by Bernard R. Baum  and Douglas A. Johnson

Received: 07 January 2022;  Published: 24 April 2022;  doi: 10.21926/obm.genet.2202152

We have investigated the utility of the 5S nrDNA, a conserved, multicopy gene family organized into tandem repeats as a tool for genetic analyses in a wide variety of genera. Previous work in the Triticeae (Poaceae) demonstrated that the prior identification of unit classes based upon the 5S nrDNA NTS, greatly facilitates analysis. We investigated the potential of defining unit classes in other plant genera and several animal genera as a step towards future phylogenetic analyses. Our results demonstrate that in in [...]

by Domenic John DiPietro  and Maria Gabriela Bidart

Received: 02 March 2023;  Published: 28 September 2023;  doi: 10.21926/obm.icm.2303039

Worldwide, human population growth has led to a higher demand for urbanization. While this development is in accordance with our gregarious lifestyles, our availability and contact with nature has consequentially been minimized. The goal of this study was to evaluate whether sounds from nature versus urban environments affect vital signs (i.e., heart rate and respiration rate) and mood states of female college students. Emotional states were assessed using the Positive and Negative Affect Schedule (PANAS) questionn [...]

by Zakhar Slukovskii  and Tatiana Shelekhova

Received: 09 March 2023;  Published: 05 July 2023;  doi: 10.21926/aeer.2303038

Core sediment (sapropel) samples were collected from Lake Okunozero, the Republic of Karelia, Russia, to assess the distribution of heavy metals and their main fractions, probable sources of pollution, and potential ecological and toxicological risks for the water body. Heavy metal concentrations were measured by the mass spectrometry method using an XSeries-2 ICP-MS. The sequential extraction of heavy metals from sapropel samples was performed using the scheme of Tessier. According to the Russian Interstate Standa [...]

by Robert Beringer  , Paneet Gill  , Gloria Gutman  and Brian de Vries

Received: 31 July 2022;  Published: 17 November 2022;  doi: 10.21926/obm.geriatr.2204213

Disasters such as the COVID-19 pandemic exact a toll on vulnerable populations in terms of morbidity and mortality, but they also provide opportunities for personal growth and development and demonstration of personal and collective resiliency. This inductive thematic analysis explores self-perceived negative and positive impacts of the COVID-19 pandemic on 2994 Canadians aged 55+. Data derive from response to two open-ended questions included in a national online survey (View Survey (sfu.ca)) conducted between Aug [...]

by Jeffrey B. Allen  , Guillermo A. Riveros  , Ivan P. Beckman  and Elton L. Freeman

Received: 22 August 2023;  Published: 25 October 2023;  doi: 10.21926/rpm.2304033

In this work, we apply a multiphysics approach to fused deposition modeling to simulate extrusion and solidification. Restricting the work to a single line scan, we focus on the application of polylactic acid. In addition to heat, momentum and mass transfer, the solid/liquid/vapor interface is simulated using a front-tracking, level-set method. The results focus on the evolving temperature, viscosity, and volume fraction and are cast within a set of parametric studies, to include the printing and extrusion speed, a [...]

by A. Guillermo Bracamonte

Received: 16 September 2023;  Published: 26 December 2023;  doi: 10.21926/rpm.2304037

This review intended to resume key Research reports and publications that open many themes and topics related to Carbon-based semiconductors and Quantum emitters. The Design and synthesis of highly pure materials such as Graphene, Carbon Nanotubes, fullerenes, and other Carbon-based allotropes were shown. They presented their most important and promising properties concerning new studies and developments in photonics. Carbon-based Quantum dots, semiconductors, and higher sized Nanoplatforms allowed us to discuss fu [...]

by Marcel Mannens

Received: 24 April 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902075

none

by Ken Sato  , Atsushi Naganuma  , Shuichi Saito  , Yuichi Yamazaki  , Takeshi Kobayashi  , Hiroki Tojima  , Norio Horiguchi  , Satoru Kakizaki  , Toshio Uraoka  , Hiroshi Ohnishi  and Hiroaki Okamoto

Received: 29 September 2019;  Published: 17 December 2019;  doi: 10.21926/obm.hg.1904041

Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV/BCV in patients experiencing treatment failure with interferon (IFN)-free direct-acting antiviral agent (DAA)-based therapies, which have not been fully evaluated. Methods: We evaluated the efficacy and safety of 12-week DCV/ASV/BCV combination therapy for CHG1 patients experien [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 18 December 2024;  Published: 26 May 2025;  doi: 10.21926/obm.neurobiol.2502288

The present study investigates the association between anger, stress, psychological distress and mood disorders among Egyptian entrepreneurs. Approach-wise, the study is quantitative, and its cross-sectional data were collected using a questionnaire. The study’s respondents are Egyptian entrepreneurs involved in several business activities. Hence, the study concluded based on 286 valid responses. We used analysis of moment structures (AMOS) software, where we conducted path analysis to conclude the results. C [...]

