by Daniela Milagros Rivas Aybar  , Wahidul Biswas  and Michele John

Received: 18 December 2024;  Published: 27 February 2025;  doi: 10.21926/aeer.2501014

The construction industry, a cornerstone of global economic and social progress, is under increasing pressure to adopt sustainable practices due to its significant environmental footprint. Industrial hemp (Cannabis sativa L.) has gained attention as a renewable material for building applications, offering potential reductions in greenhouse gas emissions and resource consumption. However, its broader sustainability performance remains underexplored. This study develops a comprehensive Life Cycle Sustainability Asses [...]

by Lynne Uhl  , Taye H. Hamza  , Terry Gernsheimer  and Sherrill J. Slichter

Received: 30 December 2021;  Published: 26 April 2022;  doi: 10.21926/obm.transplant.2202158

In the multi-institutional platelet dose trial (PLADO Trial), there were 1,077 hematology/oncology patients ≥18 years of age who received at least one platelet transfusion. These patients were analyzed for types and severity of organ system bleeding based on baseline patient characteristics, laboratory assays, primary diagnosis, and type of treatment. Patients were randomly assigned to receive one of three different prophylactic platelet doses for morning platelet counts of ≤10 × 109 /L. Daily assessmen [...]

by Shili Lin  and Hengrui Luo

Received: 23 May 2018;  Published: 10 December 2018;  doi: 10.21926/obm.genet.1804053

DNA methylation is an epigenetic change that is not only important in normal cell development, but also plays a significant role in human health and disease. Therefore, studies of DNA methylation have been actively pursued to clarify the precise role of this modification in disease etiology and its potential as a biomarker of disease. One key issue in analyzing DNA methylation data is the detection of significant differences in methylation levels between diseased individuals and healthy controls. In recent years, m [...]

by Junhyeong T. Park  , Junseong A. Park  , Igor F. Tsigelny  and Valentina L. Kouznetsova

Received: 07 December 2021;  Published: 13 February 2022;  doi: 10.21926/obm.genet.2201147

The occurrence of various mutation patterns, such as changes in the DNA sequence and the loss of some sequences, is called a “mutational signature,” and they represent the molecular fingerprints that exist for the type of mutation occurring in a specific gene. Our study elucidates the correlations of mutational signatures in frequently mutated cancer genes with general mutational signatures previously found for different cancers. We hypothesized that the top twenty most frequently mutated genes (MFMG) of a cancer t [...]

by Anthony L. Dellinger  , Lowell Hughes  , Lesma Griffith  , Terry E. Brady  , Abed Alqader Ibrahim  and Melinda K. M. Goddard

Received: 19 July 2024;  Published: 13 November 2024;  doi: 10.21926/rpn.2404018

Recent advances in obesity management reflect the integration of pharmacological, surgical, and behavioral interventions, yet sustainable long-term outcomes remain elusive due to high attrition rates, the complexity of protocol compliance – and for some, costs, risks, and serious side effects. This research combined a patented nutraceutical designed to naturally stimulate serotonin, a biologic hunger agonist, to thereby aid in appetite control and facilitate weight loss through ‘Targeted Eating,’ a single, unrestri [...]

by Vipin Kumar Sharma  , Sunil Kumar Thamida  , B. Naveen Kumar Reddy  and Raja Sinha

Received: 28 November 2024;  Published: 07 May 2025;  doi: 10.21926/aeer.2502022

The hydrocarbon sector in India plays a pivotal role in the country's energy landscape, encompassing exploration, production, refining, and distribution activities. This abstract provides a concise overview of the sector's current status, challenges, and prospects. India's hydrocarbon reserves range from conventional to unconventional sources, with significant potential yet to be tapped. However, the sector faces challenges such as declining production from mature fields, technological limitations in ex [...]

by Maya Kudo  , Misa Hayashi  , Peng Tian  , Danyang Liu  , Lili Wu  , Wei Li  , Zhaoyang Hong  , Yitang Zhao  , Toshiaki Nishigaki  , Masaaki Nishihara  , Kazuo Koike  , Tonghua Liu  and Ming Gao

