by Jeffrey B. Allen  , Guillermo A. Riveros  , Ivan P. Beckman  and Elton L. Freeman

Received: 22 August 2023;  Published: 25 October 2023;  doi: 10.21926/rpm.2304033

In this work, we apply a multiphysics approach to fused deposition modeling to simulate extrusion and solidification. Restricting the work to a single line scan, we focus on the application of polylactic acid. In addition to heat, momentum and mass transfer, the solid/liquid/vapor interface is simulated using a front-tracking, level-set method. The results focus on the evolving temperature, viscosity, and volume fraction and are cast within a set of parametric studies, to include the printing and extrusion speed, a [...]

by Balamurugan Sivaprakasam  and Prasanna Sadagopan

Received: 24 December 2023;  Published: 14 June 2024;  doi: 10.21926/obm.genet.2402243

The present study introduces Snips2HLA-HsG, an integrated application designed for SNP genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful ensemble classifier technique from the Bioconductor HIBAG package, Snips2HLA-HsG offers a comprehensive response for genetic analysis. Accessible via https://snips2hla.shinyapps.io/hla_home/, the application distinguishes itself by prioritizing user-friendliness and integrating all-purpose functionalities, including sample preparation, mode [...]

by Giuseppe Cocco

Received: 05 September 2020;  Published: 10 September 2020;  doi: 10.21926/obm.geriatr.2003132

Covid-19 pandemic has been infecting a substantial portion of the world population, thereby revealing quality deficits in health care in the majority of the countries around the globe. Severe illness and mortality from Covid-19 infection are present predominantly in minorities; especially they are more frequent in geriatric patients. Unfortunately, our knowledge is limited about what accounts for the variability in immune response from one person to another. This question is far from being merely academic, and find [...]

by Mohammed Naveed

Received: 22 December 2022;  Published: 12 April 2023;  doi: 10.21926/rpm.2302015

Composite materials with aluminum as matrix material have a wider amplitude of large-scale applications in engineering. Some salient features of aluminum matrix composites are, low density, low thermal coefficient of performance and low weight and high strength. Among the various series of aluminum alloy, Al6061 have been widely used by researchers due to its outstanding properties particularly as they are heat treatable. Aluminum 6061 alloys have been reinforced with various particulate reinforcements such as sili [...]

by Mojtaba Ehsanifar  , Akram Gholami  and Alireza Esmaeili

Received: 27 October 2024;  Published: 18 April 2025;  doi: 10.21926/obm.neurobiol.2502285

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which is linked t [...]

by Gopi Battineni  , Mohammad Amran Hossain  , Nalini Chintalapudi  , Giulio Nittari  , Ciro Ruocco  , Enea Traini  and Francesco Amenta

Received: 29 June 2022;  Published: 03 January 2023;  doi: 10.21926/obm.geriatr.2301220

The increasing incidence of adult-onset dementia disorders and primarily Alzheimer’s disease (AD) among the aging population around the world is increasing the social and economic burden on society and healthcare systems. This paper presents three neural networking algorithms: MobileNet, Artificial Neural Networks (ANN), and DenseNet for AD classification based on MRI imaging data. The results of each model were compared in terms of performance metrics such as accuracy, true positive rate, and receiver operating cu [...]

by Katarina Tomulic Brusich

Received: 30 August 2022;  Published: 15 November 2022;  doi: 10.21926/obm.transplant.2204169

Transplantation is a widely accepted and successful life-saving treatment for hundreds of thousands of patients. However, transplant medicine still faces a number of obstacles. One of the most significant is the large disparity between the number of donors and recipients and the growing need for re-transplantation. In the last two decades, the improvement and organization of the national transplantation program in Croatia have resulted in a steadily increasing donor rate and therefore the transplantation numbers. A [...]

by Sai Batchu  , Michael J. Diaz  , Lauren Ladehoff  and Brandon Lucke-Wold

Received: 27 September 2022;  Published: 03 February 2023;  doi: 10.21926/obm.neurobiol.2301153

Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are commonly used to mimic tumors for in vitro experiments, but the extent to which they resemble GBM tumors in relation to the membranome is unclear. The present study explores the resemblance of GBM cell lines to primary tumors regarding membranome expression. Gene expression data was [...]

by Aart Heesterman

Received: 29 November 2021;  Published: 28 November 2022;  doi: 10.21926/aeer.2204046

