by Yasuhiro Kotera  , Jenai Lieu  , Hou Tin Gillian Liu  , Christian Veasey  and Kristian Barnes

Received: 09 January 2024;  Published: 27 June 2024;  doi: 10.21926/obm.icm.2402036

Yozan Uesugi was a Daimyo (feudal lord) who governed an area called Yonezawa in Yamagata Prefecture, Japan from 1767 to 1823. Yonezawa was originally an impoverished provincial government which under his leadership regained a healthy financial status. His leadership style was unique among Daimyos, yet respected and regarded as an ideal by many including President John F. Kennedy. One of the characteristics of Yozan’s leadership was he demonstrated what he expected his people to do, instead of just telling them what [...]

by Mahintaj Dara  , Zahra Karimi  , Mehdi Dianatpour  and Hadi Aligholi

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

by Vanessa G. Oliveira  , Ana Filipa Saraiva  , Fátima Costa  and Aida Botelho de Sousa

Received: 27 February 2019;  Published: 24 September 2019;  doi: 10.21926/obm.transplant.1903086

Nowadays, hematopoietic stem cell transplantation (HSCT) is a common procedure in hematology units within reference centers, mainly for the treatment of hematological malignancies such as multiple myeloma, lymphoma, and acute leukemia. Nevertheless, HSCT has much wider applications, namely in autoimmune diseases, congenital metabolic defects, and hemoglobinopathies. Thalassemia major and sickle cell disease make up the most frequent hereditary hemoglobinopathies worldwide. Despite advances on the prevention and tre [...]

by Gerhard Litscher

Received: 18 September 2022;  Published: 19 September 2022;  doi: 10.21926/obm.icm.2203042

This editorial briefly discusses the issue of potential toxicity in the case of long-term photobiomodulation (PBM). Scientific articles from PubMed, Google Scholar, and the China National Knowledge Infrastructure were included in a heterogeneous search. There have been very few studies on the long-term effects of PBM, as well as its potential toxicity. There is no evidence that PBM is toxic when used at therapeutic or imaging doses. There are no such concerns with intracranial PBM application (e.g., optical fiber) [...]

by Angela Cheng  , Xanthe Lea  and Alice Shires

Received: 13 March 2025;  Published: 23 June 2025;  doi: 10.21926/obm.icm.2502026

This study aims to investigate the barriers and facilitators to meditation in the general population. This research is significant because understanding these factors can inform the design of more effective public mental health interventions and support the integration of meditation into daily life. A qualitative thematic analysis was conducted on the qualitative component of wider survey responses. Participants were recruited from MeditationHQ, which offers weekly group meditation sessions on beaches around Austra [...]

by Steven R. Potter

Received: 10 February 2020;  Published: 13 February 2020;  doi: 10.21926/obm.transplant.2001100

by Nicolas A. Ishiki  , Maria L. Della-Costa  , Beatriz Keller  , Kleper O. Rocha  , Francielle Bortoloti  and Antonio C. D. Ângelo

Received: 04 September 2023;  Published: 16 November 2023;  doi: 10.21926/cr.2304027

This paper investigates how the aggregation of bimetallic nanoparticles (NPs) influences the electronic condition of the surface adsorption site and, hence, the performance of materials during the electrooxidation of fuels in an alkaline medium. First, we synthesized Pt-Ni NPs in three configurations: ordered intermetallic, ordinary alloy, and core-shell. The NPs contained Pt and Ni close to a 1:1 Pt/Ni atomic ratio. They had similar particle sizes, which allowed us to evaluate their performance without the influen [...]

by James David Adams

Received: 25 February 2019;  Published: 27 February 2019;  doi: 10.21926/obm.icm.1901014

The nervous system is everywhere in the body, especially in the skin. Ancient Chinese acupuncture charts show us that the nerves are all connected and can work together to promote health. This connection occurs through the brain and brain stem. It is clear that acupuncture is analgesic by inhibition of transient receptor potential cation channels in the skin [1]. The role of chemokines in pain is becoming understood. Chemokines promote pain in the skin and activate ascending neural pathways that regulate chemo [...]

by Mariette Kokolo  and Montse Bach-Elias

Received: 25 June 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004118

Non-coding RNAs (ncRNAs) have emerged as one of the most abundant regulatory molecules. However, their roles and functions are significantly different from those of proteins. Moreover, around 95% of the human genome contains non-coding DNA. ncRNAs contribute by far the majority of human transcriptional units, and the functions of the most are yet unknown. Here, we highlight that an important RNA sequence region, encompassing an exon-intron hairpin loop (also called IDX-rasISS1), of the H-Ras pre-mRNA may encode an [...]

by Steven K. H. Aung

Received: 02 May 2017;  Published: 20 July 2017;  doi: 10.21926/obm.icm.1703003

Spirituality may be generally conceptualized as the precious, personal path of our apparently soulful vital energy within the context of the power of our compassionate consciousness. The body, mind and spirit encompasses a constantly inspiring vital energetic field that must be in diligent interaction and harmony in the interest of past, present and future generations. In the clinical application of the healing arts and sciences, as physicians or other dedicated health care providers of whatever nation, race, cultu [...]