by Irina L. Puppo  , Ziravard N. Tonyan  , Alisa N. Panina  , Ksenia V. Shunkina  , Alsu F. Saifitdinova  , Yulia A. Loginova  , Anna A. Kinunen  , Julia R. Pastuhova  , Olga A. Leonteva  , Olga G. Chiryaeva  , Olga V. Malysheva  , Elena M. Fedorova  , Tatyana V. Vavilova  and Natalia K. Bichevaya

Received: 28 March 2022;  Published: 22 June 2022;  doi: 10.21926/obm.genet.2202157

Robertsonian translocations (RTs) are very common balanced structural chromosome rearrangements in humans. Due to alterations in the chromosome segregation pattern and the formation of unbalanced gametes and embryos, the carriers of RTs have a significant risk of reproductive failure. For over 30 years, fluorescent in situ hybridization (FISH) has been used for preimplantation genetic testing for chromosomal structural rearrangement (PGT-SR) in carriers of RTs. The data obtained by performing FISH for PGT-SR can be [...]

by Abdullah S. Binsaeedu  , Moustafa Khalifa  and Jocelyn Tan-Shalaby

Received: 30 December 2021;  Published: 19 April 2023;  doi: 10.21926/rpn.2302007

The ketogenic diet (KD) is currently well known in the lay media as a quick way to lose weight. However, the KD is not a new medical concept. The KD was used in the early 1900s to control seizures. However, as we developed more effective pharmacological agents, we used the KD less until it became practically obscure by the 1980s. Similar to the effects of fasting, the KD leads to the production of ketones as an alternative energy source to glucose. Therefore, the KD has many beneficial metabolic effects, such as an [...]

by Sveva Pepe  , Simone Tedeschi  , Nicolo' Brandizzi  , Samuele Russo  , Luca Iocchi  and Christian Napoli

Received: 27 May 2022;  Published: 04 October 2022;  doi: 10.21926/obm.neurobiol.2204139

Human–robot interactions require the ability of the system to determine if the user is paying attention. However, to train such systems, massive amounts of data are required. In this study, we addressed the issue of data scarcity by constructing a large dataset (containing ~120,000 photographs) for the attention detection task. Then, by using this dataset, we established a powerful baseline system. In addition, we extended the proposed system by adding an auxiliary face detection module and introducing a unique GAN [...]

by Aditi Gupta  , Bor-Jang Hwang  , Daniel Benyamien-Roufaeil  , Sara Jain  , Sophie Liu  , Rex Gonzales  , Robert A. Brown  , Michal Zalzman  and A-Lien Lu

Received: 22 July 2021;  Published: 02 April 2022;  doi: 10.21926/obm.geriatr.2202196

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9/Rad1/Hus1 checkpoint clamp, and SIRT6 aging regulator, are associated with the telomeres. MYH prevents C:G to A:T mutation by removing adenine mispaired with a frequ [...]

by Ali Al-Ragawi  , Sergey Zyryanov  , Elena Ushkalova  , Olga Butranova  and Anton Pereverzev

Received: 10 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.geriatr.1901038

Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. Prediction of ADRs is a valuable tool to improve pharmacotherapy and outcomes in this category of patients. Objective: Prediction of ADRs in patients ≥ 65 years old, based on GerontoNet risk score with emphasis on polypharmacy. Methods: Pharmacoepidemiological retrospective study of medical records of patients admitted to the Russian Gerontology Clinical Research Center (RGCRC) between 1 [...]

by Frida Milella  , Davide Donato Russo  and Stefania Bandini

Received: 15 October 2023;  Published: 15 December 2023;  doi: 10.21926/obm.geriatr.2304262

Due to aging demographics, prolonged life expectancy, and chronic diseases, European societies' increasing need for care services has led to a shift towards informal care supplied by family members, friends, or neighbors. However, the progressive decrease in the caregiver-to-patient ratio will result in a significant augmentation in incorporating intelligent aid within general care. This study aimed to build upon the authors' previous systematic literature review on technologies for informal caregivers. Specificall [...]

by Johannah Ruddy  and Kate Scarlata

Received: 05 August 2022;  Published: 13 February 2023;  doi: 10.21926/rpn.2301003

Celiac disease (CD) is a multisystem immune-mediated disorder resulting in enteropathy of the small intestine with the ingestion of gluten, in genetically susceptible individuals. This condition impact 1% of the population and can result in the development of other conditions such as chronic fatigue, anemia, osteoporosis, aphthous stomatitis, elevated liver enzymes, joint pain, infertility, peripheral neuropathy, and epilepsy. In this review, we outline the clinical presentation of CD, the physiological differences [...]

by Najmul Hoque  , Wahidul Biswas  , Ilyas Mazhar  and Ian Howard

Received: 29 June 2020;  Published: 31 July 2020;  doi: 10.21926/jept.2003013

Hydrogen is regarded as a potential solution to address future energy demands and environmental protection challenges. This study assesses the triple bottom line (TBL) sustainability performance of hydrogen as an automotive fuel for Western Australia (WA) using a life cycle approach. Hydrogen is considered to be produced through water electrolysis. Two scenarios, current grid electricity and future renewable-based hydrogen, were compared with gasoline as a base case. The results show that locally produced grid elec [...]

by Iman Rahimi  , Reza Behmanesh  and Abdollah Ahmadi

Received: 21 May 2019;  Published: 15 November 2019;  doi: 10.21926/jept.1904004

The aim of this paper is the scientometric analysis of articles on “scheduling in renewable energy” that have been published between 2000 and 2017. For this purpose, the terms “scheduling in renewable energy” and “unit commitment in renewable energy” have been searched. We have found 1009 articles in the Scopus database which include the terms mentioned above. VOSviewer and CiteSpace, as two well-known the scientometric analysis tools, have been used. Keywords analysis and citation analysis are two analysis methods [...]

by Mohammed Alsabri  , Kusum Viswanathan  , Fiorella Castillo  , Paridhi Ghai  and Maryam Hemmat Hamrah

Received: 26 December 2020;  Published: 15 April 2021;  doi: 10.21926/obm.icm.2102013

Sickle cell disease (SCD) is one of the most common hematologic disorders in the world. In the United States, it is the single most common genetic hematologic disorder. The burden of SCD and its complications on pediatric patients is tremendous, especially acute vaso-occlusive pain crises. Although allopathic medicine has provided numerous pain medications to treat this, they do not come without side effects and are not always effective. This review explores complementary and alternative medicine (CAM) methods of p [...]