by Pierre-Yves Maillard  , Sima Tokajian  , Marie Vilaire-Meunier  , Charbel Al Khoury  , Cybel Mehawej  , Eliane Chouery  , Marie-Anne Caillaud  , Louise Maillebouis  , Ines Ben Smida  , Sophie Durand  , Aimé Ravel  , Cecile Cieuta-Walti  , Marie-Noëlle Ungeheuer  , Clotilde Mircher  and André Mégarbané

Received: 05 October 2024;  Published: 03 July 2025;  doi: 10.21926/obm.genet.2503300

To investigate the potential impact of the additional chromosome 21 on the gut microbiome in patients with Down syndrome (DS), two monozygotic (MZ) and two dizygotic (DZ) twin pairs discordant for DS were studied. Whole-genome shotgun sequencing was conducted to analyze the taxonomic and functional profiles of the gut microbial community in the twins and assess whether the gut microbiome composition influences the development of psychological pathologies. Sequencing generated a total of 2,338,132 reads, combined ac [...]

by Gerhard Litscher

Received: 07 July 2025;  Published: 10 July 2025;  doi: 10.21926/obm.icm.2503030

With the passing of Prof. Dr. Frank Bahr, the field of complementary medicine has lost one of its most influential personalities. As a pioneer of auricular medicine in the German-speaking world, he helped shape the field of integrative medicine over many decades. This tribute by Prof. DDr. Gerhard Litscher honors Bahr's work, his convictions, and the legacy of a visionary whose impact on energy and spiritual medicine endures.

by Ali Asghar Fallahi  and Shahnaz Shekarforoush

Received: 27 November 2024;  Published: 05 August 2025;  doi: 10.21926/obm.icm.2503034

Cardiovascular disease remains the leading cause of death worldwide, prompting extensive research into effective methods for treatment and prevention. Among these, exercise training and physical activity are widely recognized as the safest and most effective strategies for improving health. Specifically, exercise training has been explored for its role in cardioprotection, particularly in reducing damage caused by ischemia-reperfusion (I/R) injury and myocardial infarction (MI). Both high-intensity interval trainin [...]

by Rodolfo Pessina  , Fabrizia Colmegna  , Massimo Clerici  and Ester di Giacomo

Received: 26 December 2023;  Published: 13 June 2024;  doi: 10.21926/obm.icm.2402034

Therapeutic termination of pregnancy (TToP) is performed for maternal health risks or severe fetal malformations. Research focuses on women's psychopathological outcomes after TToP, noting that 10-22% of women experience psychiatric disorders, especially depressive symptoms and post-traumatic stress disorder (PTSD). However, little is known about paternal mental outcomes. This study analyzed biological fathers' mental health at a 1-year follow-up after TToP. Results indicate biological fathers show no alarming psyc [...]

by Irene Andressa  , Glauce Kelly Silva do Nascimento  , Daniela de Oliveira Teotônio  , Nathalia de Andrade Neves  , Josimar Rodrigues Oliveira  , Elizabeth Harumi Nabeshima  , Vivian Machado Benassi  and Marcio Schmiele

Received: 14 October 2024;  Published: 28 July 2025;  doi: 10.21926/rpn.2503015

Germination is a viable, cost-effective, and environmentally friendly biotechnological process that enhances the industrial applications of cereals. This study evaluated the impact of germination (86 hours at 30°C) on soluble solids, proximate composition, and total phenolic compounds (TPC) in water-soluble extracts. It also included imaging analyses using scanning electron microscopy (SEM), X-ray diffraction (XRD), apparent amylose content, and starch pasting properties of purple pericarp Creole corn (PPCC) fr [...]

by OBM Neurobiology Editorial Office

Received: 03 January 2024;  Published: 02 January 2024;  doi: 10.21926/obm.neurobiol.2401204

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the [...]

by OBM Transplantation Editorial Office

Received: 03 January 2024;  Published: 04 January 2024;  doi: 10.21926/obm.transplant.2401205

