by Abhijit Jagdale  , C. Adam Banks  , Hayato Iwase  , David K.C. Cooper  and Hidetaka Hara

Received: 29 December 2020;  Published: 30 June 2021;  doi: 10.21926/obm.transplant.2102146

It has been speculated that the immunomodulation associated with pregnancy, e.g., decreasing pro-inflammatory cytokines, increasing anti-inflammatory cytokines, upregulation of T regulatory cells (Tregs), is in part due to the effect of human chorionic gonadotropin (hCG). In this study, we tested the effect of hCG on proliferation of human peripheral blood mononuclear cells (PBMCs) stimulated by irradiated pig PBMCs. Mixed lymphocyte reaction (MLR) was carried out with human PBMCs as responders and irradiated wild- [...]

by Gabriel de Bem  , Marlon Mülhbauer  , Pablo La Roche  , André Matias  , Ricardo Almeida  and Eduardo Krüger

Received: 30 May 2022;  Published: 29 September 2022;  doi: 10.21926/aeer.2203038

This study evaluates three shading configurations designed and tested in a preliminary stage of responsive shading device development. The strategy is based on trigonometric relationships focused on solar angles at any given moment. The configurations are thus related to the ratio of the window area shaded by a responsive brise-soleil that provides 0%, 50%, or 100% shading of the indoor space, based on the daylight needs and the indoor thermal control realized. Shading simulations were performed for Pomona, Califor [...]

by Annette Siakamba  , Mehdi Seraj  and Huseyin Ozdeser

Received: 20 June 2024;  Published: 01 January 2025;  doi: 10.21926/aeer.2501001

Over the years, energy poverty has been seen as a major struggle in Zimbabwe and globally. This paper tries to find the relationship between energy poverty and environmental change. Ecological footprint represents a degradation in this paper. The findings showed an insignificant relationship between renewable energy and ecological footprint in Zimbabwe. This study employs the ARDL technique. This study employs time series data from 1990-2021. This study uses the ARDL framework to get robust results. The ARDL bound [...]

by Enrico Capobianco

Received: 15 June 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004077

Marks of brain disorders may be visible through abnormal networks characterized by states with distinct signatures or connectivity patterns. Apart from neurodegenerations, drug abuse or eventually addiction may exert complex perturbative effects over human health, including damage to various organs and especially brain inflammation, volume shrinkage and functional deficits. These can also be regarded as signs of accelerated ageing, which involve multiple comorbidities associated with long-lasting cognitive impairme [...]

by Katie Conlon

Received: 04 September 2023;  Published: 04 January 2024;  doi: 10.21926/aeer.2401002

Unsustainable material extraction, use and disposal - the ‘take-make-waste’ model - places communities globally in a state of social inequalities and environmental conflict (the slow violence of polluting the air, water, and soil we all depend). Current waste management practices are designed for efficiency of disposal but do not address increasing waste generation and waste externalities. The present global waste situation is magnified by exponential increases in plastic production; misconceptions of recycling; an [...]

by Christopher Lam

Received: 25 April 2019;  Published: 08 July 2019;  doi: 10.21926/obm.icm.1903044

Compassion and kindness can be cultivated and enhanced. Over the years in medical practice I have witnessed many healthcare workers, after having worked with kind and caring practitioners, become progressively more humane. Those of us who are teachers need to be mindful of that. In educating new physicians, compassion should play a central role and we as practicing doctors are well placed to model a caring and empathetic approach to our patients. There is also a fundamental need to look after ourselves and main [...]

by Shaymaa Azawi  , Lisa-Marie Barf  , Thomas Liehr  , Stefanie Kankel  and Martina Rincic

Received: 25 March 2022;  Published: 27 June 2022;  doi: 10.21926/obm.genet.2202159

After being established in 1967, the commercially available murine Leydig cell tumor line I-10 has been used in almost 50 published studies. I-10 has not been characterized, either at the chromosomal/ cytogenetic level or the genetic level, similar to many other murine tumor cell lines. In this study, we performed molecular karyotyping and multicolor banding-based molecular cytogenetics. A slightly hyperdiploid karyotype with 43 chromosomes was described. The main aberrations comprised several unbalanced translocat [...]

by Kurt Grüngreiff  , Thomas Gottstein  and Dirk Reinhold

Received: 15 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.hg.1902023

Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connective tissue (scar tissue) as a consequence of chronic liver damage, is a connecting pathogenic process in all chronic liver diseases. Zinc is an essential micronutrient in human health, playing a fundamental role in cellu [...]

by Joni Indah Sari  , Nydia Rena Benita Sihombing  , Nani Maharani  , Tri Indah Winarni  and Agustini Utari

Received: 30 December 2024;  Published: 14 February 2025;  doi: 10.21926/obm.genet.2501285

DiGeorge syndrome (DGS) or 22q11.2 deletion syndrome (22q11.2DS) is the most common genetic microdeletion in humans, with an incidence rate of 1:3000 to 6000 live births. Early detection and diagnosis of DiGeorge syndrome are challenging to clinicians due to its phenotype variability. We report two cases of DiGeorge syndrome, each demonstrating a different combination of clinical phenotypes. Two girls (2 years-3 months old and 2 years-2 months old) were diagnosed with 22q11.2DS following chromosomal microarray anal [...]

by Kazuyuki Suzuki  , Akinobu Kato  and Yasuhiro Takikawa

Received: 04 February 2019;  Published: 16 July 2019;  doi: 10.21926/obm.hg.1903027

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minimal HE and is identified solely through psychometric or neurological tests, and overt HE (coma grade II-IV). Although recent therapies based on evidence-based results have improved the therapeutic outcomes of HE patients, [...]