by Babak Sokouti

Received: 30 October 2024;  Published: 14 March 2025;  doi: 10.21926/obm.neurobiol.2501276

Delirium is an acute neurocognitive disorder marked by disruptions in attention, cognition, and awareness, particularly prevalent among older and critically ill patients. This study applies a systems biology framework to dissect the molecular underpinnings of delirium and evaluate natural compounds for potential therapeutic roles. Through bioinformatics analyses, key biomarkers related to delirium, including IL6, AKT1, JUN, APP, and PPARGC1A, were identified, implicating pathways tied to neuroinflammation, oxidativ [...]

by Jennifer Vasquez  , Michele Quill  and Chase Bossart

Received: 17 January 2025;  Published: 14 March 2025;  doi: 10.21926/obm.icm.2501014

In this qualitative study, the impact of therapeutic Viniyoga on health and healing was explored from the perspective of 14 Viniyoga therapists who were interviewed on their perceptions of how yoga therapy contributes to the health and healing of their clients. A philosophical definition of Therapeutic Viniyoga was developed. Three themes related to health and healing from the perspective of Viniyoga therapists were identified using NVivo and Interpretative Phenomenological Analysis procedures: The definition of he [...]

by Liana Spytska

Received: 04 December 2024;  Published: 14 March 2025;  doi: 10.21926/obm.neurobiol.2501275

The relevance of studying the cognitive and behavioral dynamics of psychopathy lies in its importance for improving diagnosis, therapeutic interventions, and reducing crime, thereby contributing to public safety. This study aimed to investigate how cognitive and behavioral mechanisms influence psychopathy. A combination of methods was employed, including the Levenson Self-Report Psychopathy Scale, semi-structured interviews, and the analysis of non-verbal reactions. The sample consisted of eight participants (four [...]

by Koji Kawago  , John A Farag  , Yujiro Kawai  , Umayr Syed  , Eric Pfrender  , Satoshi Miyairi  and Yasuhiro Shudo

Received: 21 October 2024;  Published: 14 March 2025;  doi: 10.21926/obm.transplant.2501242

Heterotopic heart transplantation (HHT) in rats is a valuable tool for cardiac transplantation research. While abdominal HHT has been established in rats for nearly 90 years, novel approaches involving cervical and femoral techniques have also been explored. The abdominal HHT model, despite its long history, is technically demanding and has a steep learning curve. In contrast, the cervical HHT model enables surgeons with more basic microsurgical skills to achieve competency more quickly while producing comparable o [...]

by Ajay Kumar  and Juveriya Israr

Received: 03 August 2024;  Published: 12 March 2025;  doi: 10.21926/obm.transplant.2501241

Allogeneic stem cell transplantation (allo-SCT) improves the treatment of hematopoietic cancer and non-malignant disease. In this case, stem cells from a genetically similar but not identical donor may stimulate immune-mediated tumor cell destruction. Allogeneic stem cell transplantation, or allo-SCT, has significantly extended the life expectancy of numerous people. Nevertheless, complications such as infections, graft-versus-host disease (GVHD), and recurrence continue. This paper provides a thorough analysis of [...]

by Babkir Ali  and Ahmed Gamil

Received: 16 November 2024;  Published: 10 March 2025;  doi: 10.21926/rpse.2501003

Carbon capture and storage (CCS) technology mitigates greenhouse gas (GHG) emissions. However, comprehensive studies assessing the sustainability of coal-based power generation (CBPG) with CCS remain limited. This study focuses on developing comparative sustainability indicators across the entire life cycle of CBPG integrated with CCS technology. Sixty-six pathways were analyzed after establishing five sustainability indicators for each. These indicators were standardized per megawatt-hour (MWh) of energy, encompas [...]

by Deanna Gray-Miceli  and Sarah J. Ratcliffe

Received: 30 January 2024;  Published: 10 March 2025;  doi: 10.21926/obm.geriatr.2501303

This research sought to determine feasibility for RNs to use the Post Fall Index™ (PFI) and to determine if an RN could identify underlying causal event factors for falls, would it be congruent with other providers (advanced practice nurse [APN], physician [MD])? PFI data from 23 falling residents of a nursing home were compiled into clinical vignettes and reviewed by experts for underlying causal event factors/fall sub-types. RNs used the PFI for one month in practice. The RN generated the most diagnoses; pe [...]

