by Kyungmin Ko  , Juan F. Guerra  and David F. Garvin

Received: 29 August 2019;  Published: 28 October 2019;  doi: 10.21926/obm.transplant.1904089

Background: Graft site candidiasis is a serious complication after solid organ transplantation, often presenting as invasive arteritis leading to graft loss or even death. Case Report: We report a case of anastomotic site candidiasis leading to arterial rupture and death at postoperative day 10 with no clinical warning signs. Preservation fluid cultures were negative and postoperative Doppler ultrasonography did not show vascular compromise. Postmortem examination revealed microscopic arterial wall abscesses harbou [...]

by Anis Chaba  , Manon Dekeyser  , Julie Oniszczuk  and Antoine Durrbach

Received: 30 August 2020;  Published: 11 January 2021;  doi: 10.21926/obm.transplant.2101133

Kidney transplantation has become the preferred treatment option in end-stage chronic renal failure as it provides significant improvements over dialysis in terms of both quality and duration of life. Even after several randomized studies conducted in the last 20 years, the combination of CNI, MMF, and steroids continues to be considered the gold standard for kidney transplantation. However, novel molecules aimed at minimizing renal and cardiovascular toxicity, particularly with CNI sparing, are being identified. T [...]

by Cherechi Ndukwe  , M. Tariq Iqbal  , Jahangir Khan  and Mohsin Jamil

Received: 18 April 2022;  Published: 26 June 2022;  doi: 10.21926/jept.2202022

One important aspect toward proper and stable functioning of a communication-based controlled microgrid is data transmission. Consequently, an analysis of the effect of data transmission delay is of significance for any chosen communication protocol. This paper focuses on the effect of employing LoRa for data transfer at the secondary control level of a standalone DC microgrid. It analyses the effect of LoRa transmission delay on the dynamic performance of DC microgrids. This paper simulates a community DC microgri [...]

by Gabriele Saretzki

Received: 21 May 2025;  Published: 09 September 2025;  doi: 10.21926/obm.geriatr.2503324

Telomeres are repetitive structures at the ends of linear chromosomes. Due to incomplete DNA replication at the end of linear DNA molecules, the so called “end replication problem”, telomeres shorten consecutively during cell division. In addition, telomere sequences are highly susceptible to oxidative stress damaging telomeres and resulting in their dysfunction even in non-dividing cells. Telomere shortening has been identified as one of the underlying causes for replicative senescence that can also contribute to [...]

by Ahmad R. Alsayed  and Andi Dian Permana

Received: 28 February 2024;  Published: 28 May 2024;  doi: 10.21926/obm.genet.2402237

Bacteriophages, or phages, are viruses that infect bacteria, exhibiting specificity towards particular bacterial strains. Despite being overshadowed by traditional antibiotics in the West, interest in phage therapy has resurged due to the escalating antimicrobial resistance crisis. Understanding phage biology, selection, production, and pharmacology is crucial for their clinical application. Phages interact intricately with the human microbiome, influencing bacterial populations and potentially offering therapeutic [...]

by Aline Duarte Folle  , Kimberly C Paul  , Cynthia D Kusters  , Jeff M Bronstein  , Adrienne M Keener  and Beate Ritz

Received: 30 June 2020;  Published: 26 August 2020;  doi: 10.21926/obm.geriatr.2003131

Insomnia and excessive daytime sleepiness are the most common sleep disturbances in Parkinson’s disease. This study aims at better understanding how severity of PD motor and non-motor features and dopaminergic treatments contribute to these sleep symptoms in the first decade of PD. Data from a community-based cohort of PD patients was used to model cross-sectional PD-related risk factors for insomnia and EDS sleep scores using linear regression models adjusted for age, gender, and PD duration. Longitudinal changes [...]

by Joanna K. Nelson  and Aruna Subramanian

Received: 30 November 2018;  Published: 01 February 2019;  doi: 10.21926/obm.transplant.1901047

Nontuberculous mycobacteria (NTM) infections are relatively rare but carry significant morbidity in solid organ transplant (SOT) recipients. Given the rarity of disease and diagnostic limitations, a high index of suspicion is required for accurate diagnosis and initiation of appropriate treatment. We discuss the challenges in diagnosis and management of NTM infections specific to the SOT population.

by Heather Mary Kempton

Received: 23 November 2021;  Published: 11 March 2022;  doi: 10.21926/obm.icm.2201011

Mindfulness practices have exploded in popularity in public awareness and in therapeutic applications. While mindfulness in a therapeutic context is presented as a secular practice, its primarily Buddhist heritage may make some Christian clients wary of engaging. Research indicates that both reflection (co-creation) on poetry and creation of poetry can be therapeutic, and that both Buddhist and secular/therapeutic mindfulness texts use poetry to convey meaning through key themes of nature, change/impermanence, stag [...]

by Victoria Gómez-Dos-Santos  , Vital Hevia-Palacios  , Edurne Ramos-Muñoz  , María Laura García-Bermejo  , Esperanza Macarena Rodríguez-Serrano  , Ana Saiz-González  , Jose Manuel Del Rey-Sánchez  and Francisco Javier Burgos-Revilla

Received: 22 March 2018;  Published: 21 June 2018;  doi: 10.21926/obm.transplant.1802012

Background: Extended criteria donors and donation after cardiac death donors provide organs which tend to be more sensitive to the stress of preservation. There is a lack of evidence about the potential role of oxygen in preservation techniques, and literature comparing oxygenated and non-oxygenated techniques is very limited. The aim of the study was to compare HMP with oxygen versus HMP without oxygen in a pig model of kidney auto-transplantation (KT) reproducing conditions of DCD. We have also set up miRNAs expr [...]

by Marina Moguilevitch  and Tracey Straker

Received: 05 July 2020;  Published: 12 November 2020;  doi: 10.21926/obm.transplant.2004123

Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson’s disease is based on the combination of specific clinical findings, laboratory and genetic testing. There are different modalities of treatment available for this condition. Liv [...]