by Sumant Chavda  , Subhranshu Sekhar Kar  and Alyaa Kamal Al Ramah

Received: 05 July 2023;  Published: 30 October 2023;  doi: 10.21926/obm.genet.2304202

Progressive pseudo-rheumatoid dysplasia (PPRD) is an uncommon genetic condition inherited in an autosomal recessive mode caused by a mutation in the WNT1-inducible signaling pathway protein 3 (WISP3) located on chromosome 6q21. In this condition, the articular cartilage gradually deteriorates, causing severe discomfort, stiffness, and joint deformities with a relatively high prevalence in Middle Eastern countries. Camptodactyly and platyspondyly are the standard features found in this condition. We present a very y [...]

by Roy G Beran

Received: 01 July 2022;  Published: 13 September 2022;  doi: 10.21926/obm.geriatr.2203204

This paper examines sleep disorders in older people, focusing on Parkinson’s disease (PD). It defines PD and explores those conditions associated with sleep disorders and their relationship to PD. It identifies specific conditions which cause sleep disoders in patients with PD, namely: REM sleep behaviour disorder (RDB) which may be a precursor to PD; obstructive sleep apnoea (OSA) which is very prevalent amongst people with PD; depression and mood disorders which both increase with age and are more common in peopl [...]

by Rohman Hikmat  , Iyus Yosep  , Popy Siti Aisyah  and Shella Febrita Puteri Utomo

Received: 03 December 2024;  Published: 26 March 2025;  doi: 10.21926/obm.neurobiol.2501281

This study aims to describe the application of forgiveness therapy as a psychosocial intervention for a schizophrenia patient with violent behavior. Mr. M, a 19-year-old male diagnosed with schizophrenia, exhibited psychotic symptoms, including auditory hallucinations, persecutory delusions, agitation, and aggression. He had a history of trauma due to physical violence from his brother. The patient was diagnosed with a risk for violence toward others. Forgiveness therapy was implemented over six sessions, each last [...]

by Nour Ben Abdeljelil  , Rimmel Yosra Kanoun  , Roua Hsasna  , Rabeb Jaied  , Sabrine Mekni  , Siwar Frigui  , Lamia Torjemane  , Dorra Belloumi  , Ines Turki  , Rihab Ouerghi  , Insaf Ben yaiche  , Wafa Achour  , Saloua Ladeb  and Tarek Ben Othman

Received: 12 April 2023;  Published: 12 September 2023;  doi: 10.21926/obm.transplant.2303195

Cytomegalovirus (CMV) infection is a common and severe complication following allogeneic stem cell transplantation (ASCT) and requires effective preemptive antiviral therapy. Both oral and intravenous (IV) antiviral agents effectively reduce CMV viral load and achieve viral clearance. Studies comparing oral and IV anti-CMV preemptive treatment in ASCT patients with CMV reactivation showed a potential difference in treatment response and safety profiles between the two administration routes. We retrospectively compa [...]

by Penko Spetsov  and Nadia Daskalova

Received: 27 February 2024;  Published: 09 April 2024;  doi: 10.21926/obm.genet.2402225

High-molecular-weight glutenin subunits (HMW-GS) encoded by alleles at the Glu-A1, Glu-B1, and Glu-D1 loci confer unique bread-making properties of common wheat (Triticum aestivum L.). The identification of HMW-GS is the prerequisite for pyramiding high-quality glutenin genes. The present review is designed to list all published HMW-GS alleles in Triticum species and triticale (A- and B genomes), focusing on methods for their identification. T. monococcum is characterized by 37 alleles at the Glu-1 locus versus fou [...]

by Hsuan-Wei Chen  , Hsuan-Hwai Lin  , Yu-Lueng Shih  , Tsai-Yuan Hsieh  and Jung-Chun Lin

Received: 23 February 2020;  Published: 30 March 2020;  doi: 10.21926/obm.hg.2001044

by Giuseppe Cocco  and Stefano Pandolfi

Received: 27 July 2023;  Published: 11 October 2023;  doi: 10.21926/obm.geriatr.2304253

