by Naira Sahakyan  and Margarit Petrosyan

Received: 10 June 2022;  Published: 08 October 2022;  doi: 10.21926/obm.neurobiol.2204140

The present article describes some characteristics of the effect of essential oil (EO) extracted from Ziziphora clinopodioides harvested from Armenian highlands on microglial cell lines (BV-2 wild-type (WT) and acyl-CoA oxidase1 (ACOX1)-deficient (Acox1–/–) cells). The mutant cell line was used as a model to investigate cellular oxidative damage following EO treatment. The main components of the tested EO were pulegone, isomenthone, 1,8-cineole, piperitone, and neomenthole, with concentrations of 42.1%, [...]

by Edmund Zolnik

Received: 14 January 2022;  Published: 02 August 2022;  doi: 10.21926/jept.2203026

Monetary incentives to accelerate the transition of private vehicle fleets to zero emissions promote sustainability in the transportation sector. Clean Cars for America to incentivize transactions for new battery power vehicles is a program in furtherance of sustainable transportation goals in the United States. Unfortunately, data on transactions for new alternative fuel vehicles (AFVs) are scarce so empirical research to explore the costs and/or the benefits of such programs is also scarce. Analysis of transactio [...]

by Gaëtan Collignon  , Aminata Bicego  , Marie-Elisabeth Faymonville  , Olivia Gosseries  , Vincent Bonhomme  , Dominique Dive  , Corine Sombrun  , Antoine Bioy  and Audrey Vanhaudenhuyse

Received: 14 August 2024;  Published: 05 March 2025;  doi: 10.21926/obm.icm.2501012

Auto-induced cognitive trance (AICT) is a method for voluntarily entering modified state of consciousness. The therapeutic implications of AICT are still unknown. Since complementary approaches based on modified states of consciousness are recognized to be beneficial for patients suffering from chronic pain (e.g., hypnosis, meditation), we here present the first case report of a 68-year-old man with a long history of chronic pain linked to an open Spina Bifida L4-L5, who used AICT to improve his health condition. S [...]

by Zahra Iran Pour Mobarakeh  , Mansoureh Nickbakht  , Susan Sabbagh  , Maryam Khorramizadeh  and Marzieh Amiri

Received: 02 January 2023;  Published: 29 June 2023;  doi: 10.21926/obm.genet.2302184

Congenital hearing loss can have a long-term impact on children’s speech and communication abilities. Early detection and intervention of hearing loss are important in newborns. It is well known that there are several risk factors for hearing loss; however, the relationship between these risk factors and hearing screening tests remains uncertain in Iran. Therefore, this study aimed to explore the relationship between hearing loss risk factors and Automated Auditory Brainstem Response (AABR) and Transient-Evok [...]

by Johannes Drescher  , Charly Gaul  , Peter Kropp  , Yannic Siebenhaar  , Dirk Reinel  and Jörg Scheidt

Received: 18 May 2022;  Published: 16 August 2022;  doi: 10.21926/obm.neurobiol.2203131

This citizen science project CLUE compared the attack frequency between school and vacation periods among adolescents. The data collection process adopted in citizen science projects opens up the possibility of conducting analyses by including a large number of participants over a long period and across different regions. The data on 684 migraine attacks reported by 68 adolescents aged 16 to 19 years were collected using an online platform and smartphone apps. A Fisher’s exact test was used to compare the distribut [...]

by Nasim Foroughi  , Laura Douglass  , Caroline A. Smith  and Phillipa Hay

Received: 11 July 2022;  Published: 09 October 2022;  doi: 10.21926/obm.icm.2204047

Depression and mental health-related issues are increasingly prevalent in young adolescents and adults and so is the use of Complementary Therapies (CTs) to treat depression. Systematic reviews have found that, of all CTs, acupuncture, exercise, and the herbal remedy St John’s Wort have the greatest amount of evidence for efficacy in treating depression. We aimed to assess Mental Health Literacy (MHL) levels in the treatment of depression and Complementary Therapy’s (CT) usage in adolescents and adults. Surveys wer [...]

