by Ami Rokach

Received: 24 August 2025;  Published: 25 November 2025;  doi: 10.21926/obm.neurobiol.2504312

A significant social stigma is associated with loneliness. The prevalence of social isolation, in the dawn of the 21st century points to the growing isolation in America. Lonely people who commonly display negative self-perceptions, show great difficulty to establish social ties, and that may be related to their personal inadequacies, or socially undesirable attributes. Lonely people suffer from a low social perception, painting them as less psychologically adjusted, and not very capable in relating to others. That [...]

by Recai Aci  , Adem Keskin  , Özlem Sezer  , Taner Karakaya  , Samet Semiz  and Melek Bilgin

Received: 01 October 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504318

This study investigated three novel complete blood count–derived inflammatory biomarkers Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Pan-Immune-Inflammation Value (PIV) and their relationship with clinical features of Behçet’s Disease (BD). Established markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were also analyzed. Seventy HLA-B51–positive BD patients and 114 HLA-B51–negative healt [...]

by Masahiro Sato  , Emi Inada  , Satoshi Watanabe  , Issei Saitoh  , Naoko Kubota  , Yoko Iwase  , Kazunori Morohoshi  and Shingo Nakamura

Received: 31 August 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504317

An episomal vector is a plasmid- or virus-based vector that is present extrachromosomally in cells after transfection. Although it disappears during cell proliferation, it can exist in non-dividing cells, such as neuronal and muscular cells, and continues to express a gene of interest (GOI). Such episomal vectors are usually based on sequences from DNA viruses such as bovine papillomavirus 1 and Epstein-Barr virus. When cells are transfected with an episomal vector harboring a drug-resistance gene and subsequently [...]

by Birgit M. Jürgenhake  and Leo M. Oorschot

Received: 23 March 2025;  Published: 19 November 2025;  doi: 10.21926/obm.geriatr.2504331

This article explores the ongoing work associated with the masterclasses "Towards an Inclusive Living Environment." It critically examines the concept of healthy living for all and aging in place by studying neighborhoods within Dutch cities. The article argues that creating inclusive, healthy environments fosters well-being and promotes a lifestyle of health and autonomy for all. Next to literature studies, we worked with our students in different neighborhoods of The Hague, conducting ethnographic research. Throu [...]

by Mohammad Azimi Tabas  , Maryam Kazerani  , Azam Shahbodaghi  and Reza Taherian

Received: 24 June 2025;  Published: 19 November 2025;  doi: 10.21926/obm.neurobiol.2504311

The widespread use of social media among college students has become a significant concern due to its potential impact on mental health and addictive behaviors. Social media platforms, while offering numerous benefits, can also foster environments that contribute to addiction, depression, and anxiety. College students, in particular, are vulnerable to these effects due to their high levels of social media engagement and the pressures of academic life. Mental health literacy, which involves understanding and managin [...]

by Marina M Gerges  and Vladimir Kosonogov

Received: 02 May 2025;  Published: 19 November 2025;  doi: 10.21926/obm.neurobiol.2504310

Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims to synthesize current evidence on biochemical substrates [...]

by Kuok Ho Daniel Tang

Received: 16 November 2025;  Published: 19 November 2025;  doi: 10.21926/rpse.2504016

Artificial intelligence (AI) is reshaping microplastic research by enabling faster, more accurate, and scalable detection, characterization, and modeling. Deep learning automates the identification and classification of microplastics from microscopy images, while machine learning accelerates the recognition of polymers from Raman and infrared spectra. AI-based clustering and segmentation improve the analysis of complex samples, and source-apportionment models learn morphological and chemical features to trace emiss [...]

by Icih Susanti  , Noki Irawan Saputra  , Lina Budiyanti  , Aam Amalia  , Rohman Hikmat  and Iyus Yosep

Received: 11 September 2025;  Published: 17 November 2025;  doi: 10.21926/obm.neurobiol.2504309

Adolescent depression is linked to suicidal ideation and attempts. Nurses are well-positioned to deliver brief, supportive interventions. Solution-Focused Brief Therapy (SFBT) emphasizes solutions and the activation of personal resources. To describe the feasibility and clinical utility of SFBT, delivered alongside pharmacotherapy, for reducing suicide risk in an adolescent with depression. Single-case report using a nursing process approach in a 17-year-old female inpatient with a major depressive episode and high [...]

by Jude Alhaddad  , Hawra Alkhadad  , Fatima AlHannan  , Fryad Henari  and G. Roshan Deen

Received: 16 June 2025;  Published: 17 November 2025;  doi: 10.21926/rpm.2504017

The study focuses on the rapid green synthesis of silver nanoparticles (AgNPs) and alginate-silver nanocomposite (Alg-AgNc) beads using sweet basil or Mashmoom (Ocimum basilicum), a common household medicinal herb in Bahrain. The aqueous extract of mashmoom was used as a reducing and stabilizing agent in the reduction of the precursor salt, silver nitrate, and formation of stable AgNPs. The Alg-AgNc beads were prepared by ionotropic gelation of sodium alginate-AgNPs solution in calcium chloride. A strong surface pl [...]

