]

by Tarik Wasfie  , Avery Jackson  , Cara Marie Brock  , Stefanija Galovska  and Jennifer Hille

Received: 07 November 2019;  Published: 13 November 2019;  doi: 10.21926/obm.geriatr.1904085

None.

by Sandra Mikhael  , Maria Shawky  , Gulraiz Hashmi  , Ivan Bernal  and Roger A. Lalancette

Received: 28 June 2020;  Published: 23 July 2020;  doi: 10.21926/acr.2003006

It is historically interesting to note that, whereas the [Co(NH3)6]3+ cation was isolated by Tassaert in 1798 (which he described as the tri-chloride) and that, in the early days of Coordination Chemistry, Jørgensen and Werner isolated many of its other salts, the fluoride was never reported. In fact, in relatively modern times, lack of success was, invariably, the result of attempting its isolation and full characterization. Significantly, there is no entry for its structure in standard sources such as Inorganic C [...]

by Srinivasan Periasamy  , Se-Ping Chien  , Chen Hsu  , Dur-Zong Hsu  and Ming-Yie Liu

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047

Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hyperglycemia and diabetes. We studied the role of metformin in reversing sleep deprivation-induced hyperglycemia and pancreatic and liver dysfunction in mice. Mice were kept in cages and fed water and food ad libitum. Mice wer [...]

by Oswaldo Núñez  , Mohammad Fereidooni  , Victor Márquez  , Duangthip Sattayamuk  , Piyasan Praserthdam  and Supareak Praserthdam

Received: 25 August 2023;  Published: 05 December 2023;  doi: 10.21926/cr.2304029

To improve CH4 and H2 formation from CO2 photoreduction using non-organic, non-laborious, and inexpensive photocatalysts, we have prepared two surface-silicate-modified TiO2 catalysts: P25-SiO2 and AmTiO2-SiO2 (amorphous TiO2) to be tested in water and using UV light. The last catalyst produces more CH4 and H2 in water than P25 (3:1 TiO2 anatase: rutile) under UV light irradiation of HCO3- and CO2; am-TiO2-SiO2 at pH = 7, produces 8 times more CH4 and H2 than P25 with selectivity at the reactor headspace of 30% and [...]

by Johanne Traeger-Synodinos  and François Rousseau

Received: 06 September 2019;  Published: 11 September 2019;  doi: 10.21926/obm.genet.1903094

We present here the content and articles of this special issue on genetic screening, putting them in perspective with the field and between themselves.

by Olivia L. Pastore  , Michelle S. Fortier  , Leah J. Ferguson  and Shane N. Sweet

Received: 23 August 2023;  Published: 20 December 2023;  doi: 10.21926/obm.icm.2304061

Self-compassion involves being touched by and open to one's own suffering, coupled with the desire to alleviate it and heal oneself with kindness. While self-compassion has gained significant attention in research, certain conceptual and methodological complexities have evolved over time and led to ambiguity surrounding the concept. As such, the overall purpose of this commentary was to highlight and discuss the different perspectives of self-compassion in the literature. We opted to centralize our focus primarily [...]

by Mariusz KSIĄŻEK

Received: 24 March 2021;  Published: 15 June 2021;  doi: 10.21926/rpm.2102024

Metal parts of endoprosthesis have a detrimental effect on the bones that come into contact with them and on the entire body of the patient. Coating them with biocompatible layers (hydroxyapatite and bioglass) has not yet brought about permanent results. In this study, the author showed the possibility of using a binder containing sulfur waste for this purpose. The sulfur binder is used industrially in electrical engineering and construction applications. The chemical properties of elemental sulfur indicate that it [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 16 August 2024;  Published: 10 January 2025;  doi: 10.21926/obm.neurobiol.2501263

This review aims to explore research on the development of emotions in organisms at the simple reflexes substage of the sensorimotor stage of cognitive development. We review the literature on alterations in spontaneous blinking in children under 6 months of age. Then, we extract the data from the selected studies that allow us to examine whether simple reflexes in infants reveal the emotion signature in the altered reflective responses. The significance of this study is that it is the first review to demonstrate t [...]

by Rastislav Burda  , Viera Danielisová  and Jozef Burda

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Background: Many experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. However, the translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-Methyltin (TMT) poisoning and short-term transient cerebral ischemia cause similar damage, especially, to selectively vulnerable brain regions such as hippocampal CA1 and CA3. Methods: Using dual conditioning, we activated the full [...]

