by Macyn Leung  , Alexander Pipchuk  and Xiaolong Yang

Received: 11 January 2021;  Published: 24 March 2021;  doi: 10.21926/obm.genet.2101127

PD-L1 is an immune checkpoint protein that is frequently overexpressed by the cells in the tumor microenvironment. PD-L1 binds to PD-1 present on the activated antitumor T-cells, which allows for tumor immune escape. The ability of the PD-1/PD-L1 axis to suppress antitumor immunity enables its application as a potential target for small-molecule-based immunotherapies. Targeting the PD-L1-mediated tumor immune evasion represents a promising approach for immune checkpoint blockade therapies. However, the existing mon [...]

by Oscar Daoura  , Maya Boutros  and Franck Launay

Received: 01 September 2020;  Published: 26 January 2021;  doi: 10.21926/jept.2101007

CO2 reforming of CH4, also referred to as the Dry Reforming of Methane (DRM), is considered an excellent method to produce H2 and CO (syngas), which are known to be used for the production of higher alkanes and oxygenates. Despite nickel’s moderate toxicity, Ni-based heterogeneous catalysts are considered excellent candidates for use in DRM due to their reasonable performances and economic advantages. However, these materials also present severe drawbacks, such as sintering of the active phase and coke (carbo [...]

by Ayub Nor Hanin  , Mat Yunus Abdul Masani  , Ong-Abdullah Janna  , Omar Abdul Rasid  and Ghulam Kadir Ahmad Parveez

Received: 18 December 2024;  Published: 15 April 2025;  doi: 10.21926/obm.genet.2502292

Oil palm is the most productive vegetable oil crop compared to other oil-bearing crops because it produces the highest oil yield per hectare. Palm oil is very versatile since it is used for producing food and beverages, personal care and cosmetics, cleaning products, biofuel, and bioenergy. To cater to the increasing demand in the global palm oil market, much research has been done to improve the oil's yield and modify its quality in addition to the oil palm height through breeding. Due to its long breeding cyc [...]

by Joana Sousa

Received: 05 October 2023;  Published: 29 February 2024;  doi: 10.21926/aeer.2401008

The consistent associations between dampness and health-related problems, such as allergies and asthma symptoms, explain the growing scientific interest in assessing housing characteristics. Due to a growing interest in the built environment, the present study performed a systematic review to investigate the prevalence of dampness related to specific building characteristics. The built environment is gaining significance in population well-being due to the substantial time spent indoors. This aspect is especially n [...]

by Enrico Facco

Received: 04 February 2020;  Published: 08 July 2020;  doi: 10.21926/obm.icm.2003032

The topic of resilience is of paramount importance. Although the term resilience was coined in the fields of physics and engineering, its use has spread to the fields of social sciences, biology, psychology, and psychiatry, as well as to the industry. Moreover, the term is now endowed with a wide range of meanings. The topic of resilience plays a central role in all critical life events. It is of paramount importance in medicine as well as in psychology and psychotherapy, where it is involved in both psychiatric di [...]

by Laura S. Kabiri  , Amanda M. Perkins-Ball  , Cassandra S. Diep  , Uma Kelavkar  and Augusto X. Rodriguez

Received: 17 December 2021;  Published: 15 March 2022;  doi: 10.21926/rpn.2201009

Most children do not meet physical activity guidelines, and school-based programs often fail to increase physical activity levels. However, there has been no intervention pairing college mentors with elementary students to date. The purpose of this paper is to report the feasibility and acceptability, both quantitative and qualitative, of an undergraduate-mentored running program designed to increase physical activity in elementary students. A convergent parallel mixed methods design was used to evaluate the feasib [...]

by Yang Eun Kim  and Boram Lee

Received: 07 March 2024;  Published: 21 May 2024;  doi: 10.21926/obm.neurobiol.2402224

Preschool teachers are at high risk of depression. Therefore, emphasis should be placed on evaluating a valid and reliable instrument to measure depressive symptomatology for this population. One such promising instrument is the Beck Depression Inventory (BDI-II), a 21-item self-report measure designed to assess the presence and severity of depression. Although the tool’s psychometric properties have been analyzed in different samples, they have not been validated with a Korean preschool teacher sample. Hence, this [...]

by Fernando Cabo  and Isaac Aguaristi

Received: 01 September 2019;  Published: 05 March 2020;  doi: 10.21926/obm.icm.2001013

Several manual bodywork therapies that originated in Asia are related to the theory and practice of acupuncture and Traditional Chinese Medicine (TCM). One of the aims of these therapies is to stimulate specific points on the body called acupoints which are the same points in which needles are inserted in acupuncture. These manual therapies, however, vary in their interpretation and explanation of the theories of TCM, and even more so, in the practical way the stimulation is applied. The aim of this paper is to cla [...]

by James Farag  and Silvana Marasco

Received: 13 February 2019;  Published: 08 April 2019;  doi: 10.21926/obm.transplant.1902060

Left ventricular assist devices (LVADs) improve quality of life in end-stage heart failure patients but a frequent complication is Right heart failure (RHF) causing significant morbidity and mortality. This review article discusses key issues that need to be considered in the assessment and clinical management of RHF in LVAD patients including the use of Right Ventricle (RV) support devices and off-label LVADs as temporary or permanent RV support.

by Manal Al-Eid  , Lianhui Ding  , Donya Sewdan  , Emad N. AL-Shafei  , Rasha Al-Ghamdi  , Abdulaziz Alqarawi  and Essa Al naimi

Received: 13 August 2022;  Published: 17 October 2022;  doi: 10.21926/cr.2204035

Parent ZSM-5 and Ga-modified ZSM-5 catalysts with different Si/Al ratios and particle sizes were prepared. The physicochemical properties of the prepared catalysts were investigated by performing X-ray powder diffraction analysis, BET surface area analysis, and NH3-TPD analysis. The performance of the aromatization reaction of the prepared catalysts was evaluated with 1-hexane as a model compound. The zeolite catalysts with a low SiO2/Al2O3 ratio possessed better activity than those with a high SiO2/Al2O3 ratio. Ga [...]