by Garzain Bint e Attar  and Mohd. Ashif Khan

Received: 15 May 2025;  Published: 31 December 2025;  doi: 10.21926/obm.transplant.2504262

Bone grafting remains a cornerstone technique in orthopedic and reconstructive surgery, yet achieving successful graft integration continues to pose significant challenges, particularly in conditions such as osteoporosis, diabetes mellitus, and large bone defects. Traditional graft materials such as autografts, allografts, xenografts, and synthetics, often encounter limitations including immune rejection, poor vascularization, and insufficient osteogenic support. Emerging pharmacological strategies have shown promi [...]

by Chawannuch Ruaengsri  , Miguel Alvarez-Cortes  , Marc Leon  , Manuel Quiroz-Flores  , Masafumi Shibata  and Yasuhiro Shudo

Received: 30 June 2025;  Published: 30 December 2025;  doi: 10.21926/obm.transplant.2504261

Donation after circulatory death (DCD) offers a vital strategy to expand the donor lung pool; however, DCD lungs are uniquely susceptible to warm ischemic injury during procurement. This chapter reviews evidence-based and emerging donor management strategies aimed at mitigating ischemic damage and optimizing the suitability of DCD lungs for transplantation, encompassing hemodynamic and ventilatory optimization, bronchoscopic clearance, targeted pharmacological interventions, and strategies to minimize transfusion r [...]

by Konstantinos Agiannitopoulos  and Elisavet Kouvidi

Received: 02 May 2025;  Published: 25 December 2025;  doi: 10.21926/obm.genet.2504321

Leukemia is a heterogeneous group of hematologic malignancies characterized by the dysfunctional proliferation of white blood cells in the bone marrow. Genetic alterations are important risk factors for the development and progression of leukemia, and their detection is crucial. Although many genetic techniques, including karyotyping, fluorescence in situ hybridization (FISH), and polymerase chain reaction (PCR), have provided valuable information, they all have the limitation of incomplete genomic coverage. The ev [...]

by Hanuman Singh Jatav

Received: 21 December 2025;  Published: 24 December 2025;  doi: 10.21926/aeer.2504035

The rising concerns of soil erosion, organic waste generation and global warming have shown the need to address them through multifaceted methods that transcend conventional linear models of resource utilization. Circular economy is a regenerative model that is anchored on caring about waste valorisation, resource effectiveness and environmental fortitude. In this paradigm, biochar has been developed as a multifunctional compound capable of integrating waste management, soil rehabilitation, climate control and rene [...]

by Ola A. E. Mohamed  and Ibtisam E. M. El Zubeir

Received: 30 July 2025;  Published: 22 December 2025;  doi: 10.21926/rpn.2504026

This study was conducted to process frozen yoghurt (FY) from camel milk (CM) flavored with either 5% or 8% banana (B) or dates (D). The mix of FY consists of stirred yoghurt, sugar, Gum Arabic, and banana (Musa lutea) or dates (Phoenix dactylifera). The mix was divided into 4 portions and then each mix was sub-derived into an ice-cream machine and then packed into plastic cups that were stored at -18°C for 5 weeks. The chemical composition and sensory evaluation were conducted weekly. The chemical composition of FY [...]

by Mosebetsi J. Leotlela

Received: 21 April 2025;  Published: 19 December 2025;  doi: 10.21926/jept.2504018

The effective neutron multiplication factor (keff) of a fissile system is a function of space and time f(x, y, z, t), where (x, y, z) are the coordinates of the reference point in space, and t is time. The evidence of the time-dependence of the neutron multiplication factor of a fissile system was published in 2017. The spatial dependence is as important as the time dependence, as interacting arrays of fissile material during storage can lead to an increase in the system (keff). Therefore, evaluation of how the sto [...]

by María Montero-López Lena  , Livia Sánchez Carrasco  and Montserrat Celdrán Castro

Received: 20 June 2025;  Published: 17 December 2025;  doi: 10.21926/obm.geriatr.2504332