by Carlos Armenta-Déu  and Ángela Trujillo

Received: 10 October 2024;  Published: 07 March 2025;  doi: 10.21926/jept.2501005

The growing demand for energy and the need to reduce dependence on non-renewable sources have driven the research and application of sustainable technologies. In this context, an integrated solution that combines distributed energy generation from renewable sources, such as wind and hydro, with efficient management of household energy consumption is proposed. This study focuses on the hybrid renewable energy system simulation analysis designed to meet the demand of an off-grid household in a self-consumption mode. [...]

by Jessica Palacios  , Odin Ramírez-Fernández  and Esmeralda Zuñiga-Aguilar

Received: 22 August 2024;  Published: 07 March 2025;  doi: 10.21926/obm.transplant.2501240

Tissue engineering offers alternatives when it comes to health problems such as trauma or pathologies. One of them is the scaffolds, which provide a favorable architecture, mechanics, and biocompatibility for the fixation of cells. Therefore, the following research aims to design and simulate scaffolds with mixed geometric structures to create a hybrid architecture for osseointegration while maintaining structural properties similar to subchondral bone and hyaline cartilage. Three scaffolds were designed for this p [...]

by Abel Kolawole Oyebamiji  , Ifeoluwa Samson Ajayi  , Faith Eniola Olujinmi  , Godwin O. Olujinmi  , Sunday A. Akintelu  , Emmanuel T. Akintayo  , Cecilia O. Akintayo  and Oluwakemi Ebenezer

Received: 22 October 2024;  Published: 06 March 2025;  doi: 10.21926/rpse.2501002

The biochemical properties of metal complexes containing benzo hydrazide Schiff base have been reported by numerous researchers worldwide in various ways. In this work, the evaluation of biochemical roles of the metal complexes with benzo hydrazide Schiff base activity as anti-gram positive and gram-negative bacteria, as well as antifungal agents, were observed. The use of various techniques, including the induced fit docking methodology, the density functional theory method, and pharmacokinetics investigations wit [...]

by Fatemeh Mollaamin

Received: 11 November 2024;  Published: 06 March 2025;  doi: 10.21926/cr.2501003

Being critical to achieving Sustainable Development Goals (SDGs) of the United Nations, strengthening understanding of the properties and processes of soil at national and regional scales is imperative. The target of this research is removing transition metals of Cr, Mn, Fe, Zn, W, Cd from soil due to nanomaterial-based boron nitride nanocage (B5N10-nc). The electromagnetic and thermodynamic attributes of toxic transition metals trapped in B5N10-nc were depicted by materials modeling. It has been studied the behavi [...]

by John Salmon  and Peter D. Drummond

Received: 24 November 2024;  Published: 05 March 2025;  doi: 10.21926/obm.neurobiol.2501274

The aim of this study was to identify methodological issues that might influence comparison of burst versus sham spinal cord stimulation for treating chronic pain. Six patients with an implanted BurstDR spinal cord stimulator were assessed double-blind during eight 3-to-4-day ON or OFF cycles over a 28-day period. The stimulator was switched off during two randomly selected cycles. Pain intensity was the primary outcome, and secondary outcomes included analgesic consumption, activity estimation and sleep quality. T [...]

by Ian Marburger  , Anna Scheyett  and Kaitlin Brianna Yoo

Received: 30 September 2024;  Published: 05 March 2025;  doi: 10.21926/obm.icm.2501013

Farmers experience high levels of stress, with negative sequelae including physical illness, depression, anxiety, and suicide. Despite this, farmers are often reluctant to adopt stress management behaviors. This study collected survey data on motivators and barriers to stress management behavior change among farmers from 162 participants at a regional fruit and vegetable growers’ conference. Survey findings were analyzed using the Health Beliefs Model (HBM) as an organizing framework, calculating the frequency of s [...]

by Gaëtan Collignon  , Aminata Bicego  , Marie-Elisabeth Faymonville  , Olivia Gosseries  , Vincent Bonhomme  , Dominique Dive  , Corine Sombrun  , Antoine Bioy  and Audrey Vanhaudenhuyse