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to t [...]

by Robert Marx

Received: 24 April 2024;  Published: 20 August 2024;  doi: 10.21926/obm.icm.2403047

It is an axiomatic in secular mindfulness that to become present is to direct attention away from thinking to physical sensation. While this can be a useful strategy to manage depressive rumination, as an automatic default position, it risks demonising our fundamental human capacity to purposefully think about the causes of suffering and how to reduce it. Many approaches within Mahayana Buddhism in particular explicitly use reflection on key ideas as necessary pre-requisites to meditation, and in these traditions, [...]

by Jessica Palacios  , Odin Ramírez-Fernández  and Esmeralda Zuñiga-Aguilar

Received: 22 August 2024;  Published: 07 March 2025;  doi: 10.21926/obm.transplant.2501240

Tissue engineering offers alternatives when it comes to health problems such as trauma or pathologies. One of them is the scaffolds, which provide a favorable architecture, mechanics, and biocompatibility for the fixation of cells. Therefore, the following research aims to design and simulate scaffolds with mixed geometric structures to create a hybrid architecture for osseointegration while maintaining structural properties similar to subchondral bone and hyaline cartilage. Three scaffolds were designed for this p [...]

by Buket Kılıç  and Dilek Ünal

Received: 31 May 2025;  Published: 27 October 2025;  doi: 10.21926/obm.neurobiol.2504307

Although anxiety and Autism Spectrum Disorder (ASD) are common co-morbidities, the relationship between autistic traits and anxiety disorders/symptoms has been increasingly researched in recent years. This review aims to compile the studies conducted on this topic and enhance our understanding of it. All publications up to September 1, 2024, on PubMed that contained the terms ‘anxiety’, ‘autistic traits’, ‘autism feature’, ‘autism-like symptoms’, and ‘ASD-like symptoms’, in their titles or abstracts were reviewed. [...]

by Sergey Lytaev  and Ksenia Belskaya

Received: 18 December 2024;  Published: 29 August 2025;  doi: 10.21926/obm.neurobiol.2503299

Consciousness is an integrative process that combines several executive functions, as well as the analytical and synthetic activity of the brain. In some psychopathological conditions, in particular, in schizophrenia, low-information "borderline" disorders of the executive functions and consciousness are often formed at the onset. The present study was aimed at assessing the integration of the bran alpha regulatory system and the modulation of consciousness based on the data of recording the alpha rhythm of resting [...]

by Giulio E. Lancioni  , Gloria Alberti  , Chiara Filippini  , Nirbhay N. Singh  , Mark F. O’Reilly  , Jeff Sigafoos  and Serafino Buono

Received: 14 October 2024;  Published: 12 February 2025;  doi: 10.21926/obm.neurobiol.2501268

People with severe-to-profound intellectual disability and blindness tend to be sedentary and detached, given their orientation and mobility problems, often combined with their limited interest in their surroundings. An approach to address this problem may involve the use of technology systems guiding the participants through mobility and occupational activity (object use) with a combination of spatial/orientation cues, basic instructions for the responses required by the activity, and positive stimulation during t [...]

by Michael Y. Shino  , Francisco Javier Ibarrondo  , Jesse L. Clark  , Adreanne Rivera  , Marlene Florian  , Allison Ramsey  , Ariss Derhovanessian  , Rajan Saggar  , Olawale O. Amubieya  , Grant Turner  , Joanna M. Schaenman  , Pryce T. Gaynor  , Omer E. Beaird  , Ashrit Multani  , Reshma M. Biniwale  , Murray H. Kwon  , Christos J. Petropoulos  , Yolanda Lie  , Terri Wrin  , Amparo L. Figueroa  , Brett Leav  , Zelalem Endale  , Kate Anteyi  , Jacqueline M. Miller  , Abbas Ardehali  , David M. Sayah  , David Elashoff  , John A. Belperio  , Otto O. Yang  and S. Sam Weigt

