by Abdul Al-Toma  and Harry R. Koene

Received: 16 December 2019;  Published: 18 February 2020;  doi: 10.21926/obm.transplant.2001101

Refractory celiac disease (RCD) is a rare condition in which a known celiac patient, usually an adult, suffers from persistence or recurrence of gluten-related symptomatology, laboratory abnormalities, and inflammatory enteropathy despite following an optimal dietary therapy with gluten-free diet (GFD). Arbitrarily, a duration of at least 12 months of GFD has been recommended prior to establishing such a diagnosis. Furthermore, exclusion of the other possible causes of non-celiac villous atrophy, particularly enter [...]

by Danielle Gentile  , Danielle Boselli  , Matthew Flores  , Susan Yaguda  , Rebecca Greiner  , Paulomi Campbell  and Chasse Bailey-Dorton

Received: 31 October 2019;  Published: 21 February 2020;  doi: 10.21926/obm.icm.2001008

Literature suggests Oncology Massage (OM) reduces anxiety. However, research is limited in large, diverse, nonexperimentally manipulated outpatient samples of cancer patients. The purpose of this study was to 1) describe OM visit patterns, 2) describe anxiety response to OM, and 3) determine if OM resulted in significantly reduced anxiety at first visit, across all visits, and longitudinally over time controlling for demographic factors. From January 2015-June 2019, a cohesive, consecutive, retrospective sample eva [...]

by Peter Bauer  , Gabriele Wildhardt  , Dieter Gläser  , Clemens Müller-Reible  , Hanno J. Bolz  , Hanns-Georg Klein  , Ulrich Finckh  and Ute Hehr

Received: 24 September 2017;  Published: 28 April 2018;  doi: 10.21926/obm.genet.1802019

On behalf of the German Society of Human Genetics, we present guidelines for molecular genetic diagnostic testing using high-throughput technology, such as next-generation sequencing (NGS). These guidelines have been formulated by an expert group and reviewed by members of the German Society of Human Genetics. Building on the existing EuroGentest guidelines for diagnostic NGS, these updated guidelines incorporate additional aspects and country-specific topics. New considerations include the introduction of a check [...]

by Frida Milella  , Davide Donato Russo  and Stefania Bandini

Received: 15 October 2023;  Published: 15 December 2023;  doi: 10.21926/obm.geriatr.2304262

Due to aging demographics, prolonged life expectancy, and chronic diseases, European societies' increasing need for care services has led to a shift towards informal care supplied by family members, friends, or neighbors. However, the progressive decrease in the caregiver-to-patient ratio will result in a significant augmentation in incorporating intelligent aid within general care. This study aimed to build upon the authors' previous systematic literature review on technologies for informal caregivers. Specificall [...]

by Jih-Huah Wu

Received: 04 March 2019;  Published: 15 July 2019;  doi: 10.21926/obm.icm.1903046

Sleep has played a critical role in maintaining the physical and psychological health of humans, especially for women. Many studies reveal that sleep disturbance can cause more inflammation, coagulation, insulin resistance, and psychosocial distress in women than in men. A lot of medications are used to treat sleep disorders, but they can cause various adverse effects. Photobiomodulation therapy (PBMT) has been proved as a safe and easy-to-use therapy. We propose two methods of affecting the autonomic nervous syste [...]

by Ian Seels  and Rowena J. Field

Received: 16 May 2024;  Published: 27 September 2024;  doi: 10.21926/rpn.2403015

Musculoskeletal (MSK) pain is a multifaceted problem, with many contributors. The assessment of these contributions by clinicians has evolved to include not only the musculoskeletal and nervous systems, but also psychosocial contributions. Nutrition, however, has not been considered as a potential contributor in the same way, despite a significant body of evidence showing that amending one’s diet may significantly reduce pain and inflammation. Historically, when the biomedical model was considered the gold standard [...]

by Raquel López-Vilella  , Alba Cecilia Ruiz Gaitán  , José Ricardo Gimeno Costa  , Elena Marqués-Sulé  , Rosario Vicente Guillén  , Javier Pemán García  , Ignacio Sánchez-Lázaro  and Luis Almenar Bonet

Received: 15 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.transplant.1901053

In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multidrug-resistant yeast that is associated with serious infections and with a mortality rate that can reach 70%. This problem is especially serious in transplant recipients receiving intense immunosupressive therapy. There are no established criteria on the relevance of this colonization or on when the transplant should be contraindicated in these cases. Five cases of colonization and two of candidemia have been [...]

by Edda Cava  , Alessandro Collo  , Marcella Serioli  and Sergio Riso

Received: 30 June 2020;  Published: 12 October 2020;  doi: 10.21926/obm.neurobiol.2004073

We report, for the first time, the case of amyotrophic lateral sclerosis (ALS) onset in a 54-year-old woman not following a strict gluten-free diet (GFD) for six years after the diagnosis of celiac disease (CD). The patient did not display any sign of gluten toxicity, malabsorption, or CD-related comorbidity. Previous cases reported in medical literature showed ALS-like forms secondary to gluten intolerance, with symptom remission after a strict GFD. Even after correcting dietary flaws, the clinical manifestation o [...]

by Joel J. Lee  , Hyunho Song  , Jaeyoung Park  and S. Joon Lee

Received: 14 August 2023;  Published: 03 October 2023;  doi: 10.21926/aeer.2304046

Decomposition of spent coffee grounds (SCGs), a byproduct of brewing coffee, in disposed landfill sites releases significant amounts of potent greenhouse gases. This study aims to investigate the maximum recycling proportions of SCGs, a nonconventional filler material, for permeable interlocking concrete paving (PICP) blocks. These blocks have a porous structure that helps mitigate surface ponding while maintaining sound structural performance. Using Scanning Electron Microscope image analysis, the water absorbency [...]

by Julianna Holzer  , John Wu  , Yi He  , Mingyang Ma  , Yuan Xing  , Jose Oberholzer  and Yong Wang

Received: 08 November 2018;  Published: 21 December 2018;  doi: 10.21926/obm.transplant.1804034

In this review, we discuss the application of microfluidic devices in studying the physiology and pathophysiology of human islets and beta-cells, especially its application for human islet transplantation. Human islet transplantation is a promising therapy for Type I diabetes; however, the islet transplant outcomes for achieving complete insulin independence are far from perfect and face many challenges. This review focuses on the microfluidic devices developed in our laboratory, which can address these challenges [...]