by Hannah O'Connor  , Joseph Biederman  , Maura DiSalvo  , Gagan Joshi  , Stephen V. Faraone  and Janet Wozniak

Received: 25 January 2024;  Published: 04 June 2024;  doi: 10.21926/obm.icm.2402031

The aim of this paper is to examine effects of stimulant treatment in children and adolescents with high levels of emotional dysregulation in a psychiatric outpatient clinic. Subjects were referred children and adolescents 6-17 years of age who presented to a child psychiatric outpatient clinic between September 2016-November 2021 and received a prescription for a stimulant medication. Children were stratified into those with low and high levels of emotional dysregulation as defined by an aggregate T-score of <1 [...]

by Subhranshu Sekhar Kar  , Rajani Dube  , Biji Thomas George  and Malay Jhancy

Received: 07 April 2024;  Published: 20 December 2024;  doi: 10.21926/obm.genet.2404276

There is a high prevalence of genetic abnormalities that significantly contribute to overall morbidity and mortality in neonates. Since early diagnosis is crucial for the optimal administration of conventional and customized medications, neonatal acute care has the most significant potential to benefit from genomic medicine. Genome sequencing has been demonstrated to have diagnostic, therapeutic and informational value in many investigations. With underlying genetic disorders, genome sequencing has the power to cha [...]

by Gerasimos Rigatos  , Pierluigi Siano  , Mohammed AL-Numay  , Masoud Abbaszadeh  and Gennaro Cuccurullo

Received: 16 September 2023;  Published: 21 February 2024;  doi: 10.21926/jept.2401006

This article aims to treat the nonlinear control problem for the complex dynamics of a wave energy unit (WEC) that consists of a Permanent Magnet Linear Synchronous Generator (PMLSG) and a Voltage Source Converter (VSC). The article has developed a globally stable nonlinear optimal control method for this wave power generation unit. The new method avoids complicated state-space model transformations and minimizes the energy dispersion by the control loop. A novel nonlinear optimal control method is proposed for the [...]

by Leonid Dvorkin  , Vadim Zhitkovsky  and Ruslan Makarenko

Received: 12 January 2023;  Published: 24 February 2023;  doi: 10.21926/rpm.2301009

The article proposes a method that considers the parameters of heat and moisture treatment of concrete when designing its composition. Based on the analysis of experimental data, formulas are proposed that allow taking into account the type and characteristics of cement, the characteristics of aggregates, the effect of temperature and duration of steaming, and the water-cement ratio. Graphs and nomograms have been obtained, which makes it possible to simplify the calculation procedure according to the proposed meth [...]

by Babak Sokouti

Received: 30 October 2024;  Published: 14 March 2025;  doi: 10.21926/obm.neurobiol.2501276

Delirium is an acute neurocognitive disorder marked by disruptions in attention, cognition, and awareness, particularly prevalent among older and critically ill patients. This study applies a systems biology framework to dissect the molecular underpinnings of delirium and evaluate natural compounds for potential therapeutic roles. Through bioinformatics analyses, key biomarkers related to delirium, including IL6, AKT1, JUN, APP, and PPARGC1A, were identified, implicating pathways tied to neuroinflammation, oxidativ [...]

by Nils Altner  and Jasmin Friedrich

Received: 05 September 2022;  Published: 14 November 2022;  doi: 10.21926/obm.icm.2204049

In this study, we present the results of a 48-hour mindfulness-based and compassion-based training for teachers (N = 59). This study included 3,250 students in two years. We strengthened the resources of teachers and students for health, especially for preventing addiction. The didactic approach was based on the concepts of embodiment and resonance. We first trained teachers and then encouraged them to teach students in the classroom. Qualitative data were collected on the presence of teachers, relationship buildin [...]

by Kristi R. Mitchell  , Margaret Dittloff  , Jasmine Larson  and Donna Belcher

Received: 10 April 2024;  Published: 10 September 2024;  doi: 10.21926/obm.geriatr.2403287

Effective January 2024, the United States Centers for Medicare & Medicaid Services (CMS) for the first time has included a nutrition-focused quality measure in the Hospital Inpatient Prospective Payment System (IPPS) Inpatient Quality Reporting (IQR) Program: the Global Malnutrition Composite Score (GMCS). The GMCS is an electronic clinical quality measure (eCQM) that hospitals can choose to report voluntarily to meet the requirements for IPPS IQR payments. The GMCS can help improve hospital malnutrition care and h [...]

by Roy G Beran

Received: 01 July 2022;  Published: 13 September 2022;  doi: 10.21926/obm.geriatr.2203204

This paper examines sleep disorders in older people, focusing on Parkinson’s disease (PD). It defines PD and explores those conditions associated with sleep disorders and their relationship to PD. It identifies specific conditions which cause sleep disoders in patients with PD, namely: REM sleep behaviour disorder (RDB) which may be a precursor to PD; obstructive sleep apnoea (OSA) which is very prevalent amongst people with PD; depression and mood disorders which both increase with age and are more common in peopl [...]

by Paola Romecín  , Joaquin García-Estañ  and Noemí M. Atucha

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3) Results: We have found several alterations compatible with the existence of a hyperaggregatory state. These alterations are related to a defective platelet calcium handling, spec [...]

by Manuel De Jesus Encarnacion Ramirez  , Nikolay Konovalov  , Stanislav Kaprovoy  , Gennady Chmutin  , Geovany Venegas Cerna  , Renat Nurmukhametov  , Andreina Rosario Rosario  , Kalin Ivan Yakovlevich  , Jesus Lafuente  , Eric Suero Molina  and Nicola Montemurro

Received: 20 April 2024;  Published: 09 September 2024;  doi: 10.21926/obm.neurobiol.2403244

Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...]