by Svetlana G. Vorsanova  , Yuri B. Yurov  , Ilia V Soloviev  , Alexei D Kolotii  , Irina A Demidova  , Viktor S Kravets  , Oxana S Kurinnaia  , Maria A Zelenova  and Ivan Y. Iourov

Received: 08 February 2019;  Published: 20 March 2019;  doi: 10.21926/obm.genet.1901068

Recently, numerous studies have reported convincing data suggesting that chromosome instability may be not only a trigger of cancers but a possible mechanism for a wide spectrum of brain diseases. According to our original experience, chromosome instability is commonly observed during karyotyping of children with neuropsychiatric diseases and congenital malformations. To understand mechanisms of non-cancerous diseases potentially mediated by chromosome instability, which may represent an important target for molecu [...]

by Alberto Feletti  , Elena Bianchini  , Anna De Gaetano  , Lara Gibellini  , Sara De Biasi  , Giacomo Pavesi  , Anna Vittoria Mattioli  , Milena Nasi  , Andrea Cossarizza  and Marcello Pinti

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.neurobiol.1901021

Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. Approximately 75% of HBs are sporadic, while 25% are associated with von Hippel–Lindau (VHL) disease. HBs consist of two main components: a rich capillary network composed of vascular endothelia and pericytes, within large vacuolated stromal cells, which harbor the genetic defect. The mechanism by which the VHL gene product (pVHL) causes HB is not completely clear. Wild-type pVHL is involved in the response to hypoxia, tar [...]

by Ashrit Multani  , Libby S. Allard  and Joanna K. Nelson

Received: 03 June 2019;  Published: 29 July 2019;  doi: 10.21926/obm.transplant.1903076

Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a series of five cases of Candida pneumonia and five cases of enterococcal pneumonia found on autopsy in hematopoietic cell transplantation recipients. We will also review the literature regarding the epidemiology, risk facto [...]

by Susana Ruiz-Ruiz  , Carolina A Ponce  , Nicole Pesantes  , Rebeca Bustamante  , Gianna Gatti  , Viviana San Martin  , Mireya Gutierrez  , Mariana Izquierdo  , Sergio L Vargas  , Fabien Magne  and Vicente Pérez-Brocal

Received: 30 January 2019;  Published: 18 March 2019;  doi: 10.21926/obm.genet.1901066

Background: Pneumocystis jirovecii colonization in patients is associated with a low organism burden, which supports the need to use highly sensitive molecular techniques, such as nested-PCR to determine the presence of the organism. However, few studies have considered the effect of nucleic acid extraction methods on the detection of P. jirovecii. Here, we evaluate how pre-treatment affects microbial detection. Methods: Lung tissue samples from fifteen autopsied infants were processed using two different DNA extra [...]

by Akash Dakhane  and Narayanan Neithalath

Received: 03 February 2022;  Published: 08 April 2022;  doi: 10.21926/rpm.2202006

The influence of different levels of alkalinity, expressed using M2O-to-binder ratio (n) and activator SiO2-to-M2O ratio (Ms), (M being the Na+ or K+ cation) on the reaction kinetics, compressive strength development and the reaction product formation in slag-based systems activated using alkali powders are discussed. The fundamental idea is to better understand one-part, “just-add-water” type alkali activated binders that are easy-to-use than the systems that rely on liquid activators. The difference in the behavi [...]

by Selvaraju Sivamani  , Rajoo Baskar  and Balasubramanian Lakshmi

Received: 29 April 2021;  Published: 14 September 2021;  doi: 10.21926/rpm.2103037

One of the crucial steps in the enzymatic hydrolysis of biomass is pretreatment. We investigated the applicability of a hybrid pretreatment method, This involved acid treatment followed by alkali before the production of fermentable sugars from cassava stem. The substrate was initially treated with acid (1% oxalic acid at 100 °C for 2 h), followed by treatment with a 10% NaOH–urea mixture (by mixing 5 g each of NaOH and urea in 100 mL of water) at 100 °C for 1 h. A cellulose recovery of 98.55% was obtained with the [...]

by Pithchai Pandian Sivakumar  , Elke Gruyaert  , Nele De Belie  and Stijn Matthys

Received: 09 March 2021;  Published: 02 June 2021;  doi: 10.21926/rpm.2102022

Depending on the availability of aggregate sources pertaining to their geographic locations, the concrete industry utilizes conventional aggregates such as marine sand, dredged gravel, or crushed rocks. This method requires high energy and high processing costs for washing and grinding. The objective of this work is to use Modified Ferro silicate slag (MFS), a by-product obtained from the copper industry, as an alternative to the conventional fine aggregates found in mortar. No additional processing such as washing [...]

by Clint Sutherland  and Beverly S. Chittoo

Received: 29 July 2024;  Published: 28 November 2024;  doi: 10.21926/aeer.2404024

Global efforts to develop low-cost solutions for the treatment of contaminants in wastewater continue unabated. The conversion of eggshells, a waste material, into a high-value product can be economical and environmentally sustainable. The recent developments in applying eggshells towards the biosorption of contaminants are presented. Eggshells effectively remove pollutants such as metal cations, metal anions, and reactive, basic, and direct dyes. Promising advances in modifying eggshells, elucidating the critical [...]

by Waqar Husain  , Farrukh Ijaz  , Muhammad Ahmad Husain  , Marwa Zulfiqar  and Javeria Khalique

Received: 20 December 2023;  Published: 23 January 2024;  doi: 10.21926/obm.icm.2401011

The assessment of mental health and mental disorders has undergone extensive exploration within the field of psychology, resulting in various models and approaches. In addition to traditional ways like the Diagnostic and Statistical Manual of Mental Disorders, psychologists have proposed alternative perspectives for evaluating mental health. One such innovative approach is the psychosocial health model, which defines mental well-being as sexual, emotional, social, environmental, cognitive, religious, moral, and spi [...]

by Morisaki Naoko

Received: 23 October 2020;  Published: 28 July 2021;  doi: 10.21926/obm.geriatr.2103177

Objective: The present study aimed to elucidate the relationship between oral exercise and oral function among older adults requiring care in the nursing facilities of Japan. Methodology: The subjects were adults aged 65 years or above, requiring care and admitted to the nursing facilities for older adults in Japan. The subjects performed the assigned oral exercises, which included the exercises focused on the neck, shoulder, upper limbs, tongue, lips, cheek movement, vocalization, and deep breathing, in groups und [...]