by Florence Naillat

Received: 25 August 2021;  Published: 26 April 2022;  doi: 10.21926/obm.genet.2202153

In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. In this review, we highlighted some of the main gene networks and regulatory mechanisms involved in the plasticity of sex-determining pathways that help to establish a functiona [...]

by Marta Evelia Aparicio-García  and Roberto Andrés Lasso Báez

Received: 06 November 2023;  Published: 27 February 2024;  doi: 10.21926/obm.geriatr.2401271

Older trans people have been largely unaddressed both in the context of the LGBTIQ+ community and in studies on geriatrics and aging. This literature review compiles up-to-date information on transgender elders, providing a summary of the Spanish historical context in which trans people have been raised, and analyzes the areas in which to center possible courses of action and research on a global scale. The themes tackled are the presence of victimization and violence; the effects of medical transition, taking into [...]

by Sharon Clevenger

Received: 02 April 2020;  Published: 18 May 2020;  doi: 10.21926/obm.icm.2002031

The novel coronavirus COVID-19 is a viral pathogen that first emerged in Wuhan, China in 2002 and has spread to 202 countries (as of March 28, 2020) [1]. Despite the fact that the 2005 SARS-CoV pandemic infected over 8,500 people, and caused over 800 deaths with billions of dollars in economic loss worldwide, as of 2015 there were still no clinically approved antiviral drugs, vaccines or monoclonal antibody therapies to treat SARS-CoV infections [2]. Antiviral medications that have been used to treat or control oth [...]

by Oghenerume Lucky Emakpor  , Great Iruoghene Edo  , Emad Yousif  , Princess Oghenekeno Samuel  , Agatha Ngukuran Jikah  , Khalid Zainulabdeen  , Athraa Abdulameer Mohammed  , Winifred Ndudi  , Susan Chinedu Nwachukwu  , Ufuoma Ugbune  , Joy Johnson Agbo  , Irene Ebosereme Ainyanbhor  , Huzaifa Umar  , Helen Avuokerie Ekokotu  , Ephraim Evi Alex Oghroro  , Patrick Othuke Akpoghelie  , Joseph Oghenewogaga Owheruo  , Lauretta Dohwodakpo Ekpekpo  , Priscillia Nkem Onyibe  , Ufuoma Augustina Igbukuc  , Endurance Fegor Isojec  and Arthur Efeoghene Athan Essaghahk

Received: 28 December 2023;  Published: 28 June 2024;  doi: 10.21926/obm.icm.2402038

The optimal enhancement of athletic performance, recovery from exhaustion after exercise, and injury prevention are products of appropriate nutrition. Nutritional supplements that contain proteins, carbohydrates, vitamins, and minerals are frequently utilized in various sports to complement the recommended daily amounts. Several of these supplements have been identified to have physiological effects and, thus, are known to help enhance athletic performance and prevent injuries. Our review intends to show the interp [...]

by Maurizio Salvadori  and Aris Tsalouchos

Received: 13 October 2019;  Published: 02 December 2019;  doi: 10.21926/obm.transplant.1904093

Antibody-mediated rejection represents a significant barrier to favorable long-term outcomes after kidney transplantation and remains the most common cause of allograft failure. Therapeutic apheresis techniques are commonly used, in combination with other treatments such as immunosuppressive drugs, in the pre-transplant and post-transplant protocols for the prevention and treatment of antibody-mediated injury. The rationale is to remove the donor-specific antibodies and the other inflammatory mediators, which inclu [...]

by Pavel Ustin  , Fail Gafarov  and Andrey Berdnikov

Received: 27 April 2023;  Published: 24 August 2023;  doi: 10.21926/obm.neurobiol.2303180

The emergence of the social networking phenomenon and the sudden spread of the coronavirus pandemic (COVID-19) around the world have significantly affected the transformation of the system of interpersonal relations, partly shifting them towards virtual reality. Online social networks have greatly expanded the boundaries of human interpersonal interaction and initiated processes of integration of different cultures. As a result, research into the possibilities of predicting human behavior through the characteristic [...]

by Holly Hazlett-Stevens

Received: 26 July 2021;  Published: 23 November 2021;  doi: 10.21926/obm.icm.2104049

Mindfulness-Based Stress Reduction (MBSR) is an evidence-based health education program for medical patients with a variety of chronic conditions. MBSR also benefits health care providers themselves, decreasing work-related stress and preventing burnout. The objectives of this study were to describe an abbreviated MBSR curriculum developed for health care providers and to present initial program evaluation data assessing acceptability and outcomes. This program was implemented outside the research context with an o [...]

by Pan Xie  , Dongdong Du  , Cheng Xue  and Sanshan Shi

Received: 01 April 2022;  Published: 10 May 2022;  doi: 10.21926/cr.2202014

The process of light-induced C-H oxygenation is of high interest as it can be used for the construction of oxygenated compounds. Herein, we report a mild and general method for the efficient synthesis of aromatic ketones following the process of metal-free C-H oxygenation. With air as the oxidant, high functional tolerance was demonstrated, and the desired ketones were obtained in moderate to excellent yields at room temperature (25 oC). Mechanistic studies suggested that the oxidative transformation potentially oc [...]

by Aly Mousaad Aly  and Milad Rezae

Received: 26 December 2020;  Published: 04 March 2021;  doi: 10.21926/jept.2101011

During their lifecycle, wind turbines can be subjected to multiple hazard loads, such as high-intensity wind, earthquake, wave, and mechanical unbalance. Excessive vibrations, due to these loads, can have detrimental effects on energy production, structural lifecycle, and the initial cost of wind turbines. Vibration control by various means, such as passive, active, and semi-active control systems provide crucial solutions to these issues. We developed a novel control theory that enables semi-active controller tuni [...]

by Danielle Graham  , Takahiro Ito  , Ronald Busuttil  and Fady Kaldas

Received: 05 May 2019;  Published: 29 July 2019;  doi: 10.21926/obm.hg.1903029

Acute pancreatitis is a highly morbid condition widely recognized and well-defined in the general population. In this article, we summarize the current literature on acute pancreatitis in the setting of solid organ transplant axiom, including patients who are listed for or have undergone transplantation. The literature is summarized by organ transplant type, including cardiac, lung, pancreas, kidney, intestine, and liver. Our review suggests that providers should have a high index of suspicion for acute pancreatiti [...]