by Alicia Brown  , Caitlin Woodcock  , Kelly Cocallis  and Alan Robert Bowman

Received: 26 May 2022;  Published: 14 November 2022;  doi: 10.21926/obm.icm.2204050

Chronic pain affects around 28 million people in the UK. Those living with chronic pain can frequently experience internalised self-stigma and negative self-evaluations as a result of the pain itself and due to difficult life experiences. Previous research has found Compassion Focused Therapy to be effective for people living with long term health conditions like chronic pain. The current study sought to evaluate a routine Virtual Compassionate Living Group for patients with chronic pain on the measures of self-com [...]

by Nicole Dawson  , Ashleigh Trapuzzano  and Katherine S. Judge

Received: 08 December 2023;  Published: 03 April 2024;  doi: 10.21926/obm.geriatr.2402275

Latest estimates indicate that 5-7% of the population are living with Alzheimer’s disease and related dementias worldwide with a doubling in incidence expected every 20 years. Rehabilitation professionals are challenged with the complex needs of these patients. It is commonly thought that patients with dementia do not benefit from rehabilitation because of cognitive decline, behaviors, lack of communication, or difficulties in learning; however, current literature indicates this is not accurate. With proper knowled [...]

by Jacques De Reuck  , Florent Auger  , Nicolas Durieux  , Claude-Alain Maurage  , Vincent Deramecourt  , Charlotte Cordonnier  , Florence Pasquier  , Didier Leys  and Regis Bordet

Received: 24 September 2020;  Published: 10 December 2020;  doi: 10.21926/obm.geriatr.2004142

The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. The examined post-mortem brains included 30 AD-CAA cases and 20 AD [...]

by Michael B. Keller  , Temesgen E. Andargie  and Sean Agbor-Enoh

Received: 16 March 2023;  Published: 26 June 2023;  doi: 10.21926/obm.transplant.2302190

Advances in the use of molecular biomarkers to guide management of lung transplant recipients are emerging. One such biomarker, donor-derived cell-free DNA (dd-cfDNA), has the potential to alter traditional approaches of lung transplant management, including the detection of acute rejection or infection, surveillance monitoring strategies, risk stratification of vulnerable patient populations and molecular phenotyping of various forms of allograft injury. The emergence of novel genetic and epigenetic approaches uti [...]

by Pier Alberto Testoni  and Sabrina Testoni

Received: 17 October 2019;  Published: 23 December 2019;  doi: 10.21926/obm.hg.1904042

Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found either on the occasion of the first episode of pancreatitis or during the follow-up. The etiology of RAP can be identified in up to 70% of cases; for the remaining cases the term “idiopathic” is used. Most common caus [...]

by Alessia Bartolacci  , Fabrizio Stocchi  , Vilberto Stocchi  and Sabrina Donati Zeppa

Received: 17 November 2024;  Published: 08 April 2025;  doi: 10.21926/rpn.2502007

In recent years, there has been an alarming increase in the incidence of inflammatory bowel disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), particularly in Western countries. This chronic condition is intricately linked to the composition and health of the gut microbiota (GM) — a complex community of microorganisms residing in the gastrointestinal (GI) tract. Despite extensive research, the underlying pathogenesis of IBD remains poorly understood, making it a wide area of invest [...]

by OBM Genetics Editorial Office

Received: 07 July 2022;  Published: 13 July 2022;  doi: 10.21926/obm.genet.2203160

by Nicole Mölders

Received: 11 August 2020;  Published: 17 August 2020;  doi: 10.21926/aeer.2003001

by Rene J. Duquesnoy

Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018

The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes

by Mahmoud F. Elmorshedy  , Abualkasim Bakeer  and Dhafer Almakhles

Received: 14 February 2023;  Published: 09 May 2023;  doi: 10.21926/jept.2302017

The special design of linear induction machines (LIMs) leads to adverse effects caused by the longitudinal and end effects. These effects make the thrust control of the LIMs most attractive because its value decreases sharply with the speed increase. Thus, finite-state model predictive control (FS-MPC) is developed to increase the performance of the LIMs. However, the variable switching frequency is the main drawback of this control. Consequently, the main objectives of this paper are to propose FS-MPC with a const [...]