This study aimed to evaluate the psychometric properties of the Family Inclusion Scale (FIS) for administration to adults and older Mexican adults. To this end, a questionnaire was structured with scales to evaluate family inclusion, loneliness, and perceived stress; the last two scales were previously validated. The sample (n = 347) consisted of young university adults aged 20 to 24 years and their grandparents aged 60 years. The conceptual emphasis of the Family Inclusion Scale generated was the identification of [...]

by Adel Razek

Received: 07 October 2025;  Published: 17 December 2025;  doi: 10.21926/rpse.2504017

A relevant objective of managing an electromagnetic (EM) device is to improve its expected results and reduce its undesirable side effects. In this context, this paper aims to evaluate the interest of the two One Health and Responsible Attitude methods in the daily practice of wireless transmission (or transfer) in EM energy devices. These approaches are respectively linked to device eco-design and optimization, as well as to the protection of biodiversity and ecosystems against device side effects related to EM fi [...]

by Victoria Flores  , Arjun Ramani  , Edwin Rodriguez  , Reid Hayward  and Laura Stewart

Received: 18 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.icm.2504054

Complementary and integrative medicine (CIM) is commonly used by cancer survivors; however, patterns of use among individuals engaged in structured exercise rehabilitation remain understudied. This cross-sectional survey examined CIM use among 157 cancer survivors enrolled in a structured exercise-based rehabilitation program. CIM modality use (dependent variable) was grouped into herbal supplements, mind-body practices, and manipulative and body-based categories and analyzed with demographic and clinical character [...]

by Giustino Varrassi  , Matteo Luigi Giuseppe Leoni  , Giacomo Farì  , Annalisa Caruso  , Ameen Abdulhasan Al-Alwany  , Marco Mercieri  , Joseph V. Pergolizzi  and Rocìo Guillen

Received: 10 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.neurobiol.2504315

Chronic cancer pain results from the complex interaction of nociceptive, neuropathic, and neuroimmune mechanisms, which vary according to tumor type, location, stage, and treatment history. Recent advances in cancer neuroscience have reframed pain as a dynamic manifestation of reciprocal tumor–nerve–immune interactions, rather than a mere consequence of tissue damage. In this model, malignant, stromal, and immune cells remodel nociceptive circuits at peripheral and central levels. This narrative review, conducted i [...]

by Marcella Anggatama  , Hanggoro Tri Rinonce  , Dwinanda Almira Rizkiani  , Eddy Supriyadi  , Raden Roro Rini Andayani  , Yohanes Widodo Wirohadidjojo  and Retno Danarti

Received: 26 October 2025;  Published: 11 December 2025;  doi: 10.21926/obm.genet.2504320

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by early-onset poikiloderma and multisystem abnormalities. Diagnosis is often confirmed through genetic testing, but in many resource-limited settings, molecular studies are unavailable, necessitating reliance on clinical and histopathological evaluation. We report a 1-year-old boy referred for assessment of progressive pigmented skin lesions. The patient was referred by a pediatrician with febrile neutropenia, bicytopenia suspicio [...]

by Chuan-Tsung Lee

Received: 15 September 2025;  Published: 10 December 2025;  doi: 10.21926/jept.2504017

Taiwan relies heavily on imported fossil fuels, with over 98% of its energy demand supplied by foreign sources, posing significant challenges to national energy security. To explore alternatives, this study investigates the potential of marine renewable energy by developing a 20 kW floating hydrokinetic turbine prototype designed for deployment in the Kuroshio Current. The research encompasses system design, model validation, and both tank and at-sea testing to evaluate hydrodynamic performance and power generation [...]

by Gerhard Litscher

Received: 08 December 2025;  Published: 09 December 2025;  doi: 10.21926/obm.icm.2504053

Acupuncture has become an increasingly relevant complementary modality in modern gynecology and assisted reproduction. Its uses include the management of menstrual disorders, menopausal symptoms, infertility, polycystic ovary syndrome (PCOS), endometriosis, and others. Scientific progress in neurophysiology, laser acupuncture, and biomedical imaging has enabled a deeper understanding of the central and peripheral mechanisms underlying acupuncture’s effects. This editorial summarizes current evidence regarding physi [...]