Around 1600 AD the carbon dioxide content of the earth’s atmosphere started to rise, even whilst according to the Milankovitch [1] astronomical theory of climate variation it was due to fall. On the natural earth the carbon dioxide count of the atmosphere is a delayed response and an enhancing feedback on the basic cause of the Milankovitch astronomical cycle, the intensity of the June sunshine. If the Milankovitch cycle had continued its natural course, the medevial cold period known as the little ice age. Human i [...]

by Fernando Cabo  and Isaac Aguaristi

Received: 01 April 2020;  Published: 02 April 2020;  doi: 10.21926/obm.icm.2002018

by Richard A. Manfready  , Jack Husney  , Swan Thung  and Ilan S. Weisberg

Received: 04 March 2020;  Published: 25 September 2020;  doi: 10.21926/obm.hg.2003051

Patients receiving immunosuppressive therapy for inflammatory bowel disease may be susceptible to non-cirrhotic portal hypertension, now referred to as porto-sinusoidal vascular disease. Here we describe a patient treated with long-term azathioprine for Crohn’s disease who developed porto-sinusoidal vascular disease with obliterative portal venopathy without nodular regenerative hyperplasia on histology. Specific signs of portal hypertension were present, including porto-systemic collaterals on imaging. Histopathol [...]

by Omotayo B. Ilesanmi  , Rosephine Enadeghe  , Chinenyenwa U. Aleneme  , Esther F. Adeogun  and Ufuoma J. Okotie

Received: 29 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203135

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and Cd [...]

by Xiaofei Qin  , Yongren Feng  , Lejun Wu  , Zhongjian Tan  , Yanmin Zhou  and Wilson Chin

Received: 12 April 2023;  Published: 10 July 2023;  doi: 10.21926/jept.2303023

In conventional wireline and LWD/MWD formation testing, downhole predictions for rock and fluid properties are based on simplified Darcy flow models, but only for mathematical expediency. These require initially constant pressures that are uniform throughout the reservoir. This limitation precludes common applications in overbalanced drilling, so that supercharge or near-well invasion effects - associated with rapidly decreasing pressures at the sandface where pressures are measured - are completely ignored. Such 1 [...]

by Daniel Hughes  , Alex Gordon-Weeks  and Michael A Silva

Received: 30 April 2019;  Published: 19 July 2019;  doi: 10.21926/obm.hg.1903028

(1) Background: Hereditary Pancreatitis is a rare cause of acute pancreatitis. These patients usually present at a young age with recurrent episodes of acute pancreatitis that usually progresses to chronic pancreatitis with associated endocrine and exocrine failure. Hereditary pancreatitis also carries an increased lifetime risk of pancreatic adenocarcinoma. These high risk patients need early intervention where appropriate by specialist multidisciplinary teams and tailored long term management. (2) Methods [...]

by Aniebiet D. Udoh  , Ogheneruona E. Diemuodeke  , Mohammed M. Ojapah  , Fidelis I. Abam  and Joseph C. Ofodu

Received: 29 December 2022;  Published: 13 April 2023;  doi: 10.21926/jept.2302015

The quest to decarbonize the energy space to avert the negative climate change consequences calls for using low/zero-carbon energy conversion technologies in the energy generation space. The Organic Rankine Cycle is a low/zero-carbon energy conversion technology for recovering waste heat from low to medium-temperature heat sources and for biomass conversion. Therefore, this paper presents the thermodynamic optimization, with an artificial bee colony algorithm, of different ORC configurations, including simple organ [...]

by Andrey Nasledov  , Sergey Miroshnikov  , Liubov Tkacheva  and Sergey Fedorov

Received: 08 June 2023;  Published: 19 October 2023;  doi: 10.21926/obm.neurobiol.2304190

The study aims to reveal autism vectors that are inherent in 3-4-year-olds with ASD. Three hundred eighty-three children with ASD took part in the research. An online questionnaire developed earlier by our research group was used. In the first stage, with the repeated use of exploratory factor analysis, the task of identifying the simplest factor structure was solved. As a result, a 7-factor system was obtained, including from 9 to 14 items in each factor (78 items in total): 1) "Persistence on sameness" (Sam); 2) [...]

by Brian D. Barkdoll

Received: 26 May 2023;  Published: 21 November 2023;  doi: 10.21926/jept.2304037

Global climate change has necessitated the reduction of GHG emissions. Water distribution system (WDS) pumping adds to these emissions and, therefore, should be reduced. Under electricity hourly cost tariffs, utilities are incentivized to pump during the nighttime hours. This can have a deleterious effect, however, on GHG emissions. To quantify this effect, a modeling study of twelve real WDSs was performed with an electricity tariff. The systems all had the typical tank-level-based pump controls but also time-base [...]