Received: 16 August 2024;  Published: 20 November 2024;  doi: 10.21926/obm.transplant.2404227

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher-dose mRNA-1273 booster vaccination enrolled nineteen adult LTRs into the 50 µg (n = 8) vs. 100 µg (n = 11) groups before enrollment was terminated due to the availability of the bivalent mRNA-1273.222 vaccine [...]

by Muhammad Zahid  , Amir Shakeel  , Dilawar Aslam  , Qumber Abbas  , Basharat Ali  , Yasir Niaz  , Javed Iqbal  , Fatih Çiğ  , Murat Erman  , Hakkı Akdeniz  , Mohammad Sohidul Islam  , Muhammad Aamir Iqbal  , Disna Ratnasekera  , Ömer Konuşkan  and Ayman El Sabagh

Received: 09 July 2025;  Published: 10 November 2025;  doi: 10.21926/obm.genet.2504316

Wheat constitutes the backbone of global food supplies, and its production is directly linked to the food and nutritional security of the mounting population. Wheat is vulnerable to abiotic stresses like heat, salinity, and drought. These abiotic stresses tend to reduce the food security of the increasing population by reducing wheat production and nutritional quality. Among abiotic stresses, salinity stress (SS) has emerged as the most prevailing stress in modern high-input wheat farming systems, as it severely ha [...]

by Annie J. Keeney  , Anabel Rodriguez  , Jaime Murillo  and Savannah S. Ingold

Received: 20 August 2024;  Published: 06 January 2025;  doi: 10.21926/obm.icm.2501002

Farmworkers are the backbone of the agricultural economy in the US yet are disproportionately burdened with economic-related stress and adverse behavioral health outcomes. How these stressors translate to children and family well-being is poorly understood. Grounded in Transactional Stress and Coping Theory, we aimed to understand how children and families adapt and respond to the stressors associated with farm labor occupations in a rural, underserved, bi-national community. We utilized focus groups with adult chi [...]

by Negar Gorjizadeh  , Payam Saadat  , Abbas Azadmehr  and Saeed Irian

Received: 09 June 2025;  Published: 11 September 2025;  doi: 10.21926/obm.genet.2503310

Genetic factors including TNF-β and DRD2 have been considered as essential components in the etiology of migraine. Several studies have investigated the association between TNF-β +A252G or DRD2 C939T polymorphisms and migraine risk, with debatable results. We aimed to examine whether TNF-β +A252G and DRD2 C939T polymorphisms confer genetic susceptibility to migraine in a Northern Iranian case-control sample. In total, 151 migraineurs (105 with MO 46 with MA) and 144 healthy control subjects were included in this st [...]

by G.-Fivos Sargentis  and Nikolaos Papadodimas

Received: 11 June 2025;  Published: 11 November 2025;  doi: 10.21926/aeer.2504032

This study proposes a novel creative tourism model integrating artistic creation with circular economy principles to foster regional revitalization in North Euboea, Greece. Employing a case study approach, it develops the concept of “Cultural Cells”—dedicated hubs for artists and art students specializing in painting and sculpture—designed to enhance tourism through immersive engagement. The methodology combines qualitative analysis of regional cultural and environmental assets with theoretical estimates of circula [...]

by Sara Evans  , Ariba Moin  and Ashwini Arjuna

Received: 13 June 2024;  Published: 09 April 2025;  doi: 10.21926/obm.transplant.2502246

Varicella-zoster virus (VZV) significantly impacts the central and peripheral nervous systems, particularly in immunocompromised individuals. This case report details a rare presentation of VZV meningoencephalitis in a 42-year-old woman with interstitial lung disease and connective tissue disease undergoing lung transplant evaluation who presented with a thunderclap headache and a new-onset seizure. Despite normal initial MRI findings, further investigation with PCR of the cerebrospinal fluid (CSF) revealed the pre [...]

by Mina Zeinalzadeh  , Alireza Ala  , Samad Shams Vahdati  and Elyar Sadeghi-Hokmabadi

