by Pietro Gareri

Received: 28 February 2022;  Published: 19 May 2022;  doi: 10.21926/obm.geriatr.2202198

The omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFAs) family includes eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA). Although seafood is the richest source of omega-3 LC-PUFAs, because diet alone is often insufficient in older people, they may require food supplements and enriched food as sources of omega-3 LC-PUFAs. It has been reported that long-term intake of 3-5 g/d EPA + DHA as supplements is safe for adults; omega-3 LC-PUFAs exert cardio-metabolic pro [...]

by Joep P.M. Geraedts

Received: 15 December 2020;  Published: 28 January 2021;  doi: 10.21926/obm.neurobiol.2101085

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic te [...]

by Erina White  , Farzane Mohseni  and Meisam Amani

Received: 28 August 2021;  Published: 04 November 2021;  doi: 10.21926/aeer.2104028

The vitality of the Great Barrier Reef (GBR) is threatened by many human-made impacts. Monitoring this ecosystem makes it possible to study the general condition and the health of the GBR. However, due to the large extent of the GBR and limited accessibility in the ocean environment, mapping and monitoring this ecosystem has been always challenging task and connived. In this regard, Remote Sensing (RS) is an effective technique that provides valuable information for mapping and monitoring this ecosystem. In an atte [...]

by Hadi Heidari  and Neil S Grigg

Received: 27 May 2021;  Published: 30 August 2021;  doi: 10.21926/aeer.2103021

The coronavirus disease 2019 (COVID-19) is a global crisis spreading to all countries. This study explains and documents the first-order effects of the new coronavirus on the urban water cycle. Urban water systems play an important role in public health because people rely so heavily on water services. Findings address short- and long-term changes in climate variables; availability and accessibility of clean water to prevent and control the spread of coronavirus in water-scarce cities; shifts in habits, behavior, a [...]

by Mahintaj Dara  , Negin Shafieipour  , Mahsa Saffar  , Mehdi Dianatpour  , Seyed-Mohammad-Bagher Tabei  and Seyed-Alireza Dastgheib

Received: 18 November 2024;  Published: 01 April 2025;  doi: 10.21926/obm.genet.2502289

Since the initial discovery of the CRISPR system in bacteria as an adaptive immune system, a deeper understanding of CRISPR structure and function has made it possible to perform gene editing, gene therapy, and revolutionize the diagnostic field. One of the exciting applications of the CRISPR-Cas system is used as a tool for the rapid diagnosis of infectious diseases and their treatment and the prevention of infection spread among people. The CRISPR-based diagnostic system could be the next-generation standard beca [...]

by Namita A. Goyal  and Tahseen Mozaffar

Received: 11 November 2020;  Published: 21 January 2021;  doi: 10.21926/obm.geriatr.2101154

Inclusion body myositis is one of the most common acquired myopathies seen in the aging population. The muscle weakness is of insidious onset, frequently starting in the legs, but over time gradually progresses to eventually involve all skeletal muscles of the limbs, face, swallowing and respiratory muscles, leading to significant morbidity and mortality. Complications resulting from dysphagia are the leading cause of poor quality of life and mortality, while highly prevalent, are still underappreciated and underre [...]

by Christin Deal  , Kara Coffey  and Hey Chong

Received: 02 June 2023;  Published: 04 August 2023;  doi: 10.21926/obm.genet.2303190

Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) has been successfully implemented in all 50 United States and Puerto Rico from 2008-2018. This life-saving screening tool has drastically improved overall survival of babies diagnosed with SCID from 74% to 96%. TREC is a stable, circular DNA molecule that is produced during the process of T-cell receptor (TCR) rearrangement and is the target of the quantitative PCR screen on Guthrie cards. Low TRECs are a marker of low naive T cell numbers. This ne [...]

by Mathivathani Kandiah  , Dharsha Bhaskaran  and Ominda Perera

Received: 29 April 2024;  Published: 22 July 2024;  doi: 10.21926/cr.2403010

Nanotechnology is a fast-rising market in catalytic research; however, the production of eco-friendly nanoparticles remains a significant challenge. In this study, silver nanoparticles (AgNPs) were synthesized from the agro-industrial waste of leaves of C. longa, C. aromatica, C. caesia, C. zedoaria, and C. amada at RT after 24 h, which was confirmed with UV-spectrophotometric evaluation between 320-520 nm. SEM revealed cubic and 30-50 nm AgNPs, while band-gap energy was presented as semi-conductors. Synthesized Ag [...]

by Cheng Siew Goh  , Jia Ning Ting  and Arun Bajracharya

Received: 31 May 2022;  Published: 17 January 2023;  doi: 10.21926/aeer.2301010

Following the establishment of the United Nations’ Sustainable Development Goals, sustainability has been given increasing attention in the agenda of the built environment. Sustainability embraces three key elements, i.e., environment, economy and society. However, the social dimension receives the least attention and is largely overlooked compared to the environmental and economic sustainability. To bridge the gap, this paper will examine the various dimensions of social sustainability involved in the built enviro [...]

by Hehe Zhang  , Ruihan Xu  and Shasha Zheng

Received: 03 March 2023;  Published: 28 September 2023;  doi: 10.21926/rpn.2303019

Uric acid (UA) metabolism, which includes uric acid production controlled by purine metabolism and uric acid excretion controlled by the gastrointestinal tract and kidneys, is the primary way to maintain the concentration of uric acid in the body. Abnormal functionalizing of the metabolism may cause hyperuricemia, gout, kidney injury, and other diseases. Over the last decade, numerous studies have been conducted on the effect of natural products, including active ingredients of medicinal plants, natural compounds, [...]