by Charitha Thambiliyagodage  , Madara Jayanetti  , Geethma Ekanayake  , Amavin Mendis  , Heshan Liyanaarchchi  and Supuni Wijayawardana

Received: 10 April 2024;  Published: 13 June 2024;  doi: 10.21926/cr.2402006

Ilmenite is a mineral whose crystallinity can be altered by chemical treatment, producing TiO2 and iron and titanium-based metal nanocomposites, which are applicable mainly for photocatalysis. Porous and crystalline biomass-derived carbon materials include graphene oxide, reduced graphene oxide, graphitic carbon nitride, catalytically graphitized sucrose and chitosan, and activated carbon. Ilmenite-based metal oxides coupled with biomass-based carbon materials are effective in environmental remediation, especially [...]

by Joana Sousa

Received: 15 May 2023;  Published: 15 January 2024;  doi: 10.21926/aeer.2401003

The climate change and the social crisis launched the basis for the policy discussion about future trajectories of development and sustainability. Innovation policies are expected to promote the transformation of complex socio-technical systems and call for fundamentally different societal production and consumption patterns. This is strictly associated with energy systems and energy policies. A policy framework was conceptualized considering three levels approach: the policy shape at the micro level, the policy co [...]

by Ute Moog  and Domenico Coviello

Received: 14 August 2018;  Published: 13 September 2018;  doi: 10.21926/obm.genet.1803034

he publication of the double helix DNA structure in 1953 [1] was the kick-off of numerous efforts to understand and unravel the complexity of the human genome. It took 50 years until the human genome project, based on Sanger sequencing, was completed in 2003 [2]. This was followed by what may be considered a revolution in the field of DNA analysis: the introduction of Next Generation Sequencing (NGS) in 2005 consisting of massively parallel sequencing of DNA fragments which allows the high throughput analysis of la [...]

by Dimitris Kouzoudis  , Georgios Samourgkanidis  and Christos I. Tapeinos

Received: 12 December 2020;  Published: 06 April 2021;  doi: 10.21926/rpm.2102010

In the current work, to identify the bending mode harmonics, 30 microns thin magnetoelastic ribbons made of metallic glass are embedded inside 6 mm thick PLA plastic cantilever beams made by 3-D printing. This is possible because the ribbons are of magnetoelastic nature and thus change their mechanical state inducing a corresponding change in their magnetic state. The ribbons are placed at four different depths, starting with zero depth at the beam’s external surface all the way inside to the beam’s mid-plane. This [...]

by Vsévolod Mymrin  , Reinaldo H. G. Alarcon  , Marilia A. Guidolin  , Kirill Alekseev  , Rogerio J. Hultmann  , Walderson Klitzke  , Karina Q. Carvalho  , Fernando H. Passig  , Charles W.I. Haminiuk  and Rodrigo E. Catai

Received: 08 December 2022;  Published: 27 February 2023;  doi: 10.21926/cr.2301009

Methanol synthesis catalyst (MSC) waste was applied as the principal component (till 70 wt.%) of sustainable ceramics in composites with bauxite processing waste (RM), and waste foundry sand (FS). The results of the initial components' chemical interaction studies by a complex of methods (XRD, SEM/EDS/mapping, AAS and LAMMA) during heating demonstrated the synthesis of amorphous glasslike new formation, their filling of pores and compaction of the ceramic’s structure. In this case, a strong chemical and mechanical [...]

by G. S. N. V. K. S. N. Swamy Undi  and Rohit Kantikar

Received: 07 September 2023;  Published: 01 March 2024;  doi: 10.21926/aeer.2401009

Particulate matter (PM) constitutes a significant risk factor for environmental health regarding ambient air quality. An epidemiological investigation has determined that inadequate air quality is associated with the development of lung and cardiovascular diseases, chronic ailments, respiratory infections, and a significant number of fatalities on a global scale. According to the World Health Organization (WHO), the annual mortality rate due to air pollution is around 7 million individuals. The necessity for resear [...]

by Solaf Alaakel  and Youssef. AL-Ammouri

Received: 29 July 2023;  Published: 26 October 2023;  doi: 10.21926/obm.genet.2304200

