by Oluwafemi G. Oluwole

Received: 25 April 2024;  Published: 06 December 2024;  doi: 10.21926/obm.genet.2404273

Precision medicine describes the definition of disease at a higher resolution by genomic and other technologies to enable more precise targeting of disease subgroups with new therapies. Preventative or therapeutic interventions can be developed with the knowledge of how a compound acts safely in the body to target receptors and produce the desirable effect. With the completion of the Human Genome Project in 2003 and the rapid increase in sequencing and bioinformatics tools, obtaining information about a person's ge [...]

by Melisa S. Romano  , Valeria Corne  , Ricardo R. Azario  , Emiliano Centurión  and María del Carmen García

Received: 24 October 2024;  Published: 10 January 2025;  doi: 10.21926/rpm.2501002

Lead is a non-biodegradable toxic heavy metal. Biosorption is a simple, cost-effective and eco-friendly method for remediating lead-contaminated environments. Additionally, rice husk is a highly available residual biomass that can be used as a biosorbent. This study aimed to analyze the biosorption of Pb2+ using both natural and chemically treated rice husk and to evaluate the incorporation of the resulting biomass-contaminant residue into ceramic matrices to immobilize the removed Pb2+. Natural and alkaline-activa [...]

by David F. Bayne  , Willow Keefe  and Samantha E. Shune

Received: 01 July 2024;  Published: 28 September 2024;  doi: 10.21926/obm.geriatr.2403289

Informal caregivers play a critical role in supporting individuals with dementia, yet often face significant challenges that impact their own quality of life (QoL). This exploratory study investigates the multifaceted factors contributing to caregiver QoL, particularly focusing on care recipient factors including dysphagia, dietary restriction, dementia severity, and care recipient QoL. A total of 24 informal caregivers of persons with dementia (PWD) participated in an online survey assessing various factors believ [...]

by Faezeh Kouhakan  , Sepideh Ganjalikhan  , Alireza Sarhadizadeh  , Khadijeh Esmaeilpour  , Khatereh Akbari  , Leila Jafaripour  and Majid Asadi-Shekaari

Received: 26 December 2023;  Published: 23 April 2024;  doi: 10.21926/obm.neurobiol.2402218

Oleuropein (OP) is a phenolic compound in olives. OP possesses potent antioxidant activity and an extensive spectrum of other pharmacological properties, including antiviral, anti-inflammatory, and antimicrobial activities. This study investigated the effects of OP on neural injuries caused by bile duct ligation (BDL) in male mice. The mice were randomly allocated to three groups: sham, BDL, and BDL + OP. Neurobehavioral tests histological and biochemical evaluations were accomplished to assess cerebral damage. The [...]

by Michael Falkenstein  and Ute Brüne-Cohrs

Received: 03 April 2023;  Published: 04 April 2023;  doi: 10.21926/obm.geriatr.2302232

EditorialDriving Safety in Healthy Aging and Age-Related DiseasesMichael Falkenstein *, Ute Brüne-CohrsALA Institute, 44805 Bochum, Germany; E-Mails: falkenstein@ala-institut.de; Ute.Bruene-Cohrs@ruhr-uni-bochum.de * Correspondence: Michael Falkenstein; E-Mail: falkenstein@ala-institut.deSpecial Issue: Driving Safety in Healthy Aging and Age-Related DiseasesOBM Geriatrics 2023, volume 7, issue 2 doi:10.21926/obm.geriatr.2302232Received: April 03, 2023Accepted: April 03, 2023Published: April 04, 2023

by Pamela Whitaker

Received: 07 June 2024;  Published: 25 September 2024;  doi: 10.21926/obm.icm.2403056

This concept paper is proposing the inclusion of the home studio as an art making location for art therapy trainees who assemble personal belongings, within the context of their domestic lives. A collection of belongings can become an installation which brings together associations to identities in juxtaposition. The material culture of art therapy trainees, the objects which they live by, is a new contribution to art therapy pedagogy, as it designates the art of personal collections as a life archive (or accumulat [...]

by OBM Geriatrics Editorial Office

Received: 04 January 2023;  Published: 04 January 2023;  doi: 10.21926/obm.geriatr.2301221

The editors of OBM Geriatrics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2022. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition dire [...]

by Masahiro Sato  , Emi Inada  , Satoshi Watanabe  , Issei Saitoh  , Naoko Kubota  , Yoko Iwase  , Kazunori Morohoshi  and Shingo Nakamura

Received: 31 August 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504317

An episomal vector is a plasmid- or virus-based vector that is present extrachromosomally in cells after transfection. Although it disappears during cell proliferation, it can exist in non-dividing cells, such as neuronal and muscular cells, and continues to express a gene of interest (GOI). Such episomal vectors are usually based on sequences from DNA viruses such as bovine papillomavirus 1 and Epstein-Barr virus. When cells are transfected with an episomal vector harboring a drug-resistance gene and subsequently [...]

by A. Isabella Shanker  , Lauren T. Maloney  and Julia M. Boster

Received: 23 September 2024;  Published: 10 January 2025;  doi: 10.21926/obm.transplant.2501230

Infection is a leading cause of short-term morbidity and mortality in pediatric patients after liver transplant (LT). Diagnosing infection in this population can be challenging, requiring consideration of laboratory results and clinical context. The prevalence and significance of post-operative leukocytosis has not yet been explored in children after LT. Our goals were to characterize post-transplant leukocytosis in pediatric patients after LT for biliary atresia (BA) and evaluate the relationship between post-LT l [...]

by Fatemeh Mollaamin  , Majid Monajjemi  and Ahmad R. Alsayed

Received: 22 February 2024;  Published: 19 June 2024;  doi: 10.21926/obm.genet.2402245

The potential and selective inhibitors of protein tyrosine phosphatase 1B (PTP1B) are therapeutically useful in treating type 2 diabetes. N-Benzoyl-L-glutamyl-[4-phosphono(difluoromethyl)]-L-phenylalanine-[4-phosphono(difluoro-methyl)]-L-phenylalanineamide (BzN-EJJ-amide) (BGD) which is the ligand of 1LQF protein code extracted from protein data bank (PDB) is an inhibitor of PTP-1B that indicates selectivity over several protein tyrosine phosphatases. In this research, the interaction between the anti-diabetic drug [...]