by Tatsuya Nogami  , Makoto Arai  and Koh Iwasaki

Received: 12 January 2022;  Published: 28 February 2022;  doi: 10.21926/obm.geriatr.2201191

Several countries have entered the super-aging era. In Japan, the recently reported average life expectancy is approximately 90 years. Kampo medicine (a form of traditional Japanese medicine) is a part of the official medical service in Japan and is widely used for treating various illnesses of older people. However, although general physicians often prescribe Kampo preparations, most Japanese general physicians do not have an intimate understanding of the iatrology of Kampo. Kampo is based on traditional Chinese m [...]

by Caymen M. Novak  , Eric N. Horst  , Shreya Raghavan  and Geeta Mehta

Received: 17 June 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903092

Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, and metastasis, and has been linked to the mechanotransduction of breast cancers. However, it is not currently known if shear stress mediated mechanotransduction is affected by COX-2. Therefore, in this report, we hypothesized that COX-2 m [...]

by Hehe Zhang  , Ruihan Xu  and Shasha Zheng

Received: 03 March 2023;  Published: 28 September 2023;  doi: 10.21926/rpn.2303019

Uric acid (UA) metabolism, which includes uric acid production controlled by purine metabolism and uric acid excretion controlled by the gastrointestinal tract and kidneys, is the primary way to maintain the concentration of uric acid in the body. Abnormal functionalizing of the metabolism may cause hyperuricemia, gout, kidney injury, and other diseases. Over the last decade, numerous studies have been conducted on the effect of natural products, including active ingredients of medicinal plants, natural compounds, [...]

by Amy Anne D. Lassig  , Anna C. Wilson  , Walter N. Jungbauer  , Anne M. Joseph  , Bruce Lindgren  and Rick Odland

Received: 23 June 2023;  Published: 21 November 2023;  doi: 10.21926/rpn.2304021

Vitamin C is an oxidative stress mediator and essential cofactor in wound healing. The objective of this study was to investigate the clinical and biochemical effects of vitamin C supplementation on outcomes in patients undergoing mandibular fracture repair. We also aimed to evaluate the effects of sociodemographic, fracture, and treatment characteristics on post-operative clinical outcomes in these patients. The investigators conducted a double-blind, placebo-controlled, randomized clinical trial at Two Metropolit [...]

by Zsuzsanna M. Schmidt  and Gyula Poor

Received: 07 May 2022;  Published: 27 July 2022;  doi: 10.21926/obm.geriatr.2203202

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical "polymyalgic" musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck. PMR is a member of the so-called giant cell arteritis complex; however, in spite of the marked systemic inflammation in PMR, the local vasculitis process aborts. The pa [...]

by John Old  and Cornelis Harteveld

Received: 03 July 2017;  Published: 14 August 2017;  doi: 10.21926/obm.genet.1703005

Carrier screening for the haemoglobinopathies has undergone many technological improvements in haematological and molecular diagnostic techniques since the first prenatal diagnoses by DNA analysis in the 1970s by Southern blot analysis enabled the implementation of effective successful prevention programmes for beta thalassaemia involving public education, carrier screening, genetic counselling and prenatal diagnosis in Mediterranean countries. The application of a wide variety of PCR-based molecular diagnostic tec [...]

by Jim Anbazu  and Nana Serwaa Antwi

Received: 14 February 2023;  Published: 17 October 2023;  doi: 10.21926/aeer.2304047

Urban heat island (UHI) effects are evident in many cities globally. Studies have revealed that UHI impacts air pollution and vice versa. However, it is observed that these two severe problems are addressed independently instead of interrelatedly. The study seeks to provide an in-depth understanding of the relationship between air pollution and heat and how they constantly shape urban areas for planning and future research purposes. A global shift from sustainable planning practices to building urban resilience exi [...]

by Darren E. Stewart  , Amber R. Wilk  and David K. Klassen

Received: 14 December 2018;  Published: 22 January 2019;  doi: 10.21926/obm.transplant.1901041

Background: This study examines very recent trends in deceased donor kidney transplantation to assess the performance of the kidney allocation system (KAS), implemented December 4, 2014, and whether bolus effects associated with KAS have stabilized nearly four years after implementation. Methods: The overall number of deceased donor kidney transplants, as well as the proportion of transplants by recipient and transplant characteristics, were calculated monthly from December 2013 through September 2018 and examined [...]

by Alice Walton  , Mustafa Faruk Usta  , Melissa Wong  and Wayne Hellstrom

Received: 01 August 2021;  Published: 02 November 2021;  doi: 10.21926/obm.icm.2104042

Metabolic syndrome (MetS) is considered a risk factor for erectile dysfunction (ED), and ED is almost three times more prevalent in men with MetS. Vascular pathologies are a significant factor for the development of ED, and many experts suggest endothelial dysfunction (EnD) as a likely explanation for the association between ED and MetS. Studies also show that corporal vascular and trabecular smooth muscle dysfunction leads ultimately to corporal veno-occlusive dysfunction. Different functional system abnormalities [...]

by Amber Bonnington  , Meisam Amani  and Hamid Ebrahimy

Received: 13 August 2021;  Published: 14 October 2021;  doi: 10.21926/aeer.2104024

Since oil exploration began, oil spills have become a serious problem. When drilling for oil, there is always a risk of an oil spill. With the new development of technology over the years, oil spill detection has become much easier making the clean-up of a spill to happen much faster reducing the risk of a large spread. In this study, remote sensing techniques were used to detect the Deep-water Horizon oil spill through a change detection method. The change detection method allows the viewer to determine the differ [...]