Acute Liver Failure Due to Assumed Drug Induced Liver Injury but Lack of Any Validated Causality Algorithm: Evidence by 36 Cohort Reports with 21,709 Cases
Abstract
1220 6597
Acute Liver Failure Due to Assumed Drug Induced Liver Injury but Lack of Any Validated Causality Algorithm: Evidence by 36 Cohort Reports with 21,709 Casesby
Abstract
Liver transplantation (LT) can be the only option for patients with acute liver failure (ALF) where medical approaches are ineffective. Causes of ALF are multiple and commonly easily detectable, but uncertainty remained on the role of drug-induced liver injury (DILI) within the published ALF cohorts. Therefore, an analysis was undertaken to clarify which drugs may have caused the DILI and how the diagnosis of the liver injury was established. Using the PubMed database and Google Science, the search term of acute li [...] 1220 6597 |
Influence of Thermal Environment Conditions on Mechanical Properties of MEX Printed 17-4 PH Stainless Steelby
Abstract
This study investigates the influence of thermal environmental conditions during printing and their effects on the mechanical properties of material extrusion (MEX) 3D-printed 17-4 PH stainless steel. Various ambient temperatures and cooling behaviors were used during the printing process of the tensile specimens. Following DIN EN ISO 50125 and DIN EN ISO 6892, the study analyzes tensile strength, elongation and yield strength. The results demonstrate that the thermal environmental conditions affect both tensile an [...] 1005 6591 |
Prevention of Drug Resistant Epilepsy and Developmental Epileptic Encephalopathy: Preventative Vigabatrin Treatment in Tuberous Sclerosis Complex and the Case for Fenfluramine Treatment of Children with Newly Diagnosed Dravet Syndromeby
Abstract
Tuberous sclerosis complex (TSC) is caused by mutations of hamartin (TSC1) or tuberin (TSC2) resulting in disinhibition of the mTOR pathway of cellular proliferation and differentiation and severe neurocognitive impairment, intractable epilepsy and tumors. Epilepsy develops in ~90% folllowed by drug-resistant epilepsy (DRE). Recently, prevention of DRE and developmental encephalopathy was shown to be possible in TSC using early administration of vigabatrin. For the first time, medical treatment successfully prevent [...] 1141 6583 |
Morpho-Biochemical Characterization and Genetic Analyses of the Traits of Mungbean Genotypes Confined with Yield Attributing Traits and Salinity Stress Toleranceby
Abstract
Low phenotypic and genotypic variability for yield-attributing traits and susceptibility to salinity stress are constraints of mungbean productivity. The objectives of the study are to phenotype a set of exotic mungbean genotypes for yield-attributing traits and salinity tolerance, as well as to conduct genetic analysis of these traits for efficient selection. Three consecutive experiments were conducted to fulfill these objectives. In the first experiment, 26 mungbean genotypes were evaluated for yield traits unde [...] 1346 6578 |
Correction: Armstrong C. Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic Perspective. OBM Integrative and Complementary Medicine 2021; 6: 16Abstract
CorrectionCorrection: Armstrong C. Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic Perspective. OBM Integrative and Complementary Medicine 2021; 6: 16Colin Armstrong *Osteopathic Centre, 1732 Voie Aurelienne, 13450 Grans, France; E-Mail: arm.colin@gmail.com*Correspondence: Colin Armstrong; E-Mail: arm.colin@gmail.comAcademic Editor: Nancy Nies Byl Special Issue: The Importance of the Fascia for [...] 1084 6566 |
Creating through COVID-19 - An Art-Based Autoethnographic AccountAbstract
The experience of painting during the COVID-19 period initiated this art-based autoethnographic account. The pandemic affected various fields of life; the discussion is thus pursued from a few interrelated points of view: of an individual coping with the COVID-19 crisis on a personal level, of a painter, of an art therapist, of an art therapy lecturer and supervisor, and an artist involved in community interventions. Artmaking and viewing artworks can enhance communication with the beholder and encourage others to [...] 1079 6558 |
Models for Predicting Risk of Acute Kidney Injury after Liver SurgeryAbstract
Background & Aims. Acute kidney injury (AKI) is a serious complication of liver surgery and associated with significant morbidity and mortality. The incidence of AKI following hepatic surgery can be as high as 94%, with highest rates seen following orthotopic liver transplantation, particularly when extended criteria grafts are used. Strategies to identify patients at risk of AKI may enable early interventions to prevent or minimise AKI.
Methods. A systematic review was conducted using PubMed, Medline, Cochrane and [...] 1485 6553 |
Acknowlegement to Reviewers of Advances in Environmental and Engineering Research in 2020Abstract
The editors of Advances in Environmental and Engineering Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can do [...] 1211 6545 |
Unraveling and Expanding the Genotypic Spectrum of Kabuki Syndrome with Identification of de Novo Protein-Truncating Mutations in the KMT2D Gene: Insights into the Role of Premature Stop Codons in the Etiology of the Disorderby
Abstract
Kabuki Syndrome (KS) is a rare, multisystem congenital disorder with five foremost clinical manifestations encompassing dysmorphic facial characteristics, postnatal growth constraint, craniofacial/skeletal anomalies, mild to moderate intellectual disability, and dermatoglyphic abnormalities. We analyzed two unrelated Iranian patients suspected of having KS using whole-exome sequencing. An in silico analysis was performed to evaluate the potential effects of the discovered variants on the structure and function of t [...] 1139 6526 |
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