Both from a healthcare and a socioeconomic perspective, research on senescence is increasingly essential. Indeed, in industrialized countries, the increased human longevity confronts medicine with many old patients with age-related pathologies. The paper reviews the biological theories on aging, the impact of reactive oxygen species, telomers, epigenetics, and genetics (e.g., gerontogenes) on-age-related pathologies. Also, the paper reviews available and under research therapeutic approaches (e.g., senolytics) aime [...]

by Wasim A. Dar

Received: 03 September 2018;  Published: 29 September 2018;  doi: 10.21926/obm.transplant.1803021

liver transplantation

by OBM Geriatrics Editorial Office

Received: 06 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.geriatr.2201186

The editors of OBM Geriatrics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition [...]

by Nils Altner  and Jasmin Friedrich

Received: 05 September 2022;  Published: 14 November 2022;  doi: 10.21926/obm.icm.2204049

In this study, we present the results of a 48-hour mindfulness-based and compassion-based training for teachers (N = 59). This study included 3,250 students in two years. We strengthened the resources of teachers and students for health, especially for preventing addiction. The didactic approach was based on the concepts of embodiment and resonance. We first trained teachers and then encouraged them to teach students in the classroom. Qualitative data were collected on the presence of teachers, relationship buildin [...]

by Antonio Meola

Received: 05 May 2019;  Published: 08 May 2019;  doi: 10.21926/obm.neurobiol.1902025

by Tyrone Pretorius  and Anita Padmanabhanunni

Received: 28 April 2023;  Published: 03 July 2023;  doi: 10.21926/obm.neurobiol.2303173

University students have been identified as a particularly vulnerable group for adverse mental health outcomes owing to the distinctive implications of the COVID-19 prevention measures on the educational sector. Even prior to the pandemic, university students were identified as being at increased risk for adverse mental health outcomes and suicidality. Although various factors can enhance the risk of suicide, one of the strongest predictors of suicidality is the presence of depressive symptomology. The current stud [...]

by Brizeida Hernández Sánchez  , Massiel Coronado-Morán  , Greisy González-Cedeño  and Tancredi Pascucci

Received: 15 July 2024;  Published: 19 February 2025;  doi: 10.21926/aeer.2501012

Equity in the educational system is crucial to addressing the needs of all students without distinction, from their initial access to education through to graduation. Achieving equity requires implementing reasonable adjustments to ensure that all students can attend classes, actively participate, and learn effectively. Equity entails transforming inequality into inclusion, enhancing students' well-being and quality of life. Education for all prioritizes equity and quality as fundamental principles of the education [...]

by Kristi R. Mitchell  , Margaret Dittloff  , Jasmine Larson  and Donna Belcher

Received: 10 April 2024;  Published: 10 September 2024;  doi: 10.21926/obm.geriatr.2403287

Effective January 2024, the United States Centers for Medicare & Medicaid Services (CMS) for the first time has included a nutrition-focused quality measure in the Hospital Inpatient Prospective Payment System (IPPS) Inpatient Quality Reporting (IQR) Program: the Global Malnutrition Composite Score (GMCS). The GMCS is an electronic clinical quality measure (eCQM) that hospitals can choose to report voluntarily to meet the requirements for IPPS IQR payments. The GMCS can help improve hospital malnutrition care and h [...]

by Herbert Van Kruiningen

Received: 05 April 2019;  Published: 30 September 2019;  doi: 10.21926/obm.hg.1903036

by Leona A. Holmberg  , Michael Linenberger  and Laura Connelly-Smith

Received: 06 May 2022;  Published: 30 March 2023;  doi: 10.21926/obm.transplant.2301178

RICE is salvage therapy for treating CD20+non-Hodgkin lymphoma (NHL). It is combined with G-CSF to collect autologous peripheral blood stem cells (aPBSC). Little data exists, though, on the combination of G-CSF and Plerixafor after RICE in mobilizing adequate number of CD34 cells and the product’s immune content. We report on the results of twenty CD20+ NHL patients after RICE, G-CSF and Plerixafor were given to collect aPBSC. The median number of cells collected was 12.92 × 106 CD34 cells/kg (range 5.4 [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 21 May 2024;  Published: 18 September 2024;  doi: 10.21926/obm.neurobiol.2403245

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...]