by Tyrone Pretorius  and Anita Padmanabhanunni

Received: 15 June 2025;  Published: 14 November 2025;  doi: 10.21926/obm.neurobiol.2504308

First responders are routinely exposed to traumatic events in the line of duty, placing them at heightened risk for adverse mental health outcomes, including substance use. This study investigated the psychological mechanisms linking trauma exposure to alcohol use, specifically examining the serial mediating roles of insomnia and depression. A sample of 429 first responders (309 police officers and 120 paramedics) from the Western Cape, South Africa, completed an online survey comprising the Life Events Checklist-5 [...]

by G.-Fivos Sargentis  and Nikolaos Papadodimas

Received: 11 June 2025;  Published: 11 November 2025;  doi: 10.21926/aeer.2504032

This study proposes a novel creative tourism model integrating artistic creation with circular economy principles to foster regional revitalization in North Euboea, Greece. Employing a case study approach, it develops the concept of “Cultural Cells”—dedicated hubs for artists and art students specializing in painting and sculpture—designed to enhance tourism through immersive engagement. The methodology combines qualitative analysis of regional cultural and environmental assets with theoretical estimates of circula [...]

by Isadora Muller de Oliveira  , Letícia Caroline de Oliveira Vital  , Izabela de Siqueira Reis Regueira  and Marcos Paulo Gomes Mol

Received: 02 July 2025;  Published: 11 November 2025;  doi: 10.21926/aeer.2504031

The management of healthcare waste (HCW) presents a significant environmental and public health challenge, aggravated by gaps in current Brazilian federal regulations. This study provides a comprehensive analysis of specific state and municipal legislation on HCW, comparing it with ANVISA Resolution No. 222/2018 and CONAMA Resolution No. 358/2005 to ascertain whether local regulations enhance management practices and can act as supplementary instruments to federal guidelines. The methodology was structured into thr [...]

by Takashiro Akitsu

Received: 09 November 2025;  Published: 11 November 2025;  doi: 10.21926/rpse.2504015

by Gerhard Litscher

Received: 10 November 2025;  Published: 10 November 2025;  doi: 10.21926/obm.icm.2504049

During this year’s World Congress on Medical Acupuncture, the ICMART (International Council of Medical Acupuncture and Related Techniques) Science Award 2025 was presented in recognition of excellence in research and innovation within the field of medical acupuncture. The award honored pioneering work on acupuncture and moxibustion in chronic fatigue syndrome (CFS), conducted in collaboration with the team at Hubei University of Chinese Medicine, Wuhan. The study, a randomized controlled trial (RCT), showed that ac [...]

by Muhammad Zahid  , Amir Shakeel  , Dilawar Aslam  , Qumber Abbas  , Basharat Ali  , Yasir Niaz  , Javed Iqbal  , Fatih Çiğ  , Murat Erman  , Hakkı Akdeniz  , Mohammad Sohidul Islam  , Muhammad Aamir Iqbal  , Disna Ratnasekera  , Ömer Konuşkan  and Ayman El Sabagh

Received: 09 July 2025;  Published: 10 November 2025;  doi: 10.21926/obm.genet.2504316

Wheat constitutes the backbone of global food supplies, and its production is directly linked to the food and nutritional security of the mounting population. Wheat is vulnerable to abiotic stresses like heat, salinity, and drought. These abiotic stresses tend to reduce the food security of the increasing population by reducing wheat production and nutritional quality. Among abiotic stresses, salinity stress (SS) has emerged as the most prevailing stress in modern high-input wheat farming systems, as it severely ha [...]

by Norbert Maurer  , Helmut Nissel  , Reginald Bittner  , Richard Crevenna  , Marion Mucha  , Erich Gornik  and Georg Feigl

Received: 11 November 2024;  Published: 09 November 2025;  doi: 10.21926/obm.icm.2504048

Morphological evidence of peripheral glial cell involvement is lacking. Therefore, we investigated the presence of Schwann cells in acupuncture meridians. Eight legs of four unembalmed cadavers were used. Along the stomach meridian and a control meridian, quadrangular samples were taken from skin to the deep subcutaneous fascia and embedded in paraffin. 5 µm sections were stained for H&E and processed for immunolabeling using antibodies against S100 and NFP, respectively. In the stomach meridian, a large assembly o [...]

by Hira Khalid  , Muhammad Asim  , Akbar Hussain  , Tehmeena Maryum Butt  , Sadia Kanwal  and Naveed Kausar Janjua

Received: 09 August 2025;  Published: 07 November 2025;  doi: 10.21926/cr.2504009

The electrochemical water oxidation application of CuO@Fe2O3 materials as potential catalysts is being reported for the first time. A series of CuO@Fe2O3 with different molar ratios of CuO (5, 7, 10, 12, and 15%) was fabricated through precipitation followed by the impregnation method. Structural and electrochemical studies were carried out by using different analytical platforms, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Energy dispersive [...]

