by Ramareddy V Guntaka

Received: 20 December 2018;  Published: 13 March 2019;  doi: 10.21926/obm.hg.1901014

Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such as YB-1, which is implicated in inflammation, angiogenesis and accumulation of extracellular matrix (ECM). In addition we observed and showed that the end product of fibrosis, collagen gene, itself is a direct target fo [...]

by Samantha Varley  , Kirsten Rossi  , Meghan Murray  and Alissa Nichole

Received: 17 May 2019;  Published: 12 July 2019;  doi: 10.21926/obm.hg.1903026

Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms, and diagnostic criteria of AP are well established in the literature and multiple studies. Multiple scoring systems have been used to predict the severity, prognosis, and mortality a [...]

by Bahar Onaran Acar  , Hakan Şenarısoy  and Erhan Keyvan

Received: 31 July 2024;  Published: 05 January 2025;  doi: 10.21926/obm.genet.2501278

Antimicrobial resistance is one of the most significant threats to our present and future. Recently, it has been suggested that antibiotic-resistant microorganisms also exhibit resistance to heavy metals and disinfectants, and these resistance profiles may interact with each other. Microorganisms can be exposed to heavy metals and disinfectants in different ways in various environments. They are especially likely to be exposed to quaternary ammonium compounds used in the food industry or heavy metals due to tap wat [...]

by Tommy Sundqvist  , Lars Stenhammar  , Bo Tjellström  , Karl-Eric Magnusson  , Tore Midtvedt  , Elisabeth Norin  and Lotta Högberg

Received: 07 February 2020;  Published: 09 March 2020;  doi: 10.21926/obm.hg.2001043

by OBM Genetics Editorial Office

Received: 17 February 2022;  Published: 22 February 2022;  doi: 10.21926/obm.genet.2201148

by Fabiana Cristina Lima Barbosa  , Ana Carolina Teles de Aquino  , Marcos Paulo Gomes Mol  and Raphael Tobias de Vasconcelos Barros

Received: 16 October 2024;  Published: 10 April 2025;  doi: 10.21926/aeer.2502018

When addressing Healthcare Waste Management (HCWM), numerous factors play a crucial role in ensuring its safety and environmentally responsible handling within institutional processes. Recognizing this imperative, this study employed the Analytical Hierarchical Process (AHP) methodology to establish a comprehensive assessment of 10 primary criteria and 66 sub-criteria concerning the governance and operational aspects of Healthcare Waste Management. This evaluation was based on the insights of 14 specialists in the [...]

by Kurumi Taniguchi  , Haruka Sawamura  , Yuka Ikeda  , Ai Tsuji  and Satoru Matsuda

Received: 02 May 2022;  Published: 30 August 2022;  doi: 10.21926/obm.transplant.2203165

Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. Calcineurin inhibitors, such as cyclosporine, are widely used to enhance the survival of patients who have undergone HSCT. Unfortunately, both GVHD and cyclosporine occasionally cause nephropathy. Several studies have shown that th [...]

by Nour Ben Abdeljelil  , Rimmel Yosra Kanoun  , Roua Hsasna  , Rabeb Jaied  , Sabrine Mekni  , Siwar Frigui  , Lamia Torjemane  , Dorra Belloumi  , Ines Turki  , Rihab Ouerghi  , Insaf Ben yaiche  , Wafa Achour  , Saloua Ladeb  and Tarek Ben Othman

Received: 12 April 2023;  Published: 12 September 2023;  doi: 10.21926/obm.transplant.2303195

Cytomegalovirus (CMV) infection is a common and severe complication following allogeneic stem cell transplantation (ASCT) and requires effective preemptive antiviral therapy. Both oral and intravenous (IV) antiviral agents effectively reduce CMV viral load and achieve viral clearance. Studies comparing oral and IV anti-CMV preemptive treatment in ASCT patients with CMV reactivation showed a potential difference in treatment response and safety profiles between the two administration routes. We retrospectively compa [...]

by Giuseppe Cocco  and Stefano Pandolfi

Received: 27 July 2023;  Published: 11 October 2023;  doi: 10.21926/obm.geriatr.2304253

Both from a healthcare and a socioeconomic perspective, research on senescence is increasingly essential. Indeed, in industrialized countries, the increased human longevity confronts medicine with many old patients with age-related pathologies. The paper reviews the biological theories on aging, the impact of reactive oxygen species, telomers, epigenetics, and genetics (e.g., gerontogenes) on-age-related pathologies. Also, the paper reviews available and under research therapeutic approaches (e.g., senolytics) aime [...]