by Kamyar Afshar  , Michelle N Bremer  , Deepa Kurup  , Michael Bernales  , Elizabeth Schonhoft  , Luis Santana  , Caro Davila  , Gina Schooler  , Gordon Yung  , Travis Pollema  and Eugene Golts

Received: 07 November 2022;  Published: 14 March 2023;  doi: 10.21926/obm.transplant.2301177

Lung transplant (LTx) survival and quality of life have been steadily improving, partially from changes in candidate selection for transplantation. There are well-known high-risk factors that lead to poor LTx outcomes, which may be referred to as ‘accounted’ risks. However, there are also other ‘unaccounted’ risks that are not included in the existing model for expected LTx survival to help programs for resource allocation. We performed a retrospective cohort study of all LTx recipients over the age of 18 at UC San [...]

by Kurumi Taniguchi  , Haruka Sawamura  , Yuka Ikeda  , Ai Tsuji  and Satoru Matsuda

Received: 02 May 2022;  Published: 30 August 2022;  doi: 10.21926/obm.transplant.2203165

Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. Calcineurin inhibitors, such as cyclosporine, are widely used to enhance the survival of patients who have undergone HSCT. Unfortunately, both GVHD and cyclosporine occasionally cause nephropathy. Several studies have shown that th [...]

by Bruno A Lima

Received: 15 December 2023;  Published: 11 March 2024;  doi: 10.21926/obm.transplant.2401208

Human Leucocyte Antigens (HLA) constitute a highly polymorphic set of genes pivotal to the immune response. The HLA heterozygous advantage hypothesis assumes that heterozygous individuals at the HLA level have a wider range of peptides for T cell recognition than homozygous individuals. Consequently, they possess an enhanced capacity to trigger a targeted immune reaction. The divergent allele advantage hypothesis is an extension of heterozygous advantage, considering the excessive sequence divergence between allele [...]

by Yumiko Nagao  , Shinji Nishioka  and Keizo Koresawa

Received: 12 January 2019;  Published: 02 April 2019;  doi: 10.21926/obm.hg.1902016

Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP), an extrahepatic manifestation, is well known. There are still patients with viral liver disease in this country who are not receiving appropriate treatment. This prospective study aimed to evaluate the prevalence of OLP and untreated hepatitis virus infection in patients who visited dental clinics in Ehime prefecture, in western Japan. Methods: Patients who visited 35 dental clinics in Japan from March 2018 to June 2 [...]

by OBM Genetics Editorial Office

Received: 17 February 2022;  Published: 22 February 2022;  doi: 10.21926/obm.genet.2201148

by Jianquan Xu  , Jinwen Liu  , Wen Lei  , Zhong Lu  and Long Ying

Received: 01 September 2024;  Published: 10 January 2025;  doi: 10.21926/aeer.2501005

To study the environmental impact of automobile components, life cycle assessment (LCA) is adopted to study the environmental impact of instrument cross beams made of steel and magnesium alloy crossbeams. Comparative environmental impact analyses of both instrument crossbeams are conducted through parametric analysis, scenario analysis, sensitivity analysis, and future forecasting in GaBi10. The results show that global warming potential (GWP), acidification potential (AP), eutrophication potential (EP), ozone depl [...]

by Manuel De Jesus Encarnacion Ramirez  , Nikolay Konovalov  , Stanislav Kaprovoy  , Gennady Chmutin  , Geovany Venegas Cerna  , Renat Nurmukhametov  , Andreina Rosario Rosario  , Kalin Ivan Yakovlevich  , Jesus Lafuente  , Eric Suero Molina  and Nicola Montemurro

Received: 20 April 2024;  Published: 09 September 2024;  doi: 10.21926/obm.neurobiol.2403244

Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...]

by Carlos Armenta-Déu

Received: 18 May 2023;  Published: 27 July 2023;  doi: 10.21926/jept.2303025

The paper analyses the performance of a spherical solar collector compared to the efficiency of a flat-plate solar collector, which is the type of solar collector that does not use a tracking system in collecting solar radiation for energy conversion. Spherical solar collector benefits from a constant value of the angle of incidence, which optimizes the solar radiation that strikes the absorber of the solar device and maximizes the energy collection. Besides, the spherical geometry has a larger area for equal dimen [...]