Received: 13 April 2020;  Published: 09 July 2020;  doi: 10.21926/obm.icm.2003033

Increased body fat mass can lead to lifestyle diseases such as hypertension, diabetes, and hyperlipidemia. Metabolic syndrome is a cluster of conditions that increases the onset of multiple diseases, such as cardiovascular diseases, stroke, and type 2 diabetes, which are closely related to lipid metabolism; therefore, new prevention approaches and treatments are needed. Our study investigated the effects and mechanism of YNCRG on anti-obesity in metabolic syndrome model SHR.Cg-Leprcp/NDmcr (SHRCP) rats. Eight-week- [...]

by Mohsen Pourfallah  and Ethan Languri

Received: 19 October 2024;  Published: 15 January 2025;  doi: 10.21926/jept.2501003

Parabolic trough collectors (PTCs) are essential for solar thermal energy systems, and their thermal efficiency can be significantly enhanced using turbulators and nanofluids. This numerical study introduces three novel fin-spiral turbulator configurations (4, 7, and 10 blades) to enhance heat transfer within the absorber tube. Additionally, three nanofluid types including water-based single-walled carbon nanotubes (SWCNT), cupric oxide (CuO), and a hybrid SWCNT-CuO, at concentrations of 1%, 3%, and 5% were evaluat [...]

by Tina Huang  , Tony Hung  , S. Irene Kim  and Ka Kit Hui

Received: 07 October 2019;  Published: 02 March 2020;  doi: 10.21926/obm.icm.2001011

Acupuncture has increasingly been used to address a variety of symptoms in patients with cancer. Here we present a case to illustrate the use of acupuncture in a 35-year-old female with metastatic breast cancer who presented to the UCLA Center for East-West Medicine (CEWM) with physical and psychological symptom clusters of insomnia, anxiety, and joint pain.

by Jane Anastassopoulou  , Ioannis Mamarelis  and Theophile Theophanides

Received: 07 March 2021;  Published: 12 October 2021;  doi: 10.21926/obm.geriatr.2104180

In the present study, Fourier-transform infrared (FTIR) spectroscopy and Scanning Electron Microscopy (SEM) were used to investigate the formation and development of carotid artery atherosclerosis. The FTIR spectra showed that with the progression of atheromatic plaque formation, the collagen changed its native structure from ɑ-helix to random coil, amyloid, and cross-links. The infrared spectra and SEM analysis of carotid arteries showed that higher than 65% of the atheromatic plaque in patients with stenosis cons [...]

by Hisayuki Komaki  and Tomohiko Tamura

Received: 19 April 2019;  Published: 23 August 2019;  doi: 10.21926/obm.genet.1903091

Background: Streptomyces avermitilis is an actinomycete that produces avermectins. The complete genome sequence of S. avermitilis K139 was determined in 2003. In our previous study, we revealed that S. avermitilis NBRC 14893T harbors two extra secondary metabolite-biosynthetic gene clusters (smBGCs), com and ptx, which are not present in strain K139. Methods: Whole-genome sequencing for S. avermitilis NBRC 14893T and ATCC 31267T was carried out by the SMRT DNA sequencing technology to determine the genomic loci enc [...]

by Ethan Fitzgerald  , Dorian Mateusz Kusyk  and Nestor D Tomycz

Received: 02 December 2020;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102170

Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Dis [...]

by Masahiro Sato  , Yuki Kiyokawa  , Emi Inada  , Eri Akasaka  , Satoshi Watanabe  and Issei Saitoh

Received: 15 March 2021;  Published: 04 November 2021;  doi: 10.21926/obm.transplant.2104155

Although the aging process expands the adipose tissue habitation in mice and due to its close association with the female reproductive system, it can be easily exposed surgically under anesthesia when reproductive organs (including ovary, oviduct, and part of the uterus) are pulled and exposed onto the dorsal skin. This study aimed to consider the suitability of adipose tissue as a target for manipulation, particularly for the grafting of cells or small-sized tissue sections due to its ease of handling. Subsequentl [...]

