by Rene J. Duquesnoy  and Marilyn Marrari

Received: 13 December 2019;  Published: 10 February 2020;  doi: 10.21926/obm.transplant.2001099

Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus class II eplets shared between HLA-DR, HLA-DQ and/or HLA-DP alleles. This report summarizes current information about antibody-verified interlocus class II eplets. It describes a structural modeling method to determine po [...]

by Hanny Tanasal  , Iline Michaela  and Retno Danarti

Received: 28 October 2024;  Published: 08 January 2025;  doi: 10.21926/obm.genet.2501281

Harlequin ichthyosis (HI) is among the most severe hereditary skin conditions of autosomal recessive congenital ichthyosis (ARCI) in newborns, associated with a mutation of the ABCA12 gene. Patients have a typical clinical appearance at birth. A thick layer of armor-like scales covers the entire body. Affected newborns have abnormal facial features, such as ectropion, eclabium, and ears and nose flattening. Although HI was formerly assumed to be fatal, more intensive neonatal care and early retinoid therapy may imp [...]

by Noorhazlina Ali  , Cai Ning Tan  , Jasmine Kang  , Aik Phon Chew  , Caroline Caroline  , Mary Lee  and Wee Shiong Lim

Received: 27 October 2020;  Published: 04 December 2020;  doi: 10.21926/obm.geriatr.2004140

A locally-adapted, multisensory, psychosocial intervention called Namaste Care program was developed to improve the daily life of persons with advanced dementia (PwAD) through arranging meaningful activities and physical interactions by healthcare staff (Namaste Carers). Congruent with Asian values, the families of PwAD were invited to participate in Namaste Care sessions. The study aimed to explore the influence of Namaste Care on cognitive status and quality of life (QOL) of PwAD, and perceptions and attitudes of [...]

by Margaret E. Newman  , Kenneth Pursell  and David Pitrak

Received: 05 November 2018;  Published: 20 January 2019;  doi: 10.21926/obm.transplant.1901040

Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection. Clinical disease can occur due to acute infection, chronic persistent viremia, rarely secondary infection, or possibly viral reactivation of latent virus. The clinical presentation of primary infection depends on age, the presence of a hematologic condition, and immune status. We report a renal transplant recipient who developed transfusion dependent anemia refractory to erythropoietin that responded [...]

by K. Jason Crandall  , Matthew Shake  and Uta Ziegler

Received: 11 April 2019;  Published: 04 July 2019;  doi: 10.21926/obm.icm.1903041

Background: Older adults experience normative age-graded declines in physical and cognitive performance and many must manage one or more chronic conditions. Exercise programs can help to improve both their physical health and their knowledge, skill, and confidence in managing aspects of their own healthcare, yet a significant barrier is motivating them to adhere to such programs. The purpose of this investigation was to evaluate the impact of a game-centered mobile app (Bingocize®) on older adults' knowledge [...]

by Brandis M. Ansley  and Meagan A. Wander

Received: 07 July 2021;  Published: 28 October 2021;  doi: 10.21926/obm.icm.2104039

Self-Care Options for Resilient Educators (SCORE) is an 8-week, asynchronous virtual training program that teaches stress management skills relevant to educators’ job-related responsibilities and interpersonal interactions. From January-April 2020, 27 pre-service teachers participated in a quasi-experimental study of SCORE’s feasibility and preliminary efficacy. Volunteers chose to either complete SCORE concurrent with their teaching internship or to complete the same assessments for comparison purposes. Recruitmen [...]

by Dagan Coppock  , Caytlin Deering  , Shara Epstein  and Dong Heun Lee

Received: 23 December 2018;  Published: 01 March 2019;  doi: 10.21926/obm.transplant.1901054

Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation of PCTs value in the different types of infections, transplanted organs, and post-operative courses can be challenging. We review the role of PCT in the management of infections in SOT recipients. First, the PCT level c [...]

by Maïté Van Hentenryck  , Zhanzhuo Li  , Philip M. Murphy  and Agnieszka Czechowicz

Received: 24 November 2021;  Published: 08 July 2022;  doi: 10.21926/obm.transplant.2203162

The ability to successfully transplant cells and organs from a donor into an immunologically disparate recipient is one of the greatest treatment advances in the history of medicine. Nevertheless, acute and chronic rejection, graft versus host disease, and the inability to identify suitable donors continue to be challenges and limit broader application of cell and organ transplantation to the many patients that could benefit. Immunosuppression before and after allogeneic transplant has been found to dramatically im [...]

by Franco Cracolici  , Simonetta Bernardini  and Rosaria Ferreri

Received: 14 October 2018;  Published: 30 January 2019;  doi: 10.21926/obm.icm.1901006

Background: Acupuncture is an innovative and scientifically supported treatment for oncologic patients, as well as an effective palliative care option. At the Palliative Care Department of "Misericordia" Grosseto Hospital in Tuscany, real integration of acupuncture in palliative medicine has been possible. The objective of this work is to retrospectively evaluate patient treatment outcomes obtained using an integrated medical care approach administered within a palliative care unit. Methods: Medical records of onco [...]

by Osaretin Albert T. Ebuehi  , Lasekan Oyindamola Ayobami  and Olufemi Mulkah Ajagun-Ogunleye

Received: 12 June 2022;  Published: 02 March 2023;  doi: 10.21926/rpn.2301004

Plant-based products have been utilized for nutritional and medicinal purposes for decades. Although the reported benefits of Carica papaya (Pawpaw) leave extract, its role in hematology, brain histology, and the possible side effect are still areas of research deliberation. Thirty (30) male Sprague Dawley rats, divided into three groups, were fed on rat chow and normal saline, Carica papaya leaves extract and Ruzu bitters, respectively. Blood chemistry, hematology, and brain histology were assayed to ascertain the [...]