The experiment was carried out at the laboratories of the National Commission for Biotechnology in Syria during the period 2020-2022 to detect the somaclonal genetic variation occurring in callus cultures at different ages and to compare them with the In vitro growing plants and introduced species of Rose Periwinkle that grew up in the Syrian environment, in addition, exploring the effect of abiotic stresses in causing genetic variations in callus, by the Inter Simple Sequence Repeats technique (ISSR) using 21 prim [...]

by Ferdaouss Qassimi  , Saïd Boujraf  , Adam Khlifi  , Ghizlane Lamgari  , Zineb El Bourachedy  , Chadya Aarab  , Rachid Aalouane  and Amine Bout

Received: 17 January 2023;  Published: 04 August 2023;  doi: 10.21926/obm.neurobiol.2303176

Alexithymia and personality disorders are common in substance use (SUD) patients. This association remains understudied and is considered to hurt the course and management of substance use disorder patients. To determine the prevalence of personality disorders (PD) and alexithymia in addiction care patients. Besides, we targeted investigating a possible link between alexithymia, different personality disorders and clinical aspects of substance use disorder including severity. This cross-sectional study was conducte [...]

by Melissa Lopez-Pentecost  , Francine C. Gachupin  , Robin Hazelwood  , Otellie Honanie  , Jessica Quamahongnewa  and Cynthia Thomson

Received: 27 September 2022;  Published: 12 January 2023;  doi: 10.21926/rpn.2301002

American Indians (AI) suffer the highest rates of diabetes in the United States (US); a chronic disease that is increasingly prevalent among AI children and is associated with increased risk of cancer. A summer camp was developed to improve disease risk-reducing behaviors, including diet, among AI youth in Arizona. The aim of this study was to examine the efficacy of a one-week intensive summer health camp conducted from 2016 to 2019 on change in dietary behaviors and compliance for Dietary Guidelines for Americans [...]

by Charles Heriot-Maitland  and Jo Taylor

Received: 22 March 2024;  Published: 11 June 2024;  doi: 10.21926/obm.icm.2402033

This article describes the development and delivery of a novel model of supervision for senior teachers in schools, informed by Compassion Focused Therapy (CFT). It explores whether this model can be considered acceptable and valuable to senior teachers, and is able to be delivered by multiple supervisors using a manual. Surveys, interviews, and focus groups were used to gather feedback about the value and impact of the supervision. Data were gathered from 39 senior teachers across three phases to assess feedback o [...]

by Ivan M. Lang

Received: 17 August 2020;  Published: 02 November 2020;  doi: 10.21926/obm.hg.2004052

Several digestive tract reflexes involving the esophagus and its sphincter muscles have been identified, but to date, no comprehensive review has addressed most of these reflexes. The current review presents the known physiology of different esophageal reflexes in which either the esophagus or its sensory or motor portion of the reflex response is elaborated. The current review comprehensively examines the known and possible mechanisms underlying major esophageal reflexes, highlights the huge gaps in current knowle [...]

by Olushola S. Ayanda  , Cecilia C. Oforkansi  , Omolola H. Aremu  , Oluwakemi E. Ogunjemiluyi  , Ololade L. Olowoyeye  and Cecilia O. Akintayo

Received: 26 June 2022;  Published: 25 July 2022;  doi: 10.21926/cr.2203022

In this study, we investigated the degradation of amido black dye in an aqueous solution using ultra-violet (UV) light catalyzed by iron oxide nanoparticles (nano-Fe). The nano-Fe was synthesized by sodium borohydride reduction of ferric chloride solution and was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray fluorescence spectrophotometry (XRF). The SEM of the nano-Fe showed regular spherical particles, the XRD examination showed a weak and broad peak at Fe (1 1 0), and the [...]

by Rie Sasaki  , Hiroto Ito  and Masami Okamoto

Received: 01 March 2022;  Published: 14 June 2022;  doi: 10.21926/obm.genet.2202155

In this study, we examined the effect of a combination of surface topographies (fiber alignments) and different stiffness of poly(L-lactic acid) (PLLA) substrates on the direct relationship between anti-cancer drug (CDDP) sensitivity for MDA-MB-231 cells and mesenchymal properties under both normal and hypoxic conditions. In addition, we studied the induction of epithelial–mesenchymal transition (EMT). The CDDP treatment under hypoxia indicated poor adhesion of MDA-MB-231 cells as well as significant repression of [...]