by M Wehming  , A Briem-Richter  , R Ganschow  , F Brinkert  , B Winkler  , L Fischer  and Enke Grabhorn

Received: 07 June 2020;  Published: 25 January 2021;  doi: 10.21926/obm.transplant.2101135

Some malignancies such as hepatoblastoma may be an indication for liver transplantation (LT) or some, for example, post-transplant lymphoproliferative disease (PTLD) may develop after successful LT. An immunosuppressive therapy after LT can promote the recurrence of the primary malignancy. The mammalian target-of-rapamycin inhibitors (mTORi) are immunosuppressive agents with anti-tumor properties. We examined the impact of everolimus (EVL) together with calcineurin inhibitors on allograft outcome and patient surviv [...]

by Daniela Milagros Rivas Aybar  , Wahidul Biswas  and Michele John

Received: 18 December 2024;  Published: 27 February 2025;  doi: 10.21926/aeer.2501014

The construction industry, a cornerstone of global economic and social progress, is under increasing pressure to adopt sustainable practices due to its significant environmental footprint. Industrial hemp (Cannabis sativa L.) has gained attention as a renewable material for building applications, offering potential reductions in greenhouse gas emissions and resource consumption. However, its broader sustainability performance remains underexplored. This study develops a comprehensive Life Cycle Sustainability Asses [...]

by Birthe Osorio  and Karsten Münstedt

Received: 27 February 2019;  Published: 05 July 2019;  doi: 10.21926/obm.icm.1903043

Background: In particular, the women with breast cancer seek methods offered by complementary and alternative medicine (CAM). Unfortunately, the value of most of such methods remains unclear. Methods: The present review was aimed at identifying reasonable strategies for patients with breast cancer on the basis of the current literature. Results: The analyses revealed that there is no evidence of alternative medicine which might result in healing. However, several strategies are available which could improve patient [...]

by Patrick Hagen  , William Adams  , Shruti Singh  , Shuai Qin  , Loredana Campo  , Stephanie Tsai  , Nasheed Hossain  , Scott E Smith  and Patrick J Stiff

Received: 04 November 2020;  Published: 07 February 2021;  doi: 10.21926/obm.transplant.2101136

Allogeneic stem cell transplantation remains the only curative option for many hematological malignancies. Umbilical cord blood (UCB) is an alternate donor source with potentially increased morbidity in elderly patients. We evaluated outcomes in alternate donor sources, prior to the initiation of haploidentical transplantation at our institution, of matched unrelated donor (MUD) and UCB in elderly patients (mean age 64, range 60-75). One hundred and eighty-four patients were included (MRD: 57; MUD: 69; UCB: 58). Th [...]

by Joseph S. D'Arrigo

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

by Jéssica A.P. Ponciano  and Marcelo S. Batista

Received: 01 December 2021;  Published: 26 January 2022;  doi: 10.21926/cr.2201002

In this paper, the relationship between activity and structure of Cu2+ in different chemical environments of Cu-BETA, La2CuO4, and CuO nanocatalysts was systematically investigated for acetonitrile combustion. The study revealed that exchanged and octahedral species of Cu2+ coexist in Cu-BETA, while octahedral species are dominant in CuO and La2CuO4. All nanocatalysts achieved high conversion rates of acetonitrile, which rapidly increased with temperature. CuO and La2CuO4 led to the formation of undesired products [...]

by Lordwin Girish Kumar Jeyakumar  , David B. McKenzie  , Laura E. Christianson  and Evan Derdall

Received: 29 December 2020;  Published: 15 April 2021;  doi: 10.21926/aeer.2102005

Denitrifying bioreactor technology, where a solid carbon source (woodchips) acts as a reactive medium to intercept agricultural tile drainage water, has been successfully used to convert N (NO3-) to di-nitrogen (N2) gas. Four replicated field-scale (24 m long × 3 m wide × 1 m deep), bioreactors were built and operated at the St. John's Research and Development Centre and were successful at removing a notable amount of nitrate (N) from agricultural subsurface drainage water. The objective of this study [...]

by Steven R. Brenner

Received: 29 August 2018;  Published: 26 February 2019;  doi: 10.21926/obm.geriatr.1901035

Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self-recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloid production (a component of the innate immune system) causing cytosolic calcium overload. Excessive cytosolic calcium may cause over activation of calcineurin and inactivation of cis-trans prolyl isomerase (Pin1), with [...]

by Katrine Hygum  , Jakob Starup-Linde  , Torben Harsløf  and Bente Langdahl

Received: 29 August 2019;  Published: 04 December 2019;  doi: 10.21926/obm.geriatr.1904090

Background: The increased risk of fractures in individuals with diabetes has been underestimated by conventional fracture predictors such as the bone mineral density T-score or the Fracture Risk Assessment Tool. The present study conducted a systematic review and a meta-analysis to investigate the association between the levels of bone turnover markers (BTMs) and fractures in patients with diabetes. Methods: We conducted a systematic literature search. Eligibility criteria were studies investigating BTMs in patient [...]

by Gerhard Litscher

Received: 18 January 2021;  Published: 20 January 2021;  doi: 10.21926/obm.icm.2101003

Neuro-photobiomodulation (PBM) is a relatively novel optical stimulation method that is not yet generally accepted in conventional medicine. Therefore, evidence-based research in this sub-area, which is important for laser medicine, is necessary in order to provide appropriate scientific evidence for a better understanding of neuro-PBM. In this editorial, a summary of the recent results with stimulation using different frequencies (e.g., 40 Hz, 136.1 Hz) is presented. The contribution is intended to stimulate resea [...]