by Nicola Cantasano

Received: 12 June 2022;  Published: 05 January 2023;  doi: 10.21926/aeer.2301003

Posidonia oceanica (Linnaeus) Delile is one of the most important endemic species of the Mediterranean Sea. The long phylogenetic pathway of this species deserves special attention because its evolutionary history allows us to think back over the debated issue of life evolution on Earth. Hence, this marine plant, by terrestrial origin, was born from an ancient ancestor named Posidonia cretacea Hosius & Von der Marck. This seagrass species, currently extinct, lived in the coastal waters of the Tethys Ocean about [...]

by Yiu Lin Wong  , Jialing Zhang  , Linda LD Zhong  , David Moher  and Zhaoxiang Bian

Received: 04 December 2023;  Published: 06 March 2024;  doi: 10.21926/obm.icm.2401018

The modified Jade Wind-Barrier formula (MJWB) may prevent the common cold in the elderly with a Qi-deficiency Constitution. Previously, no controlled trial evidence existed to illuminate the concept of “preventive treatment of disease” as outlined in the constitution theory of Traditional Chinese Medicine. This theory distinctly suggests that enhancing the Qi-deficiency Constitution and modulating its functional state can prevent the occurrence of the common cold. This controlled trial (ClinicalTrials.gov identifie [...]

by Tina Huang  , Tony Hung  , S. Irene Kim  and Ka Kit Hui

Received: 07 October 2019;  Published: 02 March 2020;  doi: 10.21926/obm.icm.2001011

Acupuncture has increasingly been used to address a variety of symptoms in patients with cancer. Here we present a case to illustrate the use of acupuncture in a 35-year-old female with metastatic breast cancer who presented to the UCLA Center for East-West Medicine (CEWM) with physical and psychological symptom clusters of insomnia, anxiety, and joint pain.

by Bart A. Ellenbroek  and Weiwen Wang

Received: 20 March 2018;  Published: 29 March 2018;  doi: 10.21926/obm.neurobiol.1801008

by Junhyeong T. Park  , Junseong A. Park  , Igor F. Tsigelny  and Valentina L. Kouznetsova

Received: 07 December 2021;  Published: 13 February 2022;  doi: 10.21926/obm.genet.2201147

The occurrence of various mutation patterns, such as changes in the DNA sequence and the loss of some sequences, is called a “mutational signature,” and they represent the molecular fingerprints that exist for the type of mutation occurring in a specific gene. Our study elucidates the correlations of mutational signatures in frequently mutated cancer genes with general mutational signatures previously found for different cancers. We hypothesized that the top twenty most frequently mutated genes (MFMG) of a cancer t [...]

by T V Ramachandra  , Bharath Setturu  , Karthik R. Naik  and Jagadessha B Pai

Received: 29 December 2021;  Published: 22 April 2022;  doi: 10.21926/aeer.2202014

Ecologically susceptible zones (ESZs) are endowed with the distinct bio, geo, climatic, hydrological, and ecological integrity that sustain natural resources to support the livelihood of dependent populations. However, globalization and consequent anthropogenic activities have led to the erosion of the natural resource base and enhanced the levels of pollutants, triggering global environmental change, evident from changes in the climate. Alterations in the structure and the ecological integrity of ESZs may lead to [...]

by Shili Lin  and Hengrui Luo

Received: 23 May 2018;  Published: 10 December 2018;  doi: 10.21926/obm.genet.1804053

DNA methylation is an epigenetic change that is not only important in normal cell development, but also plays a significant role in human health and disease. Therefore, studies of DNA methylation have been actively pursued to clarify the precise role of this modification in disease etiology and its potential as a biomarker of disease. One key issue in analyzing DNA methylation data is the detection of significant differences in methylation levels between diseased individuals and healthy controls. In recent years, m [...]

by Masahiro Sato  , Yuki Kiyokawa  , Emi Inada  , Eri Akasaka  , Satoshi Watanabe  and Issei Saitoh

Received: 15 March 2021;  Published: 04 November 2021;  doi: 10.21926/obm.transplant.2104155

Although the aging process expands the adipose tissue habitation in mice and due to its close association with the female reproductive system, it can be easily exposed surgically under anesthesia when reproductive organs (including ovary, oviduct, and part of the uterus) are pulled and exposed onto the dorsal skin. This study aimed to consider the suitability of adipose tissue as a target for manipulation, particularly for the grafting of cells or small-sized tissue sections due to its ease of handling. Subsequentl [...]

by Diane B. Paul

Received: 29 March 2021;  Published: 14 May 2021;  doi: 10.21926/obm.genet.2102130

This article explores difficulties encountered by those with no personal experience of a chronic disease or disability in accurately evaluating the quality of life with a condition present from birth. In most countries, cost-effectiveness analysis relies on ratings of health states by members of the general population, who must try to imagine what life for those affected is like based on (usually brief) descriptions of the conditions. That task is challenging for reasons that have been well-discussed in the literat [...]

by Ethan Fitzgerald  , Dorian Mateusz Kusyk  and Nestor D Tomycz

Received: 02 December 2020;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102170

Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Dis [...]