by Brizeida Hernández Sánchez  , Massiel Coronado-Morán  , Greisy González-Cedeño  and Tancredi Pascucci

Received: 15 July 2024;  Published: 19 February 2025;  doi: 10.21926/aeer.2501012

Equity in the educational system is crucial to addressing the needs of all students without distinction, from their initial access to education through to graduation. Achieving equity requires implementing reasonable adjustments to ensure that all students can attend classes, actively participate, and learn effectively. Equity entails transforming inequality into inclusion, enhancing students' well-being and quality of life. Education for all prioritizes equity and quality as fundamental principles of the education [...]

by Andrey Nasledov  , Liubov Tkacheva  and Sergey Miroshnikov

Received: 03 July 2024;  Published: 27 November 2024;  doi: 10.21926/obm.neurobiol.2404259

The work identifies the factor structure of autism symptoms in older preschoolers to check their age dynamics. An Autism Marker Questionnaire containing 330 potential symptoms of autism spectrum disorder (ASD) was developed to be implemented as an online survey. 501 children were examined (371 with ASD) already classified by experts as a group of ASD, typically developing (TD) or with developmental delay (DD). At the exploratory stage, a relatively simple 8-factor structure was obtained: Speech Understanding (SU), [...]

by Vasiliy A. Chokheli  , Semyon D. Bakulin  , Olga Yu. Ermolaeva  , Vishnu D. Rajput  , Anatoly S. Azarov  , Arpna Kumari  , Victoriya V. Stepanenko  , Anastasia A. Bushkova  , Pavel A. Dmitriev  , Marcos Edel Martinez-Montero  and Tatiana V. Varduni

Received: 11 November 2022;  Published: 20 July 2023;  doi: 10.21926/obm.genet.2303187

Hedysarum cretaceum Fisch is a critically endangered herbaceous species with high ornamental and phytomeliorative properties; thus, it needs urgent conservation and protection methods to conserve. In the present study, an efficient method for microtonal propagation of H. cretaceum is developed. The seed sterilization was optimized as treatment with 96% alcohol (2 min) and burned (1 sec) through a burner flame. Murashige and Skoog (MS) medium with the addition of 0.5 mg/L 6-Benzylaminopurine (BAP) (shoots per explan [...]

by Kamyar Afshar  , Michelle N Bremer  , Deepa Kurup  , Michael Bernales  , Elizabeth Schonhoft  , Luis Santana  , Caro Davila  , Gina Schooler  , Gordon Yung  , Travis Pollema  and Eugene Golts

Received: 07 November 2022;  Published: 14 March 2023;  doi: 10.21926/obm.transplant.2301177

Lung transplant (LTx) survival and quality of life have been steadily improving, partially from changes in candidate selection for transplantation. There are well-known high-risk factors that lead to poor LTx outcomes, which may be referred to as ‘accounted’ risks. However, there are also other ‘unaccounted’ risks that are not included in the existing model for expected LTx survival to help programs for resource allocation. We performed a retrospective cohort study of all LTx recipients over the age of 18 at UC San [...]

by Fiona Bénard

Received: 15 June 2022;  Published: 16 November 2022;  doi: 10.21926/aeer.2204045

In the context of resource depletion and global warming, the energy transition has become a necessity. To provide a basis for analysis and to support countries in this transition, it is necessary to better understand this transition. The creation of a good measurement tool could help. This paper proposes a measure of national resilience through an analogy to kinetic energy. Preliminary results show that some countries have strong potential for resilience in the energy transition. Inequalities exist and still exist [...]

by Joep Geraedts

Received: 16 January 2017;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701001

by OBM Integrative and Complementary Medicine Editorial Office

Received: 02 April 2022;  Published: 18 April 2022;  doi: 10.21926/obm.icm.2202018

Interview with Dr. James David Adams. The skin is where pain is sensed and where chronic pain is created. The safest and most effective treatment for pain is topical plant medicines. Chronic pain can be cured with topical plant medicines. Transient receptor potential cation channels in the skin sense pain. Chronic pain involves a pain chemokine cycle. Monoterpenoids and diterpenoids from plants can stop this pain chemokine cycle and cure chronic pain.

