by Mouna Daldoul  , Rim Charfi  , Khouloud Ferchichi  , Mouna Ben Sassi  , Syrine Ben Hammamia  , Fatma Medhioub  , Emna Gaies  , Rym Enneifer  , Hanene Eljebari  , Anis Klouz  , Riadh Daghfous  and Sameh Trabelsi

Received: 20 August 2024;  Published: 13 December 2024;  doi: 10.21926/obm.transplant.2404228

A high intra and interindividual pharmacokinetics variability characterize Tacrolimus. Data regarding factors influencing its pharmacokinetics and pharmacodynamics in liver transplantation are limited. This study aimed to assess tacrolimus therapeutic response, pharmacokinetics and adherence in liver transplant recipients. The study was conducted at the Clinical Pharmacology Department for 12 years, from January 2009 to March 2021. We included liver transplant patients treated with tacrolimus referred to our depart [...]

by Stefan Hardy Lung  and Thomas Lung

Received: 30 November 2024;  Published: 14 April 2025;  doi: 10.21926/obm.geriatr.2502307

Cellular senescence (aging) is a physiological process that plays a role in tissue remodeling, wound healing, and embryogenesis. Prolonged senescence of cells can have detrimental effects and trigger a secretory phenotype (SASP, senescence-associated secretory phenotype), degenerative disorders, cancer, and age-related diseases. Suitable biomarkers and a range of different laboratory methods are used to investigate these complex relationships in vitro and in vivo. Since a universal biomarker for cell senescence has [...]

by Christine Demanche  , Jacques Guillot  and Magali Chabé

Received: 22 February 2019;  Published: 15 May 2019;  doi: 10.21926/obm.genet.1902078

Pneumocystis spp. are a group of fungi that are known for causing opportunistic infections in immunocompromised individuals. It was only at the end of the 20th century that the scientific community challenged the notion of a unique species in the genus Pneumocystis (i.e., Pneumocystis carinii) that drastically changed the understanding of the natural history of pneumocystosis. It is now accepted that the Pneumocystis genus comprises a group of heterogenous fungi having multiple stenoxenic biological entities. These [...]

by Ashley Lahr  , Nadene Henderson  , Lee Williams  , Georgianne Arnold  and Damara Ortiz

Received: 14 June 2023;  Published: 25 September 2023;  doi: 10.21926/obm.genet.2303194

Lysosomal storage disorders (LSD) are caused by enzymatic failure to degrade specific cellular byproducts of metabolism within the lysosome. They have a wide range of presentations involving multiple body systems and can manifest from infancy through adulthood. As treatments have become available for many of these disorders, newborn screening has been adapted for early identification and pre-symptomatic treatment. This article will review some of the LSD that are now being added to newborn screening panels, includi [...]

by Pavel Ustin  , Fail Gafarov  and Andrey Berdnikov

Received: 27 April 2023;  Published: 24 August 2023;  doi: 10.21926/obm.neurobiol.2303180

The emergence of the social networking phenomenon and the sudden spread of the coronavirus pandemic (COVID-19) around the world have significantly affected the transformation of the system of interpersonal relations, partly shifting them towards virtual reality. Online social networks have greatly expanded the boundaries of human interpersonal interaction and initiated processes of integration of different cultures. As a result, research into the possibilities of predicting human behavior through the characteristic [...]

by Sarah Long  , Roanna Lobo  , Peter O'Leary  and Jan E. Dickinson

Received: 07 September 2021;  Published: 03 November 2021;  doi: 10.21926/obm.genet.2104142

Non-invasive prenatal testing (NIPT) for a panel of 25 single gene disorders became available in Western Australia in 2020 and potentially may be able to test for panels of hundreds of disorders as is the case with reproductive carrier screening. How this information would be used by parents in a population screening model is unknown. We used a phenomenological approach to explore retrospectively whether mothers of children with single gene or chromosomal disorders would have wanted to know about their child’ [...]

by Andrew Weems  , Wenyan Li  , Duncan Maitland  and Luz Marina Calle

Received: 12 September 2019;  Published: 31 December 2019;  doi: 10.21926/rpm.1904008

Biomedical applications of shape memory polymers (SMPs) are limited by their biostability, degradability, and possible toxicity risks after implantation. Mesoporous silica nanoparticles (MSNs) were used to increase the oxidative biostability (increase time until degradation occurs) using antioxidants and to induce oxidative degradation through incorporation of hydrogen peroxide-containing MSNs with modified surfaces. The presented results confirm increased oxidative stability using antioxidants, and alternatively, [...]

by Malcolm Voyce

Received: 22 July 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004124

This article aims to describe the relationship between donors and their recipients in the context of organ transplants. This analysis is made in the light of Marcel Mauss’s work, offering an expansion on an analysis of his discussion on the “spirit of the gift” and his idea that gifts require reciprocation. It is argued that some recipients of donated organs receive a personal element from the donor in that there is a transfer or sharing of the donors’ personality and spiritual qualities. The article examines the n [...]

by Ganga R. Neupane  , Amrit Kaphle  , David N. Mcllroy  , Elena Echeverria  , Prasanna Sankaran  and Parameswar Hari

Received: 12 May 2021;  Published: 04 August 2021;  doi: 10.21926/jept.2103035

Iron doped ZnO (Fe-ZnO) nanoparticles were synthesized using two techniques that are economical as well as scalable to yield tunable properties of nanoparticles for facilitating down conversion in an absorbing layer of a solar cell. To evaluate the suitability of Fe-ZnO nanoparticles prepared by two deposition methods, we present a comparison of optical, electrical, and structural properties of Fe-ZnO using several experimental techniques. Structural properties were analyzed using transmission electron microscopy a [...]

by Jacob G. Monroe  , Elizabeth Ramsey Bolton  and Emily Zechman Berglund

Received: 14 June 2022;  Published: 02 February 2023;  doi: 10.21926/aeer.2301017

The diffusion of distributed energy resources can overcome some challenges associated with the historical centralized model of electric power distribution. Decentralized generation by residential solar photovoltaic cells creates the potential for peer-to-peer (P2P) electricity trading, where households can act as consumers and prosumers to buy and sell renewable electricity. P2P energy markets are emerging at locations across the globe, and market performance is affected by various social, economic, and environment [...]