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Open Access Case Report

A Case of Coincidental Association of Amyotrophic Lateral Sclerosis in a Patient with Celiac Disease Consuming a Gluten-Free Diet

Received: 30 June 2020;  Published: 12 October 2020;  doi: 10.21926/obm.neurobiol.2004073

Abstract

We report, for the first time, the case of amyotrophic lateral sclerosis (ALS) onset in a 54-year-old woman not following a strict gluten-free diet (GFD) for six years after the diagnosis of celiac disease (CD). The patient did not display any sign of gluten toxicity, malabsorption, or CD-related comorbidity. Previous cases reported in medical literature showed ALS-like forms secondary to gluten intolerance, with symptom remission after a strict GFD. Even after correcting dietary flaws, the clinical manifestation o [...]

1844 11518

Open Access Original Research

Genes Coding for GPI Biosynthesis in Pneumocystis Experienced Relaxed Selection: A Follow-up Study

Received: 05 May 2019;  Published: 11 July 2019;  doi: 10.21926/obm.genet.1903083

Abstract

Background: Phylogenetic analysis shows that Pneumocystis have coevolved with their mammalian hosts for millions of years. As a result, infection by Pneumocystis is species specific (i.e. a given Pneumocystis species can infect only a single species of host). This specificity suggests the existence of a Red-Queen dynamic between Pneumocystis and its host. Evidence of this dynamic is provided by the molecular diversity and the elevated rate of non-synonymous versus synonymous (dN/dS) codon substitutions among Pneumo [...]

2019 11513

Open Access Concept Paper

Enhancing Biodiversity Education and Outreach for Conservation Awareness and Environmental Stewardship

Received: 15 August 2024;  Published: 02 April 2025;  doi: 10.21926/aeer.2502016

Abstract

Biodiversity—the rich variety of life on Earth—is essential for ecosystem stability and resilience, which, in turn, supports human well-being. However, human activities, such as habitat destruction, pollution, overexploitation, and climate change, are placing unprecedented pressures on global biodiversity, emphasizing the need for urgent conservation measures. In response, biodiversity education and outreach initiatives have become pivotal in fostering conservation awareness and action. This paper critically evalua [...]

1891 11510

Open Access Original Research

Role of Activity Professionals in Applying APIE Model to Enhance Residents’ Activity and Engagement in Long-Term Care Settings

Received: 23 August 2022;  Published: 25 June 2023;  doi: 10.21926/obm.geriatr.2302239

Abstract

Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A sur [...]

1448 11503

Open Access Case Report

Candida auris and Heart Transplantation. Preoperative Attitude.

Received: 15 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.transplant.1901053

Abstract

In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multidrug-resistant yeast that is associated with serious infections and with a mortality rate that can reach 70%. This problem is especially serious in transplant recipients receiving intense immunosupressive therapy. There are no established criteria on the relevance of this colonization or on when the transplant should be contraindicated in these cases. Five cases of colonization and two of candidemia have been [...]

1812 11503

Open Access Review

Mechanisms of Origin and Clinical Effects of Multiple Small Supernumerary Marker Chromosomes, Each Derived from a Different Chromosome

Received: 15 November 2016;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701002

Abstract

Small supernumerary marker chromosomes (sSMCs) are centric chromosome fragments additionally present in an otherwise normal human chromosome set that cannot be characterized by classical cytogenetic techniques alone. The majority of sSMCs are not yet related to a defined clinical phenotype. We compiled from the literature all 78 cases with multiple sSMCs per cell in which the chromosomal origin of the sSMCs has been identified. The number of sSMCs varies from 2 to 7; 64% have 2 sSMCs, 14% have 3 sSMCs, and the freq [...]

1794 11502

Open Access Review

Application of Microfluidic Biochips for Human Islet Transplantation

Received: 08 November 2018;  Published: 21 December 2018;  doi: 10.21926/obm.transplant.1804034

Abstract

In this review, we discuss the application of microfluidic devices in studying the physiology and pathophysiology of human islets and beta-cells, especially its application for human islet transplantation. Human islet transplantation is a promising therapy for Type I diabetes; however, the islet transplant outcomes for achieving complete insulin independence are far from perfect and face many challenges. This review focuses on the microfluidic devices developed in our laboratory, which can address these challenges [...]

1690 11498

Open Access Review

Bacterial Infections after Liver Transplantation: Updates in Post-Surgical Infections, Vancomycin-Resistant Enterococcus, and Multi-Drug Resistant Enterobacteriaceae

Received: 29 March 2018;  Published: 02 November 2018;  doi: 10.21926/obm.transplant.1804023

Abstract

Liver transplantation is a life-saving procedure available worldwide. Despite advances in its surgical and immunosuppressive strategies, infectious complications carry significant morbidity and mortality. Bacterial infections are the most common infective etiologies, and the majority are seen during the first four weeks post liver transplantation. Infectious complications are often intra-abdominal in origin, such as biliary complications and abdominal abscesses. Infections due to multi-drug resistant organisms are [...]