by Md. Robeul Islam  , Avijit Banik  , Hasnain Anjum  , Nusrat Nabila Fariha  , Zarin Rushni  , Maruf Abony  , Dipa Rani Bhowmik  and Zakaria Ahmed

Received: 01 May 2025;  Published: 09 December 2025;  doi: 10.21926/rpn.2504025

Enteropathogenic strains of Escherichia coli, like the serotype O157:H7, can cause significant health issues if consumed. Milk and dairy products can serve as a reservoir for the bacteria. Dissemination of multidrug-resistant E. coli through dairy products can become a potential health hazard if consumed. The present study investigates the occurrence of multidrug-resistant E. coli O157:H7 in raw milk obtained from farms and markets around Dhaka, Bangladesh. A Total of 50 milk samples were collected in this study fr [...]

by Rustam Nailevich Mustafin

Received: 17 August 2025;  Published: 08 December 2025;  doi: 10.21926/obm.neurobiol.2504314

Schizophrenia is a multifactorial mental disorder associated with multiple SNPs in the human genome, located mainly outside the annotated protein-coding genes. These regions contain a large number of retroelements, which drive epigenetic regulation. Therefore, it is suggested that schizophrenia-associated SNPs exert their influence on the pathological functioning and activation of retroelements, which contribute to epigenetic imbalance in the brain with the development of pathological processes. A reflection of the [...]

by Divya Mobarsa  , Kedar Mehta  , Amit Sata  and Minal Shukla

Received: 11 June 2025;  Published: 05 December 2025;  doi: 10.21926/jept.2504016

This research introduces a blockchain framework to improve security and transparency for the use of renewable energy in power systems. The framework utilizes a permissioned blockchain architecture and IoT-based real-time monitoring to ensure data integrity and confidentiality and support efficient peer-to-peer (P2P) energy trading. Compared with traditional centralized energy management systems, the proposed design increases transaction security by 35%, decreases verification wait times by 28%, and decreases the ri [...]

by Míriam de Fátima Soares  , Frederico Keizo Odan  and Marcos Paulo Gomes Mol

Received: 09 June 2025;  Published: 04 December 2025;  doi: 10.21926/aeer.2504034

The development and utilization of pharmaceuticals, notably antiretrovirals (ARVs), have significantly enhanced both human quality of life and life expectancy. Nevertheless, the excretion of these compounds into aquatic environments, often exacerbated by inadequate sanitation infrastructure, poses considerable risks to biota. This investigation evaluated the environmental impact of 14 ARVs consumed within the municipality of Belo Horizonte (BH), Brazil. The assessment employed the Environmental Risk Assessment (ERA [...]

by Carlos Armenta-Déu

Received: 04 June 2025;  Published: 03 December 2025;  doi: 10.21926/aeer.2504033

The rising pollution levels in congested urban areas pose a serious threat to human health. Many solutions have been proposed to control and reduce gas emissions from road traffic, with results that are not entirely satisfactory. The adoption of new techniques and methodologies for early detection of pollutant emissions may enable effective management and control of road traffic contamination. The proposed method introduces an interactive protocol that facilitates communication between the traffic control center an [...]

by Soledad Banega  , Cintia Bertoncini  , Marcelo Guerin  and Alba Güerci

Received: 17 June 2025;  Published: 02 December 2025;  doi: 10.21926/obm.icm.2504052

While radiotherapy is one of the main treatments for head and neck cancer, adverse effects limit its effectiveness and affect patients' quality of life. Although various radioprotective substances have been proposed, comprehensive strategies are needed to modulate radiotoxicity. In this regard, compounds from green tea (Camellia sinensis), with antioxidant, anti-inflammatory, and antiproliferative properties, could be suitable for optimizing the radiotherapy relationship. A descriptive, prospective study was conduc [...]