Received: 14 August 2024;  Published: 05 March 2025;  doi: 10.21926/obm.icm.2501012

Auto-induced cognitive trance (AICT) is a method for voluntarily entering modified state of consciousness. The therapeutic implications of AICT are still unknown. Since complementary approaches based on modified states of consciousness are recognized to be beneficial for patients suffering from chronic pain (e.g., hypnosis, meditation), we here present the first case report of a 68-year-old man with a long history of chronic pain linked to an open Spina Bifida L4-L5, who used AICT to improve his health condition. S [...]

by Nicole E. Mahrer  , Gabrielle R. Rinne  , Christine M. Guardino  , Danielle A. Swales  , Madeleine Ullman Shalowitz  , Sharon Landesman Ramey  and Christine Dunkel Schetter

Received: 02 September 2024;  Published: 04 March 2025;  doi: 10.21926/obm.icm.2501011

Certain observable parenting behaviors contribute to the risk of children developing internalizing and externalizing problems. Yet parenting behaviors do not affect all children uniformly and effects may depend on identifiable child characteristics. One factor is a child’s biological sensitivity to the caregiving environment, an indicator of which is a stress hormone, cortisol. This longitudinal study examines two dimensions of observable parenting behaviors, responsive and rejecting/harsh. These parenting behavior [...]

by Esra Pehlivan

Received: 11 December 2024;  Published: 03 March 2025;  doi: 10.21926/obm.transplant.2501239

Cystic fibrosis (CF) is a genetic disorder that significantly impacts respiratory function, leading to progressive lung damage and ultimately respiratory failure. Lung transplantation (LTx) is a critical intervention for CF patients with end-stage lung disease, offering improved survival and quality of life. Pulmonary rehabilitation (PR) plays a pivotal role both preoperatively and postoperatively in optimizing outcomes for LTx candidates and recipients. Pre-transplant PR interventions, including exercise programs, [...]

by Sudha Ramaprasad  , Atmakur Snigdha  , Nandi Krishnamurthy Manjunath  and Vijaya Majumdar

Received: 14 October 2024;  Published: 03 March 2025;  doi: 10.21926/obm.geriatr.2501302

The COVID-19 pandemic has increased stress and disrupted routines affecting the psycho-social health of older adults, a vulnerable section of the population. Yogic practices have shown the potential to reduce stress, inflammation, and psychological health among other benefits. Hence, we explored the benefits of regular yoga practice on specific key mental health attributes in older adults amidst the pandemic. Using a case-control design, older adults (n = 54) who had been regularly practising yoga for the past six [...]

by Chuk Ling Julian Lai  , Wei Yin  and Jianwei Shi

Received: 20 July 2024;  Published: 02 March 2025;  doi: 10.21926/obm.geriatr.2501300

Based on a framework derived from theories of social integration and health, this study examined the relationships between motivation to cultivate social ties or network cultivation, and diurnal salivary cortisol in Chinese older adults. The main objective was to determine the behavioral mechanism that translated a higher motivation to cultivate social ties into healthier diurnal cortisol rhythms in 82 community-dwelling elders in Shanghai. Participants were provided four saliva samples immediately, 30 minutes, and [...]

by Majid Monajjemi  , Fatemeh Mollaamin  and Ahmad R. Alsayed

Received: 04 July 2024;  Published: 28 February 2025;  doi: 10.21926/obm.genet.2501287

Hepatitis C virus (HCV) is a primary global health concern, and though therapeutic options have improved, no very effective vaccine is available despite decades of research. The health and vitality of the organism are related to the result of homeostatic regulation of the internal environment. In contrast, it follows that disruption of homeostatic mechanisms leads to disease, particularly in liver cancer. Since HCV can rapidly mutate to evade the immune response, an effective HCV vaccine must rely on the identifica [...]

by Matilda Frimpong  , Michael Kwabena Osei  , Kingsley Osei  , Ruth Naa Ashiokai Prempeh  , Joseph Gyau  , Isaac Newton Boakye-Mensah  , Bismark Abugri  and Maxwell Darko Asante

Received: 22 August 2024;  Published: 28 February 2025;  doi: 10.21926/obm.genet.2501286