1479 11493

Open Access Original Research

New Electrocatalysts Prepared by Co-Sputter Deposition for the Direct Oxidation of Methanol

Received: 25 May 2021;  Published: 13 August 2021;  doi: 10.21926/jept.2103038

Abstract

Direct methanol oxidation catalysts Pt1-x-Tax (0

1804 11491

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

Abstract

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

1740 11487

Open Access Original Research

Social Engagement and Task Complexity: Physical Activity Characteristics and Executive Function Among Older Adults

Received: 15 May 2019;  Published: 27 November 2019;  doi: 10.21926/obm.icm.1904064

Abstract

Physical activity participation has been found to favorably influence cognitive function across the lifespan. Specific characteristics, or qualities, of physical activity involvement (e.g., type, intensity, level of cognitive demand) may yield particular benefits. The purpose of this study was two-fold. The first objective was to develop taxonomies for two physical activity characteristics of interest: the level of task complexity (motoric and cognitive) and the level of social engagement. The second objective was [...]

1867 11475

Open Access Review

A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation

Received: 02 November 2018;  Published: 08 January 2019;  doi: 10.21926/obm.transplant.1901038

Abstract

Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus (WNV) which has become endemic in the US since its arrival in 1999 and Zika virus (ZIKV) which recently spread across the Americas. These events demonstrate the speed with which a vector-borne pathogen can disseminate when introduced into a susceptible population with [...]

1925 11473

Open Access Review

Krabbe Disease–To Add or Not to Newborn Screening?

Received: 07 September 2023;  Published: 12 January 2024;  doi: 10.21926/obm.genet.2401210

Abstract

Krabbe disease (KD), a severe neurodegenerative disorder, has been controversial in the space of newborn screening (NBS) in the United States. Families continue to advocate for the addition of KD to the Recommended Uniform Screening Panel (RUSP) after being declined for the second time in February 2023. Even with significant progress in KD screening tests, uncertainty about the phenotypic presentations, and effectiveness of hematopoietic stem cell transplant (HSCT) seems to have impeded the addition of this conditi [...]

1446 11465

Open Access Research Article

Enzymatic Hydrolysis of Meat Waste for a Circular Economy

Received: 30 December 2022;  Published: 16 February 2023;  doi: 10.21926/cr.2301008

Abstract

This work demonstrates the possibility of implementing a technology that allows profitable value to be drawn from the meat waste from retail stores. Protein hydrolysate, collagen and fatty acids were recovered from meat waste through enzymatic hydrolysis using a mixture of enzymes: a protease (Alcalase) and a lipase (Resinase). Enzymatic hydrolysis was studied by response surface methodology (RMS). Four independent variables were used to study the response variables. The analysis showed that all factors including p [...]

1751 11463

Open Access Original Research

Theoretical Modelling of Liquid Crystal Electro-Optical Material Display Elements to Achieve Optimal Low Power Consumption Ship Stealth

Received: 29 December 2020;  Published: 14 May 2021;  doi: 10.21926/rpm.2102019

Abstract

Advanced optical stealth techniques are of growing importance in the role of manned and unmanned aircraft or ship platforms. We consider here the concept of using passive reflective display elements rather than high power active light projection to achieve a low observable camouflaged ship platform. This paper presents practical consideration towards minimal radiated power user-driven requirements using adaptive liquid crystal electro-optical methods. Optical reflectivity for a multi-layer liquid crystal cell struc [...]

1928 11462

Open Access Review

RNA Editors and DNA Mutators: Cancer Heterogeneity Through Sequence Diversification

Received: 03 December 2018;  Published: 08 April 2019;  doi: 10.21926/obm.genet.1902072

Abstract

Cancer development and progression is strongly associated with somatic mutations. From oncogenic hits that initiate the primary tumor formation to metastasis, the tumor mutational burden (TMB) plays a prominent role in the disease progression for the vast majority of cancer types. Not only are heterogeneous mutational loads or genetic heterogeneity causal to transcriptomic and proteomic discrepancies and to phenotypic diversity between individuals, they are also between tumor cells. But in addition to mutations, a [...]

1723 11456

Open Access Original Research

The Effect of Curing Temperature on the Morphology and Electro-Optical Properties of a Flexible UV-Cured Polymer Dispersed Liquid Crystal (PDLC)

Received: 11 October 2020;  Published: 08 December 2020;  doi: 10.21926/rpm.2004023

Abstract

In this work, the experimental data on flexible PDLC films at the industrial scale and the effect of cure temperature (Tc) on the morphology and electro-optical properties of a UV-cured PDLC system via polymer-induced phase separation (PIPS) method were studied. Under constant UV radiation intebsity and thickness, the morphological parameters such as dimension, number density, and volume fraction of the phase-separated liquid crystal droplets as well as the optical transmissions and switching voltages as a function [...]

1902 11455

Open Access Review

Prevalence of Post-Traumatic Stress Disorder in General Population During COVID-19 Pandemic: An Umbrella Review and Meta-Analysis

Received: 31 May 2023;  Published: 21 July 2023;  doi: 10.21926/obm.neurobiol.2303175

Abstract

During the COVID-19 pandemic, global populations have experienced quarantine and lockdown restrictions, adversely affecting individuals' psychological well-being. This comprehensive review aims to estimate the prevalence of Post-traumatic Stress Disorder (PTSD) within the general population amidst the COVID-19 pandemic. Employing the PRISMA guideline, the databases PubMed/Medline, Science Direct, Web of Science, Cochrane and Google Scholar were used in the data extraction process, and publications from December [...]

