by Kazuki Mochizuki  , Ayumi Osaki  , Yuko Inamochi  and Toshinao Goda

Received: 18 December 2017;  Published: 30 October 2018;  doi: 10.21926/obm.genet.1804046

Background: Histone modifications, including acetylation and H3 lysine 4 (K4) methylation, are thought to be associated with transcriptional activation during differentiation. Methods: mRNA and histone modifications around the sucrase-isomaltase (SI) gene in Caco-2 cells (a small intestine cell line) during differentiation were determined by qRT-PCR and chromatin immunoprecipitation, respectively. Results: Mono-, di-, and tri-methylation of histone H3K4 on the SI gene correlated with the induction of SI gene expres [...]

by Shalika B. Katugaha  , Amit K. Mahajan  , Meg Fregoso  , Haresh Mani  and Oksana A. Shlobin

Received: 25 October 2020;  Published: 03 July 2021;  doi: 10.21926/obm.transplant.2103147

A 65-year-old female with a history of right lung transplantation (LTx) for chronic obstructive pulmonary disease (COPD) 9-years prior complicated by grade 3 bronchiolitis obliterans syndrome (BOS) was admitted to the hospital for chest pain and dyspnea on exertion (DOE). Her bronchoscopy revealed fluffy, endobronchial lesions that were adherent to the right sided anastomosis resulting in mild obstruction of the right mainstem bronchus. Pathology from biopsies of the endobronchial lesions revealed hyphal fungal org [...]

by Gretchen Stepanovich  and Steven M. Donn

Received: 19 April 2021;  Published: 13 August 2021;  doi: 10.21926/obm.hg.2103060

Infants admitted to Neonatal Intensive Care Units (NICUs) are among the most vulnerable patients in medicine and are at risk for a variety of morbidities, many of which require pharmacologic therapy. Gastroesophageal Reflux Disease (GERD) is a common diagnosis in the NICU patient population and may or may not represent a truly pathologic process. Regardless, pharmacologic therapy is provided to many infants, who are already exposed to an inordinate number of pharmacologic agents, of which most are off label and hav [...]

by Hermann Moisl

Received: 28 August 2022;  Published: 01 February 2023;  doi: 10.21926/obm.neurobiol.2301152

Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account of the distance structure preservation that underlies the proposed mechanism of intrinsic intentionality. The three-layer autoassociative multilayer perceptron (aMLP) [...]

by Abdel Zaro  , Spencer Jones  and Ethan Languri

Received: 31 August 2023;  Published: 16 November 2023;  doi: 10.21926/jept.2304035

In this paper, an efficient industrial wastewater and leachate evaporation method is proposed and tested experimentally. The goal of this study is to investigate whether the addition of a carbon foam (CF) porous layer can lead to energy savings by evaporating more water mass per unit of energy input. The standard boiling evaporator layout was redesigned by placing the heating element in the upper region of the tank and CF underneath the heat source. The CF purposed to localize the energy in an area by the water' [...]

by Daniel Thiel

Received: 21 February 2023;  Published: 15 May 2023;  doi: 10.21926/aeer.2302031

This research aims to model and compare two strategies for locating new hydrogen refueling stations (HRS) in a context of high uncertainty on H2 demand and on the spatial distribution of demand points. The first strategy S1 represented by an agent-based model integrating a particle swarm optimization metaheuristic consists of finding the best HRS locations by adapting to the real evolution of the demand. A second strategy S2 consists in solving a classical capacitated p-median problem based on H2 consumption foreca [...]

by Damiana Scuteri  , Paolo Tonin  , Maria Tiziana Corasaniti  and Giacinto Bagetta

Received: 05 July 2022;  Published: 14 September 2022;  doi: 10.21926/obm.neurobiol.2203133

Alzheimer’s disease (AD) accounts for 50–70% of cases of dementia worldwide and is a social burden to the affected population. Although several pathogenetic hypotheses have been proposed, evidence favoring the role of aberrant neuroplasticity in the development of the neuropsychiatric symptoms associated with dementia is increasing. Specifically, agitation is resistant to treatment and affects the quality of life, also because of the lack of safe and effective treatment for AD. Alterations in pain processing due to [...]

by Joana Sousa

Received: 10 March 2022;  Published: 24 August 2022;  doi: 10.21926/rpm.2203015

Exposure to indoor pollutants may exert a significant effect on children health as they spend most of their time in enclosed environments. This research compared the association of biological concentrations with indoor characteristics and building materials in places where children spend significant time indoors. It was compared the results of two autonomous research projects conducted in Porto primary schools and households. Both the projects included a walkthrough inspection and biological measurements in indoor [...]

by Cynthia M.A. Geppert  and Ronald W. Pies

Received: 01 March 2019;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901016

Compassion in Clinical Care

by Upasana Ramphal  , Derek Tshiabuila  , Yajna Ramphal  , Jennifer Giandhari  , Carel van Heerden  , Cheryl Baxter  , Stephanie van Wyk  , Sureshnee Pillay  , Oluwakemi Laguda-Akingba  , Eduan Wilkinson  , Richard Lessells  and Tulio de Oliveira

Received: 01 March 2024;  Published: 30 May 2024;  doi: 10.21926/obm.genet.2402239

During the SARS-CoV-2 pandemic, next-generation sequencing (NGS) technologies like the Ion Torrent S5 and Illumina MiSeq, alongside advanced software, improved genomic surveillance in South Africa. This study analysed anonymized samples from the Eastern Cape using Genome Detective and NextClade, showing Ion Torrent S5 and Illumina MiSeq success rates of 96% and 94%, respectively. The study focused on genomic coverage (above 80%) and mutation detection (below 100), with the Ion Torrent S5 achieving 99% coverage comp [...]