by Konstantinos Magganas  , Sophia Delicou  , Aikaterini Xydaki  and Zoi Pallantza

Received: 19 May 2019;  Published: 17 September 2019;  doi: 10.21926/obm.genet.1903095

Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt normal hemoglobin production. Thalassemia intermedia (TI) is referred to as a group of disorders with a less severe form of the disease compared to thalassemia major. We present a case of a 60-year-old woman who was referred to a hematologist for chronic anemia and splenomegaly.

by Ahmed H Abdelhafiz

Received: 05 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002113

The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk factor and, at the same time, as a consequence of diabetes. To break the vicious circle of this complex reciprocal relationship between diabetes and mental dysfunction, early id [...]

by Kristopher M. Struckmeyer  , Alex J. Bishop  , Brenda J. Smith  and Brandt C. Gardner

Received: 27 August 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901037

Background: The purpose of this study was to examine discrepancies in self-proxy agreement of biopsychosocial factors and the influence of objective well-being and psychosocial resources self and proxy appraisals of subjective well-being in older adults. Methods: Seventy-two older adult-proxy dyads rated the biopsychosocial health of non-cognitively impaired older adults. Results: Proxies underestimated functional ability, psychosocial factors, and overrated negative health outcomes compared to older adults. Older [...]

by Joachim Andrassy  and Antje Habicht

Received: 05 November 2018;  Published: 27 June 2019;  doi: 10.21926/obm.transplant.1902070

In recent years, the potential of hematopoietic stem cells, regulatory T-cells, and mesenchymal stem cells have brought about a variety of clinical tolerance trials. Every approach has yielded promising results; however, the riddle of transplant tolerance has not been solved as of yet. The results of the ongoing trials in this field will provide additional information regarding the risks and benefits of these therapy approaches.

by Jeffrey M. Witkin  , Lalit K. Golani  , Rok Cerne  , Md. Toufiqur Rahman  , Guanguan Li  , Michael M. Poe  , James M. Cook  and Jodi L. Smith

Received: 05 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903073

Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of α5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also [...]

by Plamen Mihaylov  , Burcin Ekser  , Daiki Soma  , Andrew Lutz  , Jonathan Fridell  and Chandrashekhar A. Kubal

Received: 04 January 2021;  Published: 11 March 2021;  doi: 10.21926/obm.transplant.2101138

One of the most feared complications in liver transplantation is hepatic arterial thrombosis (HAT). The incidence of HAT in liver transplantation varies from 1.2% and 8%. One of the risk factors for this complication is anatomical complexity of hepatic arterial system. The focus of this short communication is to show our approach in dealing with aberrant left hepatic artery in settings of liver transplantation. This is a single center experience. Between January 2016 and June 2019, we procured and transplanted 357 [...]

by Lotte Hvas

Received: 28 August 2023;  Published: 30 October 2023;  doi: 10.21926/obm.geriatr.2304256

Narratives and how women interpret their symptoms have always been a part of how menopause is experienced. Today, as women feel more accessible to talk about menopause, new narratives are being formed and negotiated - both to menopause and concerning women becoming older. These different narratives mirror the fact that the transitional phase differs from woman to woman and that some women experience many symptoms while others do not seem bothered at all. Some narratives underscore menopause as a transformative peri [...]

by Lin Xie  and Donald Kirk

Received: 09 June 2021;  Published: 16 September 2021;  doi: 10.21926/cr.2103003

Fe-rich alloys have been widely studied as catalyst materials for the cathodic oxygen reduction reaction (ORR) in hydrogen fuel cells, and many have shown high activities. The stability of Fe-rich catalysts has also been researched, and some studies have shown promising results using an accelerated stress test (AST), which uses a potential cycling method. However, for commercial fuel cell applications, such as standby power systems, the catalyst has to tolerate a high potential for a long period, which can not be r [...]

by Ganga R. Neupane  , Amrit Kaphle  , David N. Mcllroy  , Elena Echeverria  , Prasanna Sankaran  and Parameswar Hari

Received: 12 May 2021;  Published: 04 August 2021;  doi: 10.21926/jept.2103035

Iron doped ZnO (Fe-ZnO) nanoparticles were synthesized using two techniques that are economical as well as scalable to yield tunable properties of nanoparticles for facilitating down conversion in an absorbing layer of a solar cell. To evaluate the suitability of Fe-ZnO nanoparticles prepared by two deposition methods, we present a comparison of optical, electrical, and structural properties of Fe-ZnO using several experimental techniques. Structural properties were analyzed using transmission electron microscopy a [...]

by Marco Barale  , Ruth Rossetto Giaccherino  , Ezio Ghigo  and Massimo Procopio

Received: 31 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.geriatr.1901033

Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. Our aim was to evaluate in elderly uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-months vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels. Methods: In an open-label pilot study, thirty type 2 diabetic patients (age 71.5 ± 3.2 years, BMI [...]