by Ivan Y. Iourov  , Ilia V. Soloviev  , Yuri B. Yurov  and Svetlana G. Vorsanova

Received: 02 February 2019;  Published: 20 March 2019;  doi: 10.21926/obm.genet.1901067

Fluorescence in situ hybridization (FISH) seems to be the most applicable and versatile molecular cytogenetic platform for visual interphase chromosome analysis offering a variety of opportunities for studying chromosomal structure and behaviour at the highest microscopic resolution and at all stages of the cell cycle. Quantitative assessment of FISH results has been repeatedly shown to increase the efficiency of FISH-based approaches. Here, we explore the potential of interphase quantitative FISH (IQ-FISH), which [...]

by Nadia A. Abdelmegeed Abdelwahed

Received: 19 September 2023;  Published: 04 January 2024;  doi: 10.21926/obm.neurobiol.2401205

Entrepreneurial intention plays a pivotal role within entrepreneurship ecosystems, acting as a catalyst for economic growth and innovation by inspiring individuals to embrace entrepreneurship as a viable career pursuit. The present research delves into the intricate dynamics between stress, entrepreneurial intention, personal income, and physical health within Egypt's entrepreneurial landscape. Grounded in a quantitative analysis of 286 valid samples and utilizing SmartPLS 4, this study unveils compelling insights. [...]

by Masahiro Sato  , Issei Saito  , Eri Akasaka  and Emi Inada

Received: 11 October 2020;  Published: 10 March 2021;  doi: 10.21926/obm.genet.2101126

Direct colony cloning of adherent mammalian cells using rings or dilution cloning has been used frequently for obtaining stable transfectants after gene delivery. As an alternative to these methods, successful isolation of the cells in a single colony is possible by placing a trypsin-immersed small paper disk onto the colony and subsequently picking up the paper with the assumption that it carries the trypsinized cells. However, the cloning success using this technique largely relies on the cell type used. In the p [...]

by Melanie J. Chandler  , Michelle Graff Radford  , Pauline Lucas  , Dona E.C. Locke  , Julia Crook  , Colleen Ball  , Maria Caselli  , Angela Lunde  , Vaishali Phatak  and Glenn E. Smith

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological well-being of care partners at 12 months. In this analysis, we sought to examine the impact of yoga training on physical performance in pwMCI and their care partners. In this multisite, randomized clinical trial, we enrol [...]

by Jesse Tanko Zarmai  , Isaac Ibitoye Alabi  , Ebimene Ezekiel Ebisine  , Musa Tanko Zarmai  and Ovis D. Irefu

Received: 26 September 2023;  Published: 03 April 2024;  doi: 10.21926/jept.2402010

Inadequate electricity supply is a global challenge that needs solutions. This situation has compelled the purchasing of fossil fuel-generating units for use in residential, commercial, and industrial sectors to generate electricity. However, using fossil fuel generating units cause greenhouse gas emissions, bringing about environmental pollution and ultimately resulting in climate change. In particular, educational institutions require adequate and reliable power supply to ensure proper learning and teaching, whic [...]

by Line L. Olesen

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

by Peta Stapleton  and Hannah Chatwin

Received: 17 May 2018;  Published: 02 July 2018;  doi: 10.21926/obm.icm.1803014

(1) Background: Because patients vary in their response to treatment, including adherence, the effect of treatment length in the use of EFT on food cravings was examined by comparing two studies in order to ascertain if shorter programs are as effective. This may then impact treatment adherence and completion. (2) Methods: In study one, 96 overweight and obese adults were randomly allocated to a 4-week treatment for their food craving or waitlist condition. In study two, an 8-week EFT program for 47 adults, the sam [...]

by Maathar Al Qasimi  , Dhafer Manna Al Zulayqa  and Mostafa Seifan

Received: 29 July 2020;  Published: 23 October 2020;  doi: 10.21926/rpm.2004022

Additive manufacturing is a recent revolution in the construction field since cementitious materials became printable. This extrusion technique has enabled the construction of very complex geometry with a reduction in costs, time and labour interventions. This study aims to evaluate the possibility of reinforcing 3D printable cementitious composites with the use of nano and micro materials, particularly nano silica, micro silica and microfibrillated cellulose (MFC) which are known for their ability to enhance the f [...]

by Camilo A. Velasquez  , Simon Yaguare  , Sabrina Gambini  , Elizabeth McElhiney  and Suresh Keshavamurthy

Received: 19 September 2024;  Published: 27 April 2025;  doi: 10.21926/obm.transplant.2502248