Plant-parasitic nematodes threaten tomato cultivation in Ghana, particularly the root-knot nematodes, causing substantial economic yield losses. However, these yield losses can be prevented through resistant varieties. This study aims to determine the type of gene action, heritability, heterosis and inbreeding depression for root-knot nematode resistance in tomato. A cross between CSIR/CRI-P005 (P1), an adapted variety with good yield but susceptible to root-knot nematode and VFNT (P2), which is resistant to root-k [...]

by Cesar Augustus Zocoler de Sousa  , Ana Paula Renno Sierra  , Giscard Humberto Oliveira Lima  , Bryan Steve Martínez Galán  , Hermes Vieira Barbeiro  , Heraldo Possolo de Souza  and Maria Fernanda Cury-Boaventura

Received: 20 August 2024;  Published: 28 February 2025;  doi: 10.21926/obm.geriatr.2501301

This study compared markers of muscle damage and myokines between adult and middle-aged runners before and after the marathon. Seventy-four male runners: 48 adults aged 30-44 years (AA group), and 26 middle-aged individuals aged 45-59 years (MA group) participated of the study. Blood samples were collected 24 hours before, immediately after, 24 hours and 72 hours after the marathon to measure skeletal and cardiac muscle damage markers (CK, LDH, troponin, and proBNP) and myokines (IL-6, IL-15, decorin, BDNF, GDF-15, [...]

by Giuseppe Merra  , Giada La Placa  , Marcello Covino  , Marcello Candelli  , Antonio Gasbarrini  and Francesco Franceschi

Received: 06 November 2024;  Published: 28 February 2025;  doi: 10.21926/obm.neurobiol.2501273

Interactions in the gut-brain crosstalk have led to the development of an entirely new concept: the "microbiota-gut-brain axis". Microbiota has gained considerable attention in relation to disorders of a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, and mood disorders. This review aims to summarize the recent trends and insights into the role and consequences of gut microbiota in brain health and pediatric neurological disorders. Dysbiosi [...]

by Daniela Milagros Rivas Aybar  , Wahidul Biswas  and Michele John

Received: 18 December 2024;  Published: 27 February 2025;  doi: 10.21926/aeer.2501014

The construction industry, a cornerstone of global economic and social progress, is under increasing pressure to adopt sustainable practices due to its significant environmental footprint. Industrial hemp (Cannabis sativa L.) has gained attention as a renewable material for building applications, offering potential reductions in greenhouse gas emissions and resource consumption. However, its broader sustainability performance remains underexplored. This study develops a comprehensive Life Cycle Sustainability Asses [...]

by Maria V. Fonseca Bauza  , Aimee H. Dubin  , Chris B. Agala  , Alexander H. Toledo  , Kristen R. Szempruch  , David A. Gerber  and Pablo Serrano Rodriguez

Received: 06 December 2024;  Published: 27 February 2025;  doi: 10.21926/obm.transplant.2501238

To evaluate the bleeding risk associated with anticoagulation (AC) in kidney transplant patients with post-operative atrial fibrillation (AF). We conducted a retrospective analysis of all adult kidney transplant recipients performed from October 2012 to February 2019 at our institution, the University of North Carolina at Chapel Hill, which accounted for 428 transplants. Variables assessed included AF occurrence, AC use, bleeding complications, stroke and bleeding risk stratification in AF (determined using CHA2DS2 [...]

by Maria Vittoria Raele  , Laura Dell’Anna  , Rachele Mancini  , Giacomo Farì  , Maurizio Ranieri  , Marisa Megna  , Riccardo Marvulli  , Marco Paoloni  , Francesco Agostini  , Massimiliano Mangone  and Andrea Bernetti

Received: 20 September 2024;  Published: 27 February 2025;  doi: 10.21926/obm.neurobiol.2501272

Upper limb dystonia is a focal locomotion disorder affecting arm, forearm, and hand muscles, causing abnormal movements given by repeated, steady, and intercontinuous contractions. There are different types of dystonia and the multifaced nature of this pathology is challenging in the treatment management, leading to a worsening of affected patients’ life quality, mainly from a psychological point of view, but also from a functional perspective. This work examines the present literature regarding upper limb dystonia [...]