by Brandi M. Crowe  , Karen Kemper  and Marieke Van Puymbroeck

Received: 11 June 2025;  Published: 05 November 2025;  doi: 10.21926/obm.geriatr.2504330

Falls and fall-related injuries are one of the leading causes of death among older adults aged 65+ in the United States. Americans’ life expectancy has increased and fall risk grows with age. While several evidence-based fall prevention programs are utilized to decrease fall risk among community-dwelling older adults, little research focuses on challenges or strategies related to sustained fall prevention program implementation. The purpose of this multi-method descriptive study was to assess fall risk outcome chan [...]

by Bachir Yaou Balarabe

Received: 24 October 2025;  Published: 03 November 2025;  doi: 10.21926/cr.2504008

by Mohammadreza Mohammadabadi  , Amin Khezri  , Olena Babenko  , Oleksandr Oleksandrovich Borshch  , Oleksandr Kalashnyk  , Iryna Starostenko  , Sergii Тkachenko  , Nataliia Klopenko  , Iryna Tytarenko  , Ivan Bezpalyi  and Aliakbar Khabiri

Received: 30 July 2025;  Published: 30 October 2025;  doi: 10.21926/obm.genet.2504315

Interleukin-8 (IL-8), a pro-inflammatory cytokine, plays a critical role in immune modulation in poultry and has potential applications in veterinary and human medicine. This study investigated the effects of dietary supplementation with mealworm (Tenebrio molitor), probiotics, or their combination on IL-8 gene expression in the livers and spleens of broiler chickens. A total of 160 one-day-old broiler chickens (Ross 308 strain) were assigned to four treatments (basal diet, basal diet + 0.2 g/kg probiotic, basal di [...]

by Yoko Kawamura

Received: 15 May 2025;  Published: 30 October 2025;  doi: 10.21926/obm.geriatr.2504329

In Japan, a super-aging society, the development of Ikigai is considered the key to extending healthy longevity in national policy. Thus, activities provided by local governments are designed to encourage Ikigai. At this point, Ikigai has developed its conceptual understanding, which includes its distinctiveness from life purposes and other closely related concepts. Empirical studies using developed measurements have shown that Ikigai has an impact on the mental and physical health of older adults across countries [...]

by Laxminarayan Sahoo  , Payal Murmu  , Mohan Krishna Ghanta  and LVKS Bhaskar

Received: 28 June 2025;  Published: 30 October 2025;  doi: 10.21926/obm.genet.2504314

Ebstein's anomaly (EA) is a rare form of congenital heart disease (CHD), characterized by abnormal cardiac anatomy involving a defective tricuspid valve (TV), resulting in tricuspid regurgitation (TR) and cyanosis. EA is represented in different case scenarios with varying degrees of complexity across various age groups. It usually affects 0.2-0.7 out of 10,000 live births and accounts for 0.3%-0.6% of all CHD cases. While its occurrence is mainly sporadic, evidence from multiple studies suggests that EA can be ass [...]

by Marcus A. Henning  , Philippa Miskelly  , Marta Gil-Lacruz  , Gary Cheung  , Frederick Sundram  and Ruth Teh

Received: 11 June 2025;  Published: 29 October 2025;  doi: 10.21926/obm.icm.2504047

Across the globe, countries are facing an ageing boom, with the proportion of the older adult population growing compared to younger age groups because of increased life expectancy and declining birth rates. Along with the ageing boom, there is increased interest in the wellbeing of older adults. Healthy ageing and social frailty are two constructs that have emerged in studying older adults and their quality of life. In this paper, we critically review salient literature defining and describing healthy ageing and s [...]

by Angelina Lamberti  , Sinan Haddad  , Stefan Wagenpfeil  , Thomas Vogt  and Jörg Reichrath

Received: 13 September 2024;  Published: 29 October 2025;  doi: 10.21926/rpn.2504024

Recommendations for vitamin D supplementation are essential for the prevention and therapy of vitamin D deficiency. However, reliable data remain lacking for children, as most intake recommendations are based on individual studies. This work aimed to obtain reliable data that allow health authorities to re-evaluate recommendations for oral vitamin D uptake in children. We conducted a systematic literature search in MEDLINE/PubMed on vitamin D supplementation in children. All randomized controlled trials (RCTs) publ [...]

by Buket Kılıç  and Dilek Ünal

Received: 31 May 2025;  Published: 27 October 2025;  doi: 10.21926/obm.neurobiol.2504307

Although anxiety and Autism Spectrum Disorder (ASD) are common co-morbidities, the relationship between autistic traits and anxiety disorders/symptoms has been increasingly researched in recent years. This review aims to compile the studies conducted on this topic and enhance our understanding of it. All publications up to September 1, 2024, on PubMed that contained the terms ‘anxiety’, ‘autistic traits’, ‘autism feature’, ‘autism-like symptoms’, and ‘ASD-like symptoms’, in their titles or abstracts were reviewed. [...]