by Karen E. Atler  , Deana Muñoz  , Carly Knowles  , Angie Noe  , Christine A. Fruhauf  , Kathryn McGirr  , Tracy L. Nelson  and Arlene A. Schmid

Received: 18 May 2021;  Published: 05 November 2021;  doi: 10.21926/obm.icm.2104043

If proper self-management behaviors are not maintained, diabetes may lead to reduced quality of life (QoL), decreased engagement in everyday activities, disabling health complications, and even death. Less advantaged adults with limited income, lower education, and fewer resources find diabetes self-management (DSM) particularly challenging due to healthcare and social inequalities. DSM education is important to understanding diabetes-related behaviors and improving QoL. There are few evidence informed DSM educatio [...]

by Lennaert Zwart  , Tjeerd Germans  , Suat Simsek  , Jaap Ruiter  and René Jansen

Received: 22 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903071

Background: Geriatric patients are at risk of atrial fibrillation (AF) and stroke, and the risk of oral anticoagulation (OAC) related bleeding is also presumed to be higher. Detailed knowledge about the prevalence of AF and bleeding pattern in this population is scarce. This study sought to assess the prevalence of AF, use of OAC, and the rate of major bleeding in geriatric patients who are prone to frequent falls. We expect to find a higher prevalence of AF among geriatric patients compared to elderly people of co [...]

by Scott A. Trudeau  and Megan E. Gately

Received: 08 February 2021;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102169

The Reading Buddies Program was developed as a service-learning component of an Occupational Therapy Practice with Older Adults course as a collaboration between Tufts University and the VA Bedford Health Care System. The purpose of this service-learning program was to challenge graduate students’ implicit biases and improve communication skills when working with older adults with significant cognitive impairments. Through this collaboration, occupational therapy students provided individualized, activity-based car [...]

by Nicola Cantasano

Received: 12 June 2022;  Published: 05 January 2023;  doi: 10.21926/aeer.2301003

Posidonia oceanica (Linnaeus) Delile is one of the most important endemic species of the Mediterranean Sea. The long phylogenetic pathway of this species deserves special attention because its evolutionary history allows us to think back over the debated issue of life evolution on Earth. Hence, this marine plant, by terrestrial origin, was born from an ancient ancestor named Posidonia cretacea Hosius & Von der Marck. This seagrass species, currently extinct, lived in the coastal waters of the Tethys Ocean about [...]

by Ken Shimomukai  , Haruka Maeda  , Zahirah binti Muhammad Azman  , Sandro Sitompul  and Goro Fujita

Received: 09 March 2023;  Published: 03 August 2023;  doi: 10.21926/jept.2303026

One way to increase solar photovoltaic penetration in the grid is the management of voltage fluctuations. This is because a photovoltaic plant cannot be interconnected to the grid if it causes voltage violations. Voltage violation is where voltage exceeds the acceptable range. Often, grid operators request photovoltaic plant owners to regulate voltage sufficiently with expensive and space-consuming static Var compensators. Unfortunately, this sometimes makes the project less feasible. This paper argues that there a [...]

by Roberto Anaya-Fernández  , Roberto Anaya-Prado  , Michelle M. Anaya-Fernández  , Miguel A. Guerrero-Palomera  , Ivan F. Garcia-Ramirez  , Daniel Gonzalez-Martinez  , Consuelo C. Azcona-Ramirez  , Citlalli S. Guerrero-Palomera  , Claudia Garcia-Perez  , Bernardo Tenorio-Gonzalez  , Jose E. Tenorio-Gonzalez  , Laisha F. Vargas-Ascencio  , Abraham I. Canseco-Villegas  , Gustavo Servin-Romero  , Allen R. Barragan-Arias  and Bruno Reyna-Rodriguez

Received: 02 May 2024;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403239

Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...]

by Gregory R. Goodwin  , Narges Sadat Shamabadi  , Pratima Pandey  , Ewen McLean  and Omar Bagasra

