by Sarah I. Willi  , Ulrike Bacher  , Marie Noelle Kronig  , Michael Daskalakis  , Lia Bally  and Thomas Pabst

Received: 29 July 2023;  Published: 04 February 2024;  doi: 10.21926/obm.transplant.2401206

Malnutrition remains a clinical challenge in AML patients undergoing autologous hematopoietic stem cell transplantation (ASCT), leading to physical deconditioning and prolonged hospitalization. Prospective data are mainly lacking to identify those patients who may particularly benefit from parenteral nutrition in this setting. This observational, non-randomized, retrospective, exploratory cohort study assessed the nutritional development in patients following high-dose chemotherapy (HDCT) with ASCT and explored the [...]

by Amanda Pong  and Pavel Klein

Received: 15 February 2024;  Published: 08 May 2024;  doi: 10.21926/obm.genet.2402234

Tuberous sclerosis complex (TSC) is caused by mutations of hamartin (TSC1) or tuberin (TSC2) resulting in disinhibition of the mTOR pathway of cellular proliferation and differentiation and severe neurocognitive impairment, intractable epilepsy and tumors. Epilepsy develops in ~90% folllowed by drug-resistant epilepsy (DRE). Recently, prevention of DRE and developmental encephalopathy was shown to be possible in TSC using early administration of vigabatrin. For the first time, medical treatment successfully prevent [...]

by Justin Cole  , Eugene Golts  , Michael Bernales  , Dina Shirazi  , Deepa Kurup  , Sarah Golts  , Gordon Yung  , Aarya Kafi  , Christine M. Lin  , Travis Pollema  and Kamyar Afshar

Received: 19 October 2023;  Published: 08 May 2024;  doi: 10.21926/obm.transplant.2402214

Despite the concerted efforts by lung transplant recipients (LTR) and their medical teams, hospital readmissions are common in the first year following transplantation. Reasons for unplanned readmissions include allograft rejection, infections, and respiratory failure before the SARS-COV-2 pandemic. Clinical predictors of readmissions have changed over time with the higher risk factors of acceptable criteria for recipients and donors. We aimed to assess more recent readmission rates based on group classifications t [...]

by Daphna Markman Zinemanas

Received: 09 November 2023;  Published: 29 November 2023;  doi: 10.21926/obm.icm.2304057

The experience of painting during the COVID-19 period initiated this art-based autoethnographic account. The pandemic affected various fields of life; the discussion is thus pursued from a few interrelated points of view: of an individual coping with the COVID-19 crisis on a personal level, of a painter, of an art therapist, of an art therapy lecturer and supervisor, and an artist involved in community interventions. Artmaking and viewing artworks can enhance communication with the beholder and encourage others to [...]

by Arbnora Batalli-Kepuska  , Lidvana Spahiu  , Emir Behluli  and Gazmend Temaj

Received: 08 February 2024;  Published: 19 July 2024;  doi: 10.21926/obm.genet.2403253

Several therapeutic methods are used to cure acute lymphoblastic leukemia (ALL). Relapsed/refractory B-cell ALL (R/R B-ALL) remains the primary cause of death worldwide due to the limitation of cure. Blinatumomab is a bispecific T-cell engaging antibody used to treat R/R B-ALL. The use of blinatumomab for treating R/R B-ALL has shown to be very efficient, especially as a bridge tool to hematopoietic stem cell transplantation (HSCT). The response to blinatumomab treatment ranged from 69% after two cycles in phase II [...]

by Justin Chin  , Alexandra Over  , Ana Christina Reyes  , Connie Chen  , Elise Hsu  , Christine Lomiguen  and Tipsuda Junsanto-Bahri

Received: 19 September 2022;  Published: 12 December 2022;  doi: 10.21926/obm.icm.2204053

Complementary and alternative medicine (CAM) is an important feature of patient medical history. This study sought to investigate the perceptions of medical students at Touro College of Osteopathic Medicine in Harlem, New York (TouroCOM-NY) regarding Asian-origin CAM practices. An anonymous survey was distributed to first and second year TouroCOM-NY medical students, asking about their familiarity with, and general attitude towards, five categories of Asian-origin CAM (acupuncture, reiki, tai chi, Ayurveda, and use [...]

by John A. T. Bye

Received: 13 November 2022;  Published: 05 February 2023;  doi: 10.21926/aeer.2301018

This paper presents a model for the similarity structure of the velocity profiles in air and water in the wave boundary layer, which provides predictions in terms of two parameters, F and R, of all its important properties, including the Charnock parameter, the surface drift velocity and the condition for the cancellation of the surface Stokes velocity by the surface current. The parameter, F, arises from the fetch variability of the wave field, and the parameter, R, arises from the duration variability of the wave [...]

by Bojana Petrovic  , Milica Komnenic Radovanovic  , Nikolina Erceg  , Srboljub Milicevic  and Marija Dusanovic Pjevic

Received: 22 November 2023;  Published: 17 January 2024;  doi: 10.21926/obm.genet.2401211

This study evaluates how chromosomal factors affect assisted reproduction techniques (ART) challenges among infertile couples, impacting their chances of conception. Chromosomal abnormalities, a leading cause of pregnancy failure and miscarriages, were investigated in a four-year retrospective study involving 100 patients with a history of infertility and unsuccessful IVF treatment. Among these cases, nine (9%) displayed aberrant chromosomal patterns, including balanced translocations (5%), sex chromosome deletions [...]

by Giuseppe Merra

Received: 03 July 2024;  Published: 10 July 2024;  doi: 10.21926/obm.genet.2403251

by Subhranshu Sekhar Kar  , Rajani Dube  , Biji Thomas George  and Malay Jhancy

Received: 07 April 2024;  Published: 20 December 2024;  doi: 10.21926/obm.genet.2404276

There is a high prevalence of genetic abnormalities that significantly contribute to overall morbidity and mortality in neonates. Since early diagnosis is crucial for the optimal administration of conventional and customized medications, neonatal acute care has the most significant potential to benefit from genomic medicine. Genome sequencing has been demonstrated to have diagnostic, therapeutic and informational value in many investigations. With underlying genetic disorders, genome sequencing has the power to cha [...]