1328 11454

Open Access Original Research

Barley and Malt as Base Ingredients for the Production of New Bio-Functional Foods

Received: 14 April 2023;  Published: 19 September 2023;  doi: 10.21926/rpn.2303018

Abstract

This work aimed to evaluate the chemical composition, bioactive compounds (phenolics and γ-aminobutyric acid, GABA), and antioxidant properties of different barley varieties (Overture, Charles, Sinfonía, Montoya, and Andreia) and their malts to weigh up them as potential ingredients for producing new bio-functional foods. For this, five barleys and five malts obtained from them were studied. Regarding chemical composition, total starch was the main component (≈62%) of barleys followed by total di [...]

1636 11451

Open Access Original Research

Wind-Stress Variations from Deep to Shallow Water during Hurricanes for Air-Sea-Land Interaction Applications

Received: 27 December 2021;  Published: 14 February 2022;  doi: 10.21926/aeer.2201006

Abstract

In September 2020 Hurricane Sally impacted two National Data Buoy Center (www.ndbc.noaa.gov) buoys near its track: 42040 in the deep water and 42012 in the shallow. Using pertinent air-sea interaction formulas from the literature, analyses of these buoy data indicate that, under fully rough airflow and wind sea conditions, U* = a Hs2 /Tp3 + b, here U* is the friction velocity, Hs is the significant wave height, and Tp is the peak wave period. It is found that a = 28 and b = 0.12 for the deep water environment, a = [...]

1399 11450

Open Access Original Research

A Simplified Optimization Model for Sizing Proton-Exchange Membrane Fuel Cells

Received: 03 June 2020;  Published: 24 July 2020;  doi: 10.21926/jept.2003011

Abstract

The fluctuations in the cost of energy coupled with the gradual decrease in natural resources (i.e., oil, natural gas, coal) and the environmental issues caused by the extensive use of fossil fuels, demand the urgent need for the development of advanced and clean energy systems. The European Union has requested new measures to target climate and energy deterioration by developing renewable energy sources by 2030. The stochastic character of the energy sources and the fluctuation in demand for the energy systems pos [...]

2105 11450

Open Access Original Research

The Impact of Operating Conditions on the Performance of a CH4 Dry Reforming Membrane Reactor for H2 Production

Received: 25 March 2020;  Published: 14 May 2020;  doi: 10.21926/jept.2002008

Abstract

Biogas is a promising resource for the production of H2 since it liberates energy by recycling waste, along with the reduction of CO2. In this paper, the biogas dry reforming membrane reactor is proposed to produce H2 for use in fuel cells. Pd/Cu alloy membrane is used to enhance the performance of the biogas dry reforming reactor. This study aims at understanding the effect of operating parameters such as feed ratio of sweep gas, pressure in the reactor, and reaction temperature on the performance of the biogas dr [...]

1965 11445

Open Access Research Article

Feasibility of Implementing Therapeutic Yoga in Assisted Living Facilities

Received: 19 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101148

Abstract

The purpose of this convergent mixed methods study was to explore the feasibility of implementing a chair yoga intervention in assisted living facilities (ALFs), evaluating reach, demand, acceptability, practicality, treatment fidelity, and safety. A yoga intervention was implemented twice a week for eight weeks at four different ALFs. Feasibility data were collected in the form of observational data, reflective field notes, and focus groups. Quantitative and qualitative data strands were compared to determine if r [...]

2058 11427

Open Access Review

Scientific Evidence in Homeopathy: A Dynamic Database

Received: 27 April 2021;  Published: 28 September 2021;  doi: 10.21926/obm.icm.2103032

Abstract

Homeopathy, a system of Traditional and Complementary Medicine (T&CM, according to WHO definition), is under frequent attack by skeptics because of its supposed “lack of evidence.” To overcome the distrust of skeptics and the public, many databases have been created, which focused on collecting all the published and indexed studies; however, none of these seem to be “comprehensive” and systematic enough. Therefore, this study aimed to evaluate the most reliable and available homeopathic studies in order to systemat [...]

1345 11408

Open Access Original Research

A Large Eddy Simulation Study of Cyclones: The Effects of Interparticle Collisions on Erosion Prediction

Received: 31 January 2022;  Published: 06 May 2022;  doi: 10.21926/jept.2202017

Abstract

Cyclone separators are widely used in fluid catalytic cracking (FCC) units due to their lack of moving parts and relatively low-pressure drop. However, cyclone separators are prone to erosion-related issues, which is a major drawback. In this paper, a large eddy simulation (LES) of the particle-gas flow in a cyclone separator is investigated using a four-way Euler-Lagrange approach to model inter-particle collisions and the exchange of momentum between particles and fluid. The effects of inter-particle and particle [...]

1778 11408

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