Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

by Ibrahim Fathi  , Takehiro Imura  , Kozue Imura  , Megumi Goto  , Yasuhiro Igarashi  , Akiko Inagaki  , Makiko Kikkawa  , Fumiko Ono  , Hiroo Iwata  , Yohichi Yasunami  and Masafumi Goto

Received: 27 March 2019;  Published: 09 July 2019;  doi: 10.21926/obm.transplant.1903071

Abstract

Background: The existing non-human primate diabetic models, particularly those induced by total pancreatectomy or streptozotocin (STZ) injection, have several disadvantages, including a lengthy surgical procedure, the need for continual supplementation of digestive enzymes, and delayed oral intake after total pancreatectomy, and severe hypoglycemia and hepatic/renal toxicity following injection of high-dose STZ. This study aimed to develop and optimize a non-human primate diabetic model that would avoid the disadva [...]

1756 12315

Open Access Review

Inclusion of Dietary-Fibers in Nutrition Provides Prebiotic Substrates to Probiotics for the Synthesis of Beneficial Metabolites SCFA to Sustain Gut Health Minimizing Risk of IBS, IBD, CRC

by Divakar Dahiya  and Poonam Singh Nigam

Received: 19 July 2023;  Published: 14 September 2023;  doi: 10.21926/rpn.2303017

Abstract

Usually, everyday meals constitute materials and ingredients for food preparation derived from different agricultural sources. Although most customers are aware of the benefits of a balanced diet, they mainly focus on a diet based on the daily requirements of protein, fat, and carbohydrates in their meals. However, the vital aspect of the including dietary fibers in diets is overlooked, which is equally important as is the daily requirement of calories and protein intake for maintaining the muscle mass. Some societ [...]

1779 12314

Open Access Original Research

Prediction of ADRs and Estimation of Polypharmacy in Older Patient’s Population: Retrospective Study in Russian Gerontology Center

by Ali Al-Ragawi  , Sergey Zyryanov  , Elena Ushkalova  , Olga Butranova  and Anton Pereverzev

Received: 10 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.geriatr.1901038

Abstract

Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. Prediction of ADRs is a valuable tool to improve pharmacotherapy and outcomes in this category of patients. Objective: Prediction of ADRs in patients ≥ 65 years old, based on GerontoNet risk score with emphasis on polypharmacy. Methods: Pharmacoepidemiological retrospective study of medical records of patients admitted to the Russian Gerontology Clinical Research Center (RGCRC) between 1 [...]

1921 12307

Open Access Original Research

New Electrocatalysts Prepared by Co-Sputter Deposition for the Direct Oxidation of Methanol

by Dan Fang  and Sri Narayan

Received: 25 May 2021;  Published: 13 August 2021;  doi: 10.21926/jept.2103038

Abstract

Direct methanol oxidation catalysts Pt1-x-Tax (0

2006 12307

Open Access Short Communication

Redefining Hypotension in Older Adults: Implications for the Prevention of Age Related Cognitive Decline

by Kenneth J. McLeod

Received: 24 April 2023;  Published: 18 September 2023;  doi: 10.21926/obm.geriatr.2303249

Abstract

Chronically low blood pressure in older adults is associated with significantly increased long-term risks of dementia and all-cause mortality risk. Yet low blood pressure is generally not treated until an individual begins to experience the acute symptoms arising from very low cerebral perfusion. However, these acute symptoms, such as dizziness, balance difficulty, syncope, increased fall occurrence, vision impairment, and nausea, begin to occur only at very low blood pressure levels, such that mean arterial pressu [...]

1348 12303

Open Access Review

Addressing Uncertainty: The Emergence of the CRMS/CFSPID Diagnostic Category Following Newborn Screening for Cystic Fibrosis

by Michelle Lynne LaBonte

Received: 29 July 2021;  Published: 29 September 2021;  doi: 10.21926/obm.genet.2103139

Abstract

This article uses cystic fibrosis as a case study to examine how physicians and scientists have navigated uncertainty following newborn screening. Despite the many benefits of newborn screening, including earlier diagnosis, therapeutic intervention, and a reduced diagnostic odyssey, this public health approach also comes with challenges. For example, physicians began to document infants with indeterminate diagnoses - those with a positive screen who did not clearly fit into the cystic fibrosis or “normal” categorie [...]

1758 12301

Open Access Original Research

Barley and Malt as Base Ingredients for the Production of New Bio-Functional Foods

by Raúl E. Cian  , Antonela G. Garzón  , Micaela Albarracín  and Silvina R. Drago

Received: 14 April 2023;  Published: 19 September 2023;  doi: 10.21926/rpn.2303018

Abstract

This work aimed to evaluate the chemical composition, bioactive compounds (phenolics and γ-aminobutyric acid, GABA), and antioxidant properties of different barley varieties (Overture, Charles, Sinfonía, Montoya, and Andreia) and their malts to weigh up them as potential ingredients for producing new bio-functional foods. For this, five barleys and five malts obtained from them were studied. Regarding chemical composition, total starch was the main component (≈62%) of barleys followed by total di [...]

1826 12296

Open Access Original Research

Low-Velocity Impact Resistance of Glass Laminate Aluminium Reinforced Epoxy (GLARE) Composite

by Abolfath Askarian Khoob  , Mohammad Javad Ramezani  and Seyed Sina Mousavi

Received: 16 June 2022;  Published: 12 May 2023;  doi: 10.21926/rpm.2302021

Abstract

This study intends to determine the behavior of glass laminate aluminum-reinforced epoxy (GLARE) and glass fiber-reinforced polymer (GFRP) composites under a low-velocity impact test. Experimental tests and numerical simulations are considered for this investigation. All samples are made by the hand lay-up method. Moreover, specimens are produced with a 7075-T6 aluminium sheet with a 0.5 mm thickness, resin 3001, and E-glass fiber. The drop weight test performs the low-velocity impact at 6.7 J and 10 J impact energ [...]

1647 12290

Open Access Research Article

Feasibility of an 8-week Yoga Intervention among Middle-aged and Older Adults

by Neha P. Gothe  and Emily Erlenbach

Received: 13 August 2020;  Published: 06 November 2020;  doi: 10.21926/obm.geriatr.2004137

Abstract

Feasibility studies play a critical role in determining whether the target population is likely to engage with larger scale efficacy and effectiveness trials. Feasibility data for yoga interventions designed and conducted with older adults is limited. In this paper we present feasibility and acceptability data from an 8-week randomized controlled trial (RCT) conducted with middle aged and older adults. Participants n=118 (Mean age: 62.0 years) were randomized to either a Hatha yoga or Stretching Control group with [...]

1955 12284

Open Access Original Research

Comparative Assessment of Seasonal Variations in the Quality of Surface Water and Its Associated Health Hazards in Gold Mining Areas of Osun State, South-West Nigeria

by Awogbami Stephen Olalekan  , Solomon Olayinka Adewoye  , Sawyerr Olawale Henry  and Morufu Olalekan Raimi

Received: 30 October 2022;  Published: 23 January 2023;  doi: 10.21926/aeer.2301011

Abstract

Industrial and urban development are contributing to an increase in global environmental degradation. Therefore, the release of heavy metals from mining-related operations into surface water is harmful to human health. But as anthropogenic influences on the environment grow, surface water characteristics are also alter, impacting aquatic creatures. In order to analyze the acceptability of the surface water in the gold mining area for drinking and irrigation uses, different quality water assessment methodologies wer [...]

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