Malignancies and Pediatric Liver Transplantation: Promising Management with the mTOR-inhibitor Everolimus
Abstract
(ISSN 2577-5820)
OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor.
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Rapid publication: manuscripts are undertaken in 8 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period).
Special Issue
Pediatric Liver Transplantation
Submission Deadline: October 15, 2020 (Open) Submit Now
Guest Editor
Yasuhiko Sugawara, MD, PhD
Associate Professor, Pediatric Surgery and Transplantation Division, Department of Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-5783, Japan
Research Interests: Hepatobiliary surgery; liver transplantation; pediatric surgery and transplantation
About This Topic
Liver transplantation for pediatrics has now become one of the established operations. The 1 year survival rates are around 95% in elective cases and 80% for urgent cases indicated for acute liver failure. The favorable outcome may be partly due to improvements in medical and surgical preoperative and postoperative managements. Use of split-liver and living donors grafts has provided more organs for the patients. Newer immunosuppression regimens, for example, an induction therapy, have had an impact on surgical outcome. The success in the field produces a cohort of the children who underwent transplantation around the age of 1 year and are well alive for a long term after the operation. There still remains a long term problem on the complications of immunosuppressive drugs and non-compliance.
In this special issue, submissions related to the pediatric liver transplantation will be invited. Original research, quality and quantitative systematic analysis, review article, case reports pertaining on the pediatric liver transplantation are welcome for submission.
Publication
Malignancies and Pediatric Liver Transplantation: Promising Management with the mTOR-inhibitor EverolimusAbstract Some malignancies such as hepatoblastoma may be an indication for liver transplantation (LT) or some, for example, post-transplant lymphoproliferative disease (PTLD) may develop after successful LT. An immunosuppressive therapy after LT can promote the recurrence of the primary malignancy. The mammalian target-of-rapamycin inhibitors (mTORi [...] |
Liver Transplantation as a Cure for Neurologically Advanced Wilson’s disease. Learning More from ExperienceAbstract Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson [...] |
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