by Mathivathani Kandiah  , Sivaniya Vinayagamoorthy  , Beneli Gunaratne  and Ominda Perera

Received: 19 September 2025;  Published: 01 December 2025;  doi: 10.21926/cr.2504010

Terminalia species is a widely available plant that can be used to synthesise silver nanoparticles (AgNPs) and harness their catalytic capacity. This experimental design will explore the potential of Terminalia AgNPs in contributing to the degradation process of toxic chemicals generated by industries such as textiles, food, and pharmaceuticals. This research uses four leaf varieties of Terminalia species—T. arjuna, T. bellirica, T. chebula, and T. catappa—to synthesize AgNPs, evaluate their optimal synthesis condi [...]

by Chia-Ying Chou  , Christine Valdez  , Trevor Sanchez Stevens  , Carol A. Mathews  and Martha Shumway

Received: 31 January 2025;  Published: 01 December 2025;  doi: 10.21926/obm.icm.2504051

Severe trauma has a significant impact on self-attitudes and emotions, such as self-criticism and shame, and psychological symptoms. This topic has been more well studied among populations with Trauma and Stress-Related Disorders, but examined to a lesser extent in other clinical populations where adverse life events and potentially traumatic events are highly prevalent, such as Hoarding Disorder. The current study examined trauma exposure, and the relationships between trauma, self-criticism, shame, and symptom se [...]

by Giulio E. Lancioni  , Gloria Alberti  , Chiara Filippini  , Nirbhay N. Singh  , Mark F. O’Reilly  and Jeff Sigafoos

Received: 18 August 2025;  Published: 27 November 2025;  doi: 10.21926/obm.neurobiol.2504313

Recent work with people with blindness and intellectual disability assessed a technology-aided program intended to help eight participants travel indoor routes to reach relevant destinations. The technology included a smartphone, two barcode readers worn by the participants at their ankles, barcodes displayed at specific points of the travel routes, and a mini speaker. The technology ensured that participants received verbal instructions on how to proceed (e.g., take a left turn, cross from one side to the other of [...]

by Poppy L.A. Schoenberg

Received: 26 May 2025;  Published: 26 November 2025;  doi: 10.21926/obm.icm.2504050

Legacy, profit-driven organizational structures often lack the adaptability, equity, and innovation required for the evolving complexities of contemporary patient-centered care. They can limit access, constrain options, impose financial burdens, and hinder optimized delivery. Here, we propose a new architecture for metaversal integrative healthcare using decentralized autonomous organizations (DAOs). Blockchain technology and smart contracts underpin equitable, transparent, and resilient health ecosystems beyond in [...]

by Mahintaj Dara  , Negar Azarpira  , Nasrin Motazedian  , Mahdokht Hossein-Aghdaie  , Seyed-Mohsen Dehghani  , Bita Geramizadeh  and Elaheh Esfandiari

Received: 24 May 2025;  Published: 26 November 2025;  doi: 10.21926/obm.genet.2504319

Biliary atresia (BA), a severe pediatric liver disease of unknown etiology, causes neonatal jaundice, progressive cholestasis, and life-threatening liver fibrosis. Emerging evidence suggests microRNAs (miRNAs) – small non-coding RNAs that regulate gene expression by binding target mRNAs may play a role in BA pathogenesis. Circulating miRNAs have shown diagnostic potential for various diseases, prompting our investigation of miR-21 and miR-19 as potential biomarkers in BA. We conducted a case-control study comparing [...]

by Vikash Chandra Mishra  , Dinesh Chandra  and Vimarsh Raina

Received: 15 July 2025;  Published: 25 November 2025;  doi: 10.21926/obm.transplant.2504260

Though the role of clinical histocompatibility testing is fundamental to successful transplant, systematic risk assessment and mitigation strategies remain underutilised in this domain. This review addresses risk identification, analysis, and control measures across the pre-analytical, analytical, and post-analytical phases of clinical histocompatibility testing, in line with international standards such as ISO 15189:2022. A structured, risk-based quality management system (QMS) is imperative for ensuring accurate [...]