by XinRan Quan  and Marica Bakovic

Received: 21 December 2020;  Published: 21 July 2021;  doi: 10.21926/obm.geriatr.2103176

Neurodegenerative diseases (NDs) are a diverse group of neuropathological diseases that are currently incurable due to the irreversible neuronal loss. At the present rate of the world population growth, it is projected that the number of ND cases will double by the year of 2050. With treatments only available for symptom management and relief, disease prevention may yield significant benefits. Recently, there had been association drawn between the disruption of phospholipid (PL) homeostasis and the progression of N [...]

by Alicia Stapp  , Madalyn Falkenheiner  and Kenya Wolff

Received: 15 November 2021;  Published: 13 January 2022;  doi: 10.21926/rpn.2201001

It is recommended that children ages 3-5 receive 180 minutes of physical activity a day, with at least 60 minutes of moderate-to-vigorous physical activity. Despite these recommendations, a majority of preschoolers are not provided opportunities in the early childhood education setting to meet these daily recommendations through either structured or unstructured physical activity. Accordingly, the number of young children identified as overweight or obese over the past couple of decades has increased. Critical to a [...]

by Xuhua Xia

Received: 09 June 2019;  Published: 17 October 2019;  doi: 10.21926/obm.genet.1904097

Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and initiation tRNA, respect [...]

by Aditya Sharma  , Opeyemi Bello  , Catalin Teodoriu  and Hamidreza Karami

Received: 15 February 2021;  Published: 30 June 2021;  doi: 10.21926/jept.2102030

The Industry 4.0 is here, and advanced technologies are widely available for domains such oil and gas which are traditionally slow in adopting extreme new technologies. This paper presents the design architecture and implementation of effective data acquisition (DAQ) and monitoring system applied to an experimental sucker rod pumping unit for both event occurrence and educational purpose using latest technological advancements and industry 4.0 principles. The designed framework allows control and monitoring of anal [...]

by Kevin T Ong

Received: 15 May 2018;  Published: 03 September 2018;  doi: 10.21926/obm.geriatr.1803011

Amyloid positron emission tomography (PET), fluorodeoxyglucose (FDG) PET, and magnetic resonance imaging (MRI) are three modalities in the imaging of Alzheimer’s disease (AD). This article reviews the experience and data obtained from AD research using these techniques to understand the natural history of AD and to enhance therapeutic trials. It is now realised that their use can improve early detection of AD, and has opened a new corridor which may lead toward successful treatment.

by Maurizio Salvadori  and Aris Tsalouchos

Received: 19 January 2020;  Published: 03 February 2020;  doi: 10.21926/obm.transplant.2001097

Immunosuppressive therapy in renal transplantation is divided into two phases as induction and maintenance therapy. Induction therapy is an intense immunosuppressive therapy administered at the time of kidney transplantation to reduce the risk of acute allograft rejection. In general, induction immunosuppressive strategies utilized by kidney transplant centers fall in one of the two categories. One approach relies upon high doses of conventional immunosuppressive agents, while the other uses antibodies directed aga [...]

by Shehab Mohamed  , Davide Tosi  , Sara Pieropan  , Andrea Cara  , Giovanni Caffarena  , Giorgio Alberto Croci  and Lorenzo Rosso

Received: 01 July 2020;  Published: 21 December 2020;  doi: 10.21926/obm.transplant.2004129

Pulmonary transplantation (LuTx) is established as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, and pulmonary arterial hypertension. Acute rejection and infection are implicated as potential risk factors in developing complications such as bronchiolitis obliterans syndrome (BOS) and chronic rejection, leading to high morbidity and mortality rates after the LuTx. Thus, surveillance procedures after transplanta [...]

by Robert B. Diller  , Robert G. Audet  , Mediha Gurel  , Eric E. Lee  , Aaron J. Tabor  , Peter McFetridge  and Robert S. Kellar

Received: 25 September 2019;  Published: 09 June 2020;  doi: 10.21926/obm.transplant.2002112

Mesenchymal Stromal/Stem Cells (MSCs) were originally discovered in the 1970s. MSCs are considered a multipotent population that retain tri-lineage differentiation. These cells can be sourced from a variety of tissues, including bone marrow, adipose, molar pulp, and birth tissues. Historically varying definitions of MSCs have existed, but in 2006, the International Society for Cellular Therapy (ISCT) set forth a standardized, minimal criteria for MSCs, including plastic adherence, differentiation into osteoblasts, [...]

by Alhayat Getu Temesgen  , Ömer Fırat Turşucular  and Elif Dicle Turşucular

Received: 12 December 2023;  Published: 15 March 2024;  doi: 10.21926/rpm.2401008

This mini-compilation study included the chemical structure, mechanical, thermal, and dimensional properties of silk fiber, its production process, pre-treatment, and biomedical applications from various experimental studies, which are compiled and summarized. The silk fiber should have a degumming process before using biomedical applications. The 25% concentration for Na2CO3 in ethanol solution (80%) as a coagulant chemical with a salt such as LiB2 (9 M) at a temperature of 98°C for 45 minutes at pH between 6 [...]

by Anya Ahmed  , Paula Ormandy  and Maaike L. Seekles

Received: 15 November 2018;  Published: 24 January 2019;  doi: 10.21926/obm.geriatr.1901030

Background: Promoting a good quality of life for the oldest members of society has become a top priority as evidenced in UK policy. The ‘household’ model is a departure from traditional approaches to care provision since it offers person-centred support - combing health and social care - to older people in specially-designed, small, homelike environments. Having gained increasing popularity in care homes across developed countries, the impact of this model of service delivery on residents’ quality of life and its c [...]