by Wolfgang Rennert  , Katie Cormier  and Samantha Sprott

Received: 22 November 2021;  Published: 24 December 2021;  doi: 10.21926/obm.transplant.2104156

Bone marrow transplants remain an import source of hematopoietic stem cells for patients suffering from specific diseases like aplastic anemia, for pediatric patients with malignant and non-malignant blood cell disorders, and for situations in which graft-versus-host disease (GvHD) is a concern. Identifying the optimal donor to achieve a 3-5 x 108/kg of recipient weight TNC yield may be challenging. In an analysis of 687 consecutive donors, donor and procedure characteristics were related to TNC/kg of recipient wei [...]

by Ciro Comparetto  and Franco Borruto

Received: 29 June 2021;  Published: 19 July 2021;  doi: 10.21926/obm.genet.2103132

Medical genetics plays an important role in the screening and prevention of numerous diseases. Thus, it is important to develop effective screening and prevention programs and improve the assessment of the susceptibility of diseases. The development of screening and prevention programs depends on the identification of early biomarkers (including functional and behavioral) for the risk and onset of the disease, and such programs need to be designed according to internationally accepted criteria. Cervical cancer repr [...]

by Gabriel Santos Viana  , Jorge Álef Estevam Lau Bomfim  , Gabriel Pereira da Silva  , José Faustino Souza de Carvalho Filho  , Miriam Sanae Tokumoto  , Fernando Cesário Rangel  and Rosenira Serpa da Cruz

Received: 30 June 2022;  Published: 13 September 2022;  doi: 10.21926/cr.2203026

Technological development made in the field of biomass application allows synthesizing several high-value products, such as furfuraldehyde. Furfural, produced through sequential hydrolysis and dehydration reactions from biomass, is considered a platform molecule and a precursor of several other chemicals and biofuels that are generated following reactions such as hydrogenation, hydrodeoxygenation, and decarboxylation. This review aims to reveal the environmental-friendly mechanisms followed for producing furfural d [...]

by Audrey Vanhaudenhuyse  , Anne-Sophie Nyssen  and Marie-Elisabeth Faymonville

Received: 14 February 2020;  Published: 09 May 2020;  doi: 10.21926/obm.icm.2002028

Hypnosis is a modified state of consciousness widely used to decrease pain perception in research protocols and clinical practice. In recent decades, hypnosis has been increasingly proposed to patients to re-engage their resources and capacities to modulate pain and emotional distress and to improve their treatment and recovery of well-being. Neuroimaging research helps clinicians to understand better how hypnosis works in terms of brain modulation. Hypnotic suggestions dramatically influence the self and environme [...]

by Aadharshini Ganesh  , Nisha Gupta  , Prosenjit Saha  and Pallab Bhattacharya

Received: 31 January 2023;  Published: 08 May 2023;  doi: 10.21926/rpm.2302020

Energy storage devices (ESD) including batteries, and supercapacitors are becoming progressively imperative in the transition to a renewable energy future, as they enable the integration of intermittent renewable sources into the grid and provide backup power during outages. There are already reviews available on various energy storage materials and systems. However, the challenges in the choice of suitable materials and fabrication technology are yet to establish for the commercialization of affordable and efficie [...]

by Terence Seedsman  and Nilufer Korkmaz-Yaylagul

Received: 17 July 2018;  Published: 28 November 2018;  doi: 10.21926/obm.geriatr.1804022

With rapidly aging populations worldwide there will be an increasing need to focus attention on the expected increase in disability with advancing age. Drawing upon established literature this paper aims to highlight the contribution of anthropology including selected research findings and contemporary understandings surrounding ageism, abuse and exploitation of older disabled persons. Health care providers within the context of the aged care sector are challenged to unburden themselves with negative images and pra [...]

by Kristen W. Carlson  , Jay L. Shils  , Sahil Patel  , Longzhi Mei  and Jeffrey E. Arle

Received: 23 November 2020;  Published: 14 May 2021;  doi: 10.21926/obm.neurobiol.2102095

We review the use of numerical and computational models to explore deep brain stimulation for Parkinson’s disease (DBS PD). It is a review for the modeler and those interested in PD DBS modelling methods and their value. The main model categories of active fiber, mean field, driving force, and volume of tissue activated are described as well as many modelling techniques. We give the basic requirements for a DBS PD model and current theories of DBS mechanism of action, PD etiology, and movement selection. The emphas [...]

by Mrudula Munagala  and Anita Phancao

Received: 31 August 2017;  Published: 11 January 2018;  doi: 10.21926/obm.transplant.1801007

Heart transplant remains the gold standard therapy for patients with end stage heart disease and offers improved survival and quality of life. Significant progress has been achieved in improving one-year mortality after heart transplantation. Nonetheless, long-term graft survival has not changed significantly over the past few decades. Long term survival of heart transplant recipients is limited by chronic rejection, cardiac allograft vasculopathy (CAV), and malignancy. CAV is a major contributor for graft failure [...]

by Paolo Bellavite  , Fabio Arruda-Silva  and Marta Marzotto

Received: 20 April 2021;  Published: 11 August 2021;  doi: 10.21926/obm.icm.2103023

Homeopathy is often attacked with claims of not being evidence-based or for the implausible nature of its major principles of dilution/potentization and/or the similars (“similia similibus curentur”). However, these statements have already been falsified on the experimental ground, besides being incorrect on an epistemological level. Here we provide an updated appraisal of the scientific approach to the principle of Similars and homeopathy, focusing on laboratory models. After a brief historical introdu [...]

by Pietro Gareri  , Antonino Maria Cotroneo  , Giuseppe Orsitto  , Nicola Veronese  and Salvatore Putignano

Received: 12 September 2021;  Published: 08 March 2022;  doi: 10.21926/obm.geriatr.2201193

Certain previous studies have demonstrated the benefits of the addition of citicoline, a cholinergic precursor, to acetylcholinesterase inhibitors (AchEIs) or memantine in patients with Alzheimer's disease (AD). The present study showed the effectiveness of oral citicoline plus AchEIs plus memantine in outpatients with AD. This was a retrospective case-control study involving 169 patients aged 65 years old or older having AD (mean age: 78.7 ±4.9 years). In addition, 84 patients were treated with AchEIs plus [...]