by Katsuhisa Omagari  , Risa Kumamoto  , Yuko Koyama  , Masako Suzuta  , Asami Taniguchu  , Ayumi Fukuda  , Momoe Iwami  , Kazunori Koba  , Asako Kawaguchi  and Kazunori Otsuka

Received: 10 April 2020;  Published: 19 May 2020;  doi: 10.21926/obm.hg.2002048

Chronic constipation and irritable bowel syndrome (IBS) are two of the most common functional gastrointestinal disorders, both of which negatively affect the quality of life of the patients. Since people may have co-existing symptoms of multiple disorders, chronic constipation and IBS with predominant constipation cannot be clearly distinguished. In this cross-sectional study, data were obtained from self-administered questionnaires to assess the prevalence of chronic constipation and IBS, and their overlap, among [...]

by Robert Beringer  , Paneet Gill  , Gloria Gutman  and Brian de Vries

Received: 31 July 2022;  Published: 17 November 2022;  doi: 10.21926/obm.geriatr.2204213

Disasters such as the COVID-19 pandemic exact a toll on vulnerable populations in terms of morbidity and mortality, but they also provide opportunities for personal growth and development and demonstration of personal and collective resiliency. This inductive thematic analysis explores self-perceived negative and positive impacts of the COVID-19 pandemic on 2994 Canadians aged 55+. Data derive from response to two open-ended questions included in a national online survey (View Survey (sfu.ca)) conducted between Aug [...]

by Loree Cook-Daniels

Received: 16 July 2023;  Published: 15 January 2024;  doi: 10.21926/obm.geriatr.2401266

Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) elders are vulnerable to both the “usual” types of elder abuse (physical, sexual, emotional, and financial abuse, along with neglect), and with abuse that is specific to the context and history of LGBTQ+ elders. Training for adult protective services, long-term care ombudsmen, and other professionals who work with abused elders therefore should include information and skill-building in responding to this population. Research into effective training about LGBTQ [...]

by Axel Ferreira  , Filipa Guimarães  and Paulo Simões Coelho

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

by Giuseppe Cocco

Received: 20 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002112

by Anna A. Pendina  , Mikhail I. Krapivin  , Irina D. Mekina  , Irina V. Aleksandrova  , Yanina M. Sagurova  , Evgeniia M. Komarova  , Mariia A. Ishchuk  , Andrei V. Tikhonov  , Olesya N. Bespalova  , Alexander M. Gzgzyan  , Igor Yu. Kogan  and Olga A. Efimova

Received: 13 May 2022;  Published: 23 September 2022;  doi: 10.21926/obm.genet.2203164

This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggested for the successive detection of the catalytic telomerase subunit with immunohistochemical staining and assessment of telomere length with Q-FISH on the same set of cells. The described approach uses three incontestable advantages [...]

by Maria Gladysheva-Azgari  , Natalia Slobodova  , Eugenia Boulygina  , Svetlana Tsygankova  , Fedor Sharko  and Irina Mitrofanova

Received: 16 October 2023;  Published: 24 November 2023;  doi: 10.21926/obm.genet.2304203

In this study, we report the complete chloroplast genome of Actinidia arguta var. purpurea. The chloroplast genome is 157,369 bp long as the circular (GC ratio is 37.22%). It has four subregions: a large single-copy (LSC) region of 88,609 bp, a small single-copy (SSC) region of 20,470 bp, and two inverted repeat regions (IRs) of 24,145 bp in each. The chloroplast genome of A. arguta var. purpurea contains a total of 113 unique genes, which are 79 protein-coding genes, 4 rRNA genes, and 3 [...]

by Giacomo Farì  , Enrica Chiaia Noya  , Laura Dell'Anna  , Vincenzo Ricci  , Francesco Quarta  , Laura Masiero  , Andrea Bernetti  , Marisa Megna  and Maurizio Ranieri

Received: 16 January 2024;  Published: 25 June 2024;  doi: 10.21926/obm.neurobiol.2402227

Wheelchair basketball (WB) is a health and inclusion opportunity for people with disabilities. In the scientific literature, no evidence defines WB as a symmetrical or asymmetrical sport; however, it would be helpful to deepen this aspect because it could improve the quality of training programs and consequently speed up WB performance. In WB, the biomechanical role of the shoulders is crucial. Therefore, the symmetry index and the activation of the bilateral supraspinatus and biceps brachii muscles were investigat [...]