by Marcel Tomaszewski  and Philip Wong

Received: 22 August 2018;  Published: 03 January 2019;  doi: 10.21926/obm.hg.1901013

There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has a significant negative effect upon quality of life and functional independence. Frailty, commonly encountered in geriatric patients, remains a significant negative predictor of physical, psychological, functional and survival outcomes in chronic liver disease. Despite advances in [...]

by OBM Hepatology and Gastroenterology

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.hg.2101054

The editors of OBM Hepatology and Gastroenterology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificat [...]

by Mojtaba Ehsanifar  , Akram Gholami  and Joseph P Reiss

Received: 13 June 2025;  Published: 21 October 2025;  doi: 10.21926/obm.neurobiol.2504305

Evidence from recent studies has suggested a significant association between mycotoxin exposure and neuroinflammation, potentially contributing to the onset of neurocognitive disorders during key developmental stages of the brain. Various research highlights how exposure to these toxins is correlated with a decline in cognitive performance, reduced motor skills, and behavioral issues. Mycotoxins are also implicated in interfering with neuronal signaling pathways and the functioning of neurotransmitters, which may l [...]

by Zongqi Guo  and Wenxu Wei

Received: 12 January 2024;  Published: 12 April 2024;  doi: 10.21926/rpm.2402010

Ceramic bonds are conventionally formed during the burning of refractory bricks and by using pre-fabricated blocks or monolithic lining, which is characterized as the coalescence of the particles by liquid sintering. However, the whisker bond was discovered with the outstanding performance of unburnt periclase–spinel–Al bricks while substituting magnesia–chrome bricks in the chromium-free campaign of refractory lining of RH degassers. Thanks to the prominent effect of the whisker bond, such a refr [...]

by José A. Cedeño-Escudero  , Luis A. Sotillo-Bent  , Carolina Vega- Cuellar  , Rolando González-Angulo  , Evelyn Medina-Batista  , José Sotillo-Lindo  and Luis A. Méndez-Rosado

Received: 13 August 2024;  Published: 12 October 2024;  doi: 10.21926/obm.genet.2404266

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy, affecting approximately 1 in 500 people. It is the most common genetic cardiomyopathy inherited as a Mendelian trait in approximately 50% of patients, mainly due to pathogenic variants in genes encoding sarcomeric proteins. Mutations in the sarcomeric protein filamin C (FLNC) gene, with a cytogenetic localization on 7q32.1, have been linked to hypertrophic cardiomyopathy, as they have been determined to increase the risk of ventricular a [...]

by Varrassi Giustino

Received: 01 February 2024;  Published: 02 February 2024;  doi: 10.21926/obm.neurobiol.2401210

Neurobiology is an expansive field of studies encompassing the nervous system's anatomical and physiological aspects [1]. This complex framework's deep study and understanding have facilitated a more intricate comprehension of the interconnections among various nervous system components implicated in pain perception, transmission, modulation, and adaptation.

by Fatimazahra Smaili  , Khawla Zerrouki  , Fatima Ezzahra Aouni  , Ayad Ghanam  , Maria Rkain  , Abdeladim Babakhouya  and Mariam Tajir

Received: 04 October 2024;  Published: 04 February 2025;  doi: 10.21926/obm.genet.2501283

Dystrophinopathies are genetic muscular disorders with recessive inheritance linked to the X chromosome due to mutations in the dystrophin gene, the DMD gene located in Xp21. The best-known forms are Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Our study aims to determine the molecular profile and genotype/phenotype correlations of dystrophinopathies in the eastern region of Morocco. We report patients referred for 4 years (2020-2023) to the Medical Genetics Laboratory of the Mohammed VI U [...]

by Jose Benavides  , Pushpesh Sharma  , Ahmed Al Saedi  and Shah Kabir

Received: 20 November 2023;  Published: 21 February 2024;  doi: 10.21926/jept.2401007

This article outlines an innovative approach to explore thermal energy extraction for power generation or industrial hot water applications. Unlike traditional steady-state models, this approach embraces time-variant scenarios, explicitly incorporating a cyclical fluid circulation strategy to maintain a stable surface fluid temperature or power output. By introducing an increasing and decreasing stepwise rate sequence and an intermittent circulation strategy, the method aims to optimize efficiency in response to va [...]

by Tracie D. Parkinson  and Stephen D. Smith

Received: 11 March 2025;  Published: 23 September 2025;  doi: 10.21926/obm.icm.2503039

Hatha yoga is a common style of yoga used for physical, emotional, mental, and spiritual benefits, enhancing quality of life and well-being. The current study used a randomized control trial (RCT) to investigate whether completing an eight-week posture-based Hatha yoga program would lead to greater psychological benefits than taking part in an eight-week lecture series about the history and philosophy of yoga. Fifty-five participants (42 female, age range 18-32) completed five self-report measures both before and a [...]

by Abubakar Siddiq Salihu  , Wan Mohd Nuzul Hakimi Wan Salleh  , Nurunajah Ab Ghani  , Mohd Hafiz Arzmi  , Bunleu Sungthong  and Ravikumar Kapavarapu

Received: 05 March 2025;  Published: 27 April 2025;  doi: 10.21926/obm.neurobiol.2502286

The Myristicaceae family, particularly the Knema genus, is renowned for its diverse bioactive compounds, including lignans, flavonoids, and phenolics. This study explores the phytochemical profile of Knema hookeriana Warb. leaves and evaluates their potential as acetylcholinesterase (AChE) inhibitors. Phytochemical extraction was performed using a cold maceration method with a polarity-gradient solvent system (hexane, ethyl acetate, and methanol). The isolated compounds were purified through chromatographic techniq [...]