by Aditi Gupta  , Bor-Jang Hwang  , Daniel Benyamien-Roufaeil  , Sara Jain  , Sophie Liu  , Rex Gonzales  , Robert A. Brown  , Michal Zalzman  and A-Lien Lu

Received: 22 July 2021;  Published: 02 April 2022;  doi: 10.21926/obm.geriatr.2202196

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9/Rad1/Hus1 checkpoint clamp, and SIRT6 aging regulator, are associated with the telomeres. MYH prevents C:G to A:T mutation by removing adenine mispaired with a frequ [...]

by Sarah Fogarty  and Phillipa Hay

Received: 06 August 2019;  Published: 08 October 2019;  doi: 10.21926/obm.icm.1904058

Background: Death is a universal human experience. The experience of grief is unique for each person experiencing it. There is emerging research on modalities that provide support for bereaved individuals including bereavement massage. There is limited information in the literature about the specific role that massage can play in supporting bereaved individuals. The aim of this scoping review is to explore the literature that reports on the use and outcomes of bereavement massage so that massage therapists, consume [...]

by Stamatia Spyrou  , Alexandra V. Chatzikonstantinou  , Archontoula Giannakopoulou  , Renia Fotiadou  , Silvia Priska  , Yannis V. Simos  , Aliki Tsakni  , Dimitrios Peschos  , Dimitra Houhoula  , Epaminondas Voutsas  and Haralambos Stamatis

Received: 01 December 2022;  Published: 19 January 2023;  doi: 10.21926/cr.2301004

Biomass derived from green marine macroalgae Ulva sp. is considered a rich source of bioactive compounds. In the present study, we demonstrate the increased bioactivity of a phenolic-rich extract derived from green marine macroalgae Ulva intestinalis after its treatment with fungal laccases from Trametes versicolor and Agaricus bisporus. The phenolic composition of the extract, before and after its enzymatic treatment, was determined through several analytical methods. Furthermore, the antioxidant, enzyme-inhibitor [...]

by Sharon F. Clevenger

Received: 20 December 2020;  Published: 07 February 2021;  doi: 10.21926/obm.icm.2101004

Healthcare workers (HCWs) have been adapting to the changing needs of people worldwide in response to the COVID-19 pandemic. The purpose of this descriptive study was to evaluate how HCWs are managing dietary self-care needs during the increased stress-load of the COVID-19 pandemic and determine if nutritional changes are being made that could place them at higher risk for mental health problems. A cross-sectional epidemiological nonprobability snowball sampling design was used to expand access to participants. Occ [...]

by Mohammed Alsabri  , Kusum Viswanathan  , Fiorella Castillo  , Paridhi Ghai  and Maryam Hemmat Hamrah

Received: 26 December 2020;  Published: 15 April 2021;  doi: 10.21926/obm.icm.2102013

Sickle cell disease (SCD) is one of the most common hematologic disorders in the world. In the United States, it is the single most common genetic hematologic disorder. The burden of SCD and its complications on pediatric patients is tremendous, especially acute vaso-occlusive pain crises. Although allopathic medicine has provided numerous pain medications to treat this, they do not come without side effects and are not always effective. This review explores complementary and alternative medicine (CAM) methods of p [...]

by Joun Park  , Xianzun Tao  and R. Grace Zhai

Received: 13 January 2020;  Published: 20 March 2020;  doi: 10.21926/obm.genet.2001106

By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. Here, we present 5 cases of alternative splicing conferring increased neuroprotection through diverse mechanisms. These examples highlight the enormous power of alternative splicing in maintaining viability of neurons. From pre-mRNA secondary structure al [...]

by Heizel Rosado-Galindo  and Maribella Domenech

Received: 15 March 2020;  Published: 14 May 2020;  doi: 10.21926/rpm.2002013

Cells can respond to different topographical cues in their natural microenvironment. Hence, scientists have employed microfabrication techniques and materials to generate culture substrates containing topographies for cell-based assays. However, one of the limitations of custom topographical platforms is the lack of adoption by the broad research community. These techniques and materials have high costs, require high technical expertise, and can leach components that may introduce artifacts. In this study, we devel [...]

by Angelo Morro

Received: 19 February 2021;  Published: 13 April 2021;  doi: 10.21926/rpm.2102011

The objective of the paper is twofold: first, to review the classical diffusion models and show the approximations at the origin of the parabolic character of the classical equations; second, to demonstrate a connection between the quantum and classical models of diffusion. As diffusion is inherently related to the motion of constituents, the consistent models are framed within the dynamics of mixtures. The derivation of diffusion equations is then determined based on the related, pertinent approximations.

by Hansa Patel  , Hayley Denison  , Sana Zafar  , Paul Teesdale-Spittle  and Elaine Dennison

Received: 27 July 2020;  Published: 11 January 2021;  doi: 10.21926/obm.geriatr.2101152

Osteoporosis is a major public health problem through its association with fragility fracture. Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. Despite this, most studies concentrate on older people when the window of opportunity to impact PBM has passed. This study aimed to understand what adolescents and young adults understand about PBM, the risk of osteoporotic fracture and how lifestyle factors impact PBM. Such information may inform educational interventions to reduce future risk of [...]

by Ashley M. Carter  , Emma R. Dioso  , Bethsabe Romero  , Christopher E. Clinker  and Brandon Lucke-Wold

Received: 12 October 2022;  Published: 17 January 2023;  doi: 10.21926/obm.icm.2301007

Art as a way of healing is primordial in many cultures. Expressive Arts Therapy (ExAT) uses art, music, dance, and writing to help individuals navigate their healing journey. Patient self-expression as a mode of recovery has been observed in patients with Parkinson’s disease, epilepsy, Amyotrophic Lateral Sclerosis (ALS) and cancer. Complementary medical approaches such as acupuncture and mindfulness have also demonstrated benefits in patients suffering from neurological injury. Complementary medicine and ExAT are [...]