by Ivan Y. Iourov  , Ilia V. Soloviev  , Yuri B. Yurov  and Svetlana G. Vorsanova

Received: 02 February 2019;  Published: 20 March 2019;  doi: 10.21926/obm.genet.1901067

Fluorescence in situ hybridization (FISH) seems to be the most applicable and versatile molecular cytogenetic platform for visual interphase chromosome analysis offering a variety of opportunities for studying chromosomal structure and behaviour at the highest microscopic resolution and at all stages of the cell cycle. Quantitative assessment of FISH results has been repeatedly shown to increase the efficiency of FISH-based approaches. Here, we explore the potential of interphase quantitative FISH (IQ-FISH), which [...]

by Huda Jamal Jumaah  , Mohammed Hashim Ameen  and Bahareh Kalantar

Received: 31 August 2022;  Published: 12 January 2023;  doi: 10.21926/aeer.2301006

Iraq’s lakes and rivers are currently exposed to drought because of climatic and political conditions. This study uses satellite images and geographic information systems to display the water depletion and the change in the surface water area of Hamrin Lake. Sentinel-2 imagery of 2018 and 2022 was used to analyze the surface water area changes and water depletion. A comparison was made by studying the changes that happened between 2018 and 2022 respectively. Moreover, a supervised classification technique was [...]

by Alberto Ferrarese  , Marco Senzolo  and Patrizia Burra

Received: 29 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.transplant.2002110

Bacterial infection represents a common event in the natural history of cirrhosis, especially in patients with end-stage liver disease. An episode of bacterial infection may significantly modify a patient’s outcome in the setting of liver transplantation (LT) by impairing hepatic and extrahepatic organ functions, both in pre-operative and post-operative phases. Infections caused by multidrug-resistant organisms (MDRO) are increasing in cirrhosis due to high antibiotic exposure and hospitalizations. This issue is pa [...]

by Peta Stapleton  and Hannah Chatwin

Received: 17 May 2018;  Published: 02 July 2018;  doi: 10.21926/obm.icm.1803014

(1) Background: Because patients vary in their response to treatment, including adherence, the effect of treatment length in the use of EFT on food cravings was examined by comparing two studies in order to ascertain if shorter programs are as effective. This may then impact treatment adherence and completion. (2) Methods: In study one, 96 overweight and obese adults were randomly allocated to a 4-week treatment for their food craving or waitlist condition. In study two, an 8-week EFT program for 47 adults, the sam [...]

by Abdul G. Khan

Received: 22 July 2021;  Published: 14 December 2021;  doi: 10.21926/jept.2104049

There is growing concern for the contamination of our soils and waters worldwide with heavy metals (HMs), as a result of indiscriminate use of agrochemicals for feeding growing population which require optimal use of resources and sustainable agricultural strategies. This can be simultaneously achieved by using microbes as bio-fertilizers, bio-protectants, and bio-stimulants, and suitable phytoremediation- plant capable of removing heavy metals contaminants from contaminated sites. There is a growing need to adopt [...]

by Yuan Liang  , Yu Zheng  , Brighty Renli  , David C. Zhu  , Fang Yu  and Tongtong Li

Received: 29 September 2019;  Published: 01 June 2020;  doi: 10.21926/obm.neurobiol.2002059

In this paper, motivated by the fading effect in wireless communications, where severe channel fading is related to information loss during the transmission, we evaluate and analyze the fading effect in time-varying functional connectivity of AD, MCI and NC subjects based on the resting-state fMRI data, and then apply that for AD, MCI, NC classification. We show that in some critical brain regions, compared with NC subjects, AD subjects suffer more severe and long lasting fading in the functional connectivity level [...]

by Giacinto Libertini

Received: 19 February 2017;  Published: 13 April 2017;  doi: 10.21926/obm.geriatr.1702002

Currently, geriatric medicine consists mainly of palliative treatment of the disorders that characterize senile decay. This is perfectly compatible with the prevailing view that aging is the inevitable result of multiple degenerative processes that cannot be treated effectively as they are, in themselves, inevitable and irreversible. This interpretation of aging clashes with a mass of data and arguments that, conversely, indicate that aging is a specific physiological function, favoured by supra-individual natural [...]

by Zachary Brozzesi  , Darson Dezheng Li  and Ann Lee

Received: 16 June 2023;  Published: 08 September 2023;  doi: 10.21926/jept.2303027

Buildings, with their significant energy consumption, pose a pressing concern for the future. Inadequate heating, ventilation, and air-conditioning (HVAC) systems further exacerbate thermal management difficulties and energy requirements. To address these challenges, Phase Change Materials (PCMs) offer valuable potential for sustainable energy reduction within the building sector, leveraging passive cooling and heating techniques. Numerical study has been conducted to explore the impact of embedding PCM within the [...]