by Aniebiet D. Udoh  , Ogheneruona E. Diemuodeke  , Mohammed M. Ojapah  , Fidelis I. Abam  and Joseph C. Ofodu

Received: 29 December 2022;  Published: 13 April 2023;  doi: 10.21926/jept.2302015

The quest to decarbonize the energy space to avert the negative climate change consequences calls for using low/zero-carbon energy conversion technologies in the energy generation space. The Organic Rankine Cycle is a low/zero-carbon energy conversion technology for recovering waste heat from low to medium-temperature heat sources and for biomass conversion. Therefore, this paper presents the thermodynamic optimization, with an artificial bee colony algorithm, of different ORC configurations, including simple organ [...]

by Xiaofei Qin  , Yongren Feng  , Lejun Wu  , Zhongjian Tan  , Yanmin Zhou  and Wilson Chin

Received: 12 April 2023;  Published: 10 July 2023;  doi: 10.21926/jept.2303023

In conventional wireline and LWD/MWD formation testing, downhole predictions for rock and fluid properties are based on simplified Darcy flow models, but only for mathematical expediency. These require initially constant pressures that are uniform throughout the reservoir. This limitation precludes common applications in overbalanced drilling, so that supercharge or near-well invasion effects - associated with rapidly decreasing pressures at the sandface where pressures are measured - are completely ignored. Such 1 [...]

by Omotayo B. Ilesanmi  , Rosephine Enadeghe  , Chinenyenwa U. Aleneme  , Esther F. Adeogun  and Ufuoma J. Okotie

Received: 29 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203135

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and Cd [...]

by Balamurugan Sivaprakasam  and Prasanna Sadagopan

Received: 24 December 2023;  Published: 14 June 2024;  doi: 10.21926/obm.genet.2402243

The present study introduces Snips2HLA-HsG, an integrated application designed for SNP genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful ensemble classifier technique from the Bioconductor HIBAG package, Snips2HLA-HsG offers a comprehensive response for genetic analysis. Accessible via https://snips2hla.shinyapps.io/hla_home/, the application distinguishes itself by prioritizing user-friendliness and integrating all-purpose functionalities, including sample preparation, mode [...]

by Hidehiro Kamezaki  , Tatsuo Kanda  , Osamu Yokosuka  , Yasunori Kasahara  and Takayuki Sakurai

Received: 16 November 2016;  Published: 21 January 2017;  doi: 10.21926/obm.hg.1701001

(1) Background: Preventative treatment for Pneumocystis jirovecii pneumonia (PCP) has been recommended for patients receiving ≥20 mg/day prednisolone. We describe a patient who developed PCP while receiving a dose of 15 mg/day prednisolone, and consider criteria for the initiation of preventative therapy for PCP in patients with autoimmune hepatitis (AIH) treated with prednisolone. (2) Case Report: A 71-year-old woman initially possessed dark-colored urine, white stool, and decreased appetite, which indicated hepat [...]

by Kristen R Szempruch  , Alec D Martschenko  , Harendra Arora  , Robert S Isaak  , Ravindra Prasad  , John L Schmitz  , Chuning Liu  , Fei Zou  and Pablo Serrano Rodriguez

Received: 13 February 2023;  Published: 18 April 2023;  doi: 10.21926/obm.transplant.2302181

Fluid management intra- and post-operatively for kidney transplant recipients (KTR) is essential to maintain adequate perfusion to the kidney. 0.9% normal saline (NS) is commonly used, but it can cause hyperchloremic metabolic acidosis, which may result in hyperkalemia and lead to delayed graft function (DGF). Plasma-Lyte A (PA) is an alternative option that has a lower amount of chloride and a neutral pH, which may offset the risk of hyperkalemia. The aim of this study is to determine the incidence of DGF in KTRs [...]

by Anna A. Pendina  , Mikhail I. Krapivin  , Irina D. Mekina  , Irina V. Aleksandrova  , Yanina M. Sagurova  , Evgeniia M. Komarova  , Mariia A. Ishchuk  , Andrei V. Tikhonov  , Olesya N. Bespalova  , Alexander M. Gzgzyan  , Igor Yu. Kogan  and Olga A. Efimova

Received: 13 May 2022;  Published: 23 September 2022;  doi: 10.21926/obm.genet.2203164

This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggested for the successive detection of the catalytic telomerase subunit with immunohistochemical staining and assessment of telomere length with Q-FISH on the same set of cells. The described approach uses three incontestable advantages [...]

