by Anne-Marie Laberge  and Wylie Burke

Received: 30 July 2017;  Published: 21 September 2017;  doi: 10.21926/obm.genet.1703006

Genetic screening is the process of systematically evaluating a defined population for genetic conditions or predispositions, in the hope of providing benefit to those with a positive result. With advances in sequencing technology, genetic screening is moving from phenotype-based to genotype-based testing. Although sequencing technology offers expanded opportunities for early identification of disease, the availability of a suitable and acceptable test is not a sufficient justification to proceed: established crite [...]

by Yoram Barak  and Paul Glue

Received: 04 October 2018;  Published: 26 November 2018;  doi: 10.21926/obm.geriatr.1804021

Patients with AD have shortened life expectancy than the general older population is well established. Loneliness may be another risk factor to consider if we wish to understand and improve the premature mortality of AD.

by Pavel Ustin  , Fail Gafarov  and Andrey Berdnikov

Received: 27 April 2023;  Published: 24 August 2023;  doi: 10.21926/obm.neurobiol.2303180

The emergence of the social networking phenomenon and the sudden spread of the coronavirus pandemic (COVID-19) around the world have significantly affected the transformation of the system of interpersonal relations, partly shifting them towards virtual reality. Online social networks have greatly expanded the boundaries of human interpersonal interaction and initiated processes of integration of different cultures. As a result, research into the possibilities of predicting human behavior through the characteristic [...]

by Hossein Akbari  , Seyed Mojtaba Hosseinnia  , Mikhail Sorin  , Christopher Reddick  and Dominic Laperle

Received: 13 January 2022;  Published: 12 April 2022;  doi: 10.21926/jept.2202013

Heat integration techniques such as pinch analysis can play a significant role in saving energy in the design of buildings. The application of pinch analysis in this sector encounters difficulties due to the highly time-dependent behavior of energy streams such as waste heat and solar thermal collectors, as well as the possible need for heat storage units (HSUs). The existing pinch models in the literature either bear little relation to reality because they ignore the time dependency of the streams, or they do not [...]

by Alvin Ho Kwan Cheung  , Nancy Bo-Yin Tsui  , William Chi Shing Cho  , Xiao-Meng Pei  , Yin-Kwan Evelyn Wong  , Hin-Fung Andy Tsang  , Gilberto Ka-Kit Leung  and Sze-Chuen Cesar Wong

Received: 02 May 2020;  Published: 28 June 2020;  doi: 10.21926/obm.genet.2002112

Background: Vestibular schwannoma is an intracranial tumor which can lead to devastating neurological deficit and is prone to recurrence after surgery. Patients with inherited neurofibromatosis type 2 (NF2) syndrome are particularly susceptible to bilateral and aggressive schwannomas. However, the genome of vestibular schwannomas is not well known. There is an imminent need of developing effective chemotherapeutic agents either as a primary treatment modality or as adjuvant therapy for these patients. Methods: Here [...]

by Mamta Saxena  , Anne F. Farrell  and Kari Adamsons

Received: 25 February 2019;  Published: 20 May 2019;  doi: 10.21926/obm.geriatr.1902054

Background: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. Methods: In this study, we examined caregiving processes and outcomes among 322 adult sibling support providers (SSPs) with a range of support roles. Adapting a model of caregiving outcomes, we used structural equation modeling to assess relationships amo [...]

by Robert J. Hoss  , Lynne M. Hoss  and Dawson Church

Received: 25 January 2022;  Published: 05 July 2022;  doi: 10.21926/obm.icm.2203024

The purpose of this paper is to demonstrate that the integration of dreamwork and Energy Psychology (EP) can enhance outcomes in the treatment of a range of psychological disorders. The therapeutic process often begins with a peeling away of emotional layers until underlying issues surface. When utilizing dreamwork, however, it is possible to begin at a deeper level. Because dreams address salient unresolved emotional conflicts, dreamwork can quickly bring into consciousness previously unconscious emotional issues [...]

by Rahul Abhyankar  , Divya Mella  and Edward Pan

Received: 12 November 2018;  Published: 04 January 2019;  doi: 10.21926/obm.neurobiol.1901018

Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebellopontine angle (CPA) GBMs are exceedingly rare. To our knowledge, the following case represents the tenth reported case of CPA GBM and the first with a corresponding spinal cord tumor on presentation. Methods: Retrospective cha [...]

by Pan Xie  , Dongdong Du  , Cheng Xue  and Sanshan Shi

Received: 01 April 2022;  Published: 10 May 2022;  doi: 10.21926/cr.2202014

The process of light-induced C-H oxygenation is of high interest as it can be used for the construction of oxygenated compounds. Herein, we report a mild and general method for the efficient synthesis of aromatic ketones following the process of metal-free C-H oxygenation. With air as the oxidant, high functional tolerance was demonstrated, and the desired ketones were obtained in moderate to excellent yields at room temperature (25 oC). Mechanistic studies suggested that the oxidative transformation potentially oc [...]

by Jack Deacon  , Clare Northover  , John King  and Chris Irons

Received: 21 September 2021;  Published: 23 November 2021;  doi: 10.21926/obm.icm.2104050

Compassion Focused Therapy (CFT) has increasingly been shown to have a positive impact for people experiencing a range of difficulties, and online self-help formats could provide a way of increasing its accessibility and scalability. This study explored adult participants’ subjective experiences of engaging with online self-compassion training drawn from Compassionate Mind Training (CMT) and CFT. Semi-structured interviews were conducted with 15 participants who had completed online self-compassion training, [...]