Received: 16 May 2024;  Published: 01 April 2025;  doi: 10.21926/obm.neurobiol.2502282

Cerebrovascular diseases such as strokes and cerebral hemorrhages are important causes of death in the world, which increase during pregnancy due to physiological conditions. This study investigated risk factors such as diabetes mellitus, hypertension and other factors by searching in databases. After searching, 35 articles were reviewed based on the inclusion criteria. The inclusion criteria included articles from 2014-2024 related to the words "pregnancy" AND "cerebrovascular disease." The obtained results were e [...]

by Moussa Hamidani  , Salah Aberkane  and Moudjahid Aissaoui

Received: 17 December 2024;  Published: 16 May 2025;  doi: 10.21926/obm.transplant.2502249

Although immunosuppressive drugs are essential and effective in improving the health status of renal transplant patients, they also make them more vulnerable to the risk of infection with COVID-19, which has become a significant concern for many patients. Perhaps this is what makes their way of thinking and perception impact their adherence to taking immunosuppressants. Therefore, this study reveals the possibility of an impact of illness perception and some sociodemographic and clinical factors on treatment adhere [...]

by Deanna Gray-Miceli  , Jeannette Rogowski  and Sarah J. Ratcliffe

Received: 11 March 2025;  Published: 16 September 2025;  doi: 10.21926/obm.geriatr.2503327

Evidence shows the use of interventions to prevent falls are costly to healthcare facilities. Using a sample of older adult patients who fell at least once during the intervention year of a three-year cohort study in one long term care nursing facility, at a continuing care community providing skilled nursing and assisted living, we provide detailed evidence of the number and costs of durable medical equipment and number and type of non- durable medical nursing care interventions utilized to prevent subsequent fall [...]

by Carlos Armenta-Déu

Received: 04 February 2025;  Published: 11 July 2025;  doi: 10.21926/aeer.2503025

The study aims to evaluate the progressive increase in energy systems pollutant emissions due to the efficiency loss and continuous deterioration in the energy conversion process. The paper analyzes the GHG, nitrous oxide, sulfur dioxide, and fine particle emissions from vehicles, residential and commercial heating systems, public buildings, health centers, and industrial conglomerates, with the servicing time and degradation level. The analysis applies to various emitting gases or small particle systems, which gen [...]

by Paul Ocheje Ameh  , Joseph Ameh  , Amina Bello Mahmoud  , Adabiyya Rabiu Shuaib  , Aroh Augustina Oyibo  , Fadeyi Sulayman Olusola  , Isaiah Blessing Imeh  , Egbe Hope Thankgod  , Ajagbonna Damilola Lilian  and Bitrus Nehemiah

Received: 31 March 2025;  Published: 15 July 2025;  doi: 10.21926/aeer.2503026

The high cost of chemical coagulants for water treatment leads most people in rural communities to resort to readily available surface water, which is usually of low quality, exposing them to various waterborne diseases. It is in this light, that research was conducted to assess the effectiveness of a cheap enhanced natural coagulant prepared from Chrysophyllum albidium seeds for the treatment of contaminated water sampled from River Getsi, which serves as a source of potable water for the society. The coagulants s [...]

by Walter Calderón-Gerstein  , Gabriela Torres-Samaniego  , Kevin Pazos-Sovero  and Mirella Calderón-Anyosa

Received: 07 December 2022;  Published: 20 November 2024;  doi: 10.21926/obm.genet.2404271

This study aims to validate two predictive mortality scores for patients with COVID-19 to support clinical decision-making in those who require hospitalization. The tomographic patterns found can be added to the original scores to increase their predictive power. Retrospective, analytical, observational, and cross-sectional studies were carried out in two phases. 489 medical records of patients with COVID-19 hospitalized at “Daniel A. Carrión” Hospital in Huancayo (located at 3,250 meters above sea level) were revi [...]

by Marta I. Litter

Received: 15 September 2025;  Published: 22 September 2025;  doi: 10.21926/aeer.2503029