by Michael Frass

Received: 13 November 2019;  Published: 14 November 2019;  doi: 10.21926/obm.icm.1904063

Highlights of Application of Homeopathy in Oncology Patients: An Interview with Prof. Michael Frass

by Michael D. Owens  and Megan Halliday

Received: 24 December 2020;  Published: 30 August 2021;  doi: 10.21926/obm.icm.2103025

The coronavirus (COVID-19) pandemic continues to bring challenges in identification and management of which the “happy hypoxic” or silent hypoxia presentation has been found to present its own unique challenge. A 67-year-old African American COVID-19 positive female presents to the emergency department (ED) with a chief complaint of decreased oral intake and responsiveness, oriented and stable, with oxygen saturations found to drop as low as 47%. The patient was successfully managed with supplemental oxygen and det [...]

by Oreste Piccolo  , Elisabetta Parodi  and Antonella Petri

Received: 14 September 2022;  Published: 17 November 2022;  doi: 10.21926/cr.2204041

In this study, a PoC (Proof of Concept) of a possible biomass valorization of flax and camelina oilseed press cakes was presented. Biocatalyzed hydrolysis of residual oils and proteins extracted from these wastes was studied. The biotransformation of oils was performed using commercial immobilized lipases, including Amano PS, Amano AK, and Candida Antarctica Lipase B (CALB). Acylglycerols were partially or fully hydrolyzed using Amano PS and AK. Triglycerides were not hydrolyzed by CALB, which behaved differently. [...]

by Roberto Anaya-Prado  , Ana P. Cárdenas-Fregoso  , Ana M. Reyes-Perez  , Danielle M. Ortiz-Hernandez  , Montserrat Quijano-Ortiz  , Monica V. Delgado-Martinez  , Ana S. Pelayo-Romo  , Roberto Anaya-Fernández  , Michelle M. Anaya-Fernández  , Consuelo C. Azcona-Ramirez  , Ivan F. Garcia-Ramirez  , Miguel A. Guerrero-Palomera  , Daniel Gonzalez-Martinez  , Citlalli S. Guerrero-Palomera  , Karina Paredes-Paredes  and Claudia Garcia-Perez

Received: 23 February 2024;  Published: 16 July 2024;  doi: 10.21926/obm.neurobiol.2403232

The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and b [...]

by Mojtaba Ehsanifar  , Akram Gholami  and Alireza Esmaeili

Received: 27 October 2024;  Published: 18 April 2025;  doi: 10.21926/obm.neurobiol.2502285

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which is linked t [...]

by Ginevra G Adamo  , Sergio D'Angelo  , Angeli Christy Yu  , Marco Pellegrini  , Federico Bernabei  , Vincenzo Scorcia  and Giuseppe Giannaccare

Received: 17 June 2022;  Published: 02 August 2022;  doi: 10.21926/obm.transplant.2203164

Graft-versus-host disease (GVHD) is a serious complication that may occur in patients receiving allogeneic hematopoietic stem cell transplant (HSCT). GVHD occurs because of the immunological reaction between the donor’s T cells and the recipient’s antigens; GVHD may develop in different tissues, including the eye. Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. We reported the case of a 65-year-old male patient who developed corneal perforation sequentially in both eyes 3 years afte [...]

by Carsten Croonenbroeck  and David Hennecke

Received: 06 February 2024;  Published: 15 March 2024;  doi: 10.21926/jept.2401008

We address the Wind Farm Layout Optimization (WFLO) problem and tackle the optimal placement of several turbines within a specific (wind farm) area by incorporating additional aspects of an economically driven target function. With this, we contribute three refinements for WFLO research: First, while many research contributions optimize the turbines' locations subject to maximum energy production or energy efficiency, we instead pursue a strategy of maximizing a profit objective. This enables us to incorporate inne [...]