by Loree Cook-Daniels

Received: 16 July 2023;  Published: 15 January 2024;  doi: 10.21926/obm.geriatr.2401266

Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) elders are vulnerable to both the “usual” types of elder abuse (physical, sexual, emotional, and financial abuse, along with neglect), and with abuse that is specific to the context and history of LGBTQ+ elders. Training for adult protective services, long-term care ombudsmen, and other professionals who work with abused elders therefore should include information and skill-building in responding to this population. Research into effective training about LGBTQ [...]

by Maria Gladysheva-Azgari  , Natalia Slobodova  , Eugenia Boulygina  , Svetlana Tsygankova  , Fedor Sharko  and Irina Mitrofanova

Received: 16 October 2023;  Published: 24 November 2023;  doi: 10.21926/obm.genet.2304203

In this study, we report the complete chloroplast genome of Actinidia arguta var. purpurea. The chloroplast genome is 157,369 bp long as the circular (GC ratio is 37.22%). It has four subregions: a large single-copy (LSC) region of 88,609 bp, a small single-copy (SSC) region of 20,470 bp, and two inverted repeat regions (IRs) of 24,145 bp in each. The chloroplast genome of A. arguta var. purpurea contains a total of 113 unique genes, which are 79 protein-coding genes, 4 rRNA genes, and 3 [...]

by Hermann Moisl

Received: 28 August 2022;  Published: 01 February 2023;  doi: 10.21926/obm.neurobiol.2301152

Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account of the distance structure preservation that underlies the proposed mechanism of intrinsic intentionality. The three-layer autoassociative multilayer perceptron (aMLP) [...]

by Emad Fadhal

Received: 18 January 2024;  Published: 24 May 2024;  doi: 10.21926/obm.genet.2402236

The RAS signaling pathway is a crucial cell transduction pathway central to transmitting signals from outside the cell to the cell nucleus and influencing fundamental biological mechanisms like cell growth, division, and specialization. This signaling pathway has recently received much attention in scientific research because of its involvement in various diseases, especially carcinogenesis. Our study identified the significance of crucial proteins in the RAS signaling cascade in cancer development and progression. [...]

by Dennis Gibson  , Amy Stein  , Marina Foster  and Philip S Mehler

Received: 19 December 2024;  Published: 23 May 2025;  doi: 10.21926/rpn.2502012

Inpatient care is a significant contributor to the health-care costs associated with the treatment of individuals with eating disorders (EDs). This study seeks to better understand the treatment outcomes of individuals with extreme EDs requiring inpatient medical stabilization at specialized medical versus nonspecialized medical units. Patients transferred via air ambulance to ACUTE Center for Eating Disorders and Severe Malnutrition (specialized care) from an outside hospital (nonspecialized care) between January [...]

by Abdulmalik A. Lawan  and Nadire Cavus

Received: 31 May 2022;  Published: 30 September 2022;  doi: 10.21926/obm.neurobiol.2203138

Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved the clinical relevan [...]

by Mohammed Mustafa  , Salman Pervaiz  and Ibrahim Deiab

Received: 23 February 2024;  Published: 18 June 2024;  doi: 10.21926/rpm.2402013

This paper investigates the effect of rake angle, α, cutting edge radius, r, and feed rate, f, on the cutting force and cutting zone temperature during orthogonal dry cutting of Ti6Al4V. A numerical model representative of the 2D orthogonal cutting process is developed using ABAQUS/Explicit software. Johnson-Cook, (JC) constitutive material model is used to describe material plasticity. JC damage model and energy-based fracture criterion are used to describe damage initiation and evolution. Using Minitab-19 softwar [...]

by Samhani Ismail  , Muhammad Hakimi Mohd Nashron  , Mohd Hanifah Jusoh  and Abdul Nawfar Sadagatullah

Received: 26 February 2025;  Published: 05 August 2025;  doi: 10.21926/obm.neurobiol.2503296

Chronic pain involves complex cortical and subcortical changes, suggesting that brain electrical activity may be a potential biomarker for nociceptive processing. Pain leaves its signature in the brain's oscillatory patterns, yet limited studies have explored the neurophysiological alterations associated with chronic pain. This review examines the pain detection method currently used in clinical settings, the potential of neurophysiological features to become brain oscillatory brain biomarkers, and their use in fut [...]

by Angela Cheng  , Xanthe Lea  and Alice Shires

Received: 13 March 2025;  Published: 23 June 2025;  doi: 10.21926/obm.icm.2502026

This study aims to investigate the barriers and facilitators to meditation in the general population. This research is significant because understanding these factors can inform the design of more effective public mental health interventions and support the integration of meditation into daily life. A qualitative thematic analysis was conducted on the qualitative component of wider survey responses. Participants were recruited from MeditationHQ, which offers weekly group meditation sessions on beaches around Austra [...]