by Andrew G.L. Douglas  and Diana Baralle

Received: 31 December 2020;  Published: 08 March 2021;  doi: 10.21926/obm.genet.2101125

A large proportion of rare disease patients remain undiagnosed and the vast majority of such conditions remain untreatable whether diagnosed or not. RNA splicing analysis is able to increase the diagnostic rate in rare disease by identifying cryptic splicing mutations and can help in interpreting the pathogenicity of genomic variants. Whilst targeted RT-PCR analysis remains a highly sensitive tool for assessing the splicing effects of known variants, RNA-seq can provide a more comprehensive transcriptome-wide analy [...]

by María Izal  , Roberto Nuevo  and Ignacio Montorio

Received: 19 June 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904094

Background: In the last two decades, successful aging (SA) and positive psychology (PP), the two paradigms of health have received great attention. They originate from different approaches, theoretical background, and objectives. Although they share many characteristics, their association remains understudied. This article aims to empirically analyze their possible interrelation. Methods: In this cross-sectional study, 169 healthy, old adults completed several questionnaires to assess the central framework for succ [...]

by Ibrahim Nahit Sendur  , Büsra Köksoy  and Yasemin H. Balaban

Received: 11 November 2024;  Published: 01 April 2025;  doi: 10.21926/obm.transplant.2502244

Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality in solid organ transplant (SOT) recipients. Despite advancements in prophylaxis and antiviral therapy, CMV continues to pose clinical challenges in transplant medicine. This review provides a comprehensive overview of CMV, exploring its pathophysiology, epidemiology, and clinical presentation in SOT patients, in whom CMV infection can lead to direct organ involvement and systemic symptoms. Additionally, CMV has indirect effects, including [...]

by Elisabetta Barbara Cortesi  , Sonia Baccetti  , Maria Valeria Monechi  , Mariella Di Stefano  , Barbara Cucca  , Tommaso Conti  , Antonella Traversi  , Filippa Terranova  , Roberto Montelatici  , Sylvie Yvonne Barberousse  , Federica Sabatini  , Catia Vuono  , Christian Bini  and Marco Picchi

Received: 26 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902028

Introduction: Pain in musculoskeletal disorders is a common problem that involves high social and individual costs. Systematic reviews and randomized controlled trials show that a number of treatments usually applied in this field are not effective. On the other hand, there is clinical evidence of the effectiveness of physical exercise, acupuncture, and auriculotherapy. Side effects of current medication limit their use. Aim: To evaluate the effectiveness of auriculotherapy on the pain of patients suffering from ch [...]

by Natasha Hui Jin Ng  , Wei Xuan Tan  , Ye Xin Koh  and Adrian Kee Keong Teo

Received: 11 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.transplant.1902068

The ability to routinely and reproducibly obtain purified human islets has facilitated substantial progress in providing a safe and reliable treatment option for adult patients of type 1 diabetes. The availability of human islets for basic research has also significantly improved the understanding of the biology of human islets, and consequently the pathophysiology of diabetes. Presently, about 70 human islet isolation centers are known to exist around the world, in addition to multiple coordinated human islet dist [...]

by Ki-Won Jeong  , Jeong Chan Kim  and In-Sung Luke Yeo

Received: 13 August 2020;  Published: 17 December 2020;  doi: 10.21926/rpm.2004024

A connection structure using both a screw and friction is advantageous to secure an abutment to an implant. Understanding the biomechanics of the implant-abutment connection is necessary for the long-term clinical survival of a dental implant with decreased complications. The internal conical friction connection structure and micro-threads have shown favorable biological hard tissue response with exceptional structural features. The internal conical connection structure maintains the soft tissue seal and the margin [...]

by Omar Alelweet  and Sara Pavia

Received: 09 June 2021;  Published: 13 October 2021;  doi: 10.21926/rpm.2104041

Alkali activated (AA) materials have been investigated for decades as an alternative to Portland cement (PC) products. Most consist of a silicate waste activated with alkalis, which leads to lower green-house gas emissions and a substantial drop in the use of unrenewable material resources. This paper studies the durability of AA materials made with a ground granulated blast furnace slag (GGBS) from Dublin, activated with sodium hydroxide (NaOH), and sodium silicate (Na2SiO3), both combined and separately, and cure [...]

by Harry G. Hong

Received: 10 December 2018;  Published: 25 March 2019;  doi: 10.21926/obm.icm.1901019

Background: Electrodermal measurement of acupuncture points has been correlated to physiologic and pathologic conditions with clinical and laboratory studies. Emerging evidence indicates that in addition to therapeutic effect, acupuncture points may also have diagnostic properties. However, physiologic basis of this phenomenon is still unknown. Objective: To determine how electrodermal activity of acupuncture points on hands and feet responds to exercise-induced sympathetic stress and how electrodermal measurement [...]

by Khaliq Ahmed  , Periasamy Vijay  , Moses Tadé  , Amirpiran Amiri  , Zongping Shao  and Karl Föger

Received: 31 July 2020;  Published: 18 January 2021;  doi: 10.21926/jept.2101004

This report is an account of research and development activities undertaken by the Centre for Process Systems Computations, Department of Chemical Engineering at Curtin University, Western Australia in the area of solid oxide fuel cells. The focus of work of the group included 1)effect of cell macrostructure and microstructure on electrochemical performance with a view to optimise both macro- and micro-structure 2) electrochemistry modeling for simulating electrochemical performance 3) internal reforming aspects im [...]

by Zhong Hu  and Haiping Hong

Received: 21 March 2023;  Published: 16 August 2023;  doi: 10.21926/rpm.2303031

The chemically functionalized carbon nanotubes (f-CNTs) and hydrogen bonding modified polymer composites (CPCs) exhibit unique chemical, mechanical, electrical, and thermal properties and are emerging as promising materials to achieve extraordinarily high electrical and thermal conductivity, lightweight and anticorrosion, superior strength and stiffness for potential applications in the aerospace and automotive industries, energy conversion, and optical and electronic devices, therefore, attracting considerable res [...]