by Carmelo Guido  , Valentina Selmi  , Cosimo Chelazzi  , Giulia Borsotti  , Rita Giachetti  , Vittorio Limatola  , Martina Sicurani  and Angelo Raffaele De Gaudio

Received: 29 September 2018;  Published: 28 March 2019;  doi: 10.21926/obm.icm.1901020

Background: In recent years, complementary and alternative medicine (CAM) techniques have become very widespread; among these, acupuncture can play an important role in the treatment of adverse effects related to chemotherapy. This role has been recognized by the National Institutes of Health after many clinical studies, thus allowing the official introduction of acupuncture in supportive therapy for oncological diseases, particularly to prevent nausea and vomiting. The aim of this paper is to describe the activity [...]

by Heizel Rosado-Galindo  and Maribella Domenech

Received: 15 March 2020;  Published: 14 May 2020;  doi: 10.21926/rpm.2002013

Cells can respond to different topographical cues in their natural microenvironment. Hence, scientists have employed microfabrication techniques and materials to generate culture substrates containing topographies for cell-based assays. However, one of the limitations of custom topographical platforms is the lack of adoption by the broad research community. These techniques and materials have high costs, require high technical expertise, and can leach components that may introduce artifacts. In this study, we devel [...]

by Mohammed Alsabri  , Kusum Viswanathan  , Fiorella Castillo  , Paridhi Ghai  and Maryam Hemmat Hamrah

Received: 26 December 2020;  Published: 15 April 2021;  doi: 10.21926/obm.icm.2102013

Sickle cell disease (SCD) is one of the most common hematologic disorders in the world. In the United States, it is the single most common genetic hematologic disorder. The burden of SCD and its complications on pediatric patients is tremendous, especially acute vaso-occlusive pain crises. Although allopathic medicine has provided numerous pain medications to treat this, they do not come without side effects and are not always effective. This review explores complementary and alternative medicine (CAM) methods of p [...]

by Aditi Gupta  , Bor-Jang Hwang  , Daniel Benyamien-Roufaeil  , Sara Jain  , Sophie Liu  , Rex Gonzales  , Robert A. Brown  , Michal Zalzman  and A-Lien Lu

Received: 22 July 2021;  Published: 02 April 2022;  doi: 10.21926/obm.geriatr.2202196

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9/Rad1/Hus1 checkpoint clamp, and SIRT6 aging regulator, are associated with the telomeres. MYH prevents C:G to A:T mutation by removing adenine mispaired with a frequ [...]

by Claire Thompson  , Daniela Calafiore  , Julijana Chochovski  , Steven Trawley  and Kathryn von Treuer

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their outcomes is essential. This study used mixed methods to evaluate cognitive and behavioural changes and to monitor psychological health and active ageing in participants of a longstanding positive ageing psycho [...]

by Xuhua Xia

Received: 09 June 2019;  Published: 17 October 2019;  doi: 10.21926/obm.genet.1904097

Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and initiation tRNA, respect [...]

by Mostafa T. Mohammed  , Esmat Al Sharkawy  , Amel M. Kamal Eldin  , Emad Allam  , Manal M. Saber  , Anthony Nassar  , Nour Younis  , Christa Deban  , Ahmad Jaser  , Indira Guleria  , Basset El Essawy  , Anil Chandraker  , Mahmoud Nasr  and Jamil R. Azzi

Received: 15 March 2023;  Published: 06 November 2023;  doi: 10.21926/obm.transplant.2304201

Human leukocyte antigens (HLA) are unique proteins expressed on the surface of human cells, playing a pivotal role in the immune system, particularly in the contexts of infection, cancer, and transplantation. The widespread adoption of HLA typing methods has become an essential component in assessing donor-recipient compatibility, a crucial limiting factor in solid organ transplantation. In general, the greater the disparity between a donor's and recipient's HLA types, the higher the likelihood of provoking an allo [...]

by Jordi Faig Martí

Received: 04 October 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004076

Neurological tissue along with the cartilage remains one of the tissues that escapes human efforts of regeneration after injury. The human body, after an injury, can repair its tissues only to a certain extent that can help in recovering the function of organs. However, this is not the case in some organs, such as the brain and spinal cord. For a long time, basic medical science has been investigating the regeneration process that helps the human body, which is mainly through the pharmacological agents, proteins/ot [...]

by Michelle Lynne LaBonte

Received: 29 July 2021;  Published: 29 September 2021;  doi: 10.21926/obm.genet.2103139

This article uses cystic fibrosis as a case study to examine how physicians and scientists have navigated uncertainty following newborn screening. Despite the many benefits of newborn screening, including earlier diagnosis, therapeutic intervention, and a reduced diagnostic odyssey, this public health approach also comes with challenges. For example, physicians began to document infants with indeterminate diagnoses - those with a positive screen who did not clearly fit into the cystic fibrosis or “normal” categorie [...]

by Hansa Patel  , Hayley Denison  , Sana Zafar  , Paul Teesdale-Spittle  and Elaine Dennison

Received: 27 July 2020;  Published: 11 January 2021;  doi: 10.21926/obm.geriatr.2101152

Osteoporosis is a major public health problem through its association with fragility fracture. Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. Despite this, most studies concentrate on older people when the window of opportunity to impact PBM has passed. This study aimed to understand what adolescents and young adults understand about PBM, the risk of osteoporotic fracture and how lifestyle factors impact PBM. Such information may inform educational interventions to reduce future risk of [...]