Received: 26 September 2020;  Published: 07 June 2021;  doi: 10.21926/aeer.2102011

Regressive Autism [RA] is a subtype of autism spectrum disorder (ASD) that manifests as the loss of previously acquired developmental milestones and skills. Early life dysregulation of neurodevelopment due to exposure to toxic metals has been associated with ASD, but the underlying biological mechanisms by which metals influence neurodevelopment remain unclear. We explored the potential role of thimerosal or ethylmercury on neurite formation and oxytocin receptor (OXTR) modulation in four human-developing neuronal [...]

by Francisco J Alvarez  , Antonia A. Alvarez  , Hector Lafuente  , Daniel Alonso-Alconada  , Jose L. Blanco-Bruned  , Francisco Santaolalla  and Enrique Hilario

Received: 24 June 2019;  Published: 15 November 2019;  doi: 10.21926/obm.neurobiol.1904045

Background: The newborn affected by severe hypoxic-ischemic brain injury usually end up dying, and those who survive suffer neurodevelopmental handicaps. Biomarkers are required to identify the hypoxic-ischemic insult in order to determine the early rescue treatment method to be followed. The aim of the present study was to correlate relevant biomarkers to the pathophysiological process of hypoxic-ischemic brain injury at 6 h and 72 h in newborn piglets. Methods:Hypoxia-ischemia was induced in the piglets by clampi [...]

by Inês Lopes Cardoso

Received: 17 April 2018;  Published: 27 July 2018;  doi: 10.21926/obm.genet.1803025

Some repeats of three or more nucleotides in tandem, which are present in a gene or in its vicinity, tend to increase in number and for this reason are called dynamic mutations. These triplet repeats are unstable and can expand from one generation to the next. According to the expansion size, an unaffected individual can carry a pre-mutation that will expand through generations leading to the development of triplet repeat expansion diseases. The increase in the number of repeats over time leads to earlier developme [...]

by Silvia Martini  , Ezio David  , Francesco Tandoi  , Dominic Dell Olio  , Antonio Amoroso  , Mauro Salizzoni  , Giorgio Maria Saracco  and Renato Romagnoli

Received: 27 September 2018;  Published: 04 December 2018;  doi: 10.21926/obm.transplant.1804030

Background: We performed a liver transplant (LT) with a graft from a 52-year-old donor of blood group O who was HCV viremic. The recipient was a 52-year-old male with blood group A, HCV-related cirrhosis and hepatocellular carcinoma. Methods: A liver biopsy performed on post-LT day 9 revealed acute T-cell-mediated rejection and the patient received three 1.0-g boluses of methylprednisolone. On day 9, the hemoglobin level dropped and the direct antiglobulin test became positive. Passenger lymphocyte syndrome (PLS) w [...]

by Vineela Nagamalla  , Jay Patel  and Mir Saleem

Received: 20 December 2020;  Published: 21 July 2021;  doi: 10.21926/obm.neurobiol.2103104

Alzheimer’s disease (AD) is a neurodegenerative condition which consists of stages of mental, memory, and cognitive decline. As it continues to stand as the sixth leading cause of death in the U.S., 44 million people worldwide are affected. The objective of this paper is to explore the risk factors for AD in an attempt to examine potential causes for the incidence of AD. We examined genetics, lifestyle, and pre-existing conditions as risk factors for AD. We found that there are various alleles, such as APP, P [...]

by Michael Frass

Received: 07 April 2018;  Published: 20 April 2018;  doi: 10.21926/obm.icm.1802004

Oncology patients often suffer from the side-effects of conventional therapy, such as chemotherapy, radiation and/or surgery. Additive complementary medicine, such as homeopathy might be beneficial in the support of these patients. Several case reports as well as some studies have suggested the beneficial effects of homeopathy in cancer patients. Furthermore, homeopathy may also be helpful in improving quality of life (QoL). Homeopathic remedies also offer the advantage that they can be combined with a variety of c [...]