by Boel De Paepe

Received: 28 February 2019;  Published: 16 May 2019;  doi: 10.21926/obm.genet.1902079

In order to successfully recover from damage, skeletal muscle tissue requires proper activation of a tightly orchestrated repair program. Non-coding RNAs actively participate in this complex process of demolition and rebuilding. In this review, the contribution of dysregulated non-coding RNA expression to disease-associated pathological changes is explored in hereditary muscular dystrophies and idiopathic inflammatory myopathies. Disturbances in spatiotemporal expression of non-coding RNAs appear to be key factors [...]

by Kirsten Greenlaw  and Jai Jai Shiva Shankar

Received: 07 October 2018;  Published: 13 January 2019;  doi: 10.21926/obm.neurobiol.1901019

Background: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating brain tumors and to compare it with MRP measures in the same patient population. Methods: Patients underwent CTP and MRP imaging prospectively. Images were processed with vendor-provided and vendor-neutral software. Four regions of [...]

by Caroline Soares  and Paula Ministro

Received: 04 January 2024;  Published: 19 March 2024;  doi: 10.21926/rpn.2401003

Inflammatory bowel diseases (IBD) affect primarily the bowel, but they are multisystemic diseases with a wide range of extraintestinal manifestations and complications. Nutritional imbalance occurs frequently in patients with IBD. The spectrum of malnutrition goes from undernutrition (low protein-caloric intake, disease-related malnutrition, micronutrient deficiencies) to overnutrition and obesity. The nutritional status of patients with IBD is increasingly recognized as a key aspect of the treatment and must be ad [...]

by Joseph S. D'Arrigo

Received: 26 December 2019;  Published: 28 February 2020;  doi: 10.21926/obm.geriatr.2001110

Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. These pathological cascades lead to neuronal Ca2+ increase, neurodegeneration, gradual cognitive/memory decline, and eventually Alzheimer's disease. In particular, more recent research indicates that chronic inflamm [...]

by Edmundo S. Valerio Neto  , Caio V.S. Almeida  , Giancarlo R. Salazar-Banda  and Katlin I.B. Eguiluz

Received: 24 November 2023;  Published: 11 March 2024;  doi: 10.21926/cr.2401003

In this study, we synthesized Pt-Rh nanowires (NWs) through chemical reduction of metallic precursors using formic acid at room temperature, excluding the use of surfactants, templates, or stabilizing agents. These NWs were supported on two substrates: carbon (Vulcan XC-72R) and carbon modified with tin oxide (SnO2) via the sol-gel method (10 wt.% SnO2). We explored the electroactivity of Pt/SnO2/C, Pt-Rh/C, Pt-Rh/SnO2(commercial)/C (commercial SnO2), and Pt-Rh/SnO2/C NWs toward electrochemical oxidation of ethanol [...]

by Heather Mary Kempton

Received: 23 November 2021;  Published: 11 March 2022;  doi: 10.21926/obm.icm.2201011

Mindfulness practices have exploded in popularity in public awareness and in therapeutic applications. While mindfulness in a therapeutic context is presented as a secular practice, its primarily Buddhist heritage may make some Christian clients wary of engaging. Research indicates that both reflection (co-creation) on poetry and creation of poetry can be therapeutic, and that both Buddhist and secular/therapeutic mindfulness texts use poetry to convey meaning through key themes of nature, change/impermanence, stag [...]

by Christine A. Beamish  and Omaima M. sabek

Received: 08 November 2018;  Published: 05 March 2019;  doi: 10.21926/obm.transplant.1901055

Pancreatic islet transplantation holds promise for patients with insulin-dependent diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of these diverse factors on islet health has led to a broad investigation of global influences on islet biology, not least of all, characterization of mature, functional cellular identity and maintenance of appropriate e [...]

by Jacob G. Monroe  , Elizabeth Ramsey Bolton  and Emily Zechman Berglund

Received: 14 June 2022;  Published: 02 February 2023;  doi: 10.21926/aeer.2301017

The diffusion of distributed energy resources can overcome some challenges associated with the historical centralized model of electric power distribution. Decentralized generation by residential solar photovoltaic cells creates the potential for peer-to-peer (P2P) electricity trading, where households can act as consumers and prosumers to buy and sell renewable electricity. P2P energy markets are emerging at locations across the globe, and market performance is affected by various social, economic, and environment [...]

by Olivia C Smibert  , Joseph S Doyle  , Adam WJ Jenney  , David Pilcher  , Miranda A Paraskeva  , Glen P Westall  and Greg I Snell

Received: 16 September 2020;  Published: 13 January 2021;  doi: 10.21926/obm.transplant.2101134

Since 2018 The American Society of Transplant has recommended that Hepatitis C Virus seropositive positive, non-viremic donors (HCVAb+/NAT-) be considered non-infectious and safe for transplantation. This report describes clinical outcomes and HCV serological and virological outcomes following lung transplantation (LTx) utilizing such donors. This retrospective cohort study describes seven HCVAb+/NAT- donors used for bilateral LTx. Donor information was sourced from the national organ donation service and recipient [...]

by Sonal Mishra  , Neha Kumari  , Varsha K. Singh  and Rajeshwar P Sinha

Received: 18 January 2023;  Published: 03 August 2023;  doi: 10.21926/aeer.2303041

Cyanobacteria have great potential as a platform for biofuel production because of their fast growth, ability to fix CO2 gas, and genetic tractability. They also preserve the sustainability of an ecosystem without harming the environment. High-performance biofuels made from cyanobacteria can be utilized as a base for the production of green energy. Although a lot of studies have been conducted where plants and crops are used as the source of energy, cyanobacteria have been reported to have a more efficient photosyn [...]