by Shoichiro Sumi  , Sin-Yu Yang  , Priyadarshini Canning  and Kai-Chiang Yang

Received: 29 May 2019;  Published: 24 July 2019;  doi: 10.21926/obm.transplant.1903074

Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, recent clinical trials show that micro-encapsulated islets are not fully retrievable after transplantation. By contrast, macro-encapsulated islets can be retrieved when necessary. As to the transplantation site, subcutaneous tissue can be promising, if new [...]

by Sean A. Hebert  , Aleksandra M. De Golovine  , Rita D. Swinford  , Cynthia S. Bell  , Karen J. Vigil  and Sonal Bhatnagar

Received: 30 June 2018;  Published: 14 August 2018;  doi: 10.21926/obm.transplant.1803017

Background: Human Papilloma virus (HPV) infections are an increasingly concerning etiology for post-transplantation viral-related malignancies. The nonavalent HPV vaccine (Gardasil 9) affords transplant recipients the best opportunity for malignancy prevention, but vaccine uptake remains low. Not previously reported for solid organ transplant recipients, we studied influential factors for HPV vaccine non-initiation. Methods: This survey, conducted from May to December 2017, examined influential factors for HPV vacc [...]

by Yan Yang  and Gerhard Litscher

Received: 08 January 2020;  Published: 14 January 2020;  doi: 10.21926/obm.icm.2001003

Acupuncture, being a unique method, is a millennia-old tradition in the field of Chinese medicine. However, it is surprising that there are very few scientific publications on acupuncture and its gender-specific effects. This article summarizes the previous work from the perspective of both Western and Eastern medicine, involving manual acupuncture, electro-acupuncture, and modern innovative laser acupuncture. There is scientific evidence that future gender-specific considerations should be included in the assessme [...]

by Victoria S. Jiminez  , Minh Chung  , Mohammad Saleem  and Nabiha Yusuf

Received: 02 July 2022;  Published: 17 April 2023;  doi: 10.21926/obm.geriatr.2302233

Skin aging is a complex process that involves several extrinsic and intrinsic factors and skin health is an indicator of the well-being of an individual. In recent years, there have been numerous developments using computerized systems to aid in finding solutions and treatments to skin aging processes. Tools like artificial intelligence (AI) can aid in finding solutions and treatments for skin aging. AI can also help in monitoring or identifying early signs of skin aging. Within the field of skin aging, several inn [...]

by Abanti Nag

Received: 27 July 2023;  Published: 11 October 2023;  doi: 10.21926/cr.2304024

In the era of renewable and sustainable energy, perovskite materials remain pioneers as energy harvesting materials, be it thermoelectric waste heat harvesting or photovoltaic solar cell application. Oxide perovskite material is an emerging thermoelectric material in solving energy shortage issues through waste heat recovery. The chemical and structural stabilities, oxidation resistance, and cost-effective and straightforward manufacturing process are a few advantages of the oxide-based thermoelectric materials. Th [...]

by Thibaut Triquet  , Claire Tendero  , Laure Latapie  , Romain Richard  and Caroline Andriantsiferana

Received: 20 January 2022;  Published: 15 March 2022;  doi: 10.21926/cr.2201007

This work reports the performance of a sequential adsorption/photocatalysis process using activated carbon fibers with deposited TiO2 for the elimination of the antibiotic ciprofloxacin (CIP) in water. A commercial activated carbon fiber (ACF10) was selected as the support, and a TiO2 coating was synthesized using Metal Organic Chemical Vapor Deposition (MOCVD). Experiments were carried out using a photocatalytic reactor irradiated with monochromatic LEDs (365nm). Two different processes have been studied: adsorpti [...]

by Line L. Olesen

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

by Tobias Geis  , Ute Hehr  , Roland Brandl  , Saskia Herbst  , Hugo Segerer  , Michael Melter  and Sophie Hinreiner

Received: 31 August 2017;  Published: 06 March 2018;  doi: 10.21926/obm.genet.1801015

Background: Neonatal muscular hypotonia is a common clinical feature on neonatal intensive care units with a broad spectrum of etiologies. Besides more common and obvious underlying conditions like prematurity or Down syndrome many rare disorders with often poor prognosis need to be considered. Congenital brain malformations detected on ultrasound or/and magnetic resonance imaging might constitute the clinical hallmark in differential diagnosis. We report on our approach combining cerebral imaging and application o [...]