Lung transplantation (LTx) is the gold standard for the surgical treatment of end-stage lung disease. Ongoing discussions persist whether single lung transplantation (SLT) or bilateral lung transplantation (BLT) lead to better patient outcomes and quality of life. This study analyzed 58 peer-reviewed articles from 1990 to 2024, comparing SLT and BLT across several parameters, including indications for transplantation, overall survival, pulmonary hypertension, complications, chronic rejection, functional status, and [...]

by Thibaut Triquet  , Claire Tendero  , Laure Latapie  , Romain Richard  and Caroline Andriantsiferana

Received: 20 January 2022;  Published: 15 March 2022;  doi: 10.21926/cr.2201007

This work reports the performance of a sequential adsorption/photocatalysis process using activated carbon fibers with deposited TiO2 for the elimination of the antibiotic ciprofloxacin (CIP) in water. A commercial activated carbon fiber (ACF10) was selected as the support, and a TiO2 coating was synthesized using Metal Organic Chemical Vapor Deposition (MOCVD). Experiments were carried out using a photocatalytic reactor irradiated with monochromatic LEDs (365nm). Two different processes have been studied: adsorpti [...]

by Divya B. Mella  , Josie Sewell  and Edward Pan

Received: 12 October 2018;  Published: 01 November 2018;  doi: 10.21926/obm.neurobiol.1804014

Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent used in gliomas, which has been given to patients with prolactinomas refractory to conventional treatments. Methods: Retrospective chart review was conducted for refractory prolactinoma patients treated between 2008 and 20 [...]

by Tran X Phuoc  and Mehrdad Massoudi

Received: 28 October 2021;  Published: 22 December 2021;  doi: 10.21926/jept.2104050

To store CO2 in geological reservoirs, expansion valves have been used to intentionally release supercritical CO2 from high-pressure containers at a source point to lower-pressure pipelines and transport to a selected injection site. Using expansion valves, however, has some shortcomings: (i) the fluid potential, in the form of kinetic energy and pressure which can produce mechanical work or electricity, is wasted, and (ii) due to the Joule-Thomson cooling effect, the reduction in the temperature of the released CO [...]

by Yoko Kawamura

Received: 15 May 2025;  Published: 30 October 2025;  doi: 10.21926/obm.geriatr.2504329

In Japan, a super-aging society, the development of Ikigai is considered the key to extending healthy longevity in national policy. Thus, activities provided by local governments are designed to encourage Ikigai. At this point, Ikigai has developed its conceptual understanding, which includes its distinctiveness from life purposes and other closely related concepts. Empirical studies using developed measurements have shown that Ikigai has an impact on the mental and physical health of older adults across countries [...]

by Edwin Meresh  , Clinton Korneffel  , Bavani Rajah  and Ryan Bergren

Received: 23 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101089

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Symptoms lasted severa [...]

by Yuan Liang  , Yu Zheng  , Brighty Renli  , David C. Zhu  , Fang Yu  and Tongtong Li

Received: 29 September 2019;  Published: 01 June 2020;  doi: 10.21926/obm.neurobiol.2002059

In this paper, motivated by the fading effect in wireless communications, where severe channel fading is related to information loss during the transmission, we evaluate and analyze the fading effect in time-varying functional connectivity of AD, MCI and NC subjects based on the resting-state fMRI data, and then apply that for AD, MCI, NC classification. We show that in some critical brain regions, compared with NC subjects, AD subjects suffer more severe and long lasting fading in the functional connectivity level [...]

by Yan Yang  and Gerhard Litscher

Received: 08 January 2020;  Published: 14 January 2020;  doi: 10.21926/obm.icm.2001003

Acupuncture, being a unique method, is a millennia-old tradition in the field of Chinese medicine. However, it is surprising that there are very few scientific publications on acupuncture and its gender-specific effects. This article summarizes the previous work from the perspective of both Western and Eastern medicine, involving manual acupuncture, electro-acupuncture, and modern innovative laser acupuncture. There is scientific evidence that future gender-specific considerations should be included in the assessme [...]

by Steven Hespeler  and Donovan Fuqua

Received: 31 July 2020;  Published: 12 January 2021;  doi: 10.21926/jept.2101003

This investigation presents a data-driven Long-short Term Memory battery model for predicting State of Charge for lithium-ion batteries LiFePO4 for next-generation vehicle operations. Our modified algorithm builds and updates a model using multivariate inputs that include physical properties, voltage, current, and ambient temperature during operations. The primary research goal is to improve prediction performance on future values from multiple training examples using an online learning scheme. Initial results demo [...]