by Tomomi Kogiso  , Mutsuki Kobayashi  , Kuniko Yamamoto  , Yuichi Ikarashi  , Kazuhisa Kodama  , Makiko Taniai  , Nobuyuki Torii  , Kazunari Tanabe  , Hideki Ishida  , Shohei Fuchinoue  , Hiroto Egawa  , Masakazu Yamamoto  , Etsuko Hashimoto  and Katsutoshi Tokushige

Received: 08 February 2017;  Published: 06 April 2017;  doi: 10.21926/obm.hg.1702003

Background: Hepatitis C virus (HCV) infection frequently occurs in recipients of liver or kidney transplants (LT/KT). Interferon (IFN)-based therapies are used to treat HCV, but their efficacy is low. Methods: We report 24 patients who received HCV therapy after LT/KT. Design, Setting, and Participants-Twelve LT and 12 KT recipients (median age, 59 years; 15 males; 21 serological type 1) were enrolled, of whom eight (six with LT) were treated with IFN-based therapy. Twelve received direct-acting antiviral drugs [ [...]

by Carlos Armenta-Déu

Received: 18 May 2023;  Published: 27 July 2023;  doi: 10.21926/jept.2303025

The paper analyses the performance of a spherical solar collector compared to the efficiency of a flat-plate solar collector, which is the type of solar collector that does not use a tracking system in collecting solar radiation for energy conversion. Spherical solar collector benefits from a constant value of the angle of incidence, which optimizes the solar radiation that strikes the absorber of the solar device and maximizes the energy collection. Besides, the spherical geometry has a larger area for equal dimen [...]

by Shourjo Chakravorty  and Ashka Patel

Received: 21 November 2023;  Published: 10 May 2024;  doi: 10.21926/obm.transplant.2402215

Transplanted lung allografts are particularly susceptible to infection among SOT due to the constant exposure to the environment, aggressive immunosuppressive strategies, and impaired clearance mechanisms after denervation of the transplanted lung. Though prophylactic antimicrobial, antifungal, and antiviral regimens are used as preventive strategies to mitigate the risk of infection, complications related to allograft infection remain one of the primary causes of morbidity and mortality after lung transplantation. [...]

by Babkir Ali  and Ahmed Gamil

Received: 16 November 2024;  Published: 10 March 2025;  doi: 10.21926/rpse.2501003

Carbon capture and storage (CCS) technology mitigates greenhouse gas (GHG) emissions. However, comprehensive studies assessing the sustainability of coal-based power generation (CBPG) with CCS remain limited. This study focuses on developing comparative sustainability indicators across the entire life cycle of CBPG integrated with CCS technology. Sixty-six pathways were analyzed after establishing five sustainability indicators for each. These indicators were standardized per megawatt-hour (MWh) of energy, encompas [...]

by Nils Altner  and Jasmin Friedrich

Received: 05 September 2022;  Published: 14 November 2022;  doi: 10.21926/obm.icm.2204049

In this study, we present the results of a 48-hour mindfulness-based and compassion-based training for teachers (N = 59). This study included 3,250 students in two years. We strengthened the resources of teachers and students for health, especially for preventing addiction. The didactic approach was based on the concepts of embodiment and resonance. We first trained teachers and then encouraged them to teach students in the classroom. Qualitative data were collected on the presence of teachers, relationship buildin [...]

by OBM Neurobiology Editorial Office

Received: 05 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.neurobiol.2201114

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition di [...]

by Jean-François Cadranel  and Jean-Baptiste Nousbaum

Received: 21 August 2019;  Published: 15 April 2020;  doi: 10.21926/obm.hg.2002045

The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-reviewed articles on the prevalence of SBP in ambulatory outpatients who visited the hospital for therapeutic paracentesis. Five such studies were available in the literature. It was found that the prevalence of SBP was in [...]

by Rafael B. Oliva  , Andrés Zappa  , Mariano Amadio  and Guillermo Catuogno

Received: 31 October 2024;  Published: 05 May 2025;  doi: 10.21926/jept.2502009

This work addresses the main results of a test site for small wind turbines (SWTs) located in Patagonia, and the development of the measurement systems involved, including the uncertainties calculations according to applicable IEC standards. Due to market evolution for over a decade, the test systems evolved from battery-charging SWTs to grid-connected units. The test site, developed and managed by state-owned INTI (National Institute for Industrial Technology), was established in 2012 and received support from the [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 21 May 2024;  Published: 18 September 2024;  doi: 10.21926/obm.neurobiol.2403245

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...]