by Ana Valado  , Polina Ponedilok  , Armando Caseiro  and Leonel Pereira

Received: 22 July 2023;  Published: 29 November 2023;  doi: 10.21926/rpn.2304024

Noncommunicable diseases (NCD), such as cardiovascular diseases (CVD), are responsible for the majority of annual deaths worldwide. Dyslipidemia, hypertension, diabetes, and obesity, among others, can enhance the onset of metabolic syndrome (MetS). The integration of natural products in the diet, such as marine macroalgae or hydrocolloids extracted from them, has been extensively studied. The application of these substances in the prevention of pathologies is expanding due to the high content of bioactive compounds [...]

by Michael P. Cary  , Valerie A. Smith  , Megan Shepherd-Banigan  , Jennifer H. Lindquist  , Jennifer G. Chapman  , Susan N. Hastings  and Courtney H. Van Houtven

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

by Gabriele Saretzki

Received: 21 May 2025;  Published: 09 September 2025;  doi: 10.21926/obm.geriatr.2503324

Telomeres are repetitive structures at the ends of linear chromosomes. Due to incomplete DNA replication at the end of linear DNA molecules, the so called “end replication problem”, telomeres shorten consecutively during cell division. In addition, telomere sequences are highly susceptible to oxidative stress damaging telomeres and resulting in their dysfunction even in non-dividing cells. Telomere shortening has been identified as one of the underlying causes for replicative senescence that can also contribute to [...]

by Kenneth J. McLeod

Received: 24 April 2023;  Published: 18 September 2023;  doi: 10.21926/obm.geriatr.2303249

Chronically low blood pressure in older adults is associated with significantly increased long-term risks of dementia and all-cause mortality risk. Yet low blood pressure is generally not treated until an individual begins to experience the acute symptoms arising from very low cerebral perfusion. However, these acute symptoms, such as dizziness, balance difficulty, syncope, increased fall occurrence, vision impairment, and nausea, begin to occur only at very low blood pressure levels, such that mean arterial pressu [...]

by Siti Hana Nasir  , Olga Troynikov  , Dawn Wong Lit Wan  and Zhen Zheng

Received: 25 February 2019;  Published: 02 September 2019;  doi: 10.21926/obm.icm.1903053

Background: Pressure and thermal therapy gloves are the two types of therapeutic gloves that are commonly used to relieve symptoms and improve hand function in patients with hand arthritis. However, no published clinical study exists indicating ideal pressure and thermal stimuli for the gloves. Understanding user thresholds for the pressure and thermal stimuli is crucial to improve therapeutic outcomes, wearer's comfort, and adherence to the therapy. There were two main aims of this pilot study, firstly to examine [...]

by Tobyn Bell  , Jane Montague  , James Elander  , Matthew Pugh  and Paul Gilbert

Received: 01 July 2023;  Published: 19 September 2023;  doi: 10.21926/obm.icm.2303037

Chairwork is a central component in Compassion Focused Therapy (CFT). Despite its importance, there has been no prior research on the relational factors underpinning the application of chairwork in CFT. There is also a general paucity of research on the role of the therapeutic relationship in chairwork across modalities. This paper analyses data from interviews with 21 clients following a CFT chairwork intervention to ascertain how relational factors influenced their experience of this method. An Interpretative Phe [...]

by Melanie J. Chandler  , Michelle Graff Radford  , Pauline Lucas  , Dona E.C. Locke  , Julia Crook  , Colleen Ball  , Maria Caselli  , Angela Lunde  , Vaishali Phatak  and Glenn E. Smith

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological well-being of care partners at 12 months. In this analysis, we sought to examine the impact of yoga training on physical performance in pwMCI and their care partners. In this multisite, randomized clinical trial, we enrol [...]

by Bhanuka Maheshwara Sisira Kumara Pahala Ralalage  , Nirmani Kaluarachchi  , Malshani Randunu  , Munshifa Jainulabdeen  , Rohini Nanthakumar  , Sameera Vishwakula  and B. Prasanna Galhena

Received: 01 October 2022;  Published: 06 February 2023;  doi: 10.21926/obm.genet.2301177

Fluorescence In-Situ hybridization (FISH) is a sensitive and highly efficient technique commonly used in routine diagnostics. Most of these tests that use analyte-specific reagents are not approved by US Food and Drug Administration (FDA) but are developed by individual test laboratories. There is an emerging demand for prenatal diagnosis of aneuploidies by FISH. Since most of these assays are laboratory-developed tests, it is essential to validate them prior to their use in diagnosis. However, validation procedure [...]

by Laura Alonso Canal  , María José Quiles Blanco  , David Jiménez Leiva  and María José González Iglesias

Received: 26 June 2019;  Published: 30 September 2019;  doi: 10.21926/obm.hg.1903037

Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The infection of Helicobacter pylori has been linked to multiple immuno-mediated extradigestive conditions including alopecia areata. There is scientific evidence of the usefulness of naltrexone in low doses (an opioid antago [...]