by Sheila Krishnan  , Chadi Hage  , Raymond Coakley  , David van Duin  and Leonard Jason Lobo

Received: 18 February 2019;  Published: 10 June 2019;  doi: 10.21926/obm.transplant.1902065

Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infections despite their association with increased morbidity and mortality. Various studies have linked respiratory viral infections with acute cellular rejection and chronic allograft dysfunction, and emerging data indicates a [...]

by Stamatia Stai

Received: 27 May 2018;  Published: 06 September 2018;  doi: 10.21926/obm.genet.1803032

Immunoglobin A Nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Its development is characterized by the deposition of immune complexes that consist of abnormally galactosylated IgA1 molecules and IgG or IgA autoantibodies in the mesangium and the subsequent induction of renal injury. Recent research has shed light to many aspects of the pathogenesis of the disease, including the contribution of epigenetic modifications in its onset and progression. This review aims to present some of the [...]

by Mohsen Pourfallah  and Ethan Languri

Received: 19 October 2024;  Published: 15 January 2025;  doi: 10.21926/jept.2501003

Parabolic trough collectors (PTCs) are essential for solar thermal energy systems, and their thermal efficiency can be significantly enhanced using turbulators and nanofluids. This numerical study introduces three novel fin-spiral turbulator configurations (4, 7, and 10 blades) to enhance heat transfer within the absorber tube. Additionally, three nanofluid types including water-based single-walled carbon nanotubes (SWCNT), cupric oxide (CuO), and a hybrid SWCNT-CuO, at concentrations of 1%, 3%, and 5% were evaluat [...]

by Thomas Liehr  , Monika Ziegler  , Nadezda Kosyakova  and Ahmed B.H. Al-Rikabi

Received: 16 March 2018;  Published: 17 May 2018;  doi: 10.21926/obm.genet.1802021

Background:Fluorescence in situ hybridization (FISH) can be performed on metaphase- and/or interphase cells. Metaphase cells can exclusively be obtained and studied after time-consuming cell culture. Therefore, this technique is suitable only for cells derived from peripheral blood, bone marrow or fibroblasts, the latter including skin, tumour or "prenatal tissues", such as the amnion or chorion. On the other hand, interphase cells can be gained from many different cells and even without cell culture. Methods:Here, [...]

by Areen Omary  and Tameka Chambers

Received: 17 August 2021;  Published: 22 December 2021;  doi: 10.21926/obm.geriatr.2104185

The current study aimed to examine if sex can significantly predict risk for lifetime major depressive episodes among adults aged 65 and older with and without adjustment for covariate variables of race, education, marital status, health, and poverty. Secondary data was obtained from the National Survey on Drug Use and Health public-use data file to achieve study goals. The study participants were males and females aged 65 years or older. The unweighted sample included 3,969 adults aged 65 years or older, represent [...]

by Rail M. Shamionov  , Marina V. Grigoryeva  , Elena S. Grinina  and Aleksey V. Sozonnik

Received: 25 March 2022;  Published: 01 June 2022;  doi: 10.21926/obm.neurobiol.2202124

In an age when publicity is the norm, human loneliness is a significant socio-psychological problem. Objective loneliness (e.g., as experienced during the pandemic) does not always result in subjective loneliness. Subjective loneliness directly influences various aspects of the human psyche and activities. Analysis of satisfaction with social life, as a marker of social well-being and academic adaptation of students with different loneliness types, allows determining the magnitude of subjective loneliness and how i [...]

by Michael Joseph Diaz  , Kevin Thomas Root  , Alice Beneke  , Yordan Penev  and Brandon Lucke-Wold

Received: 07 October 2022;  Published: 06 March 2023;  doi: 10.21926/obm.neurobiol.2301161

Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encourage [...]

by A. Guillermo Bracamonte

Received: 24 November 2024;  Published: 18 February 2025;  doi: 10.21926/rpm.2501007

The generation of non-classical light with improved performances within tiny sizes, intervals of lengths, and diameters is still a challenge. The generation of variable wavelengths associated with different frequencies of energy modes produced from new sources of emitters within confined scales from the Quantum to Nano-and Micro-scales are of high impact. It is noted here that the concept of the generation of non-classical light related to electronics and photonics interactions with different topological matter con [...]

by Anis Chaba  , Manon Dekeyser  , Julie Oniszczuk  and Antoine Durrbach

Received: 30 August 2020;  Published: 11 January 2021;  doi: 10.21926/obm.transplant.2101133

Kidney transplantation has become the preferred treatment option in end-stage chronic renal failure as it provides significant improvements over dialysis in terms of both quality and duration of life. Even after several randomized studies conducted in the last 20 years, the combination of CNI, MMF, and steroids continues to be considered the gold standard for kidney transplantation. However, novel molecules aimed at minimizing renal and cardiovascular toxicity, particularly with CNI sparing, are being identified. T [...]

by Monday Uchenna Obaji  , Angus Nnamdi Oli  and Malachy C Ugwu

Received: 12 December 2024;  Published: 23 April 2025;  doi: 10.21926/obm.genet.2502293

Cytokines are pivotal regulators of immune responses. They are critical in mediating inflammation, recruiting immune cells, and driving pathogen clearance. Among these, interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) stand out as key players in pediatric immunity, as they exhibit unique expression patterns that reflect the dynamic nature of the developing immune system. This review explores the dual roles of these cytokines in orchestrating immune defense and their potential as d [...]