by Shoichiro Sumi  , Sin-Yu Yang  , Priyadarshini Canning  and Kai-Chiang Yang

Received: 29 May 2019;  Published: 24 July 2019;  doi: 10.21926/obm.transplant.1903074

Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, recent clinical trials show that micro-encapsulated islets are not fully retrievable after transplantation. By contrast, macro-encapsulated islets can be retrieved when necessary. As to the transplantation site, subcutaneous tissue can be promising, if new [...]

by Hamid Ullah  , Sara Iqbal  , Blanca Lizaola Mayo  and Elizabeth Carey

Received: 31 March 2021;  Published: 20 July 2021;  doi: 10.21926/obm.transplant.2103149

Liver transplantation (LT) has grown monumentally in the last 40 years. Sarcopenia has emerged as an independent factor associated with increased mortality in patients with end stage liver disease. In this review we aim to shed light upon recent developments in assessment, clinical implications, management of sarcopenia in patients requiring a liver transplant. We also bring attention to the impact of COVID-19 pandemic on sarcopenia which ranges from the disease pathology to the unprecedented preventive measures ta [...]

by Bertrand Cassoret  and François Balavoine

Received: 20 September 2024;  Published: 30 April 2025;  doi: 10.21926/jept.2502008

This study focuses on the environmental impacts of the electricity production scenarios proposed for France for 2060 by the French electricity network manager, RTE. They consider an increasing electricity consumption and a production without fossil fuels, essentially based on wind, photovoltaic, hydraulic, and, for some, nuclear power. The total power to install is significantly higher than the current one; it is higher in the scenarios that rely more on photovoltaic and less on nuclear. Renewable energies require [...]

by Lana Isam Abu-Qulbain  and Hanan M. Taleb

Received: 29 October 2024;  Published: 01 April 2025;  doi: 10.21926/aeer.2502015

Outdoor school spaces are significant, as they provide great opportunities for outdoor exploration, leading to the overall enhancement of a student’s well-being. This paper analyzes the outdoor school spaces in Dubai to optimize them and ensure their thermal comfort. To achieve this aim, using a mixed methodology approach of survey, field observation, workshops and ENVI-met V5.3 software simulation, the existing outdoor spaces were analyzed and then enhanced using several proposed heat mitigation strategies. The im [...]

by Marta Evelia Aparicio-García  and Roberto Andrés Lasso Báez

Received: 06 November 2023;  Published: 27 February 2024;  doi: 10.21926/obm.geriatr.2401271

Older trans people have been largely unaddressed both in the context of the LGBTIQ+ community and in studies on geriatrics and aging. This literature review compiles up-to-date information on transgender elders, providing a summary of the Spanish historical context in which trans people have been raised, and analyzes the areas in which to center possible courses of action and research on a global scale. The themes tackled are the presence of victimization and violence; the effects of medical transition, taking into [...]

by Donatella Ciarmoli  and Fabrizio Stasolla

Received: 04 September 2022;  Published: 13 March 2023;  doi: 10.21926/obm.neurobiol.2301163

Neurodevelopmental disorders represent a cluster of conditions first diagnosed during childhood or adolescence (i.e., including intellectual disability, autism spectrum disorders, motor deficits, and communication deficits). The main characteristic of neurodevelopmental disorders is the presence of a deficit or a delay in the acquisition of skills that may affect different areas of evolution (e.g., cognitive, affective, and motor). These clinical conditions make the child or adolescent passive, isolated, and unable [...]

by Spiros Koutandos

Received: 21 October 2023;  Published: 07 February 2024;  doi: 10.21926/rpm.2401005

In this paper, we continue our previous work by discussing the consequences of curvature in spacetime caused by the presence of mass and the implications of this. We address the question raised by Dirac regarding the impact of a magnetic monopole on the quantum world. We discuss quantization concerning the solid angles observed, which may have a connection with a magnetic monopole.

by Tobias Geis  , Ute Hehr  , Roland Brandl  , Saskia Herbst  , Hugo Segerer  , Michael Melter  and Sophie Hinreiner

Received: 31 August 2017;  Published: 06 March 2018;  doi: 10.21926/obm.genet.1801015

Background: Neonatal muscular hypotonia is a common clinical feature on neonatal intensive care units with a broad spectrum of etiologies. Besides more common and obvious underlying conditions like prematurity or Down syndrome many rare disorders with often poor prognosis need to be considered. Congenital brain malformations detected on ultrasound or/and magnetic resonance imaging might constitute the clinical hallmark in differential diagnosis. We report on our approach combining cerebral imaging and application o [...]