by Sujeet Kumar Thakur  and Sambasivan Venkat Eswaran

Received: 17 June 2023;  Published: 01 September 2023;  doi: 10.21926/rpm.2303032

The Inert soil obtained from the Ghazipur Municipal Solid Waste landfill located in East Delhi, India has been used as the starting material for the work described in this paper. This mountain-like monster is often in the news for its bad smell, pollution of the groundwater in the area from its leachates, and the occasional fires in it endangering the lives of the people living nearby. Landfills produce many greenhouse gases (CO2, CH4, CO, HCHO, H2S, and NH3) which are poisonous and cause environmental pollution in [...]

by Raymond H. Baillargeon  , Marylène Charette  , François Tessier  and Kevin P. Brand

Received: 08 March 2022;  Published: 03 August 2022;  doi: 10.21926/obm.icm.2203031

The current recommendations of the Canadian Paediatric Society about monitoring children’s disruptive behaviors at well-child visits call for screening if behavioral concerns are being raised by parents. But do parents’ concerns about their child’s behavior constitute a reliable means for primary care providers (PCPs) to decide either in favor or against screening? We conducted a rapid systematic review of the literature by identifying documents that cited the landmark study by Glascoe and her col [...]

by Michael Falkenstein

Received: 11 August 2020;  Published: 19 August 2020;  doi: 10.21926/obm.geriatr.2003130

by Meir Djaldetti  , Chiya Moshe Leibovitch  and Hanna Bessler

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased produc [...]

by Doo-Sung Lee

Received: 09 December 2020;  Published: 02 June 2021;  doi: 10.21926/rpm.2102021

This paper concerns a poroelastic half-space in which plane compressional waves are scattered by a spherical inclusion. Addition theorems for the spherical wave functions are utilized to meet the boundary conditions on the plane, and the satisfaction of the given conditions on the boundary of the sphere leads to three infinite series equations, whose solution can be acquired by successive approximations. Further, its existence and uniqueness are discussed.

by Tara Hickey  , Sarah Strohmaier  , Ellie Fossey  and Charlie Heriot-Maitland

Received: 21 December 2023;  Published: 25 April 2024;  doi: 10.21926/obm.icm.2402023

In the compassion focused therapy (CFT) model of voice-hearing, a distressing relationship with voices is thought to be influenced by evolved threat-protection patterns, which are activated and attuned by socially threatening experiences, such as being harmed by others, as well being shamed, stigmatised, invalidated, and excluded. Therefore, the CFT approach is particularly interested in the role of voice-hearers’ relationships with others and self, as well as their social context of family/friends, professio [...]

by Navid Khaleghimoghaddam  and Sara Arzhangi

Received: 11 April 2025;  Published: 31 July 2025;  doi: 10.21926/obm.neurobiol.2503294

The acoustic design of indoor environments encompassing spatial configuration, material properties, and sound absorption significantly influences auditory perception and psychological well-being. This study examines the interaction between architectural acoustics, musical stimuli, and neural responses within a controlled therapeutic context, focusing on their effects on stress reduction and relaxation. Electroencephalography (EEG) was utilized to measure brain activity in 24 participants exposed to six musical inst [...]

by Amjad Mizyed

Received: 23 December 2024;  Published: 21 April 2025;  doi: 10.21926/jept.2502007

Water scarcity is one of the most pressing global challenges, particularly in arid and semi-arid regions. In this context, the Gaza Strip, where groundwater is the only available natural water resource, faces severe water stress due to overexploitation and drought conditions. This study aimed to review the recent water budget for the Gaza Strip by collecting data for the years (2021-2022) which was analyzed, discussed, and compared with other studies. The results showed a sharp deterioration in the Gaza Strip in te [...]