by Joun Park  , Xianzun Tao  and R. Grace Zhai

Received: 13 January 2020;  Published: 20 March 2020;  doi: 10.21926/obm.genet.2001106

By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. Here, we present 5 cases of alternative splicing conferring increased neuroprotection through diverse mechanisms. These examples highlight the enormous power of alternative splicing in maintaining viability of neurons. From pre-mRNA secondary structure al [...]

by Pei-Yu Wu  , Kristina Mjörnell  , Claes Sandels  and Mikael Mangold

Received: 22 January 2021;  Published: 11 May 2021;  doi: 10.21926/rpm.2102017

Assessment of the presence of hazardous materials in buildings is essential for improving material recyclability, increasing working safety, and lowering the risk of unforeseen cost and delay in demolition. In light of these aspects, machine learning has been viewed as a promising approach to complement environmental investigations and quantify the risk of finding hazardous materials in buildings. In view of the increasing number of related studies, this article aims to review the research status of hazardous mater [...]

by Walter Milano  , Paola Ambrosio  , Francesca Carizzone  and Anna Capasso

Received: 19 November 2019;  Published: 13 April 2020;  doi: 10.21926/obm.neurobiol.2002055

Anorexia nervosa is a psychiatric disorder, the etiopathogenesis of which is still not fully understood. Currently, the most accredited model is a multifactorial model, which involves interaction between predisposing factors of biological nature, partly genetically determined, and psychological/personological and environmental socio-cultural factors. The last 20 years have led to the advancement in our knowledge on the mechanisms of energy homeostasis maintenance. There has been a veritable explosion of studies aim [...]

by Kelly P. Attard  , Robert JT Adams  , Andrew Vakulin  and Amy C. Reynolds

Received: 22 March 2019;  Published: 27 June 2019;  doi: 10.21926/obm.neurobiol.1902029

Inadequate sleep is a largely under recognised problem in Australia despite researchers consistently highlighting it as a key component of health and wellbeing. Over a third of Australian adults now experience some form of inadequate sleep, which is consistently linked to a range of accompanying physical and mental health concerns. In addition to the health burden on the individual, the associated financial burden incurred by the community is extremely high with inadequate sleep costing over 66.3 billion annually i [...]

by Allison Ramsey  , Christine Natori  , Kristen Cisneros  , David J. Ross  and Abbas Ardehali

Received: 27 March 2020;  Published: 06 May 2020;  doi: 10.21926/obm.transplant.2002107

Biomarker surveillance after solid organ transplant is an advancing field with promise for further elucidation through high-throughput analyses and “omics” technologies. To date, Gene Expression Profiling (GEP; AlloMapâ) is the only FDA-cleared genomic assay as surveillance for moderate-severe TCMR versus allograft quiescence after heart transplantation. Clinical validity and utility, however, have been recently established after kidney and heart transplantation, for analysis of donor-derived cell-free DNA in the a [...]

by Ethan G. Lester  , Amy R. Murrell  and Dickson E. Dickson

Received: 19 June 2018;  Published: 14 October 2018;  doi: 10.21926/obm.icm.1804026

Background: Mindfulness meditation (MM) is an increasing area of interest for health professionals and the general public alike. Beneficial outcomes are associated with this practice; however, definitions of mindfulness and meditation are varied, and anecdotal accounts suggest that people hold conceptions about the constructs. Furthermore, mindfulness has been incorporated into therapeutic modalities without much consideration for context, including the client’s previous experiences with and understanding of MM. To [...]

by Marina Moguilevitch  , Michael Rufino  , Shalom Frager  and Tracey Straker

Received: 28 May 2020;  Published: 17 August 2020;  doi: 10.21926/obm.transplant.2003116

Liver transplant is a life-saving therapy for patients with end stage liver disease and liver cancer. Liver re-transplantation cases are usually more challenging and riskier than primary surgery, they require careful consideration and larger recourse utilization. Decision making on who receives transplantation surgery includes individual patient risks and benefits, physician judgment, specific transplant center policies, surgical experience, geographic organ availability, and ethical considerations. Several mathema [...]

by Natalie G. Regier

Received: 04 December 2019;  Published: 17 February 2020;  doi: 10.21926/obm.geriatr.2001106

Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfortunately, these efforts are hindered by inconsistent operational definitions and measurement tools for numerous neuropsychiatric symptoms. This review examines agitation, aggression, restlessness, and rejection of care a [...]

by Robin Junker

Received: 24 November 2022;  Published: 01 February 2023;  doi: 10.21926/obm.icm.2301011

Stress in teaching leads to many teachers suffering from burnout or leaving the profession. Therefore, it is important to identify specific correlates of teacher stress. The role of student age and social-emotional competence in teacher stress emergence is still unclear To further clarify this relationship, 284 teachers were surveyed using a questionnaire that measured teacher stress, student year grade, and student social-emotional competence. Results show a strong negative relationship between grade level and tea [...]

by Lordwin Girish Kumar Jeyakumar  , David B. McKenzie  , Yuanmei Zhang  , Lakshman Galagedara  , Shabtai Bittman  and Derek Hunt

Received: 30 December 2020;  Published: 28 June 2021;  doi: 10.21926/aeer.2102016

Subsurface tile drainage installation helps to maintain water table levels and to meet adequate crop moisture requirements. Artificial subsurface drainage continues to be a common practice in Newfoundland and Labrador (NL) and elsewhere around the world. The main objective of this study was to evaluate the performance of DRAINMOD in simulating water table depth (WTD) and water outflow from tile drained agricultural fields. This site on the Avalon Peninsula of Eastern Newfoundland has a rolling landscape with predom [...]