by Nirasha Nundkumar  , Sooboo Singh  and Moganavelli Singh

Received: 14 June 2023;  Published: 21 September 2023;  doi: 10.21926/obm.genet.2303193

Layered double hydroxides (LDHs) have interesting properties and structures that enable them to carry nucleic acids, such as deoxyribonucleic acid (DNA). This study synthesized LDHs using the co-precipitation method and functionalized with the amino acids arginine (Arg) and histidine (His) to promote proton-sponge activity for enhanced transgene expression. The LDHs were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), and nanoparticle tracking analysis (NTA). The interaction of [...]

by Paola Romecín  , Joaquin García-Estañ  and Noemí M. Atucha

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3) Results: We have found several alterations compatible with the existence of a hyperaggregatory state. These alterations are related to a defective platelet calcium handling, spec [...]

by Suhani Sharma  , Sonali Karhana  and Mohd. Ashif Khan

Received: 15 May 2025;  Published: 29 September 2025;  doi: 10.21926/rpn.2503021

Vitamin D, a fat-soluble secosteroid, plays a pivotal role beyond its functions in calcium and bone homeostasis. Emerging evidence suggests its involvement in glucose metabolism and insulin sensitivity, thus influencing the pathophysiology of Type 2 Diabetes Mellitus (T2DM). For the current review, a search was conducted across four major databases: PubMed, Embase, Google Scholar, and Web of Science. The aim was to identify relevant studies and clinical trials, published in English, reporting the mechanistic insigh [...]

by Rukiye Öztekin  and Delia Teresa Sponza

Received: 27 August 2024;  Published: 17 October 2024;  doi: 10.21926/aeer.2404019

The aim of this study was to photodegrade the Polyethersulfone (PES), Polyvinylidene fluoride (PVDF) and Polymethyl methacrylate (PMMA) microplastics using Zeolitic imidazolate framework-8/Zinc oxide/Carbon (ZIF-8/ZnO/C) nanocomposite generated under laboratory conditions. The produced nanocomposite was analysed using X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Photo Spectroscopy (XPS), Scanning Electron Microscope (SEM), Diffuse reflectance UV-vis spectra (DRS) and Electron Spin R [...]

by Elizaveta Baranova  , Vladimir Druzhinin  , Ludmila Matskova  , Pavel Demenkov  , Valentin Volobaev  and Alexey Larionov

Received: 01 August 2022;  Published: 07 November 2022;  doi: 10.21926/obm.genet.2204169

Recent findings indicate that the microbiota is involved in the development of lung cancer by inducing inflammatory responses and generating genome damage. This study aimed to compare sputum microbiomes from the mouth and oropharynx in non-small cell lung carcinoma (NSCLC) patients. A second goal was to search for bacterial taxonomic units that behave differently in the microbiome of NSCLC patients and healthy subjects. In the study, the taxonomic composition of the sputum and oropharyngeal microbiomes of 23 male p [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 17 May 2024;  Published: 30 July 2024;  doi: 10.21926/obm.neurobiol.2403234

The COVID-19 pandemic brought different intolerable and uncomfortable situations that ruined the students' academic performance, career opportunities, and social lives through depression, anxiety, fear, uncertainty, and mental illness. In this study, we examined the psychological threats of the COVID-19 among Egypt’s public-sector university students. We employed quantitative methods in this study and used a questionnaire to collect cross-sectional data. The Structural Equation Modeling (SEM) results show that Fear [...]

by José Nieto  , Carmen Vasquez  , Rubén Acevedo  , Rodrigo Ramírez-Pisco  , Luís Manuel-Navas  , Mercedes Gaitan-Angulo  , Melva Inés Gómez-Caicedo  and Catalina Altamar-Cuervo

Received: 16 June 2022;  Published: 13 October 2022;  doi: 10.21926/aeer.2204041

Because of climate change, greenhouse gas (GHG) emissions have increased, leading to the implementation of energy transition policies. Countries have adopted the Paris Agreement to curb the effects of climate change. The emergence of COVID-19 in 2020 led to the application of different measures to stop its transmission. This study evaluated the effects of COVID-19-related restrictions (such as quarantine and mobility restriction) in Chile during the first wave on compliance with the country's energy transition poli [...]

by Jennifer S. Jewell  , Ashley Brooks-Russell  and Jenn Leiferman

Received: 11 November 2022;  Published: 29 January 2023;  doi: 10.21926/obm.icm.2301010

Postpartum depression (PPD) affects a notable number of women. While many of the risk and protective factors for PPD are specific to the mother, there are also factors that are related to the partner. However, the partner is often overlooked when assessing the landscape of PPD and potential treatment programs. This study sought to expand the knowledge on partner perceptions during the perinatal period. This online, cross-sectional survey of fathers who were in relationships with mothers who had given birth within t [...]

by James David Adams, Jr.

Received: 24 May 2019;  Published: 24 May 2019;  doi: 10.21926/obm.icm.1902032

Highlights of Complementary and Alternative Medicine in Nervous System Conditions: An Interview with Dr. James David Adams, Jr.

by Muhammad Kashif Channa  , Muhammad Waris  , Sultana Rahman  and Ali Bahar Shahani

Received: 28 February 2024;  Published: 09 February 2025;  doi: 10.21926/aeer.2501011

One major cause of aquatic pollution is the accumulation of heavy metal ions. This study shows the biosorption properties of orange peel for removing chromium (CrVI) from industrial wastewater at a laboratory scale. This study focused on the biosorption of CrVI using orange peel biosorbent (OPB) from aqueous solutions in the plastic industry (PI), textile and fabrics industry (TFI), chemical industry (CI), and food industry (FI). The total Cr contents in effluents of FI, CI, TFI and PI varied between 30.0-38.0, 23. [...]

by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Habib Ghaznavi  , Mohammad Hasan Mohammadi  , Ali Reza Modarresi-Alam  , Ali Navidian  , Ali Khajeh  and Mohammad Kazem Momeni

Received: 05 December 2024;  Published: 10 June 2025;  doi: 10.21926/obm.neurobiol.2502289

This study reviews the biochemical mechanisms and clinical implications of N-heterocyclic amine drugs, particularly in the context of pain management, mental health, and opioid withdrawal. It highlights the structural diversity and receptor binding capabilities of these compounds, which enable them to target the nervous system and cross the blood-brain barrier effectively. The article discusses the role of opioids in pain relief, detailing their agonistic effects on opioid receptors and the subsequent risk of addic [...]

by Minggao Zhou  , Yongren Feng  , Yongzeng Xue  , Yanmin Zhou  , Yongchao Chen  and Wilson C. Chin

Received: 12 April 2023;  Published: 27 November 2023;  doi: 10.21926/jept.2304038

An early formation tester operating a “sink probe” that extracts fluids from the borehole, also measures pressures at its location; pressures are additionally collected at two passive sensors, one situated 180 deg away and the second about meter axially. These positions are not conducive to accurate permeability predictions, since pressure transient signals used for inverse analysis attenuate very rapidly. Closer probe spacings offer formation evaluation advantages at low mobilities because Darcy pressure dissipati [...]

by Aini Hidayati Shahrir  and Gasim Hayder

Received: 27 October 2022;  Published: 14 February 2023;  doi: 10.21926/aeer.2301020

The pandemic has shown its effect on the world regarding health, economy, society, and environment. Whether it is a negative or positive impact, the period of this pandemic has a vast open platform for further studies. This review focused on the impact of the COVID-19 pandemic lockdown on water quality. It is hypothesized that due to the reduced amount of anthropogenic activity due to the global lockdown, the water quality of water resources increased and rejuvenated. This review showed the study period, methods an [...]

by Weiyun Chen  , Zhanjia Zhang  , Bruno Giordani  and Janet L. Larson

Received: 03 July 2022;  Published: 26 December 2022;  doi: 10.21926/obm.geriatr.2204218

Physical activity is essential to delaying cognitive decline and preventing cognitive impairment in older adults. We designed and implemented two-level 4Active intervention for older adults living in retirement communities. This study aimed to examine the effectiveness of the 4Active intervention in increasing physical activity and cognitive function in older adults. Fifty-eight eligible older adults with a mean age of 83.83 years (76.3% females) living in two retirement communities voluntarily participated in this [...]

by Boju Sun  , Maya Kudo  , Misa Hayashi  , Lingling Qin  , Lili Wu  , Tonghua Liu  and Ming Gao

Received: 25 October 2021;  Published: 30 June 2022;  doi: 10.21926/obm.icm.2202023

YNCRG is a combination of five traditional Chinese ingredients with medicinal properties. We studied its effects and mechanism of action on a rat model of non-alcoholic fatty liver with metabolic syndrome. Eight-week-old male SHRcp rat(s) and Wister Kyoto (WKY) rats were adaptively fed for one week, after which they were randomly divided into three groups, including the control group (n = 9), the YNCRG group (n = 8), and the WKY group (n = 8). The WKY group could freely consume water, the control group was provided [...]

by Gerhard Litscher

Received: 18 April 2023;  Published: 19 April 2023;  doi: 10.21926/obm.icm.2302020

This editorial briefly describes possible relationships and similarities between chess and acupuncture. Although the methods of chess and acupuncture could not be more different, possible joint effects on the brain can be hypothesized. However, the effectiveness of these joint effects has yet to be proven in scientific studies. Both chess and acupuncture can be used to improve physical and mental well-being. According to the author, the Yintang point could play a key role here.

by Syd Hiskey  and Neil E Clapton

Received: 07 April 2024;  Published: 21 May 2024;  doi: 10.21926/obm.icm.2402029

The work of psychotherapy demands much of those who engage in it. Compassion provisioned by therapists requires varying competencies, yet remains a highly embodied and enactive endeavour. Therapist skill can be cultivated in this area and enhanced through a variety of body-mind trainings, including various forms of therapist personal practice. However, much clinical training/continued professional development centres on education workshops, emphasising knowledge above skill. Given this we present feasibility data f [...]

by Nydia Rena Benita Sihombing  , Nani Maharani  , Agustini Utari  and Tri Indah Winarni

Received: 29 November 2024;  Published: 05 February 2025;  doi: 10.21926/obm.genet.2501284

Deletion of chromosome 1p36 encompassed various genes; however, the role of the CAMTA1 gene in the 1p36 region is less investigated. We report a child with developmental delay, a history of congenital heart abnormality, self-injurious behavior, nystagmus, and facial dysmorphism. Chromosomal microarray revealed a 257.2 kb deletion of chromosome 1p36.31, with CAMTA1 as the only involved gene. We explore overlapping clinical features of both chromosome 1p36 deletion and CAMTA1 intragenic deletion, including intellectu [...]

by Alma Rechnitzer  , Richard Teo  , Abigail Brooks  , Juan P. Rocca  , Nidal A. Mudhi  , Julia Torabi  , Maria Ajaimy  , Luz Liriano-Ward  , Yorg Azzi  , Cindy Pynadath  , Pablo Loarte-Campos  , Enver Akalin  , Marie E. Le  , Milan M. Kinkhabwala  and Jay A. Graham

Received: 06 September 2022;  Published: 21 November 2022;  doi: 10.21926/obm.transplant.2204170

The 2014 Pancreas Allocation System established national qualifying criteria for simultaneous kidney pancreas (SPK) transplantation. The 2019 UNOS Pancreas Transplantation Committee Policy 11.3.B modified these guidelines to expand transplantation. Subsequent effects on recipient demographics have not been studied. We analyzed 81 SPK transplantations performed at our center from June 2014 to December 2020 to compare recipient demographics and outcomes before and after